HIV感染合并骨梗死的MRI动态观察
|
摘要
目的:探讨高效联合抗逆转录病毒疗法(HAART)治疗时间与骨梗死面积的相关性。方法:回顾性分析16例行HAART治疗9～32个月的HIV感染患者骨梗死MRI资料,统计分析HAART治疗时间与骨梗死的相关性。结果:16例骨梗死均发生在股骨下段、胫骨上段;均呈双侧股骨下段、胫骨上段对称性发生;均呈多发类椭圆形地图板块样改变,边界清楚,9例见双边征。随着HAART治疗时间的增加,16例骨梗死面积进行性扩大,两者呈正相关(P<0.05)。结论:HIV感染合并骨梗死的面积与HAART治疗时间呈正相关。
Objective:16 patients with HIV combined with bone infarction were followed up to explore the correlation between HAART therapy and bone infarction. Methods:MRI data of 16 HIV-infected patients with bone infarction treated with HAART for 9 to 32 months were retrospectively analyzed. The correlation between the duration of HAART treatment and bone infarction was analyzed. Results:16 cases of bone infarction occurred in the lower femur and upper tibia. 16 cases of bone infarction all showed the symmetry of the lower femur and the upper tibia. The imaging manifestations of 16 cases of bone infarction were as follows:multiple oval-like map plate-like changes,clear boundary,and "bilateral sign". Follow-up observation showed that with the prolongation of HAART treatment course,the range of bone infarction was progressively expanded in 16 patients. Statistical analysis showed that 16 cases were positively correlated with the course of HAART treatment(P< 0.05). Conclusions:The progression of bone infarction of HIV-infected patients is positively correlated with the course of HAART treatment.
Objective:16 patients with HIV combined with bone infarction were followed up to explore the correlation between HAART therapy and bone infarction. Methods:MRI data of 16 HIV-infected patients with bone infarction treated with HAART for 9 to 32 months were retrospectively analyzed. The correlation between the duration of HAART treatment and bone infarction was analyzed. Results:16 cases of bone infarction occurred in the lower femur and upper tibia. 16 cases of bone infarction all showed the symmetry of the lower femur and the upper tibia. The imaging manifestations of 16 cases of bone infarction were as follows:multiple oval-like map plate-like changes,clear boundary,and "bilateral sign". Follow-up observation showed that with the prolongation of HAART treatment course,the range of bone infarction was progressively expanded in 16 patients. Statistical analysis showed that 16 cases were positively correlated with the course of HAART treatment(P< 0.05). Conclusions:The progression of bone infarction of HIV-infected patients is positively correlated with the course of HAART treatment.
引文
[1]柳忠泉,宁铁林,夏建晖,等.天津市2005-2009年抗艾滋病病毒治疗效果分析[J].中国预防医学杂志,2011,12(2):158-160.
[2]谢桂芳,黎小平,潘玉勤.高效抗反转录病毒疗法治疗艾滋病效果分析[J].右江民族医学院学报,2013,35(3):292-293.
[3]方庆明,徐志伟,雷杰华.骨梗死X线与低场MRI表现分析对比[J].现代医用影像学,2017,26(5):1288-1292.
[4]苏仲生,蔡琳,王明,等.骨梗死影像学表现与鉴别诊断[J].临床骨科杂志,2017,20(3):325-328.
[5]董进,韩瑞,张东友,等. 3.0T磁共振成像技术对膝关节骨梗死的诊断价值[J].医学临床研究,2016,33(9):1671-1673.
[6] Kanthawang T,Pattamapaspong N,Louthrenoo W. Acute bone infarction:a rare complication in thalassemia[J]. Skeletal Radiol,2016,45:1013-1016.
[7] Zurlo JV. The double-line sign[J]. Radiology,1999,212:541-542.
[8] Robert W,Jordan,Prasad Aparajit,et al. The importance of early diagnosis in spontaneous osteonecrosis of the knee-A case series with six year follow-up[J]. Knee,2016,23:702-707.
[9] Yamagami R,Taketomi S,Inui H,et al. The role of medial meniscus posterior root tear and proximal tibial morphology in the development of spontaneous osteonecrosis and osteoarthritis of the knee[J]. Knee,2017,24:390-395.
[10] Mazzotta E,Agostinone A,Rosso R,et al. Osteonecrosis in human immunodeficiency virus(HIV)-infected patients:a multicentric case-control study[J]. J Bone Miner Metab,2011,29:383-388.
[11] Patel N,Patel N,Espinoza LR. HIV infection and rheumatic diseases:The changing spectrum of clinical enigma[J]. Rheumatic Disease Clinics of North America,2009,35:139-161.
[2]谢桂芳,黎小平,潘玉勤.高效抗反转录病毒疗法治疗艾滋病效果分析[J].右江民族医学院学报,2013,35(3):292-293.
[3]方庆明,徐志伟,雷杰华.骨梗死X线与低场MRI表现分析对比[J].现代医用影像学,2017,26(5):1288-1292.
[4]苏仲生,蔡琳,王明,等.骨梗死影像学表现与鉴别诊断[J].临床骨科杂志,2017,20(3):325-328.
[5]董进,韩瑞,张东友,等. 3.0T磁共振成像技术对膝关节骨梗死的诊断价值[J].医学临床研究,2016,33(9):1671-1673.
[6] Kanthawang T,Pattamapaspong N,Louthrenoo W. Acute bone infarction:a rare complication in thalassemia[J]. Skeletal Radiol,2016,45:1013-1016.
[7] Zurlo JV. The double-line sign[J]. Radiology,1999,212:541-542.
[8] Robert W,Jordan,Prasad Aparajit,et al. The importance of early diagnosis in spontaneous osteonecrosis of the knee-A case series with six year follow-up[J]. Knee,2016,23:702-707.
[9] Yamagami R,Taketomi S,Inui H,et al. The role of medial meniscus posterior root tear and proximal tibial morphology in the development of spontaneous osteonecrosis and osteoarthritis of the knee[J]. Knee,2017,24:390-395.
[10] Mazzotta E,Agostinone A,Rosso R,et al. Osteonecrosis in human immunodeficiency virus(HIV)-infected patients:a multicentric case-control study[J]. J Bone Miner Metab,2011,29:383-388.
[11] Patel N,Patel N,Espinoza LR. HIV infection and rheumatic diseases:The changing spectrum of clinical enigma[J]. Rheumatic Disease Clinics of North America,2009,35:139-161.