云南大理地区膝关节骨性关节炎危险因素分析
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摘要
目的:通过对大理地区人群的膝关节骨性关节炎(KOA)危险因素进行研究,为该地区KOA的预防和治疗提供参考。方法:选取315名到大理大学第一附属医院就诊的大理地区常住居民患者,进行KOA筛查及流行病学问卷调查,进行病例对照研究及非条件Logistic回归分析,研究KOA(OR=1.252,sig=0.000)、BMI(OR=1.298,sig=0.000)、家族史(OR=12.619,sig=0.002)、如厕习惯(OR=0.000,sig=0.999)、居住环境(OR=25.857,sig=0.015)、三酰甘油水平(OR=12.703,sig=0.000)、吸烟情况(OR=0.492,sig=0.466)、饮酒情况(OR=3.216,sig=0.235)、工作类型(OR=2.949E8,sig=0.999)。结论:年龄、BMI、家族史、三酰甘油水平、居住环境是大理地区KOA的危险因素。
Objective: To study the risk factors of knee osteoarthritis(KOA)in Dali area and provide evidence for prevention and treatment of KOA in Dali area. Methods: KOA screening and epidemiological survey were conducted among 315 permanent residents in Dali area who saw doctors in the First Affiliated Hospital of Dali University. Case control study and unconditional logistic regression analysis were conducted to study the risk factors of KOA. Results: Logistic regression analysis showed that sex(OR=1.827, sig=0.205), age(OR=1.252, sig=0.000), BMI(OR=1.298, sig=0.000), family history(OR=12.619, sig=0.002), toilet habits(OR=0.000,sig=0.999), living environment(OR=25.857, sig=0.015), triglyceride levels(OR=12.703, sig=0.000), smoking(OR=0.492, sig=0.466), drinking(OR=3.216, sig=0.235), type of work(OR=2.949 E8, sig=0.999). Conclusion: Age, BMI, family history, triglyceride levels, and living environment are the risk factors of KOA in Dali area.
Objective: To study the risk factors of knee osteoarthritis(KOA)in Dali area and provide evidence for prevention and treatment of KOA in Dali area. Methods: KOA screening and epidemiological survey were conducted among 315 permanent residents in Dali area who saw doctors in the First Affiliated Hospital of Dali University. Case control study and unconditional logistic regression analysis were conducted to study the risk factors of KOA. Results: Logistic regression analysis showed that sex(OR=1.827, sig=0.205), age(OR=1.252, sig=0.000), BMI(OR=1.298, sig=0.000), family history(OR=12.619, sig=0.002), toilet habits(OR=0.000,sig=0.999), living environment(OR=25.857, sig=0.015), triglyceride levels(OR=12.703, sig=0.000), smoking(OR=0.492, sig=0.466), drinking(OR=3.216, sig=0.235), type of work(OR=2.949 E8, sig=0.999). Conclusion: Age, BMI, family history, triglyceride levels, and living environment are the risk factors of KOA in Dali area.
引文
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[2]CHO H J,MOREY V,KANG J Y,et al.Prevalence and Risk Factors of Spine,Shoulder,Hand,Hip,and Knee Osteoarthritis in Community-dwelling Koreans Older Than Age 65 Years[J].Clin Orthop Relat Res,2015,473(10):3307-3314.
[3]NEOGI T,ZHANG Y.Osteoarthritis prevention[J].Curr Opin Rheumatol,2011,23(2):185-191.
[4]IOAN-FACSINAY A,KLOPPENBURG M.Bioactive lipids in osteoarthritis:risk or benefit?[J].Curr Opin Rheumatol,2018,30(1):108-113.
[5]KELLGREN J H,LAWRENCE J S,BIER F.Genetic Factors in Generalized Osteoarthrosis[J].Ann Rheum Dis,1963,22:237-255.
[6]耿云航,李桂石,刘晓阳.骨关节炎发病易感基因及环境因素的现状研究[J].实用手外科杂志,2017,31(4):477-479.
[7]LEUNG Y Y,ANG L W,THUMBOO J,et al.Cigarette smoking and risk of total knee replacement for severe osteoarthritis among Chinese in Singapore--the Singapore Chinese health study[J].Osteoarthr Cartil,2014,22(6):764-770.
[8]RANJAN K C,ROBIN VOIGT,XIN L I,et al.Induction of osteoarthritis-like pathologic changes by chronic alcohol consumption in an experimental mouse model[J].Arthritis&Rheumatology,2015,67(6):1678-1680.
[9]BASTICK A N,BELO J N,RUNHAAR J,et al.What Are the Prognostic Factors for Radiographic Progression of Knee Osteoarthritis?A Meta-analysis[J].Clin Orthop Relat Res,2015,473(9):2969-2989.
[10]李宁华,张耀南,张毅,等.国内六大行政区域六城市中老年人群膝关节骨性关节炎患病危险因素比较[J].中国组织工程研究,2007,11(39):7758-7760.