针灸对慢性疲劳综合征及肠道菌群的作用研究
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摘要
慢性疲劳综合症(CFS)病因病机尚未明确,现代研究发现其可能与肠道菌群失调密切相关,调节肠道菌群对于CFS具有明显的改善作用。研究证实针灸能够防治CFS,同时也能调节肠道菌群,对于由CFS导致的菌群紊乱可发挥调控与保护作用。本研究拟从针灸对CFS与肠道菌群的影响入手,就三者间的相关性进行探讨,为从肠道菌群角度探讨针灸防治CFS提供新思路。
The pathogenesis of chronic fatigue syndrome( CFS) has not been clear so far; however,modern research found out it might closely related to the alteration of intestinal flora,therefore regulating intestinal flora has a significant improvement on CFS. Relative researches have shown that acupuncture and moxibustion can prevent and treat CFS,it can also regulate intestinal flora. In particular,it can play a regulatory and protective role in the intestinal flora disturbance caused by CFS. This study discussed the influence of acupuncture and moxibustion on intestinal flora due to CFS,and explore the correlation among them,thus to provide new ideas for the prevention and treatment of CFS from the perspective of intestinal flora.
The pathogenesis of chronic fatigue syndrome( CFS) has not been clear so far; however,modern research found out it might closely related to the alteration of intestinal flora,therefore regulating intestinal flora has a significant improvement on CFS. Relative researches have shown that acupuncture and moxibustion can prevent and treat CFS,it can also regulate intestinal flora. In particular,it can play a regulatory and protective role in the intestinal flora disturbance caused by CFS. This study discussed the influence of acupuncture and moxibustion on intestinal flora due to CFS,and explore the correlation among them,thus to provide new ideas for the prevention and treatment of CFS from the perspective of intestinal flora.
引文
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[2]Lakhan SE,Kirchgessner A.Gut inflammation in chronic fatigue syndrome[J].Nutr Metab,2010(7):79.
[3]Hall DL,Lattie EG,Milrad SF,et al.Telephone-administered versus live group cognitive behavioral stress management for adults with CFS[J].J Psychosom Res,2017(93):41-47.
[4]Agmon-Levin N,Zafrir Y,Kivity S,et al.Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine:another angle of the‘autoimmune(auto-inflammatory)syndrome induced by adjuvants'(ASIA)[J].Immunol Res,2014(60):376-383.
[5]Aaron LA,Burke MM,Buchwald D.Overlapping conditions among patients with chronic fatigue syndrome,fibromyalgia,andtemporomandibular disorder[J].Arch Intern Med,2000,160(2):221-227.
[6]Nagy Szakal D,Williams BL,Mishra N,et al.Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome[J].Microbiome,2017,5(1):44-61.
[7]李克嵩,庄礼兴,贺君,等.基于累积Meta分析模型:针灸治疗慢性疲劳综合征系统评价[J].中华中医药学刊,2017,35(12):3087-3091.
[8]梁媚.针灸治疗对单纯性肥胖患者肠道菌群的调节效应[D].广西:广西中医药大学,2016:34.
[9]成泽东,陈以国,张涛.温和灸神阙穴对慢性疲劳大鼠肠道菌群的影响[J].上海针灸杂志,2013,32(1):56-58.
[10]成泽东,陈以国,张涛.温和灸对慢性疲劳大鼠肠道菌群的影响[J].中国中医药信息杂志,2013,20(1):45-46,63.
[11]安贵霞.俞募配穴针灸治疗慢性疲劳综合征临床分析[J].中国中医基础医学杂志,2014,20(7):970-971,991.
[12]陈兴华,黎璐茜,章闻,等.针刺治疗慢性疲劳综合征随机对照研究[J].中国针灸,2010,30(7):533-536.
[13]韦光,李雪青,石志敏.针刺二海穴治疗慢性疲劳综合征的随机对照研究[J].针灸临床杂志,2017,33(4):42-44.
[14]凌家艳,沈霖,刘庆,等.择时针刺治疗气虚型慢性疲劳综合征及对患者T细胞亚群的影响[J].中国针灸,2013,33(12):1061-1064.
[15]成词松,诸毅晖,梁繁荣,等.电针肾俞、足三里对慢性疲劳综合征事件相关电位的影响[J].中国针灸,2010,30(4):309-312.
[16]陈晓琴,黄兵,吴曦.针刺调整慢性疲劳综合征睡眠障碍的临床随机对照试验[J].时珍国医国药,2015,26(7):1669-1672.
[17]肖淦辰,崔瑾,熊芳丽,等.艾灸五脏俞穴治疗慢性疲劳综合征41例临床疗效观察[J].世界中西医结合杂志,2014,9(11):1218-1220.
[18]隋月皎,马铁明,刘峻.麦粒灸治疗心脾两虚型慢性疲劳综合征临床观察[J].针刺研究,2015,40(4):313,344.
[19]高建芸.腹针与神阙灸治疗慢性疲劳综合征临床研究[J].山东中医杂志,2016,35(4):325-327.
[20]田亮,王金海,雒成林,等.膏肓灸法治疗慢性疲劳综合征:随机对照研究[J].中国针灸,2015,35(11):1127-1130.
[21]钟伟泉,李树成,谷婷婷.温针灸治疗慢性疲劳综合征疗效观察[J].上海针灸杂志,2014,33(3):206-208.
[22]Rajili-Stojanovi M,Smidt H,VOS WMD.Diversity of the human gastrointestinal tract microbiota revisited[J].Environ Microbiol,2007,9(9):2125-2136.
[23]覃佩兰,成泽东.基于脑肠轴学说探讨针灸对肠道菌群调节的思考[J].时珍国医国药,2015,26(11):2712-2714.
[24]Wang SD,Cheng ZD,Jin D,et al.Moxibustion at Front-Mu Point of Abdomen for Intestinal Dysbacteriosis in Rats[J].Journal of Acupuncture and Tuina Science,2011,9(1):21-25.
[25]周莉萍,胡玲香,邓雪梅.针灸减肥进程中患者肠道菌群的变化规律探讨[J].四川中医,2011,29(9):124-126.
[26]侯天舒,韩晓霞,杨阳,等.电针对溃疡性结肠炎大鼠肠道微生态的保护作用[J].针刺研究,2014,39(1):27-34.
[27]司原成,苗维纳,何嘉悦,等.基于“脑-肠-菌”轴探讨健脾益气针法对肥胖鼠肠道菌群及TLR4的调控机制[J].中华中医药杂志,2017,32(10):4457-4460.
[28]Wang XM,Lu Y,Wu LY,et al.Moxibustion inhibits interleukin-12and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis[J].World Journal of Gastroenterology,2012,18(46):6819-6828.
[29]赵继梦,黄艳,窦传字,等.艾灸疗法:在调节肠易激综合征肠道菌群与黏膜免疫中的展望[J].中国组织工程研究,2015,19(2):289-293.
[30]Brugère JF,Mihajlovski A,Missaoui M,et al.Tools for stools:The challenge of assessing human intestinal microbiota using molecular diagnostics[J].Expert Rev Mol Diagn,2009,9(4):353-365.
[31]Serino M,Chabo C,Burcelin R.Intestinal microbiomics to define health and disease in human and mice[J].Curr Pharm Biotechnol,2012,13(5):746-758.
[32]Gong J,Chen G,Wang DK,et al.On Relation between diabetes and intestinal flora from theory of Pi-Wei[J].Chinese Journal of Integrated Traditional and Western Medicine,2016,36(4):484-487.
[33]Jiménez MB.Treatment of irritable bowel syndrome with probiotics.An etiopathogenic approach at last[J].Rev Esp Enferm Dig,2009,101(8):553-564.
[34]Borody TJ,Nowak A,Finlayson S.The GI microbiome and its role in chronic fatigue syndrome:a summary of bacteriotherapy[J].ACNEM J,2012,31(3):3-8.
[35]Rao AV,Bested AC,Beaulne TM,et al.A randomized,double-blind,placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome[J].Gut Pathog,2009,1(1):6.
[36]Butt H,Dunstan R,Mc Gregor N,et al.Bacterial colonosis in patients with persistent fatigue[C]//Proceedings of the AHMF international clinical and scientific conference.Sydney:Alison Hunter Memorial,2001.
[37]Logan AC,Venket Rao A,Irani D.Chronic fatigue syndrome:lactic acid bacteria may be of therapeutic value[J].Med Hypotheses,2003,60(6):915-923.
[38]Sheedy JR,Wettenhall RE,et al.Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome[J].In Vivo,2009,23(4):621-628.
[39]Maes M,Mihaylova I,Leunis JC.Increased serum Ig A and Ig M against LPS of enterobacteria in chronic fatigue syndrome(CFS):Indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability[J].J Affect Disord,2007,99(1):237-240.
[40]Frémont M,Coomans D,Massart S,et al.High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients[J].Anaerobe,2013,22:50-56.
[41]Giloteaux L,Goodrich JK,Walters WA,et al.Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome[J].Microbiome,2016,4(1):30-42.
[2]Lakhan SE,Kirchgessner A.Gut inflammation in chronic fatigue syndrome[J].Nutr Metab,2010(7):79.
[3]Hall DL,Lattie EG,Milrad SF,et al.Telephone-administered versus live group cognitive behavioral stress management for adults with CFS[J].J Psychosom Res,2017(93):41-47.
[4]Agmon-Levin N,Zafrir Y,Kivity S,et al.Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine:another angle of the‘autoimmune(auto-inflammatory)syndrome induced by adjuvants'(ASIA)[J].Immunol Res,2014(60):376-383.
[5]Aaron LA,Burke MM,Buchwald D.Overlapping conditions among patients with chronic fatigue syndrome,fibromyalgia,andtemporomandibular disorder[J].Arch Intern Med,2000,160(2):221-227.
[6]Nagy Szakal D,Williams BL,Mishra N,et al.Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome[J].Microbiome,2017,5(1):44-61.
[7]李克嵩,庄礼兴,贺君,等.基于累积Meta分析模型:针灸治疗慢性疲劳综合征系统评价[J].中华中医药学刊,2017,35(12):3087-3091.
[8]梁媚.针灸治疗对单纯性肥胖患者肠道菌群的调节效应[D].广西:广西中医药大学,2016:34.
[9]成泽东,陈以国,张涛.温和灸神阙穴对慢性疲劳大鼠肠道菌群的影响[J].上海针灸杂志,2013,32(1):56-58.
[10]成泽东,陈以国,张涛.温和灸对慢性疲劳大鼠肠道菌群的影响[J].中国中医药信息杂志,2013,20(1):45-46,63.
[11]安贵霞.俞募配穴针灸治疗慢性疲劳综合征临床分析[J].中国中医基础医学杂志,2014,20(7):970-971,991.
[12]陈兴华,黎璐茜,章闻,等.针刺治疗慢性疲劳综合征随机对照研究[J].中国针灸,2010,30(7):533-536.
[13]韦光,李雪青,石志敏.针刺二海穴治疗慢性疲劳综合征的随机对照研究[J].针灸临床杂志,2017,33(4):42-44.
[14]凌家艳,沈霖,刘庆,等.择时针刺治疗气虚型慢性疲劳综合征及对患者T细胞亚群的影响[J].中国针灸,2013,33(12):1061-1064.
[15]成词松,诸毅晖,梁繁荣,等.电针肾俞、足三里对慢性疲劳综合征事件相关电位的影响[J].中国针灸,2010,30(4):309-312.
[16]陈晓琴,黄兵,吴曦.针刺调整慢性疲劳综合征睡眠障碍的临床随机对照试验[J].时珍国医国药,2015,26(7):1669-1672.
[17]肖淦辰,崔瑾,熊芳丽,等.艾灸五脏俞穴治疗慢性疲劳综合征41例临床疗效观察[J].世界中西医结合杂志,2014,9(11):1218-1220.
[18]隋月皎,马铁明,刘峻.麦粒灸治疗心脾两虚型慢性疲劳综合征临床观察[J].针刺研究,2015,40(4):313,344.
[19]高建芸.腹针与神阙灸治疗慢性疲劳综合征临床研究[J].山东中医杂志,2016,35(4):325-327.
[20]田亮,王金海,雒成林,等.膏肓灸法治疗慢性疲劳综合征:随机对照研究[J].中国针灸,2015,35(11):1127-1130.
[21]钟伟泉,李树成,谷婷婷.温针灸治疗慢性疲劳综合征疗效观察[J].上海针灸杂志,2014,33(3):206-208.
[22]Rajili-Stojanovi M,Smidt H,VOS WMD.Diversity of the human gastrointestinal tract microbiota revisited[J].Environ Microbiol,2007,9(9):2125-2136.
[23]覃佩兰,成泽东.基于脑肠轴学说探讨针灸对肠道菌群调节的思考[J].时珍国医国药,2015,26(11):2712-2714.
[24]Wang SD,Cheng ZD,Jin D,et al.Moxibustion at Front-Mu Point of Abdomen for Intestinal Dysbacteriosis in Rats[J].Journal of Acupuncture and Tuina Science,2011,9(1):21-25.
[25]周莉萍,胡玲香,邓雪梅.针灸减肥进程中患者肠道菌群的变化规律探讨[J].四川中医,2011,29(9):124-126.
[26]侯天舒,韩晓霞,杨阳,等.电针对溃疡性结肠炎大鼠肠道微生态的保护作用[J].针刺研究,2014,39(1):27-34.
[27]司原成,苗维纳,何嘉悦,等.基于“脑-肠-菌”轴探讨健脾益气针法对肥胖鼠肠道菌群及TLR4的调控机制[J].中华中医药杂志,2017,32(10):4457-4460.
[28]Wang XM,Lu Y,Wu LY,et al.Moxibustion inhibits interleukin-12and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis[J].World Journal of Gastroenterology,2012,18(46):6819-6828.
[29]赵继梦,黄艳,窦传字,等.艾灸疗法:在调节肠易激综合征肠道菌群与黏膜免疫中的展望[J].中国组织工程研究,2015,19(2):289-293.
[30]Brugère JF,Mihajlovski A,Missaoui M,et al.Tools for stools:The challenge of assessing human intestinal microbiota using molecular diagnostics[J].Expert Rev Mol Diagn,2009,9(4):353-365.
[31]Serino M,Chabo C,Burcelin R.Intestinal microbiomics to define health and disease in human and mice[J].Curr Pharm Biotechnol,2012,13(5):746-758.
[32]Gong J,Chen G,Wang DK,et al.On Relation between diabetes and intestinal flora from theory of Pi-Wei[J].Chinese Journal of Integrated Traditional and Western Medicine,2016,36(4):484-487.
[33]Jiménez MB.Treatment of irritable bowel syndrome with probiotics.An etiopathogenic approach at last[J].Rev Esp Enferm Dig,2009,101(8):553-564.
[34]Borody TJ,Nowak A,Finlayson S.The GI microbiome and its role in chronic fatigue syndrome:a summary of bacteriotherapy[J].ACNEM J,2012,31(3):3-8.
[35]Rao AV,Bested AC,Beaulne TM,et al.A randomized,double-blind,placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome[J].Gut Pathog,2009,1(1):6.
[36]Butt H,Dunstan R,Mc Gregor N,et al.Bacterial colonosis in patients with persistent fatigue[C]//Proceedings of the AHMF international clinical and scientific conference.Sydney:Alison Hunter Memorial,2001.
[37]Logan AC,Venket Rao A,Irani D.Chronic fatigue syndrome:lactic acid bacteria may be of therapeutic value[J].Med Hypotheses,2003,60(6):915-923.
[38]Sheedy JR,Wettenhall RE,et al.Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome[J].In Vivo,2009,23(4):621-628.
[39]Maes M,Mihaylova I,Leunis JC.Increased serum Ig A and Ig M against LPS of enterobacteria in chronic fatigue syndrome(CFS):Indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability[J].J Affect Disord,2007,99(1):237-240.
[40]Frémont M,Coomans D,Massart S,et al.High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients[J].Anaerobe,2013,22:50-56.
[41]Giloteaux L,Goodrich JK,Walters WA,et al.Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome[J].Microbiome,2016,4(1):30-42.