血清神经元特异性烯醇化酶在膀胱癌中的表达水平及其临床意义
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摘要
目的探讨血清神经元特异性烯醇化酶(neuron specific enolase,NSE)在膀胱癌中的表达水平及其临床意义。方法将2014年10月至2016年10月本院收治的50例膀胱癌患者纳入观察组,将同期本院体检的50例健康成人纳入对照组,比较两组研究对象血清NSE水平,并分析膀胱癌患者血清NSE水平与患者临床特征的相关性。结果观察组患者NSE水平显著高于对照组(P <0.001)。TNM分期为Ⅲ期或Ⅳ期的膀胱癌患者血清NSE水平显著高于Ⅰ或Ⅱ期患者(P=0.008);有远处转移的膀胱癌患者血清NSE水平显著高于无远处转移患者(P <0.001);小细胞膀胱癌患者血清NSE水平显著高于非小细胞膀胱癌患者(P <0.001);2年内死亡患者血清NSE水平显著高于存活患者(P <0.001)。结论膀胱癌(尤其是小细胞膀胱癌)患者血清NSE水平升高,可作为预测膀胱癌患者预后的指标。
Objective To investigate the expression and clinical significance of serum neuron specific enolase(NSE) in bladder cancer. Method 50 patients with bladder cancer treated in our hospital from October 2014 to October 2016 were included in observation group, and 50 healthy adults who underwent physical examination in the same period were included in control group. The serum NSE levels of the two groups were compared,and the correlation between serum NSE level and clinical characteristics of patients with bladder cancer was analyzed. Result The level of NSE in observation group was significantly higher than that in control group(P < 0.001). The level of serum NSE in patients with TNM stage Ⅲ or Ⅳ was significantly higher than that in patients with stage Ⅰ orⅡ(P = 0.008); the level of serum NSE in patients with distant metastasis was significantly higher than that in patients without distant metastasis(P < 0.001); the level of serum NSE in patients with small cell bladder cancer was significantly higher than that in patients with non-small cell bladder cancer(P < 0.001); the level of serum NSE in patients who died within 2 years was significantly higher than that in patients who survived(P < 0.001). Conclusion The level of serum NSE in patients with bladder cancer(especially small cell bladder cancer) is elevated, which can be used as an index to predict the prognosis of patients with bladder cancer.
Objective To investigate the expression and clinical significance of serum neuron specific enolase(NSE) in bladder cancer. Method 50 patients with bladder cancer treated in our hospital from October 2014 to October 2016 were included in observation group, and 50 healthy adults who underwent physical examination in the same period were included in control group. The serum NSE levels of the two groups were compared,and the correlation between serum NSE level and clinical characteristics of patients with bladder cancer was analyzed. Result The level of NSE in observation group was significantly higher than that in control group(P < 0.001). The level of serum NSE in patients with TNM stage Ⅲ or Ⅳ was significantly higher than that in patients with stage Ⅰ orⅡ(P = 0.008); the level of serum NSE in patients with distant metastasis was significantly higher than that in patients without distant metastasis(P < 0.001); the level of serum NSE in patients with small cell bladder cancer was significantly higher than that in patients with non-small cell bladder cancer(P < 0.001); the level of serum NSE in patients who died within 2 years was significantly higher than that in patients who survived(P < 0.001). Conclusion The level of serum NSE in patients with bladder cancer(especially small cell bladder cancer) is elevated, which can be used as an index to predict the prognosis of patients with bladder cancer.
引文
[1]Mahdavifar N,Ghoncheh M,Pakzad R,et al.Epidemiology,Incidence and Mortality of Bladder Cancer and their Relationship with the Development Index in the World[J].Asian Pac J Cancer Prev,2016,17(1):381-386.
[2]Sun X,Hoadley KA,Kim WY,et al.Age at diagnosis,obesity,smoking,and molecular subtypes in muscle-invasive bladder cancer[J].Cancer Causes Control,2017,28(6):539-544.
[3]Adejoro O,Alishahi A,Konety B.Association of Comorbidity,Age,and Radical Surgical Therapy for Prostate Cancer,Bladder Cancer,and Renal Cell Carcinoma[J].Urology,2016,97(12):130-137.
[4]Williams SB,Huo J,Chu Y,et al.Cancer and All-Cause Mortality in Bladder Cancer Patients Undergoing Radical Cystectomy:Development and Validation of a Nomogram for Treatment Decision-Making[J].Urology,2017,12(5):882-888.
[5]Welty CJ,Sanford TH,Wright JL,et al.The Cancer of the Bladder Risk Assessment(COBRA)score:Estimating mortality after radical cystectomy[J].Cancer,2017,23(11):781-786.
[6]Zhou M,Wang Z,Yao Y,et al.Neuron-specific enolase and response to initial therapy are important prognostic factors in patients with small cell lung cancer[J].Clin Transl Oncol,2017,19(7):865-873.
[7]Suh KJ,Keam B,Kim M,et al.Serum Neuron-Specific Enolase Levels Predict the Efficacy of First-Line Epidermal Growth Factor Receptor(EGFR)Tyrosine Kinase Inhibitors in Patients With Non-Small Cell Lung Cancer Harboring EGFRMutations[J].Clin Lung Cancer,2016,17(4):245-252.
[8]Huang Z,Xu D,Zhang F,et al.Pro-gastrin-releasing peptide and neuron-specific enolase:useful predictors of response to chemotherapy and survival in patients with small cell lung cancer[J].Clin Transl Oncol,2016,18(10):1019-1025.
[9]Smith ND,Prasad SM,Patel AR,et al.Bladder Cancer Mortality in the United States:A Geographic and Temporal Analysis of Socioeconomic and Environmental Factors[J].J Urol,2016,195(2):290-296.
[10]Pakzad R,Mohammadian-Hafshejani A,Mohammadian M,et al.Incidence and Mortality of Bladder Cancer and their Relationship with Development in Asia[J].Asian Pac J Cancer Prev,2015,16(16):7365-7374.
[11]Abboud T,Mende KC,Jung R,et al.Prognostic value of early S100B protein and Neuron-specific Enolase in patients with poor grade aneurysmal subarachnoid hemorrhage,a pilot study[J].World Neurosurg,2017,8(4):665-669.
[12]Dong N,Diao Y,Ding M,et al.The effects of 7-nitroindazole on serum neuron-specific enolase and astroglia-derived protein(S100beta)levels after traumatic brain injury[J].Exp Ther Med,2017,13(6):3183-3188.
[13]Zhou Y,Chen WZ,Peng AF,et al.Neuron-specific enolase,histopathological types,and age as risk factors for bone metastases in lung cancer[J].Tumour Biol,2017,39(7):1014-1018.
[14]Inomata M,Hayashi R,Yamamoto A,et al.Plasma neuronspecific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib[J].Mol Clin Oncol,2015,3(4):802-806.
[15]Yan HJ,Tan Y,Gu W.Neuron specific enolase and prognosis of non-small cell lung cancer:a systematic review and metaanalysis[J].J BUON,2014,19(1):153-156.
[16]Naito A,Taguchi S,Nakagawa T,et al.Prognostic significance of serum neuron-specific enolase in small cell carcinoma of the urinary bladder[J].World J Urol,2017,35(1):97-103.
[17]Tawk RG,Grewal SS,Heckman MG,et al.The Relationship Between Serum Neuron-Specific Enolase Levels and Severity of Bleeding and Functional Outcomes in Patients With Nontraumatic Subarachnoid Hemorrhage[J].Neurosurgery,2016,78(4):487-491.
[18]Nakhjavan-Shahraki B,Yousefifard M,Oraii A,et al.Metaanalysis of neuron specific enolase in predicting pediatric brain injury outcomes[J].EXCLI J,2017,16:995-1008.
[19]Li Y,Yu ZX,Ji MS,et al.A Pilot Study of the Use of Dexmedetomidine for the Control of Delirium by Reducing the Serum Concentrations of Brain-Derived Neurotrophic Factor,NeuronSpecific Enolase,and S100B in Polytrauma Patients[J].J Intensive Care Med,2017,88(50):666-672.
[20]Takano K,Goto K,Motobayashi M,et al.Early manifestations of epileptic encephalopathy,brain atrophy,and elevation of serum neuron specific enolase in a boy with beta-propeller protein-associated neurodegeneration[J].Eur J Med Genet,2017,60(10):521-526.
[2]Sun X,Hoadley KA,Kim WY,et al.Age at diagnosis,obesity,smoking,and molecular subtypes in muscle-invasive bladder cancer[J].Cancer Causes Control,2017,28(6):539-544.
[3]Adejoro O,Alishahi A,Konety B.Association of Comorbidity,Age,and Radical Surgical Therapy for Prostate Cancer,Bladder Cancer,and Renal Cell Carcinoma[J].Urology,2016,97(12):130-137.
[4]Williams SB,Huo J,Chu Y,et al.Cancer and All-Cause Mortality in Bladder Cancer Patients Undergoing Radical Cystectomy:Development and Validation of a Nomogram for Treatment Decision-Making[J].Urology,2017,12(5):882-888.
[5]Welty CJ,Sanford TH,Wright JL,et al.The Cancer of the Bladder Risk Assessment(COBRA)score:Estimating mortality after radical cystectomy[J].Cancer,2017,23(11):781-786.
[6]Zhou M,Wang Z,Yao Y,et al.Neuron-specific enolase and response to initial therapy are important prognostic factors in patients with small cell lung cancer[J].Clin Transl Oncol,2017,19(7):865-873.
[7]Suh KJ,Keam B,Kim M,et al.Serum Neuron-Specific Enolase Levels Predict the Efficacy of First-Line Epidermal Growth Factor Receptor(EGFR)Tyrosine Kinase Inhibitors in Patients With Non-Small Cell Lung Cancer Harboring EGFRMutations[J].Clin Lung Cancer,2016,17(4):245-252.
[8]Huang Z,Xu D,Zhang F,et al.Pro-gastrin-releasing peptide and neuron-specific enolase:useful predictors of response to chemotherapy and survival in patients with small cell lung cancer[J].Clin Transl Oncol,2016,18(10):1019-1025.
[9]Smith ND,Prasad SM,Patel AR,et al.Bladder Cancer Mortality in the United States:A Geographic and Temporal Analysis of Socioeconomic and Environmental Factors[J].J Urol,2016,195(2):290-296.
[10]Pakzad R,Mohammadian-Hafshejani A,Mohammadian M,et al.Incidence and Mortality of Bladder Cancer and their Relationship with Development in Asia[J].Asian Pac J Cancer Prev,2015,16(16):7365-7374.
[11]Abboud T,Mende KC,Jung R,et al.Prognostic value of early S100B protein and Neuron-specific Enolase in patients with poor grade aneurysmal subarachnoid hemorrhage,a pilot study[J].World Neurosurg,2017,8(4):665-669.
[12]Dong N,Diao Y,Ding M,et al.The effects of 7-nitroindazole on serum neuron-specific enolase and astroglia-derived protein(S100beta)levels after traumatic brain injury[J].Exp Ther Med,2017,13(6):3183-3188.
[13]Zhou Y,Chen WZ,Peng AF,et al.Neuron-specific enolase,histopathological types,and age as risk factors for bone metastases in lung cancer[J].Tumour Biol,2017,39(7):1014-1018.
[14]Inomata M,Hayashi R,Yamamoto A,et al.Plasma neuronspecific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib[J].Mol Clin Oncol,2015,3(4):802-806.
[15]Yan HJ,Tan Y,Gu W.Neuron specific enolase and prognosis of non-small cell lung cancer:a systematic review and metaanalysis[J].J BUON,2014,19(1):153-156.
[16]Naito A,Taguchi S,Nakagawa T,et al.Prognostic significance of serum neuron-specific enolase in small cell carcinoma of the urinary bladder[J].World J Urol,2017,35(1):97-103.
[17]Tawk RG,Grewal SS,Heckman MG,et al.The Relationship Between Serum Neuron-Specific Enolase Levels and Severity of Bleeding and Functional Outcomes in Patients With Nontraumatic Subarachnoid Hemorrhage[J].Neurosurgery,2016,78(4):487-491.
[18]Nakhjavan-Shahraki B,Yousefifard M,Oraii A,et al.Metaanalysis of neuron specific enolase in predicting pediatric brain injury outcomes[J].EXCLI J,2017,16:995-1008.
[19]Li Y,Yu ZX,Ji MS,et al.A Pilot Study of the Use of Dexmedetomidine for the Control of Delirium by Reducing the Serum Concentrations of Brain-Derived Neurotrophic Factor,NeuronSpecific Enolase,and S100B in Polytrauma Patients[J].J Intensive Care Med,2017,88(50):666-672.
[20]Takano K,Goto K,Motobayashi M,et al.Early manifestations of epileptic encephalopathy,brain atrophy,and elevation of serum neuron specific enolase in a boy with beta-propeller protein-associated neurodegeneration[J].Eur J Med Genet,2017,60(10):521-526.