雾化吸入双黄连注射液对慢性扁桃体炎的疗效及IL-6、hs-CRP和TNF-α水平的影响
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摘要
目的:研究雾化吸入双黄连注射液对慢性扁桃体炎的疗效及IL-6、hs-CRP和TNF-α水平的影响。方法:120例慢性扁桃体炎患者,随机分为对照组和实验组,每组患者60例。对照组患者给予头孢克洛胶囊,1粒/次,3次/d,实验组患者在给予头孢克洛胶囊的基础上每日雾化吸入双黄连注射液,将20 mL双黄连注射液溶解于20 mL生理盐水中,进行超声雾化吸入治疗,2次/d。比较两组患者在治疗后的临床疗效、临床症状改善时间、疾病复发率和不良反应发生率;对比两组患者在治疗前后IL-6、hs-CRP和TNF-α等炎性因子水平。结果:经过治疗后,实验组患者治疗有效率显著高于对照组,两组差异比较,具有统计学意义(P<0.05);实验组患者疾病复发率显著低于对照组,两组差异比较,具有统计学意义(P<0.05);在治疗前,两组患者IL-6、hs-CRP和TNF-α水平相比较,两组差异具无统计学意义(P>0.05);经过治疗后,两组患者IL-6、hs-CRP和TNF-α水平显著优于治疗前,差异具有统计学意义(P<0.05);并且实验组患者改善程度优于对照组,差异具有统计学意义(P<0.05);两组患者在治疗期间不良反应发生率相比较,两组差异具无统计学意义(P>0.05)。结论:采用雾化吸入双黄连注射液对慢性扁桃体炎,具有较好的临床疗效,能够显著改善患者临床症状,改善患者IL-6、hs-CRP和TNF-α水平,降低疾病复发率,安全性较高,值得临床推广。
Objective:To study the effect of atomization inhalation of Shuanghuanglian Injection in treatment of chronic tonsillitis and its influence on levels of IL-6, hs-CRP and TNF-α.Methods: Totally 120 cases of chronic tonsillitis patients were randomly divided into two groups.The control group were treated with cefaclor capsule, 1 particle/time, 3 times/d.The experimental group was given cefaclor capsule combined with atomization inhalation of Shuanghuanglian Injection.The therapeutic efficacy,clinical symptom improvement time, disease recurrence rate and incidence of adverse reactionswereobserved. The levels of IL-6, hs-CRP and TNF-α before and after treatment were observed.Results: After treatment, the experimental group's efficiency was significantly higher than that of the control group, and the differences between the two groups had statistical significance(P<0.05). The experimental group's disease recurrence rate was significantly lower than that of the control group and the differences between the two groups had statistical significance(P<0.05). Before treatment, two groups' IL-6, hs CRP and TNF-alpha levels had no statistical significance(P>0.05). After treatment, two groups' IL-6, hs CRP and TNF-αwere significantly better than those before treatment with statistically significant differences(P<0.05). Two groups' incidence of adverse reactionsduring treatment had no statistical significance(P>0.05).Conclusion: For chronic tonsillitis,atomization inhalation of Shuanghuanglian Injection has good clinical curative effect and can improve the patients' clinical symptoms,levels of IL-6, hs-CRP and TNF-α.It has high security and is worthy of clinical promotion.
Objective:To study the effect of atomization inhalation of Shuanghuanglian Injection in treatment of chronic tonsillitis and its influence on levels of IL-6, hs-CRP and TNF-α.Methods: Totally 120 cases of chronic tonsillitis patients were randomly divided into two groups.The control group were treated with cefaclor capsule, 1 particle/time, 3 times/d.The experimental group was given cefaclor capsule combined with atomization inhalation of Shuanghuanglian Injection.The therapeutic efficacy,clinical symptom improvement time, disease recurrence rate and incidence of adverse reactionswereobserved. The levels of IL-6, hs-CRP and TNF-α before and after treatment were observed.Results: After treatment, the experimental group's efficiency was significantly higher than that of the control group, and the differences between the two groups had statistical significance(P<0.05). The experimental group's disease recurrence rate was significantly lower than that of the control group and the differences between the two groups had statistical significance(P<0.05). Before treatment, two groups' IL-6, hs CRP and TNF-alpha levels had no statistical significance(P>0.05). After treatment, two groups' IL-6, hs CRP and TNF-αwere significantly better than those before treatment with statistically significant differences(P<0.05). Two groups' incidence of adverse reactionsduring treatment had no statistical significance(P>0.05).Conclusion: For chronic tonsillitis,atomization inhalation of Shuanghuanglian Injection has good clinical curative effect and can improve the patients' clinical symptoms,levels of IL-6, hs-CRP and TNF-α.It has high security and is worthy of clinical promotion.
引文
[1] 高桂君, 金静, 刘娜,等. 中医药治疗小儿急性扁桃体炎的进展[J]. 中国中医急症, 2017, 26(2):268-270.
[2] 高玮, 刘鸣. 慢性扁桃体炎的病因及治疗研究进展[J]. 医学综述, 2017, 23(22):4518-4521.
[3] 谈杰, 顾峰, 李朝娟,等. 小剂量皮质激素用于急性化脓性扁桃体炎伴高热患者的疗效观察[J]. 江苏大学学报(医学版), 2011, 21(5):459-460.
[4] 黄俊勇. 感冒雾化液佐治小儿急性扁桃体炎疗效观察[J]. 四川中医, 2004, 22(7):71.
[5] 朱建光, 韩娜. 匹多莫德辅助治疗儿童慢性扁桃体炎急性发作疗效观察[J]. 临床肺科杂志, 2016, 21(5):844-846.
[6] 刘敏, 何彦, 杨继君. 清热利咽汤联合头孢硫脒治疗急性化脓性扁桃体炎临床观察[J]. 中国中医急症, 2017, 26(6):1033-1035.
[7] 邱文. 连花清瘟胶囊治疗急性化脓性扁桃体炎的疗效观察[J]. 西南国防医药, 2016, 26(5):536-539.
[8] 田勇泉. 耳鼻咽喉头颈外科学[M]. 8版.北京:人民卫生出版社, 2013.
[9] 李阳. 玉屏风胶囊治疗儿童慢性扁桃体炎50例[J]. 中国药业, 2013, 22(6):105-106.
[10] 高桂君, 金静, 刘娜,等. 中医药治疗小儿急性扁桃体炎的进展[J]. 中国中医急症, 2017, 26(2):268-270.
[11] 汪萍, 赵霆, 鲍东海. 碘伏涂抹治疗急性化脓性扁桃体炎疗效观察[J]. 空军医学杂志, 2005, 21(4):244.
[12] 甄兴刚,千海琴,朱永杰,等.益生菌对化脓性扁桃腺炎治疗后发生抗生素相关性腹泻的影响[J].中国现代医学杂志,2016,26(5):101-104.
[13] 王荣良,国艳艳,王玉.针刺放血辅助治疗急性扁桃体炎临床疗效及对炎性指标的影响[J].四川中医,2018,36(3):201-203.
[14] 李思, 史晓霞, 沈雁. 宣氏清解汤治疗小儿化脓性扁桃体炎的疗效评价[J].中国现代应用药学, 2017, 34(11):1593-1596.
[15] 杨雅添, 郭会义, 夏军. 蒲公英胶囊联合头孢克洛治疗扁桃体炎的临床研究[J]. 现代药物与临床, 2018, 33(3):609-612.
[16] 于春梅,王丽.血必净注射液治疗化脓性扁桃体炎临床疗效及对血清炎性因子的影响[J].现代中西医结合杂志,2016,25(23):2590-2592.
[17] 陈素华, 陈庆平. 双黄连注射液治疗儿童上呼吸道感染的疗效观察[J]. 西南国防医药, 2001, 11(2):138.
[18] 姚榕威, 欧阳绍基, 谢凤梅,等. 慢性扁桃体炎患者手术治疗前后细胞免疫功能的变化[J]. 海南医学, 2016, 27(15):2533-2534.
[19] 王绍勇. 痰热清注射液超声雾化吸入辅助治疗急性扁桃体炎疗效观察[J]. 中国中西医结合耳鼻咽喉科杂志, 2009, 17(5):275-276.
[20] 马涛, 蒋迎佳, 施红,等. 青霉素联合红霉素超声雾化吸入治疗儿童急性化脓性扁桃体炎临床疗效观察[J]. 中国循证医学杂志, 2008, 8(3):159-161.
[21] 张志颖, 赵云红, 周沛然,等. 降钙素原及白介素-6测定在急性扁桃体炎合并脓毒症患儿中的诊断价值研究[J]. 中华医院感染学杂志, 2017, 27(5):1163-1166.
[22] 沈学锋. 匹多莫德对慢性扁桃体炎患儿血清白细胞介素4和干扰素-γ的影响[J]. 医药导报, 2017, 36(1):53-55.
[2] 高玮, 刘鸣. 慢性扁桃体炎的病因及治疗研究进展[J]. 医学综述, 2017, 23(22):4518-4521.
[3] 谈杰, 顾峰, 李朝娟,等. 小剂量皮质激素用于急性化脓性扁桃体炎伴高热患者的疗效观察[J]. 江苏大学学报(医学版), 2011, 21(5):459-460.
[4] 黄俊勇. 感冒雾化液佐治小儿急性扁桃体炎疗效观察[J]. 四川中医, 2004, 22(7):71.
[5] 朱建光, 韩娜. 匹多莫德辅助治疗儿童慢性扁桃体炎急性发作疗效观察[J]. 临床肺科杂志, 2016, 21(5):844-846.
[6] 刘敏, 何彦, 杨继君. 清热利咽汤联合头孢硫脒治疗急性化脓性扁桃体炎临床观察[J]. 中国中医急症, 2017, 26(6):1033-1035.
[7] 邱文. 连花清瘟胶囊治疗急性化脓性扁桃体炎的疗效观察[J]. 西南国防医药, 2016, 26(5):536-539.
[8] 田勇泉. 耳鼻咽喉头颈外科学[M]. 8版.北京:人民卫生出版社, 2013.
[9] 李阳. 玉屏风胶囊治疗儿童慢性扁桃体炎50例[J]. 中国药业, 2013, 22(6):105-106.
[10] 高桂君, 金静, 刘娜,等. 中医药治疗小儿急性扁桃体炎的进展[J]. 中国中医急症, 2017, 26(2):268-270.
[11] 汪萍, 赵霆, 鲍东海. 碘伏涂抹治疗急性化脓性扁桃体炎疗效观察[J]. 空军医学杂志, 2005, 21(4):244.
[12] 甄兴刚,千海琴,朱永杰,等.益生菌对化脓性扁桃腺炎治疗后发生抗生素相关性腹泻的影响[J].中国现代医学杂志,2016,26(5):101-104.
[13] 王荣良,国艳艳,王玉.针刺放血辅助治疗急性扁桃体炎临床疗效及对炎性指标的影响[J].四川中医,2018,36(3):201-203.
[14] 李思, 史晓霞, 沈雁. 宣氏清解汤治疗小儿化脓性扁桃体炎的疗效评价[J].中国现代应用药学, 2017, 34(11):1593-1596.
[15] 杨雅添, 郭会义, 夏军. 蒲公英胶囊联合头孢克洛治疗扁桃体炎的临床研究[J]. 现代药物与临床, 2018, 33(3):609-612.
[16] 于春梅,王丽.血必净注射液治疗化脓性扁桃体炎临床疗效及对血清炎性因子的影响[J].现代中西医结合杂志,2016,25(23):2590-2592.
[17] 陈素华, 陈庆平. 双黄连注射液治疗儿童上呼吸道感染的疗效观察[J]. 西南国防医药, 2001, 11(2):138.
[18] 姚榕威, 欧阳绍基, 谢凤梅,等. 慢性扁桃体炎患者手术治疗前后细胞免疫功能的变化[J]. 海南医学, 2016, 27(15):2533-2534.
[19] 王绍勇. 痰热清注射液超声雾化吸入辅助治疗急性扁桃体炎疗效观察[J]. 中国中西医结合耳鼻咽喉科杂志, 2009, 17(5):275-276.
[20] 马涛, 蒋迎佳, 施红,等. 青霉素联合红霉素超声雾化吸入治疗儿童急性化脓性扁桃体炎临床疗效观察[J]. 中国循证医学杂志, 2008, 8(3):159-161.
[21] 张志颖, 赵云红, 周沛然,等. 降钙素原及白介素-6测定在急性扁桃体炎合并脓毒症患儿中的诊断价值研究[J]. 中华医院感染学杂志, 2017, 27(5):1163-1166.
[22] 沈学锋. 匹多莫德对慢性扁桃体炎患儿血清白细胞介素4和干扰素-γ的影响[J]. 医药导报, 2017, 36(1):53-55.