阿奇霉素不同用药方式治疗小儿支原体肺炎临床效果分析
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摘要
目的 :探讨阿奇霉素常规疗法和序贯疗法治疗小儿支原体肺炎的临床效果。方法 :选取2015年4月-2017年7月我院收治的支原体肺炎患者90例,按随机数字法分为对照组和观察组,各45例。对照组采用阿奇霉素(10 mg/kg加入0.9%氯化钠溶液,ivgtt,qd,连续使用3 d。停药4 d后再次给予相同的剂量治疗)常规疗法,观察组采用阿奇霉素序贯疗法(常规疗法基础上,第8 d改为口服阿奇霉素混悬液10 mg/kg,qd),比较两组的治疗效果、不良反应发生情况以及临床症状消失时间。结果 :观察组总有效率为93.33%,高于对照组的84.44%(P<0.05);观察组治疗后并发症发生率为11.11%,低于对照组的17.78%(P<0.05);观察组治疗后发热、咳嗽及肺啰音消失时间,均短于对照组(P<0.05)。结论 :采用阿奇霉素序贯疗法治疗支原体肺炎有助于提高临床疗效,缩短症状消失时间,安全性较高,值得推广应用。
Objective:To investigate the clinical effect of azithromycin routine therapy and sequential therapy on mycoplasma pneumonia in children.Methods:Ninety patients with mycoplasmal pneumonia admitted from April 2015 to July 2017 in our hospital were selected and randomized into control group(n=45)and observation group(n=45).Patients in the control group were treated with azithromycin routine therapy,the dosage of azithromycin routine therapy is 10 mg/kg formulated in 0.9% Na Cl solution by ivgtt,after dosing for continuous 3 days(qd),the treatment was suspended for 4 days and then back to the same dosage.Patients in the observation group were treated with azithromycin sequential therapy,which is based on azithromycin routine therapy,except that azithromycin mixture was applied orally at 10 mg/kg every day after the drug suspension.The treatment effect,adverse reactions and disappearance of clinical symptoms were compared between the two groups.Results:The total curative rate of the observation group was 93.33%,which was higher than that of the control group(84.44%,P<0.05).The incidence of complications in the observation group was 11.11%,which was lower than 17.78% of the control group(P<0.05).The time required for the disappearances of fever,cough and pulmonary rales were all shorter in the observation group than those in the control group(P<0.05).Conclusion:The sequential treatment of azithromycin in mycoplasma pneumonia can help to improve the clinical efficacy and shorten the disappearance of symptoms with high safety,it is worth popularizing and applying.
Objective:To investigate the clinical effect of azithromycin routine therapy and sequential therapy on mycoplasma pneumonia in children.Methods:Ninety patients with mycoplasmal pneumonia admitted from April 2015 to July 2017 in our hospital were selected and randomized into control group(n=45)and observation group(n=45).Patients in the control group were treated with azithromycin routine therapy,the dosage of azithromycin routine therapy is 10 mg/kg formulated in 0.9% Na Cl solution by ivgtt,after dosing for continuous 3 days(qd),the treatment was suspended for 4 days and then back to the same dosage.Patients in the observation group were treated with azithromycin sequential therapy,which is based on azithromycin routine therapy,except that azithromycin mixture was applied orally at 10 mg/kg every day after the drug suspension.The treatment effect,adverse reactions and disappearance of clinical symptoms were compared between the two groups.Results:The total curative rate of the observation group was 93.33%,which was higher than that of the control group(84.44%,P<0.05).The incidence of complications in the observation group was 11.11%,which was lower than 17.78% of the control group(P<0.05).The time required for the disappearances of fever,cough and pulmonary rales were all shorter in the observation group than those in the control group(P<0.05).Conclusion:The sequential treatment of azithromycin in mycoplasma pneumonia can help to improve the clinical efficacy and shorten the disappearance of symptoms with high safety,it is worth popularizing and applying.
引文
[1]任仙强.阿奇霉素不同给药方式治疗儿童支原体肺炎效果比较[J].基层医学论坛,2014,18(2):180-181.
[2]徐英.阿奇霉素不同用药方式治疗支原体肺炎患儿临床效果研究[J].大家健康(上旬版),2017,11(1):147.
[3]欧阳慧萍,陶志允,余飞苑.不同方式阿奇霉素治疗小儿支原体肺炎的临床效果比较[J].社区医学杂志,2014,12(5):47,79.
[4]余红蕾,赵红玲,王立琼,等.阿奇霉素不同用药方式治疗支原体肺炎患儿临床效果研究[J].中华医院感染学杂志,2016,26(7):1631-1633.
[5]黄炜,王曾.阿奇霉素连续和间歇给药治疗支原体肺炎的疗效及耐药性分析[J].医学信息,2015,28(7):319.
[6]李小瑜,陈少君,陈雅杏,等.甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎(RMPP)的疗效与安全性[J].北方药学,2017,14(1):151-152.
[7]杨镋灵.联用阿奇霉素和乳糖酸红霉素治疗支原体肺炎的效果探析[J].当代医药论丛,2017,15(1):68-69.
[8]高连通.阿奇霉素两种给药途径治疗支原体性肺炎的疗效及耐药性研究[J].临床医药文献杂志,2015,2(9):1626.
[2]徐英.阿奇霉素不同用药方式治疗支原体肺炎患儿临床效果研究[J].大家健康(上旬版),2017,11(1):147.
[3]欧阳慧萍,陶志允,余飞苑.不同方式阿奇霉素治疗小儿支原体肺炎的临床效果比较[J].社区医学杂志,2014,12(5):47,79.
[4]余红蕾,赵红玲,王立琼,等.阿奇霉素不同用药方式治疗支原体肺炎患儿临床效果研究[J].中华医院感染学杂志,2016,26(7):1631-1633.
[5]黄炜,王曾.阿奇霉素连续和间歇给药治疗支原体肺炎的疗效及耐药性分析[J].医学信息,2015,28(7):319.
[6]李小瑜,陈少君,陈雅杏,等.甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎(RMPP)的疗效与安全性[J].北方药学,2017,14(1):151-152.
[7]杨镋灵.联用阿奇霉素和乳糖酸红霉素治疗支原体肺炎的效果探析[J].当代医药论丛,2017,15(1):68-69.
[8]高连通.阿奇霉素两种给药途径治疗支原体性肺炎的疗效及耐药性研究[J].临床医药文献杂志,2015,2(9):1626.