钬激光碎石术、ESWL和气压弹道碎石术治疗输尿管结石对患者氧化应激蛋白和炎症因子的影响
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摘要
比较钬激光碎石术、体外冲击波碎石术、气压弹道碎石术治疗输尿管结石对患者体内氧化应激蛋白和炎症因子的影响进行研究,为临床治疗提供参考。方法采取随机、对照设计,对三组各40例患者,分别观察输尿管结石患者治疗前后血清中氧化应激酶SOD、CAT、GSHpx和MDA水平以及炎症因子白细胞介素2(IL-2)、白细胞介素6(IL-6)、白细胞介素10(IL-10)和TNFα水平。结果输尿管结石患者血清中氧化应激酶NOX1,NOX3,NOX4和NOX5及炎症因子白细胞介素2(IL-2)、白细胞介素6(IL-6)、白细胞介素10(IL-10)和TNFα明显高于对照组(P <0. 05),经三种治疗方法治疗后上述异常的氧化应激酶蛋白水平明显恢复,且与治疗前相比有显著的统计学差异性(P <0. 05)。结论腔内钬激光碎石术、ESWL和气压弹道碎石术均对输尿管结石患者有良好临床治疗效果。
Objective To study The Effect and Influence on Serum Oxidative Stress Proteins and Inflammatory Factors of Lumen Holmium Laser Lithotripsy、ESWL and pneumatic ballistic lithotripsy on Ureteral Calculi Patients. Methods To adopt randomized,controlled design,three groups( 40 cases of patients,respectively,observing an operation rate of rubble,the NOX1. NOX3,NOX4 and NOX5 and IL2,IL6,IL10 and TNFα. application SPSS20. 0 statistical software for data analysis. Results The NOX1. NOX3,NOX4 and NOX5 and IL2,IL6,IL10 and TNFα of Three ways were increased greatly in ureteral calculi patients( P < 0. 05) and these parameters were normalized greatly after operation( P < 0. 05). Conclusion Three ways are effective on Ureteral Calculi Patients,but holmium laser lithotripsy is more.
Objective To study The Effect and Influence on Serum Oxidative Stress Proteins and Inflammatory Factors of Lumen Holmium Laser Lithotripsy、ESWL and pneumatic ballistic lithotripsy on Ureteral Calculi Patients. Methods To adopt randomized,controlled design,three groups( 40 cases of patients,respectively,observing an operation rate of rubble,the NOX1. NOX3,NOX4 and NOX5 and IL2,IL6,IL10 and TNFα. application SPSS20. 0 statistical software for data analysis. Results The NOX1. NOX3,NOX4 and NOX5 and IL2,IL6,IL10 and TNFα of Three ways were increased greatly in ureteral calculi patients( P < 0. 05) and these parameters were normalized greatly after operation( P < 0. 05). Conclusion Three ways are effective on Ureteral Calculi Patients,but holmium laser lithotripsy is more.
引文
[1]万旭辉,赖建平,陈善勤,等.输尿管镜气压弹道碎石术治疗输尿管结石(附2620例报告)[J].中国内镜杂志,2012,6(2):180-183.
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[4]熊玮,王坤杰,王莉,等.坦索罗辛用于输尿管结石排石治疗随机对照试验的Meta分析[J].中国循证医学志,2007,11(7):506-515.
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[6]周莉,陆卫平.糖尿病肾病患者血清趋化因子与氧化应激水平的相关性及α-硫辛酸的治疗作用[J].南京医科大学学报(自然科学版),2013,15(10):1435-1438.
[7]窦坤,刘齐贵,周庆余,等.腔内钬激光碎石术治疗输尿管结石并肾绞痛486例[J].感染、炎症、修复,2013,8(1):47-48.
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[9]毛志敏,黄燕如,万毅刚,等.糖尿病肾病肾组织氧化应激的调控机制及中药的干预作用[J].中国中药志,2014,14(19):3707-3712.
[10]詹继红,郭银雪.刺梨干粉对CKD3-4期脾肾气虚夹湿型患者氧化应激相关指标的影响[J].中国实验方剂志,2014,9(23):224-226.
[11]杨雪蓉,姚政,陶枫,等. DM120方对糖尿病大鼠肾组织氧化应激水平的影响[J].上海中医药大学学报,2014,6(1):61-63.
[12]罗俊华,曹秋实,王林群.排石冲剂对尿路结石ESWL术后患者氧化应激的影响[J].中国中医急症,2014,8(4):704-705.
[13]谷明利,诸禹平.腔镜治疗上尿路结石术后全身炎症反应综合征的危险因素分析[J].中国内镜杂志,2015,3(9):952-955.
[14]齐勇,汤春波. ESWL治疗尿路结石致全身炎症反应综合征发生的相关因素[J].中国现代医生,2012,2(18):30-32.
[15]李佳胜,曾国华,赵志健.逆行输尿管软镜钬激光碎石术后发生全身炎症反应综合征的危险因素分析[J].临床泌尿外科杂志,2015,5(30):433-436.
[2]覃斌,黄向华,李长赞,等.输尿管镜下钬激光碎石与气压弹道碎石术治疗输尿管结石的疗效比较[J].中华腔镜泌尿外科杂志(电子版),2012,9(1):38-41.
[3]陈波特,张小明,杨槐,等.输尿管镜钬激光碎石术与体外冲击波碎石术治疗输尿管结石的临床比较[J].临床泌尿外科杂志,2014,5(2):99-102.
[4]熊玮,王坤杰,王莉,等.坦索罗辛用于输尿管结石排石治疗随机对照试验的Meta分析[J].中国循证医学志,2007,11(7):506-515.
[5]郝惠惠,汤道权.芦丁对糖尿病肾病大鼠氧化应激及醛糖还原酶的影响[J].江苏医药,2013,6(21):2520-2522.
[6]周莉,陆卫平.糖尿病肾病患者血清趋化因子与氧化应激水平的相关性及α-硫辛酸的治疗作用[J].南京医科大学学报(自然科学版),2013,15(10):1435-1438.
[7]窦坤,刘齐贵,周庆余,等.腔内钬激光碎石术治疗输尿管结石并肾绞痛486例[J].感染、炎症、修复,2013,8(1):47-48.
[8]何文强,尹继云,段峰,等.输尿管软镜钬激光碎石术治疗上尿路结石309例报告[J].临床泌尿外科杂志,2013,6(12):889-890.
[9]毛志敏,黄燕如,万毅刚,等.糖尿病肾病肾组织氧化应激的调控机制及中药的干预作用[J].中国中药志,2014,14(19):3707-3712.
[10]詹继红,郭银雪.刺梨干粉对CKD3-4期脾肾气虚夹湿型患者氧化应激相关指标的影响[J].中国实验方剂志,2014,9(23):224-226.
[11]杨雪蓉,姚政,陶枫,等. DM120方对糖尿病大鼠肾组织氧化应激水平的影响[J].上海中医药大学学报,2014,6(1):61-63.
[12]罗俊华,曹秋实,王林群.排石冲剂对尿路结石ESWL术后患者氧化应激的影响[J].中国中医急症,2014,8(4):704-705.
[13]谷明利,诸禹平.腔镜治疗上尿路结石术后全身炎症反应综合征的危险因素分析[J].中国内镜杂志,2015,3(9):952-955.
[14]齐勇,汤春波. ESWL治疗尿路结石致全身炎症反应综合征发生的相关因素[J].中国现代医生,2012,2(18):30-32.
[15]李佳胜,曾国华,赵志健.逆行输尿管软镜钬激光碎石术后发生全身炎症反应综合征的危险因素分析[J].临床泌尿外科杂志,2015,5(30):433-436.