番茄红素的生物学功能及其在动物生产中的应用
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摘要
番茄红素是一种黄/红色不含氧的类胡萝卜素,作为纯天然的饲料添加剂,具有抗氧化、提高免疫力、改善脂质代谢和繁殖能力等作用。本文综述了番茄红素的理化特性、生理功能及其在动物生产中的应用现状,以期为番茄红素开发利用和动物的健康养殖提供参考。
Lycopene,a yellowish or red carotenoid,is a naturally feed additive,which has the effects of antioxidation,improve immune function,regulate lipid metabolism and reproductive capacity,et al.This article summarized the physicochemical characteristics,physiological function,as well as the actual application status in animal production,in order to provide conference for the development and utilization of lycopene and the healthy breeding of animals.
Lycopene,a yellowish or red carotenoid,is a naturally feed additive,which has the effects of antioxidation,improve immune function,regulate lipid metabolism and reproductive capacity,et al.This article summarized the physicochemical characteristics,physiological function,as well as the actual application status in animal production,in order to provide conference for the development and utilization of lycopene and the healthy breeding of animals.
引文
[1]LAVELLI V,GIOVANELLI G.Evaluation of heat and oxidative damage during storage of processed tomato products.Ⅱ.Study of oxidative damage indices[J].Journal of the Science of Food and Agriculture,2003,83(9):966-971.
[2]VOGELE A C.Effect of environmental factors upon the color of the tomato and the watermelon[J].Plant Physiology,1937,12(4):929-955.
[3]MASCIO P D,KAISER S,SIES H.Lycopene as the most efficient biological carotenoid singlet oxygen quencher[J].Archives of Biochemistry and Biophysics,1989,274(2):532-538.
[4]GERSTER H.The potential role of lycopene for human health[J].Journal of the American College of Nutrition,1997,16(2):109-126.
[5]SHI J,LE MAGUER M,BRYAN M,et al.Kinetics of lycopene degradation in tomato puree by heat and light irradiation[J].Journal of Food Process Engineering,2003,25(6):485-498.
[6]SHI J,LE MAGUER M.Lycopene in tomatoes:chemical and physical properties affected by food processing[J].Critical Reviews in Food Science and Nutrition,2000,40(1):1-42.
[7]ROMANCHIK J E,HARRISON E H,MOREL D W.Addition of lutein,lycopene,orβ-carotene to LDL or serum in vitro:effects on carotenoid distribution,LDLcomposition,and LDL oxidation[J].The Journal of Nutritional Biochemistry,1997,8(12):681-688.
[8]JAIN C K,AGARWAL S,RAO A V.The effect of dietary lycopene on bioavailability,tissue distribution,in vivo antioxidant properties and colonic preneoplasia in rats[J].Nutrition Research,1999,19(9):1383-1391.
[9]RAO A V,WASEEM Z,AGARWAL S.Lycopene content of tomatoes and tomato products and their contribution to dietary lycopene[J].Food Research International,1998,31(10):737-741.
[10]SCHIERLE J,BRETZEL W,BHLER I,et al.Content and isomeric ratio of lycopene in food and human blood plasma[J].Food Chemistry,1997,59(3):459-465.
[11]GRTNER C,STAHL W,SIES H.Lycopene is more bioavailable from tomato paste than from fresh tomatoes[J].The American Journal of Clinical Nutrition,1997,66(1):116-122.
[12]JIANG H Q,WANG Z Z,MA Y,et al.Effects of Dietary lycopene supplementation on plasma lipid profile,lipid peroxidation and antioxidant defense system in feedlot bamei lamb[J].Asian-Australasian Journal of Animal Sciences,2015,28(7):958-965.
[13]TEKELI I O,ATEAHIN A,SAKIN F,et al.Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats[J].Inflammopharmacology,2018,doi:10.1007/s10787-018-0485-x.
[14]ZHAO Y S,XIN Z,LI N N,et al.Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism[J].Free Radical Biology and Medicine,2018,124:1-11.
[15]TORGOVNICK A,SCHIAVI A,MAGLIONI S,et al.Healthy aging:what can we learn from Caenorhabditis elegans?[J].Zeitschrift Für Gerontologie Und Geriatrie,2013,46(7):623-628.
[16]NOWAK J Z.Oxidative stress,polyunsaturated fatty acidsderived oxidation products and bisretinoids as potential inducers of CNS diseases:focus on age-related macular degeneration[J].Pharmacological Reports,2013,65(2):288-304.
[17]PRAKASH A,KUMAR A.Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats:an evidence of nitric oxide signaling[J].European Journal of Pharmacology,2013,721(1/2/3):373-381.
[18]PRASAD A K,MISHRA P C.Modeling the mechanism of action of lycopene as a hydroxyl radical scavenger[J].Journal of Molecular Modeling,2014,20:2233.
[19]ALVI S S,ANSARI I A,AHMAD M K,et al.Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity[J].Biomedicine&Pharmacotherapy,2017,96:1082-1093.
[20]ZOJA C,BENIGNI A,REMUZZI G.The Nrf2 pathway in the progression of renal disease[J].Nephrology,Dialysis,Transplantation,2014,29 Suppl 1:i19-i24.
[21]LIU Z P,XIANG Y Q,SUN G H.The KCTD family of proteins:structure,f unction,disease relevance[J].Cell&Bioscience,2013,3:45.
[22]YAMAMOTO T,SUZUKI T,KOBAYASHI A,et al.Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity[J].Molecular and Cellular Biology,2008,28(8):2758-2770.
[23]HE M H,PAN H,CHANG R C C,et al.Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage[J].PLoS One,2014,9(1):e84800.
[24]BEN-DOR A,STEINER M,GHEBER L,et al.Carotenoids activate the antioxidant response element transcription system[J].Molecular Cancer Therapeutics,2005,4(1):177-186.
[25]PALOZZA P,CATALANO A,SIMONE R,et al.Lycopene as a guardian of redox signalling[J].Acta Biochimica Polonica,2012,59(1):21-25.
[26]SAHIN K,YAZLAK H,ORHAN C,et al.The effect of lycopene on antioxidant status in rainbow trout(Oncorhynchus mykiss)reared under high stocking density[J].Aquaculture,2014,418-419:132-138.
[27]SAHIN K,ORHAN C,AKDEMIR F,et al.Tomato powder supplementation activates Nrf-2 via ERK/Akt signaling pathway and attenuates heat stress-related responses in quails[J].Animal Feed Science and Technology,2011,165(3/4):230-237.
[28]SAHIN K,TUZCU M,SAHIN N,et al.Nrf2/HO-1signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene[J].Food and Chemical Toxicology,2010,48(10):2670-2674.
[29]DAI C S,TANG S S,DENG S J,et al.Lycopene Attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway[J].Antimicrobial Agents and Chemotherapy,2015,59(1):579-585.
[30]WATZL B,BUB A,BLOCKHAUS M,et al.Prolonged tomato juice consumption has no effect on cellmediated immunity of well-nourished elderly men and women[J].The Journal of Nutrition,2000,130(7):1719-1723.
[31]潘洪志,那立欣,石刚,等.番茄红素对大鼠细胞DNA氧化损伤修复的影响[J].卫生研究,2004,33(2):189-191.
[32]柴静波,李萍,裴志萍.番茄红素对荷卵巢癌大鼠免疫功能的影响及其机制研究[J].实用肿瘤学杂志,2017,31(1):13-17.
[33]袁暾,魏大鹏,廖林川,等.番茄红素对非特异性免疫功能的体外实验研究[J]食品科学,2003,24(4):133-136.
[34]杜宏举,郑珊,马玲,等.番茄红素对小鼠免疫功能的促进作用[J].毒理学杂志,2014,28(3):211-214.
[35]陈垚,吕志敏,孙川喻,等.番茄红素增强免疫力功能的研究[J].预防医学论坛,2017,23(5):390-392,395.
[36]CONG L,WU X G.Lycopene enhances antioxidant enzyme activities and immunity function in N-methylN'-nitro-N-nitrosoguanidine-induced gastric cancer rats[J].International Journal of Molecular Sciences,2011,12(5):3340-3351.
[37]SAHIN K,YENICE E,TUZCU M,et al.Lycopene protects against spontaneous ovarian cancer formation in laying hens[J].Journal of Cancer Prevention,2018,23(1):25-36.
[38]MARCOTORCHINO J,ROMIER B,GOURANTONE,et al.Lycopene attenuates LPS-induced TNF-αsecretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media[J].Molecular Nutrition&Food Research,2012,56(5):725-732.
[39]MAKON-SEBASTIEN N,FRANCIS F,ERIC S,et al.Lycopene modulates THP1 and Caco2 cells inflammatory state through transcriptional and nontranscriptional processes[J].Mediators of Inflammation,2014,2014:507272.
[40]LEE K W,CHOO W D,KANG C W,et al.Effect of lycopene on the copper-induced oxidation of low-density lipoprotein in broiler chickens[J].Springerplus,2016,5:389.
[41]丁旭,谢羡,刘娟,等.番茄红素对反式脂肪酸致小鼠肾脏损伤的修复作用[J].湖南师范大学学报(医学版),2017,14(5):8-12.
[42]ZENG Z H,HE W,JIA Z,et al.Lycopene improves insulin sensitivity through inhibition of STAT3/Srebp-1c-mediated lipid accumulation and inflammation in mice fed a high-fat diet[J].Experimental and Clinical Endocrinology&Diabetes,2017,125(9):610-617.
[43]FORD N A,ELSEN A C,ERDMAN J W Jr.Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulate carotenoid and lipid metabolism in mice[J].Nutrition Research,2013,33(9):733-742.
[44]FUHRMAN B,ELIS A,AVIRAM M.Hypocholesterolemic effect of lycopene andβ-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages[J].Biochemical and Biophysical Research Communications,1997,233(3):658-662.
[45]SAHIN K,ORHAN C,TUZCU M,et al.Lycopene activates antioxidant enzymes and nuclear transcription factor systems in heat-stressed broilers[J].Poultry Science,2016,95(5):1088-1095.
[46]SUN B,CHEN C,WANG W,et al.Effects of lycopene supplementation in both maternal and offspring diets on growth performance,antioxidant capacity and biochemical parameters in chicks[J].Journal of Animal Physiology and Animal Nutrition,2015,99(1):42-49.
[47]王晓娟,何宇,唐炳,等.稀释液中添加番茄红素对鸡精子保护作用的研究[J].黑龙江畜牧兽医,2015(22):54-56,59.
[48]何春玫,周贞兵.日粮中添加番茄红素对蛋鸡产品脂质的影响[J].湖北农业科学,2015,54(4):917-919,925.
[49]CORREIA C S,ALFAIA C M,MADEIRA M S,et al.Dietary inclusion of tomato pomace improves meat oxidative stability of young pigs[J].Journal of Animal Physiology&Animal Nutrition,2017,101(6):1215-1226.
[50]BRIGELIUS-FLOHR.Vitamin E:the shrew waiting to be tamed[J].Free Radical Biology and Medicine,2009,46(5):543-554.
[51]王捷.番茄红素、芝麻酚和黄芩素对猪精子冷冻保存效果的影响[D].硕士学位论文.杨凌:西北农林科技大学,2017.
[52]孟妤,杨鸢劼,王建美,等.饲料中补充番茄红素对鲫鱼抗氧化能力的影响[J].安徽农业大学学报,2011,38(1):59-64.
[53]孟妤,杨鸢劼,单志萍,等.番茄红素油对鲫鱼生长性能和抗氧化性的影响[J].江苏农业学报,2011,27(1):124-128.
[54]YONAR M E.The effect of lycopene on oxytetracyclineinduced oxidative stress and immunosuppression in rainbow trout(Oncorhynchus mykiss W.)[J].Fish&Shellfish Immunology,2012,32(6):994-1001.
[55]EHSANI A,PAKTARMANI M,YOUSEFI M.Efficiency of dietary sodium alginate coating incorporated with lycopene in preserving rainbow trout[J].Food Science and Biotechnology,2017,26(1):557-562.
[56]BUCAK M N,ATAMAN M B,BAPINAR N,et al.Lycopene and resveratrol improve post-thaw bull sperm parameters:sperm motility,mitochondrial activity and DNA integrity[J].Andrologia,2015,47(5):545-552.
[57]王艳华,朱海鲸,韩聪,等.番茄红素对山羊精液冷冻保存效果的影响[J].西北农业学报,2017,26(3):336-341.
[58]TVRDE,KOVCIK A,TUIMOVE,et al.Antioxidant efficiency of lycopene on oxidative stressinduced damage in bovine spermatozoa[J].Journal of Animal Science and Biotechnology,2016,7(1):50.
[59]UYSAL O,BUCAK M N.Effects of oxidized glutathione,bovine serum albumin,cysteine and lycopene on the quality of frozen-thawed ram semen[J].Acta Veterinaria Brno,2007,76(3):383-390.
[60]蒋红琴.番茄红素对巴美肉羊肉品质的影响及其抗氧化机理研究[D].博士学位论文.北京:中国农业大学,2015.
[61]马骋远,喻倩倩,刘毅,等.番茄红素对羊肉滋味及游离脂肪酸的影响[J].食品工业,2018,39(1):136-141.
[2]VOGELE A C.Effect of environmental factors upon the color of the tomato and the watermelon[J].Plant Physiology,1937,12(4):929-955.
[3]MASCIO P D,KAISER S,SIES H.Lycopene as the most efficient biological carotenoid singlet oxygen quencher[J].Archives of Biochemistry and Biophysics,1989,274(2):532-538.
[4]GERSTER H.The potential role of lycopene for human health[J].Journal of the American College of Nutrition,1997,16(2):109-126.
[5]SHI J,LE MAGUER M,BRYAN M,et al.Kinetics of lycopene degradation in tomato puree by heat and light irradiation[J].Journal of Food Process Engineering,2003,25(6):485-498.
[6]SHI J,LE MAGUER M.Lycopene in tomatoes:chemical and physical properties affected by food processing[J].Critical Reviews in Food Science and Nutrition,2000,40(1):1-42.
[7]ROMANCHIK J E,HARRISON E H,MOREL D W.Addition of lutein,lycopene,orβ-carotene to LDL or serum in vitro:effects on carotenoid distribution,LDLcomposition,and LDL oxidation[J].The Journal of Nutritional Biochemistry,1997,8(12):681-688.
[8]JAIN C K,AGARWAL S,RAO A V.The effect of dietary lycopene on bioavailability,tissue distribution,in vivo antioxidant properties and colonic preneoplasia in rats[J].Nutrition Research,1999,19(9):1383-1391.
[9]RAO A V,WASEEM Z,AGARWAL S.Lycopene content of tomatoes and tomato products and their contribution to dietary lycopene[J].Food Research International,1998,31(10):737-741.
[10]SCHIERLE J,BRETZEL W,BHLER I,et al.Content and isomeric ratio of lycopene in food and human blood plasma[J].Food Chemistry,1997,59(3):459-465.
[11]GRTNER C,STAHL W,SIES H.Lycopene is more bioavailable from tomato paste than from fresh tomatoes[J].The American Journal of Clinical Nutrition,1997,66(1):116-122.
[12]JIANG H Q,WANG Z Z,MA Y,et al.Effects of Dietary lycopene supplementation on plasma lipid profile,lipid peroxidation and antioxidant defense system in feedlot bamei lamb[J].Asian-Australasian Journal of Animal Sciences,2015,28(7):958-965.
[13]TEKELI I O,ATEAHIN A,SAKIN F,et al.Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats[J].Inflammopharmacology,2018,doi:10.1007/s10787-018-0485-x.
[14]ZHAO Y S,XIN Z,LI N N,et al.Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism[J].Free Radical Biology and Medicine,2018,124:1-11.
[15]TORGOVNICK A,SCHIAVI A,MAGLIONI S,et al.Healthy aging:what can we learn from Caenorhabditis elegans?[J].Zeitschrift Für Gerontologie Und Geriatrie,2013,46(7):623-628.
[16]NOWAK J Z.Oxidative stress,polyunsaturated fatty acidsderived oxidation products and bisretinoids as potential inducers of CNS diseases:focus on age-related macular degeneration[J].Pharmacological Reports,2013,65(2):288-304.
[17]PRAKASH A,KUMAR A.Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats:an evidence of nitric oxide signaling[J].European Journal of Pharmacology,2013,721(1/2/3):373-381.
[18]PRASAD A K,MISHRA P C.Modeling the mechanism of action of lycopene as a hydroxyl radical scavenger[J].Journal of Molecular Modeling,2014,20:2233.
[19]ALVI S S,ANSARI I A,AHMAD M K,et al.Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity[J].Biomedicine&Pharmacotherapy,2017,96:1082-1093.
[20]ZOJA C,BENIGNI A,REMUZZI G.The Nrf2 pathway in the progression of renal disease[J].Nephrology,Dialysis,Transplantation,2014,29 Suppl 1:i19-i24.
[21]LIU Z P,XIANG Y Q,SUN G H.The KCTD family of proteins:structure,f unction,disease relevance[J].Cell&Bioscience,2013,3:45.
[22]YAMAMOTO T,SUZUKI T,KOBAYASHI A,et al.Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity[J].Molecular and Cellular Biology,2008,28(8):2758-2770.
[23]HE M H,PAN H,CHANG R C C,et al.Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage[J].PLoS One,2014,9(1):e84800.
[24]BEN-DOR A,STEINER M,GHEBER L,et al.Carotenoids activate the antioxidant response element transcription system[J].Molecular Cancer Therapeutics,2005,4(1):177-186.
[25]PALOZZA P,CATALANO A,SIMONE R,et al.Lycopene as a guardian of redox signalling[J].Acta Biochimica Polonica,2012,59(1):21-25.
[26]SAHIN K,YAZLAK H,ORHAN C,et al.The effect of lycopene on antioxidant status in rainbow trout(Oncorhynchus mykiss)reared under high stocking density[J].Aquaculture,2014,418-419:132-138.
[27]SAHIN K,ORHAN C,AKDEMIR F,et al.Tomato powder supplementation activates Nrf-2 via ERK/Akt signaling pathway and attenuates heat stress-related responses in quails[J].Animal Feed Science and Technology,2011,165(3/4):230-237.
[28]SAHIN K,TUZCU M,SAHIN N,et al.Nrf2/HO-1signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene[J].Food and Chemical Toxicology,2010,48(10):2670-2674.
[29]DAI C S,TANG S S,DENG S J,et al.Lycopene Attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway[J].Antimicrobial Agents and Chemotherapy,2015,59(1):579-585.
[30]WATZL B,BUB A,BLOCKHAUS M,et al.Prolonged tomato juice consumption has no effect on cellmediated immunity of well-nourished elderly men and women[J].The Journal of Nutrition,2000,130(7):1719-1723.
[31]潘洪志,那立欣,石刚,等.番茄红素对大鼠细胞DNA氧化损伤修复的影响[J].卫生研究,2004,33(2):189-191.
[32]柴静波,李萍,裴志萍.番茄红素对荷卵巢癌大鼠免疫功能的影响及其机制研究[J].实用肿瘤学杂志,2017,31(1):13-17.
[33]袁暾,魏大鹏,廖林川,等.番茄红素对非特异性免疫功能的体外实验研究[J]食品科学,2003,24(4):133-136.
[34]杜宏举,郑珊,马玲,等.番茄红素对小鼠免疫功能的促进作用[J].毒理学杂志,2014,28(3):211-214.
[35]陈垚,吕志敏,孙川喻,等.番茄红素增强免疫力功能的研究[J].预防医学论坛,2017,23(5):390-392,395.
[36]CONG L,WU X G.Lycopene enhances antioxidant enzyme activities and immunity function in N-methylN'-nitro-N-nitrosoguanidine-induced gastric cancer rats[J].International Journal of Molecular Sciences,2011,12(5):3340-3351.
[37]SAHIN K,YENICE E,TUZCU M,et al.Lycopene protects against spontaneous ovarian cancer formation in laying hens[J].Journal of Cancer Prevention,2018,23(1):25-36.
[38]MARCOTORCHINO J,ROMIER B,GOURANTONE,et al.Lycopene attenuates LPS-induced TNF-αsecretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media[J].Molecular Nutrition&Food Research,2012,56(5):725-732.
[39]MAKON-SEBASTIEN N,FRANCIS F,ERIC S,et al.Lycopene modulates THP1 and Caco2 cells inflammatory state through transcriptional and nontranscriptional processes[J].Mediators of Inflammation,2014,2014:507272.
[40]LEE K W,CHOO W D,KANG C W,et al.Effect of lycopene on the copper-induced oxidation of low-density lipoprotein in broiler chickens[J].Springerplus,2016,5:389.
[41]丁旭,谢羡,刘娟,等.番茄红素对反式脂肪酸致小鼠肾脏损伤的修复作用[J].湖南师范大学学报(医学版),2017,14(5):8-12.
[42]ZENG Z H,HE W,JIA Z,et al.Lycopene improves insulin sensitivity through inhibition of STAT3/Srebp-1c-mediated lipid accumulation and inflammation in mice fed a high-fat diet[J].Experimental and Clinical Endocrinology&Diabetes,2017,125(9):610-617.
[43]FORD N A,ELSEN A C,ERDMAN J W Jr.Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulate carotenoid and lipid metabolism in mice[J].Nutrition Research,2013,33(9):733-742.
[44]FUHRMAN B,ELIS A,AVIRAM M.Hypocholesterolemic effect of lycopene andβ-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages[J].Biochemical and Biophysical Research Communications,1997,233(3):658-662.
[45]SAHIN K,ORHAN C,TUZCU M,et al.Lycopene activates antioxidant enzymes and nuclear transcription factor systems in heat-stressed broilers[J].Poultry Science,2016,95(5):1088-1095.
[46]SUN B,CHEN C,WANG W,et al.Effects of lycopene supplementation in both maternal and offspring diets on growth performance,antioxidant capacity and biochemical parameters in chicks[J].Journal of Animal Physiology and Animal Nutrition,2015,99(1):42-49.
[47]王晓娟,何宇,唐炳,等.稀释液中添加番茄红素对鸡精子保护作用的研究[J].黑龙江畜牧兽医,2015(22):54-56,59.
[48]何春玫,周贞兵.日粮中添加番茄红素对蛋鸡产品脂质的影响[J].湖北农业科学,2015,54(4):917-919,925.
[49]CORREIA C S,ALFAIA C M,MADEIRA M S,et al.Dietary inclusion of tomato pomace improves meat oxidative stability of young pigs[J].Journal of Animal Physiology&Animal Nutrition,2017,101(6):1215-1226.
[50]BRIGELIUS-FLOHR.Vitamin E:the shrew waiting to be tamed[J].Free Radical Biology and Medicine,2009,46(5):543-554.
[51]王捷.番茄红素、芝麻酚和黄芩素对猪精子冷冻保存效果的影响[D].硕士学位论文.杨凌:西北农林科技大学,2017.
[52]孟妤,杨鸢劼,王建美,等.饲料中补充番茄红素对鲫鱼抗氧化能力的影响[J].安徽农业大学学报,2011,38(1):59-64.
[53]孟妤,杨鸢劼,单志萍,等.番茄红素油对鲫鱼生长性能和抗氧化性的影响[J].江苏农业学报,2011,27(1):124-128.
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