松龄血脉康胶囊联合钙通道阻滞剂治疗高血压疗效及安全性的Meta分析
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摘要
目的:评价松龄血脉康胶囊联合CCB治疗高血压的疗效及安全性。方法:计算机检索Pubmed、万方数据库、中国学术期刊全文及生物医学文献数据库、维普数据库自建库至2014年,所有松龄血脉康胶囊联合CCB治疗高血压的试验,根据纳入和排除标准共纳入12项研究,1 621例患者,将临床综合疗效、收缩压下降值、舒张压下降值、总胆固醇、甘油三酯、高密度脂蛋白胆固醇纳为效应指标,使用RevMan5.3软件进行Meta分析。结果:临床综合疗效OR合并值为2.49,95%的CI为[1.81,3.41],P<0.000 01,差异有统计学意义,治疗组疗效优于对照组。收缩压下降值(WMD=-8.58,95%的CI为[-11.17,-5.99],P=0.000 01),差异有统计学意义。舒张压下降值(WMD=-6.96,95%的CI为[-9.95,-3.97],P=0.000 01),差异有统计学意义。总胆固醇(WMD=-0.67,95%的CI为[-1.08,-0.26],P=0.001),差异具有统计学意义。甘油三酯(WMD=-0.41,95%的CI为[-0.62,-0.21],P=0.000 1),差异具有统计学意义。高密度脂蛋白胆固醇(WMD=0.89,95%的CI为[0.33,1.45],P=0.002),差异有统计学意义。结论:研究结果表明,松龄血脉康胶囊联合CCB治疗高血压疗效确切,安全性较高。
Objective:To study efficacy and safety of Songling Xuemaikang capsule combined with CCB in treating hypertension. Methods : All documents which recorded experiments on hypertension patients treated with Songling Xuemaikang capsule and CCB were retrieved by computer from Pubmed,Wanfang database, database and Chinese Biomedical Database, VIP database from setting up to 2014, According to the inclusion and exclusion criteria,a total of 12 documents with 1 621 patients was concluded. The clinical curative effect,the decrease value of systolic blood pressure and diastolic blood pressure,total cholesterol,triglyceride,high density lipoprotein cholesterol were chosen as indices, Meta analysis was performed by RevMan5.3 software.Results: ①The OR of clinical curative effect was 2.49,95% CI[1.81, 3.41],P<0.000 01. It showed that curative effect of treatment group was better than that of control group. ②The decrease values in systolic blood pressure was(WMD=-8.58,95% CI[-11.17,-5.99],P=0.000 01).③The decrease value of diastolic blood pressure was(WMD=-6.96,95% CI[-9.95,-3.97],P=0.000 01). ④ The total cholesterol was(WMD=-0.67,95% CI[-1.08,-0.26],P=0.001) ⑤The triglyceride was(WMD=-0.41,95% CI [-0.62,-0.21],P=0.000 1) ⑥The high density lipoprotein cholesterol way(WMD=0.89,95% CI [0.33, 1.45],P=0.002). Conclusion: Songling Xuemaikang capsule combined with CCB is effective, security to hypertension.
Objective:To study efficacy and safety of Songling Xuemaikang capsule combined with CCB in treating hypertension. Methods : All documents which recorded experiments on hypertension patients treated with Songling Xuemaikang capsule and CCB were retrieved by computer from Pubmed,Wanfang database, database and Chinese Biomedical Database, VIP database from setting up to 2014, According to the inclusion and exclusion criteria,a total of 12 documents with 1 621 patients was concluded. The clinical curative effect,the decrease value of systolic blood pressure and diastolic blood pressure,total cholesterol,triglyceride,high density lipoprotein cholesterol were chosen as indices, Meta analysis was performed by RevMan5.3 software.Results: ①The OR of clinical curative effect was 2.49,95% CI[1.81, 3.41],P<0.000 01. It showed that curative effect of treatment group was better than that of control group. ②The decrease values in systolic blood pressure was(WMD=-8.58,95% CI[-11.17,-5.99],P=0.000 01).③The decrease value of diastolic blood pressure was(WMD=-6.96,95% CI[-9.95,-3.97],P=0.000 01). ④ The total cholesterol was(WMD=-0.67,95% CI[-1.08,-0.26],P=0.001) ⑤The triglyceride was(WMD=-0.41,95% CI [-0.62,-0.21],P=0.000 1) ⑥The high density lipoprotein cholesterol way(WMD=0.89,95% CI [0.33, 1.45],P=0.002). Conclusion: Songling Xuemaikang capsule combined with CCB is effective, security to hypertension.
引文
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[22]龙再跟.葛根的药理临床与理化研究[J].安徽中医临床杂志,1998,10(1):62-63.
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[2]高西平,松龄血脉康胶囊治疗后循环缺血38例临床分析[J].中西医结合心脑血管病杂志,2011,9(7):803-804.
[3]中国高血压防治指南修订委员会.中国高血压防治指南(2010)[J].中华高血压杂志,2011,19(8):701-743.
[4]孙建波,梁军,闫玉仙,等.复方丹参滴丸的临床运用及作用机理[J].现代中西医结合杂志,2002,11(11):1 087-1 088.
[5]旭毓,夏旭.医学信息定量综合的新方法-Meta分析[J].医学信息,2002,15(5):303-305.
[6]陈长生,徐勇勇.第十四讲如何进行Meta分析[J].中华预防医学杂志,2003,37(2):138-140.
[7]倪宗赞.医学统计学[M].北京:高等教育出版社,2003:241-251.
[8]康德英,洪旗,刘关键,等. Meta分析中发表性偏倚的识别与处理[J].中国循证医学杂志,2003,3(1):45-49.
[9]周旭毓,方积乾. Meta分析的常见偏倚[J].循证医学,2002,2(4):216-220.
[10]刘伟强.松龄血脉康胶囊与硝苯地平控释片治疗原发性高血压的对比[J].中国实用医药,2012,7(30):127-128.
[11]常雪燕.松龄血脉康胶囊与硝苯地平控释片治疗原发性高血压患者的临床观察[J].中西医结合心脑血管病杂志,2012,10(5):619-620.
[12]张海利,李文明,步振英,等.松龄血脉康胶囊联合苯磺酸左旋氨氯地平治疗原发性高血压疗效观察[J].现代中西医结合杂志,2014,23(23):2550-2552.
[13]沈敏.氨氯地平联合松龄血脉康治疗老年高血压临床观察[J].实用医学杂志,2012,28(10):1711-1712.
[14]王功峰.松龄血脉康联合硝苯地平控释片治疗农村高血压患者的疗效观察[J].中国社区医师,2014,30(22):89-90.
[15]王燎,乔柯.松龄血脉康胶囊与硝苯地平控释片治疗原发性高血压对比[J].华西药学杂志,2006,21(1):107-108.
[16]裘继燕.松龄血脉康联用氨氯地平治疗52例老年高血压的疗效观察[J].中国民族民间医药,2015(1):40,45.
[17]郑卫武.松龄血脉康胶囊联合左氨氯地平治疗女性更年期高血压的疗效分析[J].中国实用医药,2012,7(33):29-30.
[18]高梅英,金红弟.硝苯地平联合松龄血脉康治疗原发性高血压的疗效观察[J].医学综述,2013,19(9):1686-1690.
[19]徐丽容,高白文,陈金雄.松龄血脉康治疗老年高血压肝阳上亢型180例[J].福建中医药,2010,41(5):45.
[20]黄官家,曾茂贵,郑沁鈊,等.松龄血脉康治疗肝阳上亢型1级高血压疗效观察[J].福建中医药,2013,44(1):9-10.
[21]朱梦军.松龄血脉康胶囊与硝苯地平控释片治疗原发性高血压疗效对比研究[J].亚太传统医药,2013,9(12):209-210.
[22]龙再跟.葛根的药理临床与理化研究[J].安徽中医临床杂志,1998,10(1):62-63.
[23]胡文武,姚雪艳,郑源庞,等.珍珠药理作用与临床应用研究进展[J].中医药学报,1998,26(5):53-56.