电磁辐射引起的表观遗传效应研究进展
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摘要
电磁场是关乎人类生存的重要环境要素,研究发现电磁场除了引起生物基因突变外,还具有广泛的表观遗传效应,为了引起人们对电磁环境的重视,进一步促进电磁生物效应的研究,本研究归纳了电磁辐射在植物、动物上的表观遗传效应研究,重点分析了γ射线、紫外线、微波辐射及无线电波在植物和动物学上的表观遗传效应研究进展,最后提出一些可行的研究方向。
Electromagnetic field is an important environmental element which influences the survival of human beings.Many studies show that electromagnetic field has a wide epigenetic effect in addition to biogenic mutation.In order to draw people’s attention of the electromagnetic environment,and to further promote the research of electromagnetic biological effects,we summarized the previous studies on the epigenetic effects of electromagnetic radiation in plants and animals,and focused on the progress of epigenetic effects of gamma rays,ultraviolet radiation,microwave radiation and radio waves on plants and animals.At last,we discussed some feasible research directions.
Electromagnetic field is an important environmental element which influences the survival of human beings.Many studies show that electromagnetic field has a wide epigenetic effect in addition to biogenic mutation.In order to draw people’s attention of the electromagnetic environment,and to further promote the research of electromagnetic biological effects,we summarized the previous studies on the epigenetic effects of electromagnetic radiation in plants and animals,and focused on the progress of epigenetic effects of gamma rays,ultraviolet radiation,microwave radiation and radio waves on plants and animals.At last,we discussed some feasible research directions.
引文
[1]冯奇志.非生物胁迫诱导植物表观遗传变异研究[D].长春:东北师范大学,2012.
[2]潘丽娜.表观遗传修饰调控非生物胁迫应答提高植物抗逆性[J].遗传,2013(6):745-751.
[3]郭龙芳,薛福东,郭九峰.部分物理因子在植物上的生物效应研究进展[J].中国农学通报,2014(27):246-251.
[4]王淑妍,郭九峰,刘晓婷,等.非生物胁迫下植物表观遗传变异的研究进展[J].西北植物学报,2016(3):631-640.
[5]刘永.50 Hz极低频电磁场和1800 MHz射频电磁场表观遗传学效应及其机制的研究[D].重庆:重庆大学,2016.
[6]李超.电磁辐射对内嗅相关空间学习记忆的影响及其机制研究[D].重庆:第三军医大学,2015.
[7]叶晓青,佘建明,贾新平,等.60Co-γ射线辐照对蕨类植物绿色球状体成苗的影响[J].核农学报,2016(5):835-840.
[8]蔡湘琴.卷荚相思种子60Co-γ辐射诱变效应的初步研究[D].福州:福建农林大学,2016.
[9]杨震,郭会君,赵林姝,等.60Co-γ射线诱导的小麦基因组DNA的甲基化变异[J].核农学报,2015(1):1-9.
[10] Nakazaki T, Okumoto Y, Horibata A, et al. Mobilization of a transposon in the rice genome[J]. Nature,2003,421:170-172.
[11]杨震,彭选明,张逸妍,等.植物DNA甲基化及胁迫诱导的变异[J].生物工程学报,2016(12):1642-1653.
[12]林秀云.激光辐射诱导水稻转座子m Ping、Ping及Pong的转座激活和可遗传DNA甲基化变异[D].长春:东北师范大学,2006.
[13]姜丽丽.γ射线诱导水稻转座子mPing及Pong的激活和DNA甲基化的变异[D].长春:东北师范大学,2008.
[14]叶晓青,佘建明,邓衍明,等.蕨类植物绿色球状体60Cor射线辐射诱变方法[P].江苏:CN103975861A,2014-08-13.
[15]李菲.小麦/长穗偃麦草体细胞杂种渐渗系新种质的遗传基础研究[D].济南:山东大学,2011.
[16] Nigel D Paul, Jason P M, Martin M, et al. Ecological responses to UV radiation:interactions between the biological effects of UV on plants and on associated organisms[J]. Physiologia Plantarum,2012,145(4):565-581.
[17]徐佳妮,雷梦琦,鲁瑞琪,等.UV-B辐射增强对植物影响的研究进展[J].基因组学与应用生物学,2015(6):1347-1352.
[18]侯扶江,郑文菊.紫外线-B辐射与3种植物幼苗的光合作用——光合作用对紫外线-B敏感性的比较[J].西北植物学报,2000(2):218-223.
[19]陈鹏翔.微管阵列对增强UV-B辐射导致的小麦根尖细胞染色体畸变的影响[D].临汾:山西师范大学,2015.
[20]张佩佩.景天三七对UV-B胁迫的响应[D].新乡:河南师范大学,2014.
[21]申志英,李春香,于辉.微波辐射对药用植物生长发育的影响[J].生物磁学,2005(4):77-78.
[22]丁勇,许超,吴季辉,等.表观遗传学研究进展[J].中国科学:生命科学,2017(1):3-15.
[23] Qiu Y, Liu L, Zhao C, et al. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.[J].Genes&Development,2012,26(12):1376-1391.
[24] Bedford T, Clarke Steven G. Protein arginine methylation in mammals:who, what, and why[J]. Molecular Cell,2009,33(1):1-13.
[25] Shi Y, Whetstine Johnathan R. Dynamic regulation of histone lysine methylation by demethylases[J]. Molecular Cell,2007,25(1):1-14.
[26] Florence F Wagner, Michel W, Stefan S, et al. Kinetics and Structural Insights into the Binding of Histone Deacetylase 1 and 2(HDAC1, 2)Inhibitors[J]. Bioorganic&Medicinal Chemistry,2016,15(9):4008-4015.
[27] Olivier B. On your histone mark, SET, methylate![J]. Epigenetics,2013,8(5):457-463.
[28]余运贤,姜舒莹,刘慧,等.对讲机使用产生的电磁暴露对Wif-1基因甲基化水平及血液中淋巴细胞构成的影响[J].高电压技术,2017(2):637-644.
[29]曹锐峰,曹云新,章翔,等.不同剂量γ射线照射对体外培养胶质瘤细胞系的影响及对神经功能的保护作用[J].中国临床康复,2004(1):68-69.
[30]黄铖铖.电离辐射诱发DNA甲基化改变的实验研究[D].苏州:苏州大学,2011.
[31]贾敏.组蛋白乙酰化在七氟烷麻醉致新生大鼠远期认知功能损伤中的作用及其机制[D].南京:南京大学,2015.
[32]冀胜军.bdnf基因转录的表观遗传调控在电离辐射所致神经发生损伤及认知功能障碍过程中的作用研究[D].苏州:苏州大学,2014.
[33]叶爽.长期低剂量辐射与镉暴露的细胞效应及DNA甲基化在其中的作用[D].上海:复旦大学,2013.
[34]李曼蓉.EGCG对慢性低剂量X线辐射诱导的细胞DNA甲基化影响的研究[D].扬州:扬州大学,2014.
[35] Esposito G, Campa A, Pinto M, et al. Adaptive response:modelling and experimental studies.[J]. Radiation Protection Dosimetry,2010,143(2-4):320-324.
[36] Wang B, Tanaka K, Ninomiya Y, et al. Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response(Yonezawa Effect)[J]. Journal of Radiation Research,2012,54(1):45-51.
[37]石大伟,赵永成.电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义[J].国际放射医学核医学杂志,2006(4):240-243.
[38]陈凤鸣.低剂量辐射对小鼠骨髓、肝及脾DNA甲基化的影响[D].重庆:重庆医科大学,2014.
[39] Kovalchuk O, Burke P, Besplug J, et al. Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation[J]. Mutation researchfundamental and molecular mechanisms of mutagenesis,2004,548(1-2):75-84.
[40] Pogribny I, Koturbash I, Tryndyak V, et al. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus[J]. Molecular Cancer Research,2005,3(10):553-561.
[41]季江.瘢痕疙瘩成纤维细胞电离辐射效应及诱导细胞早期衰老相关基因表达研究[D].苏州:苏州大学,2014.
[42] Moréno S G, Dutrillaux B, Coffigny H. Status of p53, p21, mdm2,pRb proteins, and DNA methylation in gonocytes of control and gamma-irradiated rats during testicular development[J]. Biology of Reproduction,2001,64(5):1422-1431.
[43]曹家雪,张红平,杜立新.环境因素对DNA甲基化的影响[J].遗传,2013(7):839-846.
[44]田宁,李贺,金亮亮,等.BTG1蛋白及其上下游信号通路对X射线和碳离子辐射的应激响应[J].原子核物理评论,2016(4):481-487.
[45]朱斌,鹿亚超,陈颖,等.辐射对小鼠精子发生过程中印记基因表达的影响[J].中华放射医学与防护杂志,2005(5):426-428.
[46]王东.电磁辐射对精子质量的影响及其相关机制研究[D].西安:第四军医大学,2015.
[47]张涛,陈斌,陈荣,等.电磁辐射对精子氧化损伤及表观遗传学影响初探[A].中华医学会生殖医学分会.中华医学会生殖医学分会人类精子库管理学组第三届年会全国男性生殖医学和精子库管理新进展第四次研讨会论文汇编[C].中华医学会生殖医学分会,2012:2.
[48]秦海燕.UVA辐射诱导成纤维细胞损伤过程中PcG蛋白的作用研究[D].长春:吉林大学,2016.
[49]余运贤,姜舒莹,刘慧,等.电磁辐射暴露通过调节Wif-1基因甲基化水平影响血液中淋巴细胞的构成[J].高电压技术,2016(42):1-8.
[2]潘丽娜.表观遗传修饰调控非生物胁迫应答提高植物抗逆性[J].遗传,2013(6):745-751.
[3]郭龙芳,薛福东,郭九峰.部分物理因子在植物上的生物效应研究进展[J].中国农学通报,2014(27):246-251.
[4]王淑妍,郭九峰,刘晓婷,等.非生物胁迫下植物表观遗传变异的研究进展[J].西北植物学报,2016(3):631-640.
[5]刘永.50 Hz极低频电磁场和1800 MHz射频电磁场表观遗传学效应及其机制的研究[D].重庆:重庆大学,2016.
[6]李超.电磁辐射对内嗅相关空间学习记忆的影响及其机制研究[D].重庆:第三军医大学,2015.
[7]叶晓青,佘建明,贾新平,等.60Co-γ射线辐照对蕨类植物绿色球状体成苗的影响[J].核农学报,2016(5):835-840.
[8]蔡湘琴.卷荚相思种子60Co-γ辐射诱变效应的初步研究[D].福州:福建农林大学,2016.
[9]杨震,郭会君,赵林姝,等.60Co-γ射线诱导的小麦基因组DNA的甲基化变异[J].核农学报,2015(1):1-9.
[10] Nakazaki T, Okumoto Y, Horibata A, et al. Mobilization of a transposon in the rice genome[J]. Nature,2003,421:170-172.
[11]杨震,彭选明,张逸妍,等.植物DNA甲基化及胁迫诱导的变异[J].生物工程学报,2016(12):1642-1653.
[12]林秀云.激光辐射诱导水稻转座子m Ping、Ping及Pong的转座激活和可遗传DNA甲基化变异[D].长春:东北师范大学,2006.
[13]姜丽丽.γ射线诱导水稻转座子mPing及Pong的激活和DNA甲基化的变异[D].长春:东北师范大学,2008.
[14]叶晓青,佘建明,邓衍明,等.蕨类植物绿色球状体60Cor射线辐射诱变方法[P].江苏:CN103975861A,2014-08-13.
[15]李菲.小麦/长穗偃麦草体细胞杂种渐渗系新种质的遗传基础研究[D].济南:山东大学,2011.
[16] Nigel D Paul, Jason P M, Martin M, et al. Ecological responses to UV radiation:interactions between the biological effects of UV on plants and on associated organisms[J]. Physiologia Plantarum,2012,145(4):565-581.
[17]徐佳妮,雷梦琦,鲁瑞琪,等.UV-B辐射增强对植物影响的研究进展[J].基因组学与应用生物学,2015(6):1347-1352.
[18]侯扶江,郑文菊.紫外线-B辐射与3种植物幼苗的光合作用——光合作用对紫外线-B敏感性的比较[J].西北植物学报,2000(2):218-223.
[19]陈鹏翔.微管阵列对增强UV-B辐射导致的小麦根尖细胞染色体畸变的影响[D].临汾:山西师范大学,2015.
[20]张佩佩.景天三七对UV-B胁迫的响应[D].新乡:河南师范大学,2014.
[21]申志英,李春香,于辉.微波辐射对药用植物生长发育的影响[J].生物磁学,2005(4):77-78.
[22]丁勇,许超,吴季辉,等.表观遗传学研究进展[J].中国科学:生命科学,2017(1):3-15.
[23] Qiu Y, Liu L, Zhao C, et al. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.[J].Genes&Development,2012,26(12):1376-1391.
[24] Bedford T, Clarke Steven G. Protein arginine methylation in mammals:who, what, and why[J]. Molecular Cell,2009,33(1):1-13.
[25] Shi Y, Whetstine Johnathan R. Dynamic regulation of histone lysine methylation by demethylases[J]. Molecular Cell,2007,25(1):1-14.
[26] Florence F Wagner, Michel W, Stefan S, et al. Kinetics and Structural Insights into the Binding of Histone Deacetylase 1 and 2(HDAC1, 2)Inhibitors[J]. Bioorganic&Medicinal Chemistry,2016,15(9):4008-4015.
[27] Olivier B. On your histone mark, SET, methylate![J]. Epigenetics,2013,8(5):457-463.
[28]余运贤,姜舒莹,刘慧,等.对讲机使用产生的电磁暴露对Wif-1基因甲基化水平及血液中淋巴细胞构成的影响[J].高电压技术,2017(2):637-644.
[29]曹锐峰,曹云新,章翔,等.不同剂量γ射线照射对体外培养胶质瘤细胞系的影响及对神经功能的保护作用[J].中国临床康复,2004(1):68-69.
[30]黄铖铖.电离辐射诱发DNA甲基化改变的实验研究[D].苏州:苏州大学,2011.
[31]贾敏.组蛋白乙酰化在七氟烷麻醉致新生大鼠远期认知功能损伤中的作用及其机制[D].南京:南京大学,2015.
[32]冀胜军.bdnf基因转录的表观遗传调控在电离辐射所致神经发生损伤及认知功能障碍过程中的作用研究[D].苏州:苏州大学,2014.
[33]叶爽.长期低剂量辐射与镉暴露的细胞效应及DNA甲基化在其中的作用[D].上海:复旦大学,2013.
[34]李曼蓉.EGCG对慢性低剂量X线辐射诱导的细胞DNA甲基化影响的研究[D].扬州:扬州大学,2014.
[35] Esposito G, Campa A, Pinto M, et al. Adaptive response:modelling and experimental studies.[J]. Radiation Protection Dosimetry,2010,143(2-4):320-324.
[36] Wang B, Tanaka K, Ninomiya Y, et al. Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response(Yonezawa Effect)[J]. Journal of Radiation Research,2012,54(1):45-51.
[37]石大伟,赵永成.电离辐射诱导的DNA甲基化模式改变及其在辐射致癌机制研究中的意义[J].国际放射医学核医学杂志,2006(4):240-243.
[38]陈凤鸣.低剂量辐射对小鼠骨髓、肝及脾DNA甲基化的影响[D].重庆:重庆医科大学,2014.
[39] Kovalchuk O, Burke P, Besplug J, et al. Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation[J]. Mutation researchfundamental and molecular mechanisms of mutagenesis,2004,548(1-2):75-84.
[40] Pogribny I, Koturbash I, Tryndyak V, et al. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus[J]. Molecular Cancer Research,2005,3(10):553-561.
[41]季江.瘢痕疙瘩成纤维细胞电离辐射效应及诱导细胞早期衰老相关基因表达研究[D].苏州:苏州大学,2014.
[42] Moréno S G, Dutrillaux B, Coffigny H. Status of p53, p21, mdm2,pRb proteins, and DNA methylation in gonocytes of control and gamma-irradiated rats during testicular development[J]. Biology of Reproduction,2001,64(5):1422-1431.
[43]曹家雪,张红平,杜立新.环境因素对DNA甲基化的影响[J].遗传,2013(7):839-846.
[44]田宁,李贺,金亮亮,等.BTG1蛋白及其上下游信号通路对X射线和碳离子辐射的应激响应[J].原子核物理评论,2016(4):481-487.
[45]朱斌,鹿亚超,陈颖,等.辐射对小鼠精子发生过程中印记基因表达的影响[J].中华放射医学与防护杂志,2005(5):426-428.
[46]王东.电磁辐射对精子质量的影响及其相关机制研究[D].西安:第四军医大学,2015.
[47]张涛,陈斌,陈荣,等.电磁辐射对精子氧化损伤及表观遗传学影响初探[A].中华医学会生殖医学分会.中华医学会生殖医学分会人类精子库管理学组第三届年会全国男性生殖医学和精子库管理新进展第四次研讨会论文汇编[C].中华医学会生殖医学分会,2012:2.
[48]秦海燕.UVA辐射诱导成纤维细胞损伤过程中PcG蛋白的作用研究[D].长春:吉林大学,2016.
[49]余运贤,姜舒莹,刘慧,等.电磁辐射暴露通过调节Wif-1基因甲基化水平影响血液中淋巴细胞的构成[J].高电压技术,2016(42):1-8.