从炎症角度研究单纯性肥胖述评
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摘要
脂肪细胞内的慢性炎症在肥胖引起的代谢紊乱(糖尿病、血脂异常症、高血压、代谢综合征等)的发生发展中起到关键作用。单纯性肥胖的发生率正在逐年增加,而单纯性肥胖所造成的相关性并发症却并未得到很好的预防和治疗,脂肪细胞是产生促炎细胞因子的重要场所,脂肪分泌炎症因子是代谢性炎症反应发生的基础。因此对于单纯性肥胖的慢性炎症状态和炎症因子等相关的研究,则能更有针对性的对其进行预防和治疗,有助于对单纯性肥胖更加积极的进行干预,从而预防和控制单纯性肥胖所导致的相关慢性疾病。
Chronic inflammation in adipocytes plays a key role in the development of metabolic disorders( such as diabetes,dyslipidemia,hypertension,metabolic syndrome,etc.) caused by obesity. The incidence of simple obesity is increasing year by year,but the related complications caused by simple obesity have not been well prevented and treated. Adipocyte is an important place to produce pro-inflammatory cytokines. Fat secretion of inflammatory factors is the basis of metabolic inflammation. Therefore,the study on chronic inflammatory state and inflammatory factors of simple obesity can be more targeted to its prevention and treatment,which is conducive to more active intervention on simple obesity,so as to prevent and control the related chronic diseases caused by simple obesity.
Chronic inflammation in adipocytes plays a key role in the development of metabolic disorders( such as diabetes,dyslipidemia,hypertension,metabolic syndrome,etc.) caused by obesity. The incidence of simple obesity is increasing year by year,but the related complications caused by simple obesity have not been well prevented and treated. Adipocyte is an important place to produce pro-inflammatory cytokines. Fat secretion of inflammatory factors is the basis of metabolic inflammation. Therefore,the study on chronic inflammatory state and inflammatory factors of simple obesity can be more targeted to its prevention and treatment,which is conducive to more active intervention on simple obesity,so as to prevent and control the related chronic diseases caused by simple obesity.
引文
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[9] MAURY E,BRICHARD S M. Adipokine dysregulation,adipose tissue inflammation and metabolic syndrome[J]. Mol Cell Endocrinol,2010,314(1):1-16.
[10] THALER J P,YI C X,SCHUR E A,et al. Obesity is associated with hypothalamic injury in rodents and humans[J]. J Clin Invest,2012,122(3):153-162.
[11]闫美玲,夏丽莎.代谢炎症与肥胖相关研究进展[J].中国动脉硬化杂志,2015,23(6):634-638.
[12]卓鉥,乐颖影. Toll样受体与代谢及代谢相关疾病[J].生命科学,2013,25(2):158-168.
[13]司原成,王晓芳,汪弋力,等,营养性肥胖之免疫机制研究进展[J].中国实验方剂学杂志,2016,22(9):230-234.
[14] SILVANA A V,RICHARD L K,CORINNE A L,et al. Adipocytes as immune regulatory cells[J]. Int Immunopharmacol,2013,16(2):224-231.
[15]刘婷婷,刘戈力,赵菁,等.肥胖SD幼鼠脂肪组织血红素加氧酶-1表达与炎症状态和抗炎机制的探讨[J].天津医药,2015,43(4):367-370.
[16] YE J,GAO Z,YIN J,et al. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice[J]. Am J Physiol Endocrinol Metab,2007,293(4):1118-1128.
[17] PASARIVA M,SEREDA O R,REDMAN L M,et al. Reduced adipose tissue oxygenation in human obesity:evidence for rarefaction,macrophage chemotaxis,and inflammation without an angiogenic response[J]. Diabetes,2009,58(3):718-725.
[18] PEREIRA S S,ALVAREZ-LEITE J I. Low-Grade Inflammation,Obesity,and Diabetes[J]. Curr Obes Rep,2014,3(4):422-431.
[19] MAURY E,BRICHARD S M. Adipokine dysregulation,adipose tissue inflammation and metabolic syndrome[J]. Mol Cell Endocrinol,2010,314(1):1-16.
[20] THALER J P,SCHWARTZ M W. Minireview:Inflammation and obesity pathogenesis:the hypothalamus heats up[J]. Endocrinology,2010,151(21):4109-4115.
[21] HOTAMISLIGIL G S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease[J]. Cell,2010,140(6):900-917.
[22] CODONER-FRANCH P,VALLS-BELLES V,ARILLACODONER A,et al. Oxidant mechanisms in childhood obesity:the link between inflammation and oxidative stress[J]. Transl Res,2011,158(6):369-384.
[23] KONNER A C,BRUNING J C. Toll-like receptors:linking inflammation to metabolism[J]. Trends Endocrinol Metab,2011,22(1):16-23.
[24]郑青,黄娇珍,李国栋,等.单纯性肥胖与胰岛素抵抗的研究进展[J].中国医师进修杂志,2013,36(22):73-76.
[25]孟宪军,邓静,朱力杰,等.北五味子藤茎总三萜对小鼠酒精性肝损伤的保护作用[J].食品科学,2013,34(15):228-231.
[26]罗劲松,秦汝丽.肥胖患者颈动脉内膜中膜厚度与血管内皮依赖性舒张功能相关性分析[J].中国卫生产业,2014,12(17):117-118.
[27]姚岚,肖扬,刘石平,等.肥胖症患者血清对人源单核细胞细胞上Toll样受体4/转录因子-κB信号通路的影响[J].中华医学杂志,2010,90(44):3119-3123.
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[29] KONNER A C,BRUNING J C. Toll-like receptors:linking inflammation to metabolism[J]. Trends Endocrinol Metab,2011,22(1):16-23.
[30] FARQUHARSON A J,STEELE R J,CAREY F A,et al. Novel multiplex method to assess insulin,leptin and adiponectin regulation of inflammatorycytokines associated with colon cancer[J].Mol Biol Rep,2012,39(5):5727-5736.
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