基于Oncomine数据库分析STC 2在肝细胞癌中的表达及意义
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摘要
目的探讨斯钙素2(STC 2)在肝细胞癌(肝癌)中的表达及临床意义。方法收集Oncomine数据库中有关STC 2的相关信息,对资料进行二次分析,并研究STC 2在肝癌中的作用。肝癌组织与癌旁组织间STC 2表达比较采用t检验。STC 2表达与肝癌患者生存预后关系分析采用Kaplan-Meier生存曲线及Log-rank检验。结果 Oncomine数据库总共收集415项不同类型的研究,STC 2表达增高24项,表达降低5项。其中有8项研究涉及STC 2在肝癌组织与癌旁组织中的表达,与癌旁组织相比,STC 2在肝癌组织中高表达(P<0.05)。两项研究发现STC 2与肝癌患者总体生存无相关性(χ~2=3.233,1.787;P>0.05),且与患者肿瘤复发率也不存在相关性(χ~2=3.195,1.514;P>0.05)。结论基于Oncomine数据库分析发现STC 2在肝癌组织高表达,但其与肝癌预后无明确相关性。
Objective To investigate the expression and clinical significance of stanniocalcin 2(STC 2) in hepatocellular carcinoma(HCC). Methods Information about STC 2 was collected from the Oncomine database and was secondarily analyzed to investigate the role of STC 2 in HCC. The expression levels of STC 2 in HCC and adjacent tissues were compared by t test. The relationship between STC 2 expression and survival prognosis in HCC patients was analyzed by Kaplan-Meier survival curve and Log-rank test. Results A total of 415 different types of studies were selected from the Oncomine database. The expression level of STC 2 was up-regulated in 24 studies and down-regulated in 5. The expression of STC 2 in HCC and the adjacent tissues was analyzed in 8 studies. STC 2 highly expressed in HCC tissues compared with that in the adjacent tissues(P<0.05). Two studies have demonstrated no correlation between STC 2 expression and the overall survival of HCC patients(χ~2=3.233, 1.787;P>0.05), and no correlation was observed between STC 2 expression and the recurrence rate(χ~2=3.195, 1.514; P>0.05). Conclusions The Oncomine database reveals that STC 2 is highly expressed in HCC tissues, but STC 2 expression is not significantly correlated with clinical prognosis of HCC patients.
Objective To investigate the expression and clinical significance of stanniocalcin 2(STC 2) in hepatocellular carcinoma(HCC). Methods Information about STC 2 was collected from the Oncomine database and was secondarily analyzed to investigate the role of STC 2 in HCC. The expression levels of STC 2 in HCC and adjacent tissues were compared by t test. The relationship between STC 2 expression and survival prognosis in HCC patients was analyzed by Kaplan-Meier survival curve and Log-rank test. Results A total of 415 different types of studies were selected from the Oncomine database. The expression level of STC 2 was up-regulated in 24 studies and down-regulated in 5. The expression of STC 2 in HCC and the adjacent tissues was analyzed in 8 studies. STC 2 highly expressed in HCC tissues compared with that in the adjacent tissues(P<0.05). Two studies have demonstrated no correlation between STC 2 expression and the overall survival of HCC patients(χ~2=3.233, 1.787;P>0.05), and no correlation was observed between STC 2 expression and the recurrence rate(χ~2=3.195, 1.514; P>0.05). Conclusions The Oncomine database reveals that STC 2 is highly expressed in HCC tissues, but STC 2 expression is not significantly correlated with clinical prognosis of HCC patients.
引文
[1]Yokobori T,Mimori K,Ishii H,et al.Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer[J].Ann Surg Oncol,2010,17(10):2601-2607.
[2]Lin S,Guo Q,Wen J,et al.Survival analyses correlate stanniocalcin 2overexpression to poor prognosis of nasopharyngeal carcinomas[J].J Exp Clin Cancer Res,2014,33:26.
[3]Meyer HA,T?lle A,Jung M,et al.Identification of stanniocalcin 2as prognostic marker in renal cell carcinoma[J].Eur Urol,2009,55(3):669-678.
[4]Wang YY,Li L,Zhao ZS,et al.Clinical utility of measuring expression levels of KAP1,TIMP1 and STC 2 in peripheral blood of patients with gastric cancer[J].World J Surg Oncol,2013,11:81.
[5]Zhou H,Li YY,Zhang WQ,et al.Expression of stanniocalcin-1and stanniocalcin-2 in laryngeal squamous cell carcinoma and correlations with clinical and pathological parameters[J].PloS One,2014,9(4):e95466.
[6]Kita Y,Mimori K,Iwatsuki M,et al.STC 2:a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma[J].Ann Surg Oncol,2011,18(1):261-272.
[7]Chen X,Cheung ST,So S,et al.Gene expression patterns in human liver cancers[J].Mol Biol Cell,2002,13(6):1929-1939.
[8]Roessler S,Jia HL,Budhu A,et al.A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients[J].Cancer Res,2010,70(24):10202-10212.
[9]Wurmbach E,Chen YB,Khitrov G,et al.Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma[J].Hepatology,2007,45(4):938-947.
[10]Guichard C,Amaddeo G,Imbeaud S,et al.Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma[J].Nat Genet,2012,44(6):694-698.
[11]Mas VR,Maluf DG,Archer KJ,et al.Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma[J].Mol Med,2009,15(3/4):85-94.
[12]Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CACancer J Clin,2011,61(2):69-90.
[13]Umemura T,Kiyosawa K.Epidemiology of hepatocellular carcinoma in Japan[J].Hepatol Res,2007,37 Suppl 2:S95-100.
[14]Zhu W,Peng Y,Wang L,et al.Identification ofα-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy[J].Hepatology,2018,DOI:10.1002/hep.29844[Epub ahead of print].
[15]Shen XJ,Gu K,Shi JP,et al.Increased expression of stanniocalcin 2is associated with tumor progression after radiotherapy in patients with cervical carcinoma[J].Int J Clin Exp Pathol,2014,7(12):8770-8776.
[16]Na SS,Aldonza MB,Sung HJ,et al.Stanniocalcin-2(STC2):a potential lung cancer biomarker promotes lung cancer metastasis and progression[J].Biochim Biophys Acta,2015,1854(6):668-676.
[17]Law AY,Wong CK.Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia[J].Exp Cell Res,2010,316(3):466-476.
[18]Law AY,Wong CK.Stanniocalcin-1 and-2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR 2 and angiopoietin signaling pathways[J].Mol Cell Endocrinol,2013,374(1/2):73-81.
[19]Chen B,Zeng X,He Y,et al.STC 2 promotes the epithelialmesenchymal transition of colorectal cancer cells through AKT-ERKsignaling pathways[J].Oncotarget,2016,7(44):71400-71416.
[20]Zhang ZH,Wu YG,Qin CK,et al.Stanniocalcin 2 expression predicts poor prognosis of hepatocellular carcinoma[J].Oncol Lett,2014,8(5):2160-2164.
[21]Wang H,Wu K,Sun Y,et al.STC 2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro[J].BMB Rep,2012,45(11):629-634.
[2]Lin S,Guo Q,Wen J,et al.Survival analyses correlate stanniocalcin 2overexpression to poor prognosis of nasopharyngeal carcinomas[J].J Exp Clin Cancer Res,2014,33:26.
[3]Meyer HA,T?lle A,Jung M,et al.Identification of stanniocalcin 2as prognostic marker in renal cell carcinoma[J].Eur Urol,2009,55(3):669-678.
[4]Wang YY,Li L,Zhao ZS,et al.Clinical utility of measuring expression levels of KAP1,TIMP1 and STC 2 in peripheral blood of patients with gastric cancer[J].World J Surg Oncol,2013,11:81.
[5]Zhou H,Li YY,Zhang WQ,et al.Expression of stanniocalcin-1and stanniocalcin-2 in laryngeal squamous cell carcinoma and correlations with clinical and pathological parameters[J].PloS One,2014,9(4):e95466.
[6]Kita Y,Mimori K,Iwatsuki M,et al.STC 2:a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma[J].Ann Surg Oncol,2011,18(1):261-272.
[7]Chen X,Cheung ST,So S,et al.Gene expression patterns in human liver cancers[J].Mol Biol Cell,2002,13(6):1929-1939.
[8]Roessler S,Jia HL,Budhu A,et al.A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients[J].Cancer Res,2010,70(24):10202-10212.
[9]Wurmbach E,Chen YB,Khitrov G,et al.Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma[J].Hepatology,2007,45(4):938-947.
[10]Guichard C,Amaddeo G,Imbeaud S,et al.Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma[J].Nat Genet,2012,44(6):694-698.
[11]Mas VR,Maluf DG,Archer KJ,et al.Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma[J].Mol Med,2009,15(3/4):85-94.
[12]Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CACancer J Clin,2011,61(2):69-90.
[13]Umemura T,Kiyosawa K.Epidemiology of hepatocellular carcinoma in Japan[J].Hepatol Res,2007,37 Suppl 2:S95-100.
[14]Zhu W,Peng Y,Wang L,et al.Identification ofα-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy[J].Hepatology,2018,DOI:10.1002/hep.29844[Epub ahead of print].
[15]Shen XJ,Gu K,Shi JP,et al.Increased expression of stanniocalcin 2is associated with tumor progression after radiotherapy in patients with cervical carcinoma[J].Int J Clin Exp Pathol,2014,7(12):8770-8776.
[16]Na SS,Aldonza MB,Sung HJ,et al.Stanniocalcin-2(STC2):a potential lung cancer biomarker promotes lung cancer metastasis and progression[J].Biochim Biophys Acta,2015,1854(6):668-676.
[17]Law AY,Wong CK.Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia[J].Exp Cell Res,2010,316(3):466-476.
[18]Law AY,Wong CK.Stanniocalcin-1 and-2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR 2 and angiopoietin signaling pathways[J].Mol Cell Endocrinol,2013,374(1/2):73-81.
[19]Chen B,Zeng X,He Y,et al.STC 2 promotes the epithelialmesenchymal transition of colorectal cancer cells through AKT-ERKsignaling pathways[J].Oncotarget,2016,7(44):71400-71416.
[20]Zhang ZH,Wu YG,Qin CK,et al.Stanniocalcin 2 expression predicts poor prognosis of hepatocellular carcinoma[J].Oncol Lett,2014,8(5):2160-2164.
[21]Wang H,Wu K,Sun Y,et al.STC 2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro[J].BMB Rep,2012,45(11):629-634.