参麦注射液对细菌感染老年患者血清PCT、sTREM-1、CRP与HBP的影响
|
摘要
目的:探究参麦注射液对细菌感染老年患者血清降钙素原(PCT)、可溶性髓细胞触发受体-1(sTREM-1)、C-反应蛋白(CRP)与肝素结合蛋白(HBP)的影响。方法:选取80例细菌感染老年患者为研究对象,依据随机数字表法分为对照组(n=40)和观察组(n=40)。两组患者均给予常规抗感染治疗,观察组在此基础上加用参麦注射液治疗。比较两组患者治疗前、治疗第3天、治疗第7天时血清PCT、sTREM-1、CRP、HBP水平、T淋巴细胞亚群。结果:治疗前观察组与对照组患者的血清PCT、sTREM-1、CRP、HBP水平比较差异无统计学意义(P>0.05);治疗第3、7天观察组患者的血清PCT、sTREM-1、CRP、HBP水平均低于对照组患者,差异具有统计学意义(P<0.05)。治疗前观察组与对照组患者的CD3、CD4、CD8和CD4/CD8比值比较差异无统计学意义(P>0.05);治疗第3天、第7天观察组患者的CD3、CD4、CD8和CD4/CD8比值均高于对照组患者,差异具有统计学意义(P<0.05)。观察组和对照组患者均随访3个月,细菌感染复发率分别为5%(2/40)和12.5%(5/40),观察组低于对照组,差异具有统计学意义(P<0.05)。结论:给予细菌感染老年患者参麦注射液治疗能够有效缓解感染,提高免疫能力,降低治疗后感染复发率。
Objective:To investigate the effects of Shenmai Injection on serum procalcitonin(PCT), soluble myeloid receptor-receptor-1(sTREM-1), C-reactive protein(CRP) and heparin-binding protein(HBP) in elderly patients with bacterial infection. Methods:Eighty elderly patients with bacterial infection were enrolled in the study. They were divided into control group(n=40) and observation group(n=40) according to the random number table method. Both groups were given conventional anti-infective treatment, and the observation group was treated with Shenmai Injection. Serum PCT, sTREM-1, CRP, HBP levels and T lymphocyte subsets were compared between the two groups before treatment, on the 3 rd and 7 th day of treatment. Results:There were no significant differences in serum PCT, sTREM-1, CRP or HBP levels between the observation group and the control group before treatment(P>0.05). Serum PCT and sTREM-1 were observed on 3 rd and 7 th day. The levels of CRP and HBP were lower than those of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the ratio of CD3, CD4, CD8 or CD4/CD8 between the observation group and the control group before treatment(P>0.05). CD3, CD4, CD8 and CD4/CD8 were observed on the 3 rd and 7 th day. The odds ratio was higher than that of the control group, and the difference was statistically significant(P<0.05). The patients in the observation group and the control group were followed up for 3 months. The recurrence rates of bacterial infection were 5%(2/40) and 12.5%(5/40), respectively. The observation group's was lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion:The treatment of Shenmai Injection in elderly patients with bacterial infection can effectively alleviate infection, improve immunity and reduce the recurrence rate of infection after treatment.
Objective:To investigate the effects of Shenmai Injection on serum procalcitonin(PCT), soluble myeloid receptor-receptor-1(sTREM-1), C-reactive protein(CRP) and heparin-binding protein(HBP) in elderly patients with bacterial infection. Methods:Eighty elderly patients with bacterial infection were enrolled in the study. They were divided into control group(n=40) and observation group(n=40) according to the random number table method. Both groups were given conventional anti-infective treatment, and the observation group was treated with Shenmai Injection. Serum PCT, sTREM-1, CRP, HBP levels and T lymphocyte subsets were compared between the two groups before treatment, on the 3 rd and 7 th day of treatment. Results:There were no significant differences in serum PCT, sTREM-1, CRP or HBP levels between the observation group and the control group before treatment(P>0.05). Serum PCT and sTREM-1 were observed on 3 rd and 7 th day. The levels of CRP and HBP were lower than those of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the ratio of CD3, CD4, CD8 or CD4/CD8 between the observation group and the control group before treatment(P>0.05). CD3, CD4, CD8 and CD4/CD8 were observed on the 3 rd and 7 th day. The odds ratio was higher than that of the control group, and the difference was statistically significant(P<0.05). The patients in the observation group and the control group were followed up for 3 months. The recurrence rates of bacterial infection were 5%(2/40) and 12.5%(5/40), respectively. The observation group's was lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion:The treatment of Shenmai Injection in elderly patients with bacterial infection can effectively alleviate infection, improve immunity and reduce the recurrence rate of infection after treatment.
引文
[1] 张杉杉,赵连礼,何泱,等.常见不同细菌感染对糖尿病足溃疡患者病情和短期预后的影响[J].中华内分泌代谢杂志,2017,33(1):11-16.
[2] 赵学慧,张晓雷,刘建,等.运用平脉辨证治疗不明原因发热一例[J].环球中医药,2018,11(5):714-716.
[3] 刘景峰,刘培,支德源,等.血清 PCT 在小儿活体肝移植术后早期细菌感染诊断中的价值[J].中华检验医学杂志,2017,40(1):46-49.
[4] 刘小艳,赵锁林,杨珍珍,等.动态监测血清PCT、sTREM-1、IL-8水平对细菌感染再发的诊断价值[J].检验医学与临床,2018,15(2):242-245.
[5] 张春云,何耀军,江雁琼,等.慢性阻塞性肺疾病急性加重期HBP和CD64表达与不同细菌感染的关系[J].广东医学,2017,38(12):1842-1844,1848.
[6] 顾梅,朱娇玉.血必净注射液联合参麦注射液对脓毒症急性肺损伤患者疗效及血清HMGB1、sTREM-1的影响[J].中国中医急症,2017,26(11):1907-1910.
[7] 宋蓓,金文波,张红瑾,等.糖尿病足细菌感染患者感染深度、C-反应蛋白、肿瘤坏死因子α、白介素-6及免疫蛋白水平与下肢血管病变的关系[J].中华医院感染学杂志,2017,27(3):586-589.
[8] 肖亦之,罗卉,周亚欧,等.五种炎性指标在特发性炎性肌病合并细菌感染中的临床意义[J].中华风湿病学杂志,2017,21(4):258-262.
[9] 张万祥,王博超,李志军,等.中药固表辟邪方预防老年院内感染的疗效观察[J].中华危重病急救医学,2017,29(5):469-472.
[10] 王锦云,徐小杰.呼吸内科老年住院患者院内感染的危险因素及病原菌分布特点[J].中国老年学杂志,2017,37(7):1680-1681.
[11] 孟泳,崔应麟,芦晓帆,等.清肺益肾方联合左氧氟沙星片对肺炎克雷伯杆菌感染老龄大鼠免疫功能的影响[J].中医杂志,2017,58(19):1681-1685.
[12] 谷孝芝,陈剑坤,李际强,等.呼吸道病毒检测阳性老年肺炎患者中医证候研究[J].中国中医急症,2018,27(1):13-15,19.
[13] 吴苑,喻丹,王海,等.肝素结合蛋白与降钙素原和C反应蛋白及白细胞计数对呼吸道局部细菌感染诊断的应用价值[J].中华检验医学杂志,2017,40(9):711-715.
[14] 庞伟,付志伟,王文敏,等.肝硬化感染性腹水中sTREM-1含量与肝纤维化、炎症及氧化应激反应的相关性[J].海南医学院学报,2017,23(24):3377-3380.
[15] 方琪,崔益明,章幽芳,等.降钙素原与C-反应蛋白对哮喘合并呼吸道感染患者的诊断及治疗意义[J].中华医院感染学杂志,2018,28(7):1005-1007,1011.
[16] 凌聪,扈晓晴,王军喜,等.肝素结合蛋白对维持性血液透析患者导管相关感染的诊断价值[J].国际检验医学杂志,2017,38(13):1776-1778.
[17] 潘立萍,苏冬菊,鲍永霞,等.IL-17、IL-10及HBP变化与AECOPD感染程度关系的研究进展[J].东南大学学报(医学版),2017,36(2):272-275.
[18] 左霞,陈红英,陈德森,等.参麦注射液对大鼠脑缺血再灌注损伤的影响[J].环球中医药,2015,8(4):407-410.
[19] 陈锋,贾月惠,刘杰,等.参麦注射液治疗感染性休克合并心肌损伤的临床观察[J].中国中医药科技,2017,24(5):624-625,652.
[20] 孟海,程辉.参麦注射液治疗急性胰腺炎患者的临床研究[J].世界中西医结合杂志,2017,12(4):527-529.
[2] 赵学慧,张晓雷,刘建,等.运用平脉辨证治疗不明原因发热一例[J].环球中医药,2018,11(5):714-716.
[3] 刘景峰,刘培,支德源,等.血清 PCT 在小儿活体肝移植术后早期细菌感染诊断中的价值[J].中华检验医学杂志,2017,40(1):46-49.
[4] 刘小艳,赵锁林,杨珍珍,等.动态监测血清PCT、sTREM-1、IL-8水平对细菌感染再发的诊断价值[J].检验医学与临床,2018,15(2):242-245.
[5] 张春云,何耀军,江雁琼,等.慢性阻塞性肺疾病急性加重期HBP和CD64表达与不同细菌感染的关系[J].广东医学,2017,38(12):1842-1844,1848.
[6] 顾梅,朱娇玉.血必净注射液联合参麦注射液对脓毒症急性肺损伤患者疗效及血清HMGB1、sTREM-1的影响[J].中国中医急症,2017,26(11):1907-1910.
[7] 宋蓓,金文波,张红瑾,等.糖尿病足细菌感染患者感染深度、C-反应蛋白、肿瘤坏死因子α、白介素-6及免疫蛋白水平与下肢血管病变的关系[J].中华医院感染学杂志,2017,27(3):586-589.
[8] 肖亦之,罗卉,周亚欧,等.五种炎性指标在特发性炎性肌病合并细菌感染中的临床意义[J].中华风湿病学杂志,2017,21(4):258-262.
[9] 张万祥,王博超,李志军,等.中药固表辟邪方预防老年院内感染的疗效观察[J].中华危重病急救医学,2017,29(5):469-472.
[10] 王锦云,徐小杰.呼吸内科老年住院患者院内感染的危险因素及病原菌分布特点[J].中国老年学杂志,2017,37(7):1680-1681.
[11] 孟泳,崔应麟,芦晓帆,等.清肺益肾方联合左氧氟沙星片对肺炎克雷伯杆菌感染老龄大鼠免疫功能的影响[J].中医杂志,2017,58(19):1681-1685.
[12] 谷孝芝,陈剑坤,李际强,等.呼吸道病毒检测阳性老年肺炎患者中医证候研究[J].中国中医急症,2018,27(1):13-15,19.
[13] 吴苑,喻丹,王海,等.肝素结合蛋白与降钙素原和C反应蛋白及白细胞计数对呼吸道局部细菌感染诊断的应用价值[J].中华检验医学杂志,2017,40(9):711-715.
[14] 庞伟,付志伟,王文敏,等.肝硬化感染性腹水中sTREM-1含量与肝纤维化、炎症及氧化应激反应的相关性[J].海南医学院学报,2017,23(24):3377-3380.
[15] 方琪,崔益明,章幽芳,等.降钙素原与C-反应蛋白对哮喘合并呼吸道感染患者的诊断及治疗意义[J].中华医院感染学杂志,2018,28(7):1005-1007,1011.
[16] 凌聪,扈晓晴,王军喜,等.肝素结合蛋白对维持性血液透析患者导管相关感染的诊断价值[J].国际检验医学杂志,2017,38(13):1776-1778.
[17] 潘立萍,苏冬菊,鲍永霞,等.IL-17、IL-10及HBP变化与AECOPD感染程度关系的研究进展[J].东南大学学报(医学版),2017,36(2):272-275.
[18] 左霞,陈红英,陈德森,等.参麦注射液对大鼠脑缺血再灌注损伤的影响[J].环球中医药,2015,8(4):407-410.
[19] 陈锋,贾月惠,刘杰,等.参麦注射液治疗感染性休克合并心肌损伤的临床观察[J].中国中医药科技,2017,24(5):624-625,652.
[20] 孟海,程辉.参麦注射液治疗急性胰腺炎患者的临床研究[J].世界中西医结合杂志,2017,12(4):527-529.