p53基因相关的细胞非经典死亡
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摘要
程序性细胞死亡是多细胞生物死亡的重要生物学过程,其调控方式复杂,对维持细胞内环境稳定十分重要。在过去的几年中,除了凋亡之外,对程序性细胞死亡的非凋亡形式的研究也取得了进展。p53作为经典的肿瘤抑制因子,除了控制细胞增殖和凋亡外,也参与非典型细胞死亡调控。p53通过对其下游靶点的转录调控以及与关键蛋白的直接作用,直接或间接调节细胞的非典型死亡。本文对p53在凋亡、铁中毒、细胞程序性坏死、自噬性细胞死亡、有丝分裂灾难、副凋亡等几种非典型细胞死亡模式中的作用作一综述,为肿瘤抑制机制的阐明及癌症药物研制提供相应参考。
引文
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[39]GAO M H,MONIAN P,QUADRI N,et al.Glutaminolysis and transferrin regulate ferroptosis[J].Mol Cell,2015,59(2):298-308.DOI:10.1016/j.molcel.2015.06.011.
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[2]PARRALES A,IWAKUMA T.Targeting oncogenic mutant p53 for cancer therapy[J/OL].Front Oncol,2015,5:288[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685147/.DOI:10.3389/fonc.2015.00288.
[3]DIEDERICH M,CERELLA C.Non-canonical programmed cell death mechanisms triggered by natural compounds[J].Semin Cancer Biol,2016,40/41:4-34.DOI:10.1016/j.semcancer.2016.06.001.
[4]AUBREY B J,KELLY G L,JANIC A,et al.How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?[J/OL].Cell Death Differ,2018,25(1):104-113[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729529/.DOI:10.1038/cdd.2017.169.
[5]ROY S,SIL A,CHAKRABORTY T.Potentiating apoptosis and modulation of p53,Bcl2,and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer[J].J Cell Physiol,2019,234(4):4888-4909.DOI:10.1002/jcp.27287.
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[7]WEI Y,YUAN F J,ZHOU W B,et al.Borax-induced apoptosis in HepG2 cells involves p53,Bcl-2,and Bax[J/OL].Genet Mol Res,2016,15(2):gmr15028300[2019-03-27].http://dx.doi.org/10.4238/gmr.15028300.DOI:10.4238/gmr.15028300.
[8]TENóRIO J R,SANTANA T,QUEIROZ S I,et al.Apoptosis and cell cycle aberrations in epithelial odontogenic lesions:An evidence by the expression of p53,Bcl-2 and Bax[J/OL].Med Oral Patol Oral Cir Bucal,2018,23(2):e120-e125[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911354/.DOI:10.4317/medoral.22019.
[9]KIM E M,JUNG C H,KIM J,et al.The P53/p21 complex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins[J].Cancer Res,2017,77(11):3092-3100.DOI:10.1158/0008-5472.CAN-16-2098.
[10]RILEY T,SONTAG E,CHEN P,et al.Transcriptional control of human p53-regulated genes[J].Nat Rev Mol Cell Biol,2008,9(5):402-412.DOI:10.1038/nrm2395.
[11]ZHANG F P,QIU Q H,SONG X C,et al.Signal-regulated protein Kinases/Protein kinase B-p53-BH3-interacting domain death agonist pathway regulates gingipain-induced apoptosis in osteoblasts[J].JPeriodontol,2017,88(11):200-210.DOI:10.1902/jop.2017.160806.
[12]MITUPATUM T,AREE K,KITTISENACHAI S,et al.MRNA expression of Bax,Bcl-2,p53,cathepsin B,caspase-3 and caspase-9in the HepG2 cell line following induction by a novel monoclonal Ab Hep88 mAb:cross-talk for paraptosis and apoptosis[J].Asian Pac J Cancer Prev,2016,17(2):703-712.
[13]LIU Y H,LIU G H,MEI J J,et al.The preventive effects of hyperoside on lung cancer in vitro by inducing apoptosis and inhibiting proliferation through Caspase-3 and P53 signaling pathway[J].Biomed Pharmacother,2016,83(10):381-391.DOI:10.1016/j.biopha.2016.06.035.
[14]ZHANG Q Y,MA S,LIU B,et al.Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells[J].Exp Ther Med,2016,12(1):469-474.DOI:10.3892/etm.2016.3282.
[15]ZHU H Z,WANG J R,YIN J J,et al.Downregulation of PRAMEsuppresses proliferation and promotes apoptosis in hepatocellular carcinoma through the activation of P53 mediated pathway[J].Cell Physiol Biochem,2018,45(3):1121-1135.DOI:10.1159/000487353.
[16]ODA E,OHKI R,MURASAWA H,et al.Noxa,a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis[J].Science,2000,288(5468):1053-1058.
[17]EDINGER A L,THOMPSON C B.Death by design:apoptosis,necrosis and autophagy[J].Curr Opin Cell Biol,2004,16(6):663-669.DOI:10.1016/j.ceb.2004.09.011.
[18]MATSUMURA H,SHIMIZU Y,OHSAWA Y,et al.Necrotic death pathway in FAS receptor signaling[J].J Cell Biol,2000,151(6):1247-1256.DOI:10.1083/jcb.151.6.1247.
[19]NEWTON K,DUGGER D L,WICKLIFFE K E,et al.Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis[J].Science,2014,343(6177):1357-1360.DOI:10.1126/science.1249361.
[20]WANG H Y,SUN L M,SU L J,et al.Mixed lineage kinase domainlike protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3[J].Mol Cell,2014,54(1):133-146.DOI:10.1016/j.molcel.2014.03.003.
[21]TU H C,REN D C,WANG G X,et al.The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNAdamage[J].Proc Natl Acad Sci U S A,2009,106(4):1093-1098.DOI:10.1073/pnas.0808173106.
[22]WANG K,LIU F,LIU C Y,et al.The long noncoding RNA NRFregulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873[J].Cell Death Differ,2016,23(8):1394-1405.DOI:10.1038/cdd.2016.28.
[23]YU G J,LI Y H,CUI Z H,et al.Combinational immunotherapy with Allo-DRibble vaccines and anti-OX40 co-stimulation leads to generation of cross-reactive effector T cells and tumor regression[J/OL].Sci Rep,2016,6:37558[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118714/.DOI:10.1038/srep37558.
[24]GUO J Y,CHEN H Y,MATHEW R,et al.Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis[J].Genes Dev,2011,25(5):460-470.DOI:10.1101/gad.2016311.
[25]YU L,CHEN Y,TOOZE S A.Autophagy pathway:Cellular and molecular mechanisms[J].Autophagy,2018,14(2):207-215.DOI:10.1080/15548627.2017.1378838.
[26]MAIURI M C,GALLUZZI L,MORSELLI E,et al.Autophagy regulation by p53[J].Cur Opin Cell Biol,2010,22(2):181-185.DOI:10.1016/j.ceb.2009.12.001.
[27]ZHANG X F,CHENG Q,YIN H J,et al.Regulation of autophagy and EMT by the interplay between p53 and RAS during cancer progression(Review)[J].Int J Oncol,2017,51(1):18-24.DOI:10.3892/ijo.2017.4025.
[28]MRSCHTIK M,O'PREY J,LAO L Y,et al.DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose[J/OL].Cell Death Differ,2017,24(8):1470[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520458/.DOI:10.1038/cdd.2017.57.
[29]TASDEMIR E,MAIURI M C,GALLUZZI L,et al.Regulation of autophagy by cytoplasmic p53[J].Nat Cell Biol,2008,10(6):676-687.DOI:10.1038/ncb1730.
[30]CONDELLO M,PELLEGRINI E,CARAGLIA M,et al.Targeting autophagy to overcome human diseases[J/OL].Int J Mol Sci,2019,20(3):E725[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387456/.DOI:10.3390/ijms20030725.
[31]ENG C H,WANG Z C,TKACH D,et al.Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy[J/OL].Proc Natl Acad Sci USA,2016,113(1):182-187[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711870/.DOI:10.1073/pnas.1515617113.
[32]CHOI S W,PARK H H,KIM S,et al.PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation[J/OL].Mol Cell,2018,70(5):920-935.e7[2019-03-27].https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30390-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518303903%3Fshowall%3Dtrue.DOI:10.1016/j.molcel.2018.05.016.
[33]DENISENKO T V,SOROKINA I V,GOGVADZE V,et al.Mitotic catastrophe and cancer drug resistance:A link that must to be broken[J].Drug Resist Updat,2016,24(1):1-12.DOI:10.1016/j.drup.2015.11.002.
[34]SALMELA A L,KALLIO M J.Mitosis as an anti-cancer drug target[J].Chromosoma,2013,122(5):431-449.DOI:10.1007/s00412-013-0419-8.
[35]MC GEE M M.Targeting the mitotic catastrophe signaling pathway in cancer[J/OL].Mediators Inflamm,2015,2015:146282[2019-03-27].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600505/.DOI:10.1155/2015/146282.
[36]SPERANDIO S,DE BELLE I,BREDESEN D E.An alternative,nonapoptotic form of programmed cell death[J].Proc Natl Acad Sci US A,2000,97(26):14376-14381.DOI:10.1073/pnas.97.26.14376.
[37]LEE D,KIM I Y,SAHA S,et al.Paraptosis in the anti-cancer arsenal of natural products[J].Pharmacol Ther,2016,162:120-133.DOI:10.1016/j.pharmthera.2016.01.003.
[38]PEHAR M,O'RIORDAN K J,BURNS-CUSATO M,et al.Altered longevity-assurance activity of P53:p44 in the mouse causes memory loss,neurodegeneration and premature death[J].Aging Cell,2010,9(2):174-190.DOI:10.1111/j.1474-9726.2010.00547.x.
[39]GAO M H,MONIAN P,QUADRI N,et al.Glutaminolysis and transferrin regulate ferroptosis[J].Mol Cell,2015,59(2):298-308.DOI:10.1016/j.molcel.2015.06.011.
[40]CAO J Y,DIXON S J.Mechanisms of ferroptosis[J].Cell Mol Life Sci,2016,73(11/12):2195-2209.DOI:10.1007/s00018-016-2194-1.
[41]XIE Y,HOU W,SONG X,et al.Ferroptosis:process and function[J].Cell Death Differ,2016,23(3):369-379.DOI:10.1038/cdd.2015.158.
[42]JIANG L,KON N,LI T Y,et al.Ferroptosis as a p53-mediated activity during tumour suppression[J].Nature,2015,520(7545):57-62.DOI:10.1038/nature14344.
[43]LOUANDRE C,MARCQ I,BOUHLAL H,et al.The retinoblastoma(Rb)protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells[J].Cancer Lett,2015,356(2 Pt B):971-977.DOI:10.1016/j.canlet.2014.11.014.
[44]ROH J L,KIM E H,JANG H J,et al.Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer[J].Cancer Lett,2016,381(1):96-103.DOI:10.1016/j.canlet.2016.07.035.