早期肠内营养对重症急性胰腺炎患者预后的影响
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摘要
目的:探讨早期肠内营养对重症急性胰腺炎患者预后的影响。方法:选取我院收治的56例重症急性胰腺炎患者,随机分为观察组(28例)与对照组(28例)。对照组患者予以早期肠外营养支持,观察组患者予以早期肠内营养支持,两组患者均营养支持10 d。结果:观察组患者治疗后的APACHE-Ⅱ评分明显低于对照组(P<0.01),血清白细胞介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平皆低于对照组(P<0.05),感染发生率14.3%与多脏器功能障碍综合征(MODS)发生率3.6%均低于对照组的46.4%、25.0%(P<0.05)。结论:早期肠内营养相较于肠外营养支持可以显著改善患者预后水平,值得临床推广应用。
Objective: To investigate the effect of early enteral nutrition on the prognosis of patients with severe acute pancreatitis. Methods: 56 patients with severe acute pancreatitis in our hospital were selected and randomied into the observation group(n = 28) and control group(n = 28). Patients in the control group were given early parenteral nutrition support,while the others in the observation group were given early enteral nutrition support. Both groups received nutritional support for 10 days. Results: The APACHE-Ⅱ score of patients in the observation group was significantly lower than that of the control group(P<0.01). The levels of serum interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) were lower than those of the control group(P<0.05). The incidence of infection and multiple organ dysfunction syndrome were 14.3% and 3.6% respectively,which were lower than those of the control group(46. 4% and 25. 0%,P < 0. 05). Conclusion: Compared with parenteral nutrition,early enteral nutrition can significantly improve the prognosis of patients and is worthy of clinical popularization.
Objective: To investigate the effect of early enteral nutrition on the prognosis of patients with severe acute pancreatitis. Methods: 56 patients with severe acute pancreatitis in our hospital were selected and randomied into the observation group(n = 28) and control group(n = 28). Patients in the control group were given early parenteral nutrition support,while the others in the observation group were given early enteral nutrition support. Both groups received nutritional support for 10 days. Results: The APACHE-Ⅱ score of patients in the observation group was significantly lower than that of the control group(P<0.01). The levels of serum interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) were lower than those of the control group(P<0.05). The incidence of infection and multiple organ dysfunction syndrome were 14.3% and 3.6% respectively,which were lower than those of the control group(46. 4% and 25. 0%,P < 0. 05). Conclusion: Compared with parenteral nutrition,early enteral nutrition can significantly improve the prognosis of patients and is worthy of clinical popularization.
引文
[1]胡军涛,潘熠平,汤展宏,等.早期经鼻肠内营养在重症急性胰腺炎治疗中的临床价值[J].重庆医学,2013,42(16):1806-1808.
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[6]彭富治,李卉.急性胰腺炎早期肠内营养研究进展[J].肠外与肠内营养,2017,24(4):249-252,256.
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[2]崔立红,王晓辉,彭丽华,等.早期肠内营养加微生态制剂对重症急性胰腺炎患者疗效的影响[J].中华危重病急救医学,2013,25(4):224-228.
[3]中华医学会外科学分会胰腺外科学组.急性胰腺炎诊治指南(2014版)[J].中华消化外科杂志,2015,14(1):1-5.
[4]金凯,王玉嘉,王志荣,等.重症急性胰腺炎患者早期应用肠内营养疗效观察[J].中国医药,2014,9(3):351-353.
[5]林松挺,陈正义.早期肠内营养治疗重症急性胰腺炎[J].贵阳医学院学报,2015,40(10):1096-1099.
[6]彭富治,李卉.急性胰腺炎早期肠内营养研究进展[J].肠外与肠内营养,2017,24(4):249-252,256.
[7]王玉,张泓.早期肠内营养对重症急性胰腺炎的疗效[J].中国急救医学,2013,33(3):250-253.