纳米粒子在甲状腺癌诊治中的研究进展
摘要
甲状腺癌是最常见的内分泌系统恶性肿瘤,其中约有20%患者进展为碘难治性分化型甲状腺癌,该型对放射性碘治疗、TSH抑制治疗等均不敏感,治疗效果极差,成为临床诊治的难点和研究热点,是甲状腺癌患者最主要的致死原因。近年来,纳米技术在医学领域的研究越来越受关注,纳米粒子已在多种肿瘤中得到研究与应用,本文将对纳米粒子在甲状腺癌成像及治疗的研究与应用进行综述。
引文
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[21]LIAO K T,CHENG J T,LI C L,et al.Ultra-sensitive detection of mutated papillary thyroid carcinoma DNA using square wave stripping voltammetry method and amplified gold nanoparticle biomarkers[J].Biosens Bioelectron,2009,24(7):1899-1904.
[22]WANG Y,GAO J,MENG X,et al.DNA microarray-based resonance light scattering assay for multiplexed detection of DNAmutation in papillary thyroid cancer[J].Analyst,2018,143(4):914-919.
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[24]GAO X J,LI A Q,ZHANG X,et al.Thyroid-stimulating hormone(TSH)-armed polymer-lipid nanoparticles for the targeted delivery of cisplatin in thyroid cancers:therapeutic efficacy evaluation[J].Rsc Advances,2015,5(129):106413-106420.
[25]LI S,ZHANG D,SHENG S,et al.Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles[J].Int J Nanomedicine,2017,12:5993-6003.
[26]ZHENG H T,LIU C R,XU J,et al.Thyroid stimulating hormone(tsh)-conjugated nanomedicine system to target tshr overexpressed thyroid cancers[J].J Biomater Tiss Eng,2016,6(6):448-455.
[27]ZHOU M,CHEN Y,ADACHI M,et al.Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer[J].Biomaterials,2015,57:41-49.
[28]DOTAN I,ROCHE P J,PALIOURAS M,et al.Engineering multi-walled carbon nanotube therapeutic bionanofluids to selectively target papillary thyroid cancer cells[J].PLoS One,2016,11(2):e0149723.
[29]KOPPOLU B,BHAVSAR Z,WADAJKAR A S,et al.Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer[J].J Biomed Nanotechnol,2012,8(6):983-990.
[30]PRAMUAL S,LIRDPRAPAMONGKOL K,SVASTI J,et al.Polymer-lipid-PEG hybrid nanoparticles as photosensitizer carrier for photodynamic therapy[J].J Photochem Photobiol B,2017,173:12-22.
[31]LOMBARDO G E,MAGGISANO V,CELANO M,et al.AntihTERT siRNA-loaded nanoparticles block the growth of anaplastic thyroid cancer xenograft[J].Mol Cancer Ther,2018,17(6):1187-1195.
[32]LIU Y,GUNDA V,ZHU X,et al.Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer[J].Proc Natl Acad Sci U S A,2016,113(28):7750-7755.
[33]HAO R T,CHEN J,ZHAO L H,et al.Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma[J].Eur J Surg Oncol,2012,38(8):718-724.
[34]ZHU Y,CHEN X,ZHANG H,et al.Carbon nanoparticleguided central lymph node dissection in clinically node-negative patients with papillary thyroid carcinoma[J].Head Neck,2016,38(6):840-845.
[35]YU W,CAO X,XU G,et al.Potential role for carbon nanoparticles to guide central neck dissection in patients with papillary thyroid cancer[J].Surgery,2016,160(3):755-761.
[36]XUE S,REN P,WANG P,et al.Short and long-term potential role of carbon nanoparticles in total thyroidectomy with central lymph node dissection[J].Sci Rep,2018,8(1):11936.
[2]KITAHARA C M,SOSA J A.The changing incidence of thyroid cancer[J].Nat Rev Endocrinol,2016,12(11):646-653.
[3]SIEGEL R,NAISHADHAM D,JEMAL A.Cancer Statistics,2012[J].CA Cancer J Clin,2012,62(1):10-29.
[4]WEISSLEDER R.Molecular imaging in cancer[J].Science,2006,312(5777):1168-1171.
[5]PEER D,KARP J M,HONG S,et al.Nanocarriers as an emerging platform for cancer therapy[J].Nat Nanotechnol,2007,2(12):751-760.
[6]BATIST G,GELMON K A,CHI K N,et al.Safety,pharmacokinetics,and efficacy of cpx-1 liposome injection in patients with advanced solid tumors[J].Clin Cancer Res,2009,15(2):692-700.
[7]SEYMOUR L W,FERRY D R,KERR D J,et al.Phase IIstudies of polymer-doxorubicin(PK1,FCE28068)in the treatment of breast,lung and colorectal cancer[J].Int J Oncol,2009,34(6):1629-1636.
[8]MATSUMURA Y,GOTOH M,MURO K,et al.Phase I and pharmacokinetic study of MCC-465,a doxorubicin(DXR)encapsulated in PEG immunoliposome,in patients with metastatic stomach cancer[J].Ann Oncol,2004,15(3):517-525.
[9]GRADISHAR W J,TJULANDIN S,DAVIDSON N,et al.PhaseⅢtrial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer[J].J Clin Oncol,2005,23(31):7794-7803.
[10]VALLE J W,ARMSTRONG A,NEWMAN C,et al.A phase2 study of sp1049c,doxorubicin in p-glycoprotein-targeting pluronics,in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction[J].Invest New Drugs,2011,29(5):1029-1037.
[11]李慧,林岩松.核医学分子影像在分化型甲状腺癌中的应用现状与进展[J].中国癌症杂志,2018,28(7):481-486.
[12]KO H Y,CHOI K J,LEE C H,et al.A multimodal nanoparticle-based cancer imaging probe simultaneously targeting nucleolin,integrin alpha(v)beta(3)and tenascin-C proteins[J].Biomaterials,2011,32(4):1130-1138.
[13]JEE H G,BAN H S,LEE J H,et al.Thermotherapy for Na+/I-symporter-expressing cancer using anti-Na+/I-symporter antibody-conjugated magnetite nanoparticles[J].J Ind Eng Chem2018,63:359-365.
[14]CHEN X,ZHU H,HUANG X,et al.Novel iodinated gold nanoclusters for precise diagnosis of thyroid cancer[J].Nanoscale,2017,9(6):2219-2231.
[15]CHENG K,CHEN H,JENKINS C H,et al.Synthesis,characterization,and biomedical applications of a targeted dual-modal near-infrared-ii fluorescence and photoacoustic imaging nanoprobe[J].Acs Nano,2017,11(12):12276-12291.
[16]HUANG Z,LI Z,CHEN R,et al.The application of Silver nanoparticle based SERS in diagnosing thyroid tissue[M].9th international conference on photonics and imaging in biology and medicine1099.2011.
[17]LI Z,LI C,LIN D,et al.Surface-enhanced Raman spectroscopy for differentiation between benign and malignant thyroid tissues[J].Laser Phys Lett,2014,11(4).
[18]KIM B A,JEE H G,YI J W,et al.Expression profiling of a human thyroid cell line stably expressing the BRAFV(600E)mutation[J].Cancer Genomics Proteomics,2017,14(1):53-67.
[19]NIKIFOROV Y E,NIKIFOROVA M N.Molecular genetics and diagnosis of thyroid cancer[J].Nat Rev Endocrinol,2011,7(10):569-580.
[20]张红梅,周红燕,汪佩,等.甲状腺癌基因检测在甲状腺结节早期诊断中的临床应用[J].实用医学杂志,2018,34(6):970-973.
[21]LIAO K T,CHENG J T,LI C L,et al.Ultra-sensitive detection of mutated papillary thyroid carcinoma DNA using square wave stripping voltammetry method and amplified gold nanoparticle biomarkers[J].Biosens Bioelectron,2009,24(7):1899-1904.
[22]WANG Y,GAO J,MENG X,et al.DNA microarray-based resonance light scattering assay for multiplexed detection of DNAmutation in papillary thyroid cancer[J].Analyst,2018,143(4):914-919.
[23]范永增,袁耿彪,朱晓娥,等.TSH受体介导高分子纳米药物对甲状腺癌的靶向性研究[J].重庆医学,2012,41(31):3286-3288.
[24]GAO X J,LI A Q,ZHANG X,et al.Thyroid-stimulating hormone(TSH)-armed polymer-lipid nanoparticles for the targeted delivery of cisplatin in thyroid cancers:therapeutic efficacy evaluation[J].Rsc Advances,2015,5(129):106413-106420.
[25]LI S,ZHANG D,SHENG S,et al.Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles[J].Int J Nanomedicine,2017,12:5993-6003.
[26]ZHENG H T,LIU C R,XU J,et al.Thyroid stimulating hormone(tsh)-conjugated nanomedicine system to target tshr overexpressed thyroid cancers[J].J Biomater Tiss Eng,2016,6(6):448-455.
[27]ZHOU M,CHEN Y,ADACHI M,et al.Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer[J].Biomaterials,2015,57:41-49.
[28]DOTAN I,ROCHE P J,PALIOURAS M,et al.Engineering multi-walled carbon nanotube therapeutic bionanofluids to selectively target papillary thyroid cancer cells[J].PLoS One,2016,11(2):e0149723.
[29]KOPPOLU B,BHAVSAR Z,WADAJKAR A S,et al.Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer[J].J Biomed Nanotechnol,2012,8(6):983-990.
[30]PRAMUAL S,LIRDPRAPAMONGKOL K,SVASTI J,et al.Polymer-lipid-PEG hybrid nanoparticles as photosensitizer carrier for photodynamic therapy[J].J Photochem Photobiol B,2017,173:12-22.
[31]LOMBARDO G E,MAGGISANO V,CELANO M,et al.AntihTERT siRNA-loaded nanoparticles block the growth of anaplastic thyroid cancer xenograft[J].Mol Cancer Ther,2018,17(6):1187-1195.
[32]LIU Y,GUNDA V,ZHU X,et al.Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer[J].Proc Natl Acad Sci U S A,2016,113(28):7750-7755.
[33]HAO R T,CHEN J,ZHAO L H,et al.Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma[J].Eur J Surg Oncol,2012,38(8):718-724.
[34]ZHU Y,CHEN X,ZHANG H,et al.Carbon nanoparticleguided central lymph node dissection in clinically node-negative patients with papillary thyroid carcinoma[J].Head Neck,2016,38(6):840-845.
[35]YU W,CAO X,XU G,et al.Potential role for carbon nanoparticles to guide central neck dissection in patients with papillary thyroid cancer[J].Surgery,2016,160(3):755-761.
[36]XUE S,REN P,WANG P,et al.Short and long-term potential role of carbon nanoparticles in total thyroidectomy with central lymph node dissection[J].Sci Rep,2018,8(1):11936.