血清Ox-LDL、Fib、PAI-1在急性缺血性脑卒中的表达及意义
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摘要
目的探讨血清氧化型低密度脂蛋白(Ox-LDL)、纤维蛋白原(Fib)、Ⅰ型纤溶酶原激活抑制剂(PAI-1)在急性缺血性脑卒中患者中的表达及意义。方法选取2017年1月-2017年12月在我院急诊科治疗的急性缺血性脑卒中患者267例(观察组),同时选取行头部影像学检查无异常者100例作为对照组,检测并对比两组血清Ox-LDL、Fib、PAI-1水平。结果观察组血清Ox-LDL、Fib、PAI-1分别为(72.01±8.28)μg/dl、(4.40±1.13)g/L和(52.29±8.10)mg/L,明显高于对照组(P<0.05);重型患者血清Ox-LDL、Fib、PAI-1分别为(83.02±9.10)μg/dl、(5.08±1.07)g/L和(60.10±9.22)mg/L,明显高于中型组和轻型组(P<0.05);预后不良患者血清Ox-LDL、Fib、PAI-1分别为(85.01±9.15)μg/dl、(5.00±1.22)g/L和(59.11±9.21)mg/L,明显高于预后良好患者(P<0.05)。结论急性缺血性脑卒中患者血清Ox-LDL、Fib、PAI-1明显升高,与患者病情程度、预后有一定关系,值得进一步研究。
Objective To investigate the expressions and significance of serum oxidized low density lipoprotein( Ox-LDL),fibrinogen( Fib) and type Ⅰ plasminogen activator inhibitor( PAI-1) in patients with acute ischemic stroke. Methods Two hundred and sixty-seven cases of acute ischemic stroke( the observation group) were selected from January 2017 to December 2017 in the Emergency Department of our hospital,and another 100 cases with no abnormality in the head imaging examination were selected as the control group. Serum levels of Ox-LDL,Fib and PAI-1 were detected in both groups.Results The serum levels of Ox-LDL,Fib and PAI-1 in the observation group were( 72. 01 ± 8.28) μg/dl,( 4. 40 ± 1. 13) g/L and( 52. 29 ±8.10) mg/L respectively,which were significantly higher than those in the control group( P < 0. 05). The serum levels of Ox-LDL,Fib and PAI-1 of severe patients were( 83.02±9.10) μg/dl,( 5.08± 1.07) g/L and( 60.10± 9.22) mg/L respectively,which were significantly higher than those in the medium and the mild group( P<0.05). These levels in patients with poor prognosis were( 85.01±9.15) μg/dl,( 5.00±1.22) g/L and( 59.11±9.21) mg/Lrespectively,which were significantly higher than those with good prognosis( P<0.05).Conclusion Serum Ox-LDL,Fib and PAI-1 levels in patients with acute ischemic stroke are increased significantly and related to the severity and prognosis of the patients,which are worthy of further study.
Objective To investigate the expressions and significance of serum oxidized low density lipoprotein( Ox-LDL),fibrinogen( Fib) and type Ⅰ plasminogen activator inhibitor( PAI-1) in patients with acute ischemic stroke. Methods Two hundred and sixty-seven cases of acute ischemic stroke( the observation group) were selected from January 2017 to December 2017 in the Emergency Department of our hospital,and another 100 cases with no abnormality in the head imaging examination were selected as the control group. Serum levels of Ox-LDL,Fib and PAI-1 were detected in both groups.Results The serum levels of Ox-LDL,Fib and PAI-1 in the observation group were( 72. 01 ± 8.28) μg/dl,( 4. 40 ± 1. 13) g/L and( 52. 29 ±8.10) mg/L respectively,which were significantly higher than those in the control group( P < 0. 05). The serum levels of Ox-LDL,Fib and PAI-1 of severe patients were( 83.02±9.10) μg/dl,( 5.08± 1.07) g/L and( 60.10± 9.22) mg/L respectively,which were significantly higher than those in the medium and the mild group( P<0.05). These levels in patients with poor prognosis were( 85.01±9.15) μg/dl,( 5.00±1.22) g/L and( 59.11±9.21) mg/Lrespectively,which were significantly higher than those with good prognosis( P<0.05).Conclusion Serum Ox-LDL,Fib and PAI-1 levels in patients with acute ischemic stroke are increased significantly and related to the severity and prognosis of the patients,which are worthy of further study.
引文
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[8]刘小英,侯玉立,张晋岳.年龄及纤维蛋白原对缺血性脑卒中患者经颅多普勒参数脉动指数影响的分析[J].中国药物与临床,2017,32(10):1498.
[9]张凯,成云云,张召,等.血清同型半胱氨酸和纤维蛋白原与急性脑卒中的相关性研究[J].中国实验诊断学,2017,21(6):980.
[10]黄晓东,曹开谊,陈东尔.观察超敏C反应蛋白及纤维蛋白原水平与急性缺血性脑卒中患者静脉溶栓疗效的关系[J].中国现代药物应用,2018,12(8):1.
[11]WANG A,LIU J,MENG X,et al.Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke[J].Eur J Neurol,2018,25(1):185.
[12]ILL-RAGA G,PALOMER E,RAMOS-FERN NDEZ E,et al.Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death[J].Biochimi Biophy Acta,2015,1852(3):421.
[13]PIKIJA S,TRKULJA V,MUTZENBACH J S,et al.Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke:a retrospective hyperdense artery study[J].J Transl Med,2016,14(1):45.
[14]于秋丽,曲晓荣,张华,等.老年缺血性脑卒中患者氧化型低密度脂蛋白与辅助性T细胞和调节性T细胞轴的关系[J].中华老年心脑血管病杂志,2017,19(3):280.
[15]SWAROWSKA M,JANOWSKA A,POLCZAK A,et al.The Sustained increase of plasma fibrinogen during ischemic stroke predicts worse outcome independently of baseline fibrinogen level[J].Inflammation,2014,37(4):1142.
[2]马修尧,任超,王强.老年急性缺血性脑卒中血管内治疗预后的影响因素[J].中国老年学杂志,2018,38(5):1068.
[3]WANG A,CUI Y,MENG X,et al.The relationship between oxidized low-density lipoprotein and the NIHSS score among patients with acute ischemic stroke:The SOS-Stroke Study[J].Atherosclerosis,2018,270(6):21.
[4]WEI C,ZHANG S,LIU J,et al.Association between fibrinogen and leukoaraiosis in patients with ischemic stroke and atrial fibrillation[J].Journal of Stroke and Cerebrovascular Diseases,2017,26(11):2630.
[5]赵晖,马瑞敏,李虓,等.缺血性脑卒中患者凝血相关指标变化规律的探讨[J].中国卫生检验杂志,2015,25(17):2901.
[6]柳立岩,王春,张雪云.血清降钙素原、C反应蛋白及纤维蛋白原检测在脑卒中相关性肺炎中的临床意义[J].贵州医科大学学报,2016,22(7):826.
[7]许寅宏,徐恩,林清原,等.急性缺血性脑卒中患者血清氧化型低密度脂蛋白水平与颈动脉易损斑块的关系[J].中国医学影像学杂志,2015,23(9):659.
[8]刘小英,侯玉立,张晋岳.年龄及纤维蛋白原对缺血性脑卒中患者经颅多普勒参数脉动指数影响的分析[J].中国药物与临床,2017,32(10):1498.
[9]张凯,成云云,张召,等.血清同型半胱氨酸和纤维蛋白原与急性脑卒中的相关性研究[J].中国实验诊断学,2017,21(6):980.
[10]黄晓东,曹开谊,陈东尔.观察超敏C反应蛋白及纤维蛋白原水平与急性缺血性脑卒中患者静脉溶栓疗效的关系[J].中国现代药物应用,2018,12(8):1.
[11]WANG A,LIU J,MENG X,et al.Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke[J].Eur J Neurol,2018,25(1):185.
[12]ILL-RAGA G,PALOMER E,RAMOS-FERN NDEZ E,et al.Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death[J].Biochimi Biophy Acta,2015,1852(3):421.
[13]PIKIJA S,TRKULJA V,MUTZENBACH J S,et al.Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke:a retrospective hyperdense artery study[J].J Transl Med,2016,14(1):45.
[14]于秋丽,曲晓荣,张华,等.老年缺血性脑卒中患者氧化型低密度脂蛋白与辅助性T细胞和调节性T细胞轴的关系[J].中华老年心脑血管病杂志,2017,19(3):280.
[15]SWAROWSKA M,JANOWSKA A,POLCZAK A,et al.The Sustained increase of plasma fibrinogen during ischemic stroke predicts worse outcome independently of baseline fibrinogen level[J].Inflammation,2014,37(4):1142.