HP与lncRNA在胃肿瘤发生发展中的相互关系
摘要
幽门螺杆菌(HP)作为胃癌的Ⅰ类致癌物质,可诱导胃组织内长链非编码RNA (lncRNA)的异常表达。同时,lncRNA可在表观遗传学、转录及转录后等多层面调控基因表达,对个体生长发育及肿瘤发生发展过程至关重要。因此本文就HP和lncRNA在胃癌发生发展中的相互关系做一综述。
引文
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[4]SHIOTA S, YAMAOKA Y . Biomarkers for Helicobacter pylori infection and gastroduodenal diseases[J]. Biomarkers in Medicine, 2014, 8(9):1127-1137.
[5]TAKE S, MIZUNO M, ISHIKI K, et al. The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori[J]. J Gastroenterol, 2011, 46(3): 318-324.
[6]DEVI S, RAJAKUMARA E, AHMED N. Induction of mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy[J]. Sci Rep, 2015(5): 15049.
[7] TIZIANA L, ISABELLA L, EVELINA S, et al. Helicobacter pylori and T helper cells: mechanisms of immune escape and tolerance[J]. Journal of Immunology Research, 2015,2015(12): 1-10.
[8]SUGIZAKI K, TARI A, KITADAI Y, et al. Anti-Helicobacter pylori therapy in localized gastric mucosa-associated lymphoid tissue lymphoma: a prospective, nationwide, multicenter study in Japan[J]. Helicobacter, 2018, 23(2): e12474.
[9]FISCHBACH W. Gastric MALT lymphoma -Update on diagnosis and treatment[J]. Best Practice & Research in Clinical Gastroenterology, 2014, 28(6): 1069-1077.
[10]WANG JJ, SUN J X, WANG J, et al. Long noncoding RNAs in gastric cancer: functions and clinical applications[J]. Onco Targets Ther, 2016,2016 (9): 681-697.
[11]KOTAKE Y, NAEMURA M, MURASAKI C. Regulation of cell proliferation and apoptosis by long noncoding RNA,ANRIL and PANDA[J]. Seikagaku, 2015, 87(2): 230-233.
[12]DERRIEN T, JOHNSON R, BUSSOTTI G, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression[J]. Genome Res, 2012, 22(9): 1775-1789.
[13]LU M H, TANG B, ZENG S, et al. Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer[J]. Oncogene, 2016, 35(27): 3524-3534.
[14]ZHU H, WANG Q, YAO Y Z, et al.Microarray analysis of long non-coding RNA expression profiles in human gastric cells and tissues with Helicobacter pylori infection[J]. BMC Med Genomics, 2015, 8(1): 1-11.
[15]GUO X, GAO L, WANG Y, et al. Advances in long noncoding RNAs: identification,structure prediction and function annotation[J]. Brief Funct Genomics, 2016, 15(1): 38-46.
[16]HARROW J, FRANKISH A, GONZALEZ J M, et al. GENCODE: the reference human genome annotation for The ENCODE Project[J]. Genome Res, 2012, 22(9): 1760-1774.
[17]陈国栋,张艳.长链非编码RNA在胃癌中的研究进展[J].微生物学免疫学进展,2016,44(6):81-84.
[18]JIN C, SHI W, WANG F, et al. Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer[J].Oncotarget, 2016, 7(32): 51763-51772.
[19]PEI P F, Li, SHENG S C, et al. Non-coding RNAs and gastric cancer[J]. World Journal of Gastroenterology, 2014, 20(18): 5411-5419.
[20]ZHOU X Y, CHEN H, ZHU L, et al.Helicobacter pylori infection related long noncoding RNA (lncRNA) AF147447 inhibits gastric cancer proliferation and invasion by targeting MUC2 and up-regulating miR-34c[J]. Oncotarget, 2016, 7(50): 82770-82782.
[21]SHAO Y, YE M, JIANG X, et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer[J]. Cancer, 2014, 120(21): 3320-3328.
[22]XIAN H P, ZHUO Z L, SUN Y J, et al. Circulating long non-coding RNAs HULC and ZNFX1-AS1 are potential biomarkers in patients with gastric cancer[J]. Oncol Lett, 2018, 16(4): 4689-4698.
[23]YANG T, ZENG H M, CHEN W Q, et al.Helicobacter pylori infection, H19 and LINC00152 expression in serum and risk of gastric cancer in a Chinese population[J]. Cancer Epidemiol, 2016, 44: 147-153.
[24]杨允奔,李田文,郭俊明.长链非编码RNA在胃癌发生中的作用及其应用[J].中国生物化学与分子生物学报,2016, 32(4): 388-395.
[25]李楠.lncRNA-MEG3在幽门螺杆菌介导MUC5AC促进胃溃疡发生的机制[D].新乡:新乡医学院,2015.
[26]YANG L, LONG Y P, LI C, et al. Genome-wide analysis of long noncoding RNA profile in human gastric epithelial cell response to helicobacter pylori[J]. Jpn J Infect Dis, 2015, 68(1): 63-66.
[27]杨柳.幽门螺杆菌感染相关的非编码RNA筛选,鉴定及其功能研究[Z].大连:大连医科大学,2016.
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[29]YAO Y, JIANG Q, JIANG L, et al. Lnc-SGK1 induced by Helicobacter pylori infection and high salt diet promote Th2 and Th17 differentiation in human gastric cancer by SGK1/Jun B signaling[J]. Oncotarget, 2016, 7(15): 20549-20560.
[30]SIEGEL R L, MILLER K D, JEMAL A. Cancer statistics, 2015[J]. CA Cancer JClin, 2015, 65(1): 5-29.
[31]ARITA T, ICHIKAWA D, KONISHI H, et al. Circulating long non-coding RNAs in plasma of patients with gastric cancer[J]. Anticancer Res, 2013, 33(8): 3185-3193.
[32]TIE J, ZHANG X Y, FAN D M. Epigenetic roles in the malignant transformation of gastric mucosal cells[J]. Cellular and Molecular Life Sciences, 2016, 73(24): 4599-4610.
[33]LIN L Y, YANG L, ZENG Q, et al. Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer[J]. Mol Cancer, 2018, 17(1): 84.
[34]YANG Y, SHAO Y, ZHU M, et al. Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker in the screening of gastric cancer[J]. Tumour Biol, 2016, 37(1): 1183-1188.
[35] PAY?O S L, RASMUSSEN L T. Helicobacter pylori and its reservoirs: a correlation with the gastric infection[J]. World J Gastrointest Pharmacol Ther, 2016, 7(1): 126-132.
[36]SALAMA N R, HARTUNG M L, MUELLER A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori[J]. Nat Rev Microbiol, 2013, 11(6): 385-399.
[37]LIBANIO D, AZEVEDO L F. Analysis of the Cochrane review: Helicobacter pylori eradication for the prevention of gastric neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583[J]. Acta Med Port, 2015, 28(6): 684-686.
[2]李凌雪, 韩涛涛, 刘彦信, 等. 长链非编码RNA LINC00260抑制幽门螺杆菌感染胃上皮细胞系引起的炎性反应和细胞迁移[J]. 基础医学与临床, 2016, 36(4):480-485.
[3]ZANDI S, HEDAYATI M A, MOHAMMADI E A. Helicobacter pylori infection increases sirt2 gene expression in gastric epithelial cells of gastritis patients[J]. Microb Pathog, 2018, 116: 120-123.
[4]SHIOTA S, YAMAOKA Y . Biomarkers for Helicobacter pylori infection and gastroduodenal diseases[J]. Biomarkers in Medicine, 2014, 8(9):1127-1137.
[5]TAKE S, MIZUNO M, ISHIKI K, et al. The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori[J]. J Gastroenterol, 2011, 46(3): 318-324.
[6]DEVI S, RAJAKUMARA E, AHMED N. Induction of mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy[J]. Sci Rep, 2015(5): 15049.
[7] TIZIANA L, ISABELLA L, EVELINA S, et al. Helicobacter pylori and T helper cells: mechanisms of immune escape and tolerance[J]. Journal of Immunology Research, 2015,2015(12): 1-10.
[8]SUGIZAKI K, TARI A, KITADAI Y, et al. Anti-Helicobacter pylori therapy in localized gastric mucosa-associated lymphoid tissue lymphoma: a prospective, nationwide, multicenter study in Japan[J]. Helicobacter, 2018, 23(2): e12474.
[9]FISCHBACH W. Gastric MALT lymphoma -Update on diagnosis and treatment[J]. Best Practice & Research in Clinical Gastroenterology, 2014, 28(6): 1069-1077.
[10]WANG JJ, SUN J X, WANG J, et al. Long noncoding RNAs in gastric cancer: functions and clinical applications[J]. Onco Targets Ther, 2016,2016 (9): 681-697.
[11]KOTAKE Y, NAEMURA M, MURASAKI C. Regulation of cell proliferation and apoptosis by long noncoding RNA,ANRIL and PANDA[J]. Seikagaku, 2015, 87(2): 230-233.
[12]DERRIEN T, JOHNSON R, BUSSOTTI G, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression[J]. Genome Res, 2012, 22(9): 1775-1789.
[13]LU M H, TANG B, ZENG S, et al. Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer[J]. Oncogene, 2016, 35(27): 3524-3534.
[14]ZHU H, WANG Q, YAO Y Z, et al.Microarray analysis of long non-coding RNA expression profiles in human gastric cells and tissues with Helicobacter pylori infection[J]. BMC Med Genomics, 2015, 8(1): 1-11.
[15]GUO X, GAO L, WANG Y, et al. Advances in long noncoding RNAs: identification,structure prediction and function annotation[J]. Brief Funct Genomics, 2016, 15(1): 38-46.
[16]HARROW J, FRANKISH A, GONZALEZ J M, et al. GENCODE: the reference human genome annotation for The ENCODE Project[J]. Genome Res, 2012, 22(9): 1760-1774.
[17]陈国栋,张艳.长链非编码RNA在胃癌中的研究进展[J].微生物学免疫学进展,2016,44(6):81-84.
[18]JIN C, SHI W, WANG F, et al. Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer[J].Oncotarget, 2016, 7(32): 51763-51772.
[19]PEI P F, Li, SHENG S C, et al. Non-coding RNAs and gastric cancer[J]. World Journal of Gastroenterology, 2014, 20(18): 5411-5419.
[20]ZHOU X Y, CHEN H, ZHU L, et al.Helicobacter pylori infection related long noncoding RNA (lncRNA) AF147447 inhibits gastric cancer proliferation and invasion by targeting MUC2 and up-regulating miR-34c[J]. Oncotarget, 2016, 7(50): 82770-82782.
[21]SHAO Y, YE M, JIANG X, et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer[J]. Cancer, 2014, 120(21): 3320-3328.
[22]XIAN H P, ZHUO Z L, SUN Y J, et al. Circulating long non-coding RNAs HULC and ZNFX1-AS1 are potential biomarkers in patients with gastric cancer[J]. Oncol Lett, 2018, 16(4): 4689-4698.
[23]YANG T, ZENG H M, CHEN W Q, et al.Helicobacter pylori infection, H19 and LINC00152 expression in serum and risk of gastric cancer in a Chinese population[J]. Cancer Epidemiol, 2016, 44: 147-153.
[24]杨允奔,李田文,郭俊明.长链非编码RNA在胃癌发生中的作用及其应用[J].中国生物化学与分子生物学报,2016, 32(4): 388-395.
[25]李楠.lncRNA-MEG3在幽门螺杆菌介导MUC5AC促进胃溃疡发生的机制[D].新乡:新乡医学院,2015.
[26]YANG L, LONG Y P, LI C, et al. Genome-wide analysis of long noncoding RNA profile in human gastric epithelial cell response to helicobacter pylori[J]. Jpn J Infect Dis, 2015, 68(1): 63-66.
[27]杨柳.幽门螺杆菌感染相关的非编码RNA筛选,鉴定及其功能研究[Z].大连:大连医科大学,2016.
[28]李凌雪.lncRNA参与幽门螺杆菌感染相关胃癌的功能及机制研究[D].北京:北京协和医学院,2016.
[29]YAO Y, JIANG Q, JIANG L, et al. Lnc-SGK1 induced by Helicobacter pylori infection and high salt diet promote Th2 and Th17 differentiation in human gastric cancer by SGK1/Jun B signaling[J]. Oncotarget, 2016, 7(15): 20549-20560.
[30]SIEGEL R L, MILLER K D, JEMAL A. Cancer statistics, 2015[J]. CA Cancer JClin, 2015, 65(1): 5-29.
[31]ARITA T, ICHIKAWA D, KONISHI H, et al. Circulating long non-coding RNAs in plasma of patients with gastric cancer[J]. Anticancer Res, 2013, 33(8): 3185-3193.
[32]TIE J, ZHANG X Y, FAN D M. Epigenetic roles in the malignant transformation of gastric mucosal cells[J]. Cellular and Molecular Life Sciences, 2016, 73(24): 4599-4610.
[33]LIN L Y, YANG L, ZENG Q, et al. Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer[J]. Mol Cancer, 2018, 17(1): 84.
[34]YANG Y, SHAO Y, ZHU M, et al. Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker in the screening of gastric cancer[J]. Tumour Biol, 2016, 37(1): 1183-1188.
[35] PAY?O S L, RASMUSSEN L T. Helicobacter pylori and its reservoirs: a correlation with the gastric infection[J]. World J Gastrointest Pharmacol Ther, 2016, 7(1): 126-132.
[36]SALAMA N R, HARTUNG M L, MUELLER A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori[J]. Nat Rev Microbiol, 2013, 11(6): 385-399.
[37]LIBANIO D, AZEVEDO L F. Analysis of the Cochrane review: Helicobacter pylori eradication for the prevention of gastric neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583[J]. Acta Med Port, 2015, 28(6): 684-686.