稳消Ⅲ号方对颈动脉粥样硬化患者不稳定斑块、脂质代谢及踝臂指数的作用
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摘要
目的:观察稳消Ⅲ号方对颈动脉粥样硬化(CAS)不稳定斑块、脂质代谢、踝臂指数(ABI)的作用。方法:将98例CAS伴不稳定斑块患者随机分为两组,每组49例。对照组给予基础治疗,治疗组在基础治疗同时加用稳消Ⅲ号方。两组疗程均为24周,观察治疗前后颈动脉斑块状况、血脂水平及ABI变化。结果:治疗组治疗后的颈动脉斑块状况、血脂水平及ABI均较本组治疗前明显改善(P<0.05,P<0.01),且治疗组各指标改善情况均明显优于对照组同期(P<0.05,P<0.01)。结论:稳消Ⅲ号不仅可以减少CAS不稳定斑块形成,还可以改善脂质代谢,降低踝臂指数,从而起到延缓动脉硬化、减少斑块的作用。
Objective: To observe the effects of Wenxiao I I Decoction on plaque instability, lipids metabolism and ankle brachial index in patients with carotid atherosclerotic(CAS). Methods: Ninety-eight patients with CAS unstable plaque were randomly divided into two groups, forty-nine cases in each group. Patients in control group were treated by routine therapy, while patients in treatment group, based on the routine therapy, were treated by Wenxiao Ⅲ Decoction, with a treatment course of 24 weeks. The characteristic, size and number of plaque, blood lipid levels and ankle brachial index were detected before and after treatment. Results: There were significant improvement in carotid atherosclerotic plaque, blood lipid levels and ankle brachial index between two groups(P<0.05, P<0.01), and the above indexes in the treatment group were more significantly than that in the control group(P<0.05, P<0.01). Conclusion: Wenxiao Ⅲ Decoction could alleviate the development of unstable plaque in CAS, improve lipid metabolism, decrease ankle brachial index, and to improve arteriosclerosis and decrease unstable carotid plaque.
Objective: To observe the effects of Wenxiao I I Decoction on plaque instability, lipids metabolism and ankle brachial index in patients with carotid atherosclerotic(CAS). Methods: Ninety-eight patients with CAS unstable plaque were randomly divided into two groups, forty-nine cases in each group. Patients in control group were treated by routine therapy, while patients in treatment group, based on the routine therapy, were treated by Wenxiao Ⅲ Decoction, with a treatment course of 24 weeks. The characteristic, size and number of plaque, blood lipid levels and ankle brachial index were detected before and after treatment. Results: There were significant improvement in carotid atherosclerotic plaque, blood lipid levels and ankle brachial index between two groups(P<0.05, P<0.01), and the above indexes in the treatment group were more significantly than that in the control group(P<0.05, P<0.01). Conclusion: Wenxiao Ⅲ Decoction could alleviate the development of unstable plaque in CAS, improve lipid metabolism, decrease ankle brachial index, and to improve arteriosclerosis and decrease unstable carotid plaque.
引文
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[14]杜文婷,杜文娇,徐辉,等.颈动脉粥样硬化患者不同中医证型间颈动脉超声的比较.中华中医药学刊,2015,33(3):694-696
[15]申定珠,陈川,迟惠英,等.从血管老化角度探讨动脉粥样硬化中医防治策略.中国中西医结合杂志,2012,32(2):266-268
[16]陈可冀,马晓昌.关于传统血瘀证的现代分类.中国中西医结合杂志,2008,20(7):487
[17]陈可冀,史载祥.实用瘀证学.北京:人民卫生出版社,1999:6
[2]孙旭文,张艳祥,张秀珍.260例脑梗死与颈动脉硬化关系的临床探讨.中风与神经疾病杂志,2004,21(1):65-66
[3]牛建一,张蕊,牛建霞.颈动脉粥样硬化与心肌梗死及脑梗死的关系.临床神经病学杂志,2000,13(2):106-107
[4]周永昌,郭万学.超声医学.6版.北京:人民军医出版社,2012:689
[5]Crouse J R,Harpold G H,Kahl F R,et al.Evaluation of a scoring system for extracranial carotid atherosclerosis extent with B-mode ultrasound.Stroke,1986,17(2):270-275
[6]Greenland P,Abrans J,Aurigemma G P,et al.Prevention Conference V:beyond secondary prevention:identifying the high risk patient for primary prevention noninvasive tests of atherosclerotic burden:Writing Group Ill.Circulation,2000,101(1):16-22
[7]Craven T E,Ryu J E,Espeland M A,et al.Evaluation of the associations between carotid atherosclerosis and coronary artery stenosis.A case-control study.Circulation,1990,82(4):1230-1242
[8]Sirimarco G,Amarenco P,Labreuche J,et al.Carotid atherosclerosis and risk of subsequent coronary event in outpatients with atherothrombosis.Stroke,2013,44(2):373-379
[9]Nakanishi N,Shiraishi T,Wada M.Brachial-ankle pulse wave velocity and metabolic syndrome in a Japanese population:the Minoh study.Hypertens Res,2005,28(2):125-131
[10]Hooi J D,Kester A D,Stoffers H E,et al.Asymptomatic peripheral arterial oculusive disease predicted cardiovascular morbidity and mortality in a 7-year follow-up study.J Clin Epidemiol,2004,57(3):294-300
[11]卢生芳,于峰,韩伏莅,等.踝臂指数与缺血性脑卒中的关系.同济大学学报(医学版),2013,34(1):81-84
[12]林细明,邹蓉,曾朝东,等.踝臂指数、脉搏波速度及血尿酸与冠心病的相关性研究.白求恩医学杂志,2014,12(2):110-111
[13]孟胜喜,霍清萍,王兵,等.从痰瘀角度论治缺血性脑血管病.山东中医杂志,2015,34(10):733-735
[14]杜文婷,杜文娇,徐辉,等.颈动脉粥样硬化患者不同中医证型间颈动脉超声的比较.中华中医药学刊,2015,33(3):694-696
[15]申定珠,陈川,迟惠英,等.从血管老化角度探讨动脉粥样硬化中医防治策略.中国中西医结合杂志,2012,32(2):266-268
[16]陈可冀,马晓昌.关于传统血瘀证的现代分类.中国中西医结合杂志,2008,20(7):487
[17]陈可冀,史载祥.实用瘀证学.北京:人民卫生出版社,1999:6