髓鞘与双相情感障碍
摘要
髓鞘是环绕轴突的多层复合膜结构,其生理活动影响着轴突的信息传递。本文综述了双相情感障碍与髓鞘的关联,关联的可能的机制及影响因素。提出了髓鞘可能为双相情感障碍发病机制、诊断和转归研究的新的方向。
引文
1.Mahon K,Burdick KE,Szeszko PR.A role for white matter abnormalities in the pathophysiology of bipolar disorder[J].Neurosci Biobehav Rev.2010,34(4):533-554.
2.Savitz JB,Price JL,Drevets WC.Neuropathological and neuromorpho-metric abnormalities in bipolar disorder:view from the medial prefrontal cortical network[J].Neurosci Biobehav Rev.2014,42:132-147.
3.Gos TG,Schroeter L,Lessel W,et al.S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differently afflicted in unipolar and bipolar depression:a postmortem study[J].J Psychiatr Res.2013,47(11):1694-1699.
4.Hayashi Y,Nihonmatsu KN,Hisanaga S,et al.Neuropathological similarities and diferences between schizophrenia and bipolar disorder:a fow cytometric postmortem brain study[J].Plos One,2012,7(3):e33019.
5.Vostrikov V,Uranova N.Age-related increase in the number of oligodendrocytes is dysregulated in schizophrenia and mood disorders[J].Schizophr Res Treatment.2011,2011:174689.
6.Bellani M,Boschello F,Delvecchio G,et al.DTi and Myelin Plasticity in Bipolar Disorder:integrating Neuroimaging and Neuropathological Findings[J].Front Psychiatry,2016,7:21.
7.Gutiérrez FA,González PA,Vega P,et al.Expression of oligodendrocyte and myelin genes is not altered in peripheral blood cells of patients with first-episode schizophrenia and bipolar disorder[J].Bipolar Disord.2010,12(1):107-109.
8.Modabbernia A,Taslimi S,Brietzke E,et al.Cytokine alterations in bipolar disorder:a meta-analysis of 30 studies.Biol Psychiatry,2013,74:15-25.
9.Konradi C,Sillivan SE,Clay HB.Mitochondria,oligodendrocytes and inflammation in bipolar disorder:evidence from transcriptome studies points to intriguing parallels with multiple sclerosis[J].Neurobiol Dis.2012,45:37-47.
10.Long P,Corfas G.Dynamic regulation of myelination in health and disease[J].JAMA Psychiatry,2014,71(11):1296-1297.
11.Makinodan M,Rosen KM,Ito S,et al.A Critical Period for Social Experience-Dependent Oligodendrocyte Maturation and Myelination[J].Science,2012,337(6100):1357-1360.
12.Liu J,Dietz K,Deloyht JM,et al.Impaired adult myelination in the prefrontal cortex of socially isolated mice[J].Nat Neurosci.2012,15(12):1621-1623.
13.Patrick L,Gabriel C.Neuroscience.To learn is to myelinate[J].Science.2014,346(6207):298-299.
14.Morelli A,Ravera S,Panfoli I,et al.Myelin sheath:A new possible role in sleep mechanism[J].Sleep Medicine,2011,12:198-199.
15.Wang HN,Liu GH,Zhang RG,et al.Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice:The Involvement of Notch Signaling Pathway[J].Int J Neuropsychopharmacol.2015,19(2).
16.Sui J,Pearlson G,Caprihan A,et al.Discriminating schizophrenia and bipolar disorder by fusing fMRI and DTI in a multimodal CCA+joint ICA model[J].NeuroImage,2011,57:839-855.
17.Lin F,Weng S,Xie B,et al.Abnormal frontal cortex white matter connections in bipolar disorder:A DTI tractography study[J].Journal of Affective Disorders,2011,131:299-306.
18.Caetano SC,Olvera RL,Hatch JP et al.Lower N-acetylaspartate levels in prefrontal cortices in pediatric bipolar disorder:a1H magnetic resonance spectroscopy study[J].J Am Acad Child Adolesc Psychiatry,2011,50(1):85-94.
19.Cercignani M,Giulietti G,Dowell NG,et al.Characterizing axonal myelination within the healthy population:a tract-bytract mapping of effects of age and gender on the fiber g-ratio[J].Neurobiol Aging,2017,49:109-118.
2.Savitz JB,Price JL,Drevets WC.Neuropathological and neuromorpho-metric abnormalities in bipolar disorder:view from the medial prefrontal cortical network[J].Neurosci Biobehav Rev.2014,42:132-147.
3.Gos TG,Schroeter L,Lessel W,et al.S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differently afflicted in unipolar and bipolar depression:a postmortem study[J].J Psychiatr Res.2013,47(11):1694-1699.
4.Hayashi Y,Nihonmatsu KN,Hisanaga S,et al.Neuropathological similarities and diferences between schizophrenia and bipolar disorder:a fow cytometric postmortem brain study[J].Plos One,2012,7(3):e33019.
5.Vostrikov V,Uranova N.Age-related increase in the number of oligodendrocytes is dysregulated in schizophrenia and mood disorders[J].Schizophr Res Treatment.2011,2011:174689.
6.Bellani M,Boschello F,Delvecchio G,et al.DTi and Myelin Plasticity in Bipolar Disorder:integrating Neuroimaging and Neuropathological Findings[J].Front Psychiatry,2016,7:21.
7.Gutiérrez FA,González PA,Vega P,et al.Expression of oligodendrocyte and myelin genes is not altered in peripheral blood cells of patients with first-episode schizophrenia and bipolar disorder[J].Bipolar Disord.2010,12(1):107-109.
8.Modabbernia A,Taslimi S,Brietzke E,et al.Cytokine alterations in bipolar disorder:a meta-analysis of 30 studies.Biol Psychiatry,2013,74:15-25.
9.Konradi C,Sillivan SE,Clay HB.Mitochondria,oligodendrocytes and inflammation in bipolar disorder:evidence from transcriptome studies points to intriguing parallels with multiple sclerosis[J].Neurobiol Dis.2012,45:37-47.
10.Long P,Corfas G.Dynamic regulation of myelination in health and disease[J].JAMA Psychiatry,2014,71(11):1296-1297.
11.Makinodan M,Rosen KM,Ito S,et al.A Critical Period for Social Experience-Dependent Oligodendrocyte Maturation and Myelination[J].Science,2012,337(6100):1357-1360.
12.Liu J,Dietz K,Deloyht JM,et al.Impaired adult myelination in the prefrontal cortex of socially isolated mice[J].Nat Neurosci.2012,15(12):1621-1623.
13.Patrick L,Gabriel C.Neuroscience.To learn is to myelinate[J].Science.2014,346(6207):298-299.
14.Morelli A,Ravera S,Panfoli I,et al.Myelin sheath:A new possible role in sleep mechanism[J].Sleep Medicine,2011,12:198-199.
15.Wang HN,Liu GH,Zhang RG,et al.Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice:The Involvement of Notch Signaling Pathway[J].Int J Neuropsychopharmacol.2015,19(2).
16.Sui J,Pearlson G,Caprihan A,et al.Discriminating schizophrenia and bipolar disorder by fusing fMRI and DTI in a multimodal CCA+joint ICA model[J].NeuroImage,2011,57:839-855.
17.Lin F,Weng S,Xie B,et al.Abnormal frontal cortex white matter connections in bipolar disorder:A DTI tractography study[J].Journal of Affective Disorders,2011,131:299-306.
18.Caetano SC,Olvera RL,Hatch JP et al.Lower N-acetylaspartate levels in prefrontal cortices in pediatric bipolar disorder:a1H magnetic resonance spectroscopy study[J].J Am Acad Child Adolesc Psychiatry,2011,50(1):85-94.
19.Cercignani M,Giulietti G,Dowell NG,et al.Characterizing axonal myelination within the healthy population:a tract-bytract mapping of effects of age and gender on the fiber g-ratio[J].Neurobiol Aging,2017,49:109-118.