对异黄酮类化合物药理作用的研究进展
摘要
异黄酮是一种黄酮类化合物,属于植物的次生代谢产物。目前,临床上对异黄酮类化合物生物活性的研究主要集中在其抗癌、抗心血管疾病及神经保护等作用方面。本文对异黄酮类化合物的药理作用做一综述。
引文
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[2]A,U.,et al.The Impact of Soy Isoflavones on MCF-7 and MDA-MB-231 Breast Cancer Cells Using a Global Metabolomic Approach[J].International journal of molecular sciences,2016.17(9):1443.
[3]L,J.,et al.,Puerarin inhibits the inflammatory response in atherosclerosis via modulation of the NF-κB pathway in a rabbit model[J].Pharmacological reports:PR,2016.68(5):1054-1059.
[4]X,L.,et al.Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension[J].Clinical and experimental hypertension(New York,N.Y.:1993),2017.39(1):58-64.
[5]C,L.,et al.Neuroprotective Effects of Soy Isoflavones o n S c o p o l a m i n e-I n d u c e d A m n e s i a i n M i c e[J].Nutrients,2018.10(7):853.
[6]P,G.,et al.Tectorigenin attenuates the MPP-induced SH-SY5Y cell damage,indicating a potential beneficial role in Parkinson’s disease by oxidative stress inhibition[J].Experimental and therapeutic medicine,2017.14(5):4431-4437.
[7]S,A.,et al.Dietary flavonoid kaempferol inhibits glucocorticoid-induced bone loss by promoting osteoblast survival[J].Nutrition(Burbank,Los Angeles County,Calif.),2018.53(2):64-76.
[8]AA,G.and H.M.Genistein attenuates D-GalN induced liver fibrosis/chronic liver damage in rats by blocking the TGF-β/Smad signaling pathways[J].Chemico-biological interactio ns,2017.261(11):80-85.
[9]GR,H.,et al.Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-catenin signalling pathway[J].World journal of gastroenter ology,2018.24(36):4178-4185.
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[11]J,Y.,et al.Isoflavones:Anti-Inflammatory Benefit and Possible Caveats[J].Nutrients,2016.8(6):361.