磁性骨水泥的材料构成及特征
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摘要
背景:磁性材料是磁性骨水泥的关键组成部分,随着磁性纳米颗粒在射频磁场中产热机制的深入研究,生物相容性好、产热效能高的纳米颗粒成为向临床转化的研究目标,以不同成分、比例磁性纳米颗粒与骨水泥基质合成的磁性骨水泥,在理化性能、体外及体内生物相容性、热疗疗效等方面出现很多新的研究成果。目的:综述磁性骨水泥研究进展。方法:由第一作者应用计算机检索PubMed、Web of science、EMbase、万方数据库关于磁性骨水泥、磁热疗研究的文章,磁性骨水泥选择关键词为"Magneticbonecement",磁热疗选择关键词为"Magnetic hyperthermia",两者采用逻辑运算符"AND"连接。结果与结论:磁性骨水泥由磁响应物质和骨水泥基质构成,磁响应物质由微米级铁氧体颗粒逐渐向纳米级铁氧体颗粒发展,其原因在于产热效能的提升,产热效能的提高有利于降低磁性骨水泥中磁性材料的质量百分比,相应地骨水泥的力学强度、凝固时间等理化性能,体内、外的生物毒性、热疗疗效等也随之发生改变。低毒、高产热效能磁性骨水泥是目前研究方向,在未来磁性骨水泥可能不仅需具有磁热疗的作用,同时还需兼备化疗、放疗,甚至免疫治疗作用,多功能磁性骨水泥可能会成为骨转移瘤的新型填充材料。
BACKGROUND: Magnetic materials are the crucial part of magnetic bone cement, with the explicit investigation of the heating emission mechanism of nanoparticles in magnetic radio-frequency fields, magnetic nanoparticles with good biocompatibility and high heating efficiency may become the hotspot for clinical transformation. Magnetic bone cement consist with magnetic nanoparticles with different ingredient, ratio and bone cement matrix, there are many research progresses in physicochemical property, in vitro and in vivo biocompatibility, heating efficiency and the hyperthermia effect.OBJECTIVE: To review the research progress of magnetic bone cement.METHODS: The articles about magnetic bone cement and magnetic hyperthermia were retrieved from PubMed, Web of science, Embase and WanFang databases. The keywords were "magnetic bone cement, magnetic hyperthermia". The logical operator between them was "AND".RESULTS AND CONCLUSION: Magnetic bone cement consists of magnetic materials and bone cement matrix, the magnetic materials were chosen from micron ferrite particles to nanoscale ferrite particles, because of the increasing of heating efficiency. Consequently, the mass percent of magnetic materials in magnetic bone cement will decrease with the increasing of heating efficiency. Then, the physicochemical property, such as, mechanical strength, and setting time, in vitro and in vivo biocompatibility, and hyperthermia effect change. The bone cements with low toxicity and high heating efficiency are the main research direction. In the future, magnetic bone cement will not only preserve the function of hyperthermia, but also have the function of chemotherapy, radiotherapy and immunotherapy. Multi-functional magnetic bone cement may become a new filling material to treat bone metastasis.
BACKGROUND: Magnetic materials are the crucial part of magnetic bone cement, with the explicit investigation of the heating emission mechanism of nanoparticles in magnetic radio-frequency fields, magnetic nanoparticles with good biocompatibility and high heating efficiency may become the hotspot for clinical transformation. Magnetic bone cement consist with magnetic nanoparticles with different ingredient, ratio and bone cement matrix, there are many research progresses in physicochemical property, in vitro and in vivo biocompatibility, heating efficiency and the hyperthermia effect.OBJECTIVE: To review the research progress of magnetic bone cement.METHODS: The articles about magnetic bone cement and magnetic hyperthermia were retrieved from PubMed, Web of science, Embase and WanFang databases. The keywords were "magnetic bone cement, magnetic hyperthermia". The logical operator between them was "AND".RESULTS AND CONCLUSION: Magnetic bone cement consists of magnetic materials and bone cement matrix, the magnetic materials were chosen from micron ferrite particles to nanoscale ferrite particles, because of the increasing of heating efficiency. Consequently, the mass percent of magnetic materials in magnetic bone cement will decrease with the increasing of heating efficiency. Then, the physicochemical property, such as, mechanical strength, and setting time, in vitro and in vivo biocompatibility, and hyperthermia effect change. The bone cements with low toxicity and high heating efficiency are the main research direction. In the future, magnetic bone cement will not only preserve the function of hyperthermia, but also have the function of chemotherapy, radiotherapy and immunotherapy. Multi-functional magnetic bone cement may become a new filling material to treat bone metastasis.
引文
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[15]Li Z,Kawamura K,Kawashita M,et al.In vitro assessment of poly(methylmethacrylate)-based bone cement containing magnetite nanoparticles for hyperthermia treatment of bone tumor.J Biomed Mater Res Part A.2012;100A:2537-2545.
[16]唐正海,王晓文,张友仁,等.磁性复合骨水泥的体外细胞毒性[J].中国组织工程研究,2013,17(21):3937-3943.
[17]VernéE,Bruno M,Miola M,et al.Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic:Leaching,bioactivity and cytocompatibility.Mater Sci Eng C Mater Biol Appl.2015;53:95-103.
[18]Miola M,Laviano F,Gerbaldo R,et al.Composite bone cements for hyperthermia:modeling and characterization of magnetic,calorimetric and in vitro heating properties.Ceram Int.2017;43(6):4831-4840.
[19]Blanco-Andujar C,Walter A,Cotin G,et al.Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia.Nanomedicine.2016;11(14):1889-1910.
[20]Di Corato R,Espinosa A,Lartigue L,et al.Magnetic hyperthermia efficiency in the cellular environment for differentnanoparticle designs.Biomaterials.2014;35(24):6400-6411.
[21]Hergt R,Dutz S.Magnetic particle hyperthermia-biophysical limitations of a visionary tumour therapy.J Magn Magn Mater.2007;311(1):187-192.
[22]Portela A,Vasconcelos M,Branco R,et al.An in vitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy.J Mater Sci Mater Med.2010;21(8):2413-2423.
[23]Guardia P,Di Corato R,Lartigue L,et al.Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment.ACS Nano.2012;6(4):3080-3091.
[24]Lee JH,Jang JT,Choi JS,et al.Exchange-coupled magnetic nanoparticles for efficient heat induction.Nat Nanotechnol.2011;6(7):418-422.
[25]He S,Zhang H,Liu Y,et al.Maximizing Specific Loss Power for Magnetic Hyperthermia by Hard-Soft Mixed Ferrites.Small.2018:e1800135.
[26]贺淑莉,刘义灏,俞翔,等.一种具有高产热效率的骨水泥[P].北京:CN106267330A,2017-01-04.
[27]Tang X,Xu Y,Chen J,et al.Intermittent time-set technique controlling the temperature of magnetic-hyperthermia-ablation for tumor therapy.RSCAdv.2018;8(30):16410-16418.
[28]Wang Y,Yang J,Liu H,et al.Osteotropic peptide-mediated bone targeting for photothermal treatment of bone tumors.Biomaterials.2017;114:97-105.
[29]Derfus AM,von Maltzahn G,Harris TJ,et al.Remotely triggered release from magneticnanoparticles.Adv Mater.2007;19(22):3932-3936.
[30]Matsumine A,Takegami K,Asanuma K,et al.A novel hyperthermia treatment for bone metastases using magnetic materials.Int J Clin Oncol.2011;16(2):101-108.
[31]Kusaka M,Takegami K,Sudo A,et al.Effect of hyperthermia by magnetite cement on tumor-induced bone destruction.J Orthop Sci.2002;7(3):354-357.
[32]Portela A,Vasconcelos M,Fernandes MH,et al.Highly focalised thermotherapy using a ferrimagnetic cement in the treatment of a melanoma mouse model by low temperature hyperthermia.Int JHyperthermia.2013;29(2):121-132.
[33]Oliveira TR,Stauffer PR,Lee CT,et al.Magnetic fluid hyperthermia for bladder cancer:A preclinical dosimetry study.Int J Hyperthermia.2013;29(8):835-844.
[34]He C,Duan X,Guo N,et al.Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy.Nat Commun.2016;7:12499.
[35]Melancon MP,Appleton Figueira T,Fuentes DT,et al.Development of an Electroporation and Nanoparticle-based Therapeutic Platform for Bone Metastases.Radiology.2018;286(1):149-157.
[36]Chen Q,Xu L,Liang C,et al.Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.Nat Commun.2016;7:13193.
[37]Shetake NG,Kumar A,Gaikwad S,et al.Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation.Int J Hyperthermia.2012;31(8):909-919.
[38]Xie J,Zhang Y,Yan C,et al.High-performance PEGylated Mn-Zn ferrite nanocrystals as a passive-targeted agent for magnetically induced cancer theranostics.Biomaterials.2014;35(33):9126-9136.
[39]Datta NR,Krishnan S,Speiser DE,et al.Magnetic nanoparticle-induced hyperthermia with appropriate payloads:Paul Ehrlich's"magic(nano)bullet"for cancer theranostics?Cancer Treat Rev.2016;50:217-227.
[2]Li S,Peng Y,Weinhandl ED,et al.Estimated number of prevalent cases of metastatic bone disease in the US adult population.Clin Epidemiol.2012;4:87-93.
[3]Yuasa T,Urakami S.Kidney cancer:decreased incidence of skeletal-related events in m RCC.Nat Rev Urol.2014;11(4):193-194.
[4]Galibert P,Deramond H,Rosat P,et al.Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty.Neurochirurgie.1987;33:166-168.
[5]田庆华,吴春根,顾一峰,等.经皮骨成形术治疗椎外转移性骨肿瘤的应用[J].介入放射学,2012,21(8):645-650.
[6]Kim YI,Kang HG,Kim JH,et al.Closed intramedullary nailing with percutaneous cement augmentation for long bone metastases.J Bone Joint J.2016;98(5):703-709.
[7]Gilchrist RK,Medal R,Shorey WD,et al.Selective inductive heating of lymph nodes.Ann Surg.1957;146(4):596-606.
[8]Takegami K,Sano T,Wakabayashi H,et al.New ferromagnetic bone cement for local hyperthermia.J Biomed Mater Res.1998;43(2):210-214.
[9]Vlad MD,del Valle LJ,BarracóM,et al.Iron Oxide Nanoparticles Significantly Enhances the Injectability of Apatitic Bone Cement for Vertebroplasty.Spine(Phila Pa 1976).2008;33(21):2290-2298.
[10]Kawashita M,Kawamura K,Li Z.PMMA-based bone cements containing magnetite particles for the hyperthermia of cancer.Acta Biomater.2010;6(8):3187-3192.
[11]Ling Y,Tang X,Wang F,et al.Highly efficient magnetic hyperthermia ablation of tumors using injectable polymethylmethacrylate-Fe3O4.RSCAdv.2017;7(5):2913-2918.
[12]Xu C,Zheng Y,Gao W,et al.Magnetic Hyperthermia Ablation of Tumors Using Injectable Fe3O4/Calcium Phosphate Cement.ACS Appl Mater Interfaces.2015;7(25):13866-13875.
[13]刘义灏,俞翔,张力,等.一种新型磁性骨水泥的制备及其在交变磁场中对骨肉瘤MG-63细胞凋亡的影响[J].江苏大学学报(医学版),2017,27(1):5-9.
[14]Frassica DA,Frassica FJ.Nonoperative management.In:Simon MA,Springfield D(eds).Surgery for bone and soft-tissue tumors.Lippincott-Raven,Philadelphia,1998:633-637.
[15]Li Z,Kawamura K,Kawashita M,et al.In vitro assessment of poly(methylmethacrylate)-based bone cement containing magnetite nanoparticles for hyperthermia treatment of bone tumor.J Biomed Mater Res Part A.2012;100A:2537-2545.
[16]唐正海,王晓文,张友仁,等.磁性复合骨水泥的体外细胞毒性[J].中国组织工程研究,2013,17(21):3937-3943.
[17]VernéE,Bruno M,Miola M,et al.Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic:Leaching,bioactivity and cytocompatibility.Mater Sci Eng C Mater Biol Appl.2015;53:95-103.
[18]Miola M,Laviano F,Gerbaldo R,et al.Composite bone cements for hyperthermia:modeling and characterization of magnetic,calorimetric and in vitro heating properties.Ceram Int.2017;43(6):4831-4840.
[19]Blanco-Andujar C,Walter A,Cotin G,et al.Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia.Nanomedicine.2016;11(14):1889-1910.
[20]Di Corato R,Espinosa A,Lartigue L,et al.Magnetic hyperthermia efficiency in the cellular environment for differentnanoparticle designs.Biomaterials.2014;35(24):6400-6411.
[21]Hergt R,Dutz S.Magnetic particle hyperthermia-biophysical limitations of a visionary tumour therapy.J Magn Magn Mater.2007;311(1):187-192.
[22]Portela A,Vasconcelos M,Branco R,et al.An in vitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy.J Mater Sci Mater Med.2010;21(8):2413-2423.
[23]Guardia P,Di Corato R,Lartigue L,et al.Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment.ACS Nano.2012;6(4):3080-3091.
[24]Lee JH,Jang JT,Choi JS,et al.Exchange-coupled magnetic nanoparticles for efficient heat induction.Nat Nanotechnol.2011;6(7):418-422.
[25]He S,Zhang H,Liu Y,et al.Maximizing Specific Loss Power for Magnetic Hyperthermia by Hard-Soft Mixed Ferrites.Small.2018:e1800135.
[26]贺淑莉,刘义灏,俞翔,等.一种具有高产热效率的骨水泥[P].北京:CN106267330A,2017-01-04.
[27]Tang X,Xu Y,Chen J,et al.Intermittent time-set technique controlling the temperature of magnetic-hyperthermia-ablation for tumor therapy.RSCAdv.2018;8(30):16410-16418.
[28]Wang Y,Yang J,Liu H,et al.Osteotropic peptide-mediated bone targeting for photothermal treatment of bone tumors.Biomaterials.2017;114:97-105.
[29]Derfus AM,von Maltzahn G,Harris TJ,et al.Remotely triggered release from magneticnanoparticles.Adv Mater.2007;19(22):3932-3936.
[30]Matsumine A,Takegami K,Asanuma K,et al.A novel hyperthermia treatment for bone metastases using magnetic materials.Int J Clin Oncol.2011;16(2):101-108.
[31]Kusaka M,Takegami K,Sudo A,et al.Effect of hyperthermia by magnetite cement on tumor-induced bone destruction.J Orthop Sci.2002;7(3):354-357.
[32]Portela A,Vasconcelos M,Fernandes MH,et al.Highly focalised thermotherapy using a ferrimagnetic cement in the treatment of a melanoma mouse model by low temperature hyperthermia.Int JHyperthermia.2013;29(2):121-132.
[33]Oliveira TR,Stauffer PR,Lee CT,et al.Magnetic fluid hyperthermia for bladder cancer:A preclinical dosimetry study.Int J Hyperthermia.2013;29(8):835-844.
[34]He C,Duan X,Guo N,et al.Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy.Nat Commun.2016;7:12499.
[35]Melancon MP,Appleton Figueira T,Fuentes DT,et al.Development of an Electroporation and Nanoparticle-based Therapeutic Platform for Bone Metastases.Radiology.2018;286(1):149-157.
[36]Chen Q,Xu L,Liang C,et al.Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.Nat Commun.2016;7:13193.
[37]Shetake NG,Kumar A,Gaikwad S,et al.Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation.Int J Hyperthermia.2012;31(8):909-919.
[38]Xie J,Zhang Y,Yan C,et al.High-performance PEGylated Mn-Zn ferrite nanocrystals as a passive-targeted agent for magnetically induced cancer theranostics.Biomaterials.2014;35(33):9126-9136.
[39]Datta NR,Krishnan S,Speiser DE,et al.Magnetic nanoparticle-induced hyperthermia with appropriate payloads:Paul Ehrlich's"magic(nano)bullet"for cancer theranostics?Cancer Treat Rev.2016;50:217-227.