染色质重塑及其参与植物病害防御应答的研究进展
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摘要
转录相关因子与特异DNA位点结合受染色质空间构象变化的调节,通过染色质重塑机制可以解除染色质高度紧密的折叠状态,改变组蛋白与DNA链间的作用力,控制基因的表达与沉默。ATP依赖的染色质重塑复合物、组蛋白的乙酰化/去乙酰化和甲基化/去甲基化共价修饰等是染色质修饰的主要类型,植物能通过染色质重塑复合物和组蛋白修饰酶复合物直接或间接介导的染色质重塑作用调控防御基因的转录,控制植物对病原体侵染的防御应答。本文结合近年来的研究进展,对植物染色质重塑如何调控防御相关基因的表达及病原体蛋白T3SEs、6b和VirE等如何利用染色质重塑干预植物防御系统的分子机制进行了论述。
Transcription-related factors can be integrated into specific DNA sites,and this molecular process is regulated by the configuration changes of chromatin.However,highly condensed chromatin is relieved through chromatin remodeling of itself with the alteration of covalence power between histone and DNA chain,and this mechanism may control gene expression and silencing.There are at least two primary modification types which contain ATP-dependent chromatin remodeling complex and covalent modifications of histone tails by histone modification complexes;the later type is made up of methylation/demethylation and acetylation/deacetylation of histone.Upon pathogen infection,the transcription of defense-related genes is regulated directly and indirectly by chromatin remodelers under the force given by chromatin remodeling in plants,and then the immune response becomes effective.This paper reviews the mechanisms by which plant chromatin remodeling regulates expression of defense-related gene and the three proteins T3 SEs,6b,VirE evade plant immune system by the pathway of modifying the chromatin structure according to recent studies.
Transcription-related factors can be integrated into specific DNA sites,and this molecular process is regulated by the configuration changes of chromatin.However,highly condensed chromatin is relieved through chromatin remodeling of itself with the alteration of covalence power between histone and DNA chain,and this mechanism may control gene expression and silencing.There are at least two primary modification types which contain ATP-dependent chromatin remodeling complex and covalent modifications of histone tails by histone modification complexes;the later type is made up of methylation/demethylation and acetylation/deacetylation of histone.Upon pathogen infection,the transcription of defense-related genes is regulated directly and indirectly by chromatin remodelers under the force given by chromatin remodeling in plants,and then the immune response becomes effective.This paper reviews the mechanisms by which plant chromatin remodeling regulates expression of defense-related gene and the three proteins T3 SEs,6b,VirE evade plant immune system by the pathway of modifying the chromatin structure according to recent studies.
引文
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