胆囊癌淋巴转移的研究现状与展望
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摘要
淋巴转移是胆囊癌(gallbladder cancer,GBC)最常见的转移方式,也是GBC预后的重要影响因素之一.因此明确GBC淋巴引流的途径,对发生转移的淋巴结进行准确分站,探讨手术清扫范围,寻找相应淋巴转移指标显得尤为重要;同时淋巴示踪剂的使用极大方便了术中淋巴结清扫;积极探索GBC淋巴转移的分子机制将可能提供新的GBC治疗靶点.本文就近年来GBC的淋巴转移途径、分站、相应评估指标、示踪剂和淋巴转移的发生机制等方面的进展进行简要总结.
Lymphatic metastasis is the most common way of metastasis in gallbladder cancer(GBC),and it is also one of the important factors influencing prognosis.Therefore,it is important to elucidate the lymphatic drainage pathways,group the metastatic lymph nodes,assess the extent of lymphadenectomy,and identify relevant predictors of lymphatic metastasis.The development of lymph node tracer technique has greatly improved the surgical procedure,and exploration of the molecular mechanisms of lymphatic metastases may provide new therapeutic targets.In the current review,we discuss the lymphatic drainage pathways as well as the substation,predictors,tracers and mechanisms of lymphatic metastasis of GBC.
Lymphatic metastasis is the most common way of metastasis in gallbladder cancer(GBC),and it is also one of the important factors influencing prognosis.Therefore,it is important to elucidate the lymphatic drainage pathways,group the metastatic lymph nodes,assess the extent of lymphadenectomy,and identify relevant predictors of lymphatic metastasis.The development of lymph node tracer technique has greatly improved the surgical procedure,and exploration of the molecular mechanisms of lymphatic metastases may provide new therapeutic targets.In the current review,we discuss the lymphatic drainage pathways as well as the substation,predictors,tracers and mechanisms of lymphatic metastasis of GBC.
引文
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