多柱色谱技术进展
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摘要
在色谱分析过程中,利用串联、并联或串并联结合的方式将多根色谱柱组合起来,可以实现高通量和高分辨的分离效果。相比于传统单柱色谱技术,多柱技术很好地满足了批量样品分析和复杂生物样品分离分析的需求,因此引起了广泛关注。该文对多柱技术在多维分离、芯片色谱、毛细管电泳、固定相筛选以及串联色谱等领域的应用进行了综述,并对其发展前景进行了展望。
Multi-column chromatographic technologies provide high throughput and high resolution separations through parallel, serial or parallel-serial column combinations. In comparison with classical single-column based chromatography, multi-column chromatography well satisfied the need for separations of large batch samples and highly complex bio-samples, and therefore attracted extensive interests. In this review, we discussed the recent developments in multi-column chromatography and its applications in multidimensional separation, chip chromatography, capillary electrophoresis, stationary-phase screening, and serial column chromatography. We also discussed the limitations and future developments in multi-column chromatography.
Multi-column chromatographic technologies provide high throughput and high resolution separations through parallel, serial or parallel-serial column combinations. In comparison with classical single-column based chromatography, multi-column chromatography well satisfied the need for separations of large batch samples and highly complex bio-samples, and therefore attracted extensive interests. In this review, we discussed the recent developments in multi-column chromatography and its applications in multidimensional separation, chip chromatography, capillary electrophoresis, stationary-phase screening, and serial column chromatography. We also discussed the limitations and future developments in multi-column chromatography.
引文
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[2]Fekete S,Guillarme D.J Chromatogr A,2013,1308:104
[3]Heaton J,Mccalley D.J Chromatogr A,2014,1371(1):106
[4]Krisp C,Yang H,Van S R,et al.Mol Cell Proteomics,2015,14(6):1708
[5]Bishop D,Blanes L,Wilson A,et al.J Chromatogr A,2017,1497:64
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[17]Phillips J B,Xu J.J Chromatogr A,1995,703(1/2):327
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[19]Geus H J D,Boer J D,Brinkman U A T.TrAC-Trends Anal Chem,1996,15(5):168
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[29]Stoll D R,Carr P W.Anal Chem,2017,89(1):519
[30]Wang F,Min Y,Geng X.J Sep Sci,2012,35(22):3033
[31]Zhang X M,Chinese Journal of Chromatography,2017,35(1):138张祥民,色谱,2017,35(1):138
[32]Li Z,Chen K,Guo M Z,et al.J Sep Sci,2016,39(1):21
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[36]Zhou D Y,Xu Q,Xue X Y,et al.J Pharm Biomed Anal,2009,49(2):207
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[39]Liu C,Zhang X.J Chromatogr A,2007,1139(2):191
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[41]Schoenmakers P,Aarnoutse P.Anal Chem,2014,86(13):6172
[42]Manz A,Graber N,Widmer H M.Sensors Actuat B-Chem,1990,1(1/6):244
[43]De M A.Lab Chip,2002,2(3):48N
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[45]Kutter J P.J Chromatogr A,2012,1221(2):72
[46]Manz A,Miyahara Y,Miura J,et al.Sensors Actuat B-Chem,1990,1(1):249
[47]Kato M,Inaba M,Tsukahara T,et al.Anal Chem,2010,82(2):543
[48]He B,Tait N,Regnier F.Anal Chem,1998,70(18):3790
[49]Ericson C,Holm J,Ericson T,et al.Anal Chem,2000,72(1):81
[50]Hlushkou D,Bruns S,Hltzel A,et al.Anal Chem,2010,82(17):7150
[51]Nagy A,Gaspar A.J Chromatogr A,2013,1304(16):251
[52]Huang L,Zhai H,Liang G,et al.J Chromatogr A,2016,1474:14
[53]Shintani Y,Hirako K,Motokawa M,et al.J Chromatogr A,2005,1073(1/2):17
[54]Huft J,Haynes C A,Hansen C L.Anal Chem,2013,85(3):1797
[55]Huft J,Haynes C A,Hansen C L.Anal Chem,2013,85(5):2999
[56]Nagy A,Tóth E L,Iván K,et al.Microchem J,2015,123:125
[57]Kircher M,Kelso J.Bioessays,2010,32(6):524
[58]Zagursky R J,Mccormick R M.Biotechniques,1990,9(1):74
[59]Huang X C,Quesada M A,Mathies R A.Anal Chem,1992,64(18):2149
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[61]Ueno K,Yeung E S.Anal Chem,1994,66(9):1424
[62]Kim S,And H J Y,Hahn J H.Anal Chem,1996,68(5):936
[63]Britz-Mckibbin P,Nishioka T,Terabe S.Anal Sci,2003,19(1):99
[64]Cheng H,Liu J,Xu Z,et al.J Chromatogr A,2016,1461:198
[65]Tang M,Zhang J,Zhuang S,et al.TrAC-Trends Anal Chem,2012,39:180
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[67]Patel D C,Breitbach Z S,Wahab M F,et al.Anal Chem,2015,87(18):9137
[68]Barhate C L,Wahab M F,Breitbach Z S,et al.Anal Chim Acta,2015,898:128
[69]Welch C J,Gong X,Schafer W,et al.Tetrahedron-Asymmetr,2010,21(13/14):1674
[70]Zawatzky K,Biba M,Regalado E L,et al.J Chromatogr A,2016,1429:374
[71]Patel D C,Wahab M F,Armstrong D W,et al.J Chromatogr A,2016,1467:2
[72]Schafer W,Bu X,Gong X,et al.Comprehensive Organic Synthesis.2nd ed.Amsterdam:Elsevier,2014:28
[73]Sajonz P,Schafer W,Gong X,et al.J Chromatogr A,2007,1145(1):149
[74]Cohen B L.J Chromatogr Sci,1987,25(5):202
[75]Letter W S.LC-GC,1997,15(6):508
[76]Beesley T E.LC-GC Eur,2011,24(5):270
[77]Zhang Y,Watts W,Nogle L,et al.J Chromatogr A,2004,1049(1/2):75
[78]Wang A X,Lee J T,Beesley T E.LC GC N Am,2000,18(6):626
[79]Alvin K,Ly J,Condon R,et al.Am Pharm Rev,2013,16(4)
[80]Gjoka X,Rogler K,Martino R A,et al.J Chromatogr A,2015,1416:38
[81]Zeng L,Burton L,Yung K,et al.J Chromatogr A,1998,794(1/2):3
[82]ZengL,Kassel D B.Anal Chem,1998,70(20):4380
[83]Welch C J,Sajonz P,Biba M,et al.J Liq Chromatogr R T,2006,29(15):2185
[84]Buckingham S.Scientist,2004,18(20):44
[85]Patel P,Herrera C.Am Lab,2004,36(2):14
[86]Gross G M,Prazen B J,Synovec R E.Anal Chim Acta,2003,490(1):197
[87]Alvarez-Segura T,Ortiz-Bolsico C,Torres-LapasióJ R,et al.J Chromatogr A,2015,1390:95
[88]Guiochon G,Shirazi S G,Katti A M.Fundamentals of Preparative and Nonlinear Chromatography.New York:Academic Press,1994
[89]Masuda T,Sonobe T,Matsuda F,et al.US Patent,US5198120.1993-03-30
[90]Heikkila H,Hyoky G,Kuisma J.EP Patent,US5127957A.1992-07-07
[91]Heinonen J,Kukkonen S,Sainio T.J Chromatogr A,2014,1358:181
[92]Heinonen J,Sainio T.Sep Purif Technol,2014,129:137
[93]Jemal M.Biomed Chromatogr,2000,14(6):422
[94]Wang H,Hanash S M.J Proteome Res,2008,7(7):2743
[95]Livesay E A,Tang K,Taylor B K,et al.Anal Chem,2008,80(1):294
[96]De B V,Haskins N,Organ A,et al.Rapid Commun Mass Sp,1999,13(12):1165
[97]Yang L,Mann T D,Little D,et al.Anal Chem,2001,73(8):1740
[98]Eldridge G R,Vervoort H C,Lee C M,et al.Anal Chem,2002,74(16):3963
[99]Alvarez-Segura T,Torres-LapasióJ R,Ortiz-Bolsico C,et al.Anal Chim Acta,2016,923:1
[100]Alvarez-Segura T,Ortiz-Bolsico C,Torres-LapasióJ R,et al.J Chromatogr A,2015,1390:95
[101]Nyiredy S,Szücs Z,Szepesy L.J Chromatogr A,2007,1157(1/2):122
[102]Haggarty J,Oppermann M,Dalby M J,et al.Metabolomics,2015,11(5):1465
[103]Bonn G.J Chromatogr A,1985,322(1):411
[104]Mao Y,Carr P W.Anal Chem,2000,72(13):2788
[105]Oda T,Kitagawa S,Ohtani H.J Chromatogr A,2006,1105(1):154
[106]Sharef O A,Feely J,Kavanagh P V,et al.Biomed Chromatogr,2007,21(11):1201
[107]BlahováE,Jandera P,Cacciola F,et al.J Sep Sci,2006,29(4):555
[108]Huidobro A L,Rupérez F J,Barbas C.J Chromatogr A,2006,1119(1/2):238
[109]Kuehnle M,Rehbein J,Holtin K,et al.J Sep Sci,2008,31(10):1655
[110]Zedda M,Tuerk J,Teutenberg T,et al.J Chromatogr A,2009,1216(51):8910
[111]Ramontorres-Lapasio J,Ortiz-Bolsico C,Garcia-AlvarezCoque M C,et al.Curr Chromatogr,2015,2(2):110
[112]de Vries R,Vereyken L,Franois I,et al.Anal Chim Acta,2017,989:104