以头痛和双侧眼肌麻痹起病的抗GQ1b抗体综合征1例
摘要
<正>抗GQ1b抗体综合征是拥有重叠临床表现和免疫学机制的一类谱系病,它主要包括Miller-Fisher综合征、咽-颈-臂丛无力、Bickerstaff脑干脑炎以及少见的急性眼科麻痹和急性共济失调性神经病变~([1])。在这种谱系病中,抗GQ1b抗体是具有高度疾病特异性的指标尤其是对于急性眼外肌麻痹(acute ophthalmoplegia,AO)而言~([2])。目前,临床上以头痛和双侧AO为首发症状的抗GQ1b抗体综合征少见。现报道1例以头痛和双侧AO为主要临床表现的抗GQ1b抗体综合征。
引文
[1]SHAHRIZAILA N,YUKI N.Bickerstaff brainstem encephalitis and Fisher syndrome:anti-GQ1b antibody syndrome[J].J Neurol Neurosurg Psychiatry,2013,84(5):576-583.
[2]WILLISON H J,O’HANLON G M.The immunopathogenesis of Miller Fisher syndrome[J].J Neuroimmunol,1999,100(1-2):3-12.
[3]JINDAL G,PARMAR V R,GUPTA V K.Isolated ptosis as acute ophthalmoplegia without ataxia,positive for antiGQ1b immunoglobulin G[J].Pediatr Neurol,2009,41(6):451-452.
[4]LOLEKHA P,PHANTHUMCHINDA K.Miller-Fisher syndrome at King Chulalongkorn Memorial Hospital[J].J Med Assoc Thai,2009,92(4):471-477.
[5]FRIEDMAN D I,POTTS E.Headache associated with miller fisher syndrome[J].Headache,2007,47(9):1347-1348.
[6]CHIBA A,KUSUNOKI S,OBATA H,et al.Ganglioside composition of the human cranial nerves,with special reference to pathophysiology of Miller Fisher syndrome[J].Brain Res,1997,745(1-2):32-36.
[2]WILLISON H J,O’HANLON G M.The immunopathogenesis of Miller Fisher syndrome[J].J Neuroimmunol,1999,100(1-2):3-12.
[3]JINDAL G,PARMAR V R,GUPTA V K.Isolated ptosis as acute ophthalmoplegia without ataxia,positive for antiGQ1b immunoglobulin G[J].Pediatr Neurol,2009,41(6):451-452.
[4]LOLEKHA P,PHANTHUMCHINDA K.Miller-Fisher syndrome at King Chulalongkorn Memorial Hospital[J].J Med Assoc Thai,2009,92(4):471-477.
[5]FRIEDMAN D I,POTTS E.Headache associated with miller fisher syndrome[J].Headache,2007,47(9):1347-1348.
[6]CHIBA A,KUSUNOKI S,OBATA H,et al.Ganglioside composition of the human cranial nerves,with special reference to pathophysiology of Miller Fisher syndrome[J].Brain Res,1997,745(1-2):32-36.