复方栀子油软胶囊药理作用的研究进展
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摘要
现代医学研究认为,不饱和脂肪酸和亚油酸具有加强机体抵抗力,抗氧化,抗缺氧,减肥增肌等功效,但当前对于复方栀子油软胶囊的抗疲劳作用及其有效剂量还未见有关报道,故本课题采用复方栀子油软胶囊作为研究目标,对近年来复方栀子油抗软胶囊抗疲劳功效的有效成分、抗疲劳作用机理以及复方栀子油软胶囊抗疲劳作用及作用机制研究状况进以综述,为复方栀子油抗疲劳的进一步研究和利用提供理论依据,期能为复方栀子油软胶囊的抗疲劳药物的开发提供科学依据。
In modern medical studies,unsaturated fatty acids and linoleic acid can enhance the body resistance,anti-oxidation,anti-anoxia,weight loss and muscle growth,but the current on the compound gardenia oil soft capsule anti-fatigue effect and effective dose Has not been reported,so this study selected compound gardenia oil soft capsule as a research object,in recent years,compound gardenia oil anti-soft capsule anti-fatigue effect of active ingredients,anti-fatigue mechanism and compound gardenia oil soft capsule anti-fatigue effect and to provide theoretical basis for the further research and utilization of compound gardenia oil anti-fatigue,and to provide scientific basis for the development of anti-fatigue drugs for compound gardenia oil soft capsules.
In modern medical studies,unsaturated fatty acids and linoleic acid can enhance the body resistance,anti-oxidation,anti-anoxia,weight loss and muscle growth,but the current on the compound gardenia oil soft capsule anti-fatigue effect and effective dose Has not been reported,so this study selected compound gardenia oil soft capsule as a research object,in recent years,compound gardenia oil anti-soft capsule anti-fatigue effect of active ingredients,anti-fatigue mechanism and compound gardenia oil soft capsule anti-fatigue effect and to provide theoretical basis for the further research and utilization of compound gardenia oil anti-fatigue,and to provide scientific basis for the development of anti-fatigue drugs for compound gardenia oil soft capsules.
引文
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[13]王守勇,谢鸣,王欣.酸枣仁汤组分与抗焦虑效用的相关性研究[J].中国实验方剂学杂志,2010,(03):104-108.
[14]Bae W,Kim J,Chung J.Production of granular activated carbon from food-processing wastes(walnut shells and jujube seeds)and its adsorptive properties.[J].J Air Waste Manag Assoc,2014,64(8):879-886.
[14]赵启铎,舒乐新,王颖,等.酸枣仁总黄酮抗抑郁作用的实验研究[J].天津中医药,2011,(04):335-337.
[15]Mishra T,Bhatia A.Augmentation of expression of immunocytes’functions by seed extract of Ziziphus mauritiana(Lamk.)[J].J Ethnopharmacol,2010,127(2):341-345.
[16]Cai X,Zhang R,Guo Y,et al.Optimization of ultrasound-assisted extraction of gardenia fruit oil with bioactive components and their identification and quantification by HPLC-DAD/ESI-MS(2)[J].Food Funct,2015,6(7):2194-2204.
[17]Wang J,Hou J,Lei H,et al.Synergistic neuroprotective effect of microglialconditioned media treated with geniposide and ginsenoside Rg1 on hypoxia injured neurons.[J].Mol Med Rep,2015,2(4):5328-5334.
[18]辛海涛,王卫宁.栀子苷对大鼠局灶性脑缺血模型缺血脑组织HIF-1α蛋白和RTP801的影响[J].当代医学,2010,(36):25-26.
[19]Lv C,Wang L,Liu X,et al.Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model[J].Neuropharmacology,2015,89 175-84.
[20]郝昭琳,江璐,车会莲,等.栀子苷和栀子黄色素改善睡眠作用的研究[J].食品科学,2009,(15):208-210.
[21]李智欣,肖韦华,何计国,等.栀子中改善睡眠成分的研究[J].农产品加工(学刊),2006,(08):79-80+82.
[22]Zhang S,Zhang L,Chai Y,et al.Physiology and proteomics research on the leaves of ancient Platycladus orientalis(L.)during winter[J].J Proteomi cs,2015,126(3),263-278.
[23]李海生,王安林,于利人.柏子仁单方注射液对睡眠模型猫影响的实验研究[J].天津中医学院学报,2000,(03):38-40.
[24]余正文,杨小生,范明.柏子仁促鸡胚背根神经节生长活性成分研究[J].中草药,2005,(01):28-29.
[25]王宁.柏子仁研究进展[J].生物技术世界,2015,(08):249.
[2]李宝莉,陈雅慧,张正祥,等.复方酸枣仁油栀子油对小鼠学习记忆的影响[J].西安交通大学学报,2010,31(6):674-707.
[3]Cai X,Zhang R,Guo Y.Optimization of ultrasound-assisted extraction of gardenia fruit oil with bioactive components and their identification and quantification by HPLC-DAD/ESI-MS(2)[J].Food Funct,2015,6(7):2194-2204.
[4]国家药典委员会.中华人民共和国药典一部[S].北京:中国医药科技出版社.2010:343-344.
[5]高学敏.中药学[M].北京:中国中医药出版社,2007:455
[6]谭云龙,孙晖,孙文军,等.酸枣仁化学成分及其药理作用研究进展[J].时珍国医国药,2014,(01):186-188.
[7]Oshima N,Zaima K,Kamakura H,et al.Identification of marker compounds for Japanese Pharmacopoeia non-conforming jujube seeds from Myanmar[J].J Nat Med,2015,69(1):68-75.
[8]Chen KX,Zhao LM,Ji CJ,et al.Flavone C-glycosides from seeds of Ziziphus jujuba var.spinosa[J].Zhongguo Zhong Yao Za Zhi,2015,40(8):1503-1507.
[9]Li M,Wang Y,Tsoi B,et al.Indoleacetic acid derivatives from the seeds of Ziziphus jujuba var.spinosa[J].Fitoterapia,2014,99(3):48-55.
[10]吴玉兰,许惠琴,陈诜.酸枣仁不同炮制品及炒酸枣仁中总黄酮与总皂苷的镇静催眠作用比较[J].时珍国医国药,2005,(09):868-869.
[11]Xu MY,Lee SY,Kang SS,et al.Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy[J].J Nat Prod,2014,77(2):370-376.
[12]赵连红,乔卫,许岚.酸枣仁中生物碱抗惊厥作用的实验研究[J].天津药学,2007,(01):4-5.
[13]王守勇,谢鸣,王欣.酸枣仁汤组分与抗焦虑效用的相关性研究[J].中国实验方剂学杂志,2010,(03):104-108.
[14]Bae W,Kim J,Chung J.Production of granular activated carbon from food-processing wastes(walnut shells and jujube seeds)and its adsorptive properties.[J].J Air Waste Manag Assoc,2014,64(8):879-886.
[14]赵启铎,舒乐新,王颖,等.酸枣仁总黄酮抗抑郁作用的实验研究[J].天津中医药,2011,(04):335-337.
[15]Mishra T,Bhatia A.Augmentation of expression of immunocytes’functions by seed extract of Ziziphus mauritiana(Lamk.)[J].J Ethnopharmacol,2010,127(2):341-345.
[16]Cai X,Zhang R,Guo Y,et al.Optimization of ultrasound-assisted extraction of gardenia fruit oil with bioactive components and their identification and quantification by HPLC-DAD/ESI-MS(2)[J].Food Funct,2015,6(7):2194-2204.
[17]Wang J,Hou J,Lei H,et al.Synergistic neuroprotective effect of microglialconditioned media treated with geniposide and ginsenoside Rg1 on hypoxia injured neurons.[J].Mol Med Rep,2015,2(4):5328-5334.
[18]辛海涛,王卫宁.栀子苷对大鼠局灶性脑缺血模型缺血脑组织HIF-1α蛋白和RTP801的影响[J].当代医学,2010,(36):25-26.
[19]Lv C,Wang L,Liu X,et al.Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model[J].Neuropharmacology,2015,89 175-84.
[20]郝昭琳,江璐,车会莲,等.栀子苷和栀子黄色素改善睡眠作用的研究[J].食品科学,2009,(15):208-210.
[21]李智欣,肖韦华,何计国,等.栀子中改善睡眠成分的研究[J].农产品加工(学刊),2006,(08):79-80+82.
[22]Zhang S,Zhang L,Chai Y,et al.Physiology and proteomics research on the leaves of ancient Platycladus orientalis(L.)during winter[J].J Proteomi cs,2015,126(3),263-278.
[23]李海生,王安林,于利人.柏子仁单方注射液对睡眠模型猫影响的实验研究[J].天津中医学院学报,2000,(03):38-40.
[24]余正文,杨小生,范明.柏子仁促鸡胚背根神经节生长活性成分研究[J].中草药,2005,(01):28-29.
[25]王宁.柏子仁研究进展[J].生物技术世界,2015,(08):249.