miRNA介导PGR信号通路在雌性生殖功能调节中的作用机制
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摘要
Micro RNA(miRNA)作为重要的后转录调节因子参与多种生理活动。孕酮(Progesterone,P4)是重要的甾类激素,通过结合特异性受体——孕酮受体(Progesterone receptors,PGR)发挥生理作用。PGR作为核受体超家族的一员参与调控生殖相关组织或非生殖相关组织的功能。P4/PGR和miRNA可单独在雌性生殖中发挥调控作用。然而,在雌性生殖过程中,miRNA和P4/PGR的相互作用对调控排卵等雌性生殖活动起到非常重要的作用,但作用机制还未阐明。本文综述了mi RNA调节P4产生、PGR基因表达以及P4/PGR调节miRNA表达的可能作用方式,为更好地研究mi RNA和P4/PGR在雌性生殖中的作用提供理论基础。
Micro RNAs(mi RNAs) are involved in several physiological processes as important post-transcriptional regulators. Progesterone(P4), an important steroid hormone, produces physiological effect through binding specific receptor progesterone receptors(PGR) which regulates functions of both reproductive and non-reproductive tissues as a member of the nuclear receptor superfamily. P4/PGR and mi RNAs could regulate female reproduction independently, however, it is still unclear how mi RNAs and P4/PGR interaction regulates female reproductive activities such as ovulation in female reproduction. In this review, we summarize the possible ways inwhich mi RNAs regulate P4 production and PGR gene expression as well as P4/PGR regulate mi RNAs expression,which provide a theoretical basis for further studying the role of mi RNAs and P4/PGR in female reproduction.
Micro RNAs(mi RNAs) are involved in several physiological processes as important post-transcriptional regulators. Progesterone(P4), an important steroid hormone, produces physiological effect through binding specific receptor progesterone receptors(PGR) which regulates functions of both reproductive and non-reproductive tissues as a member of the nuclear receptor superfamily. P4/PGR and mi RNAs could regulate female reproduction independently, however, it is still unclear how mi RNAs and P4/PGR interaction regulates female reproductive activities such as ovulation in female reproduction. In this review, we summarize the possible ways inwhich mi RNAs regulate P4 production and PGR gene expression as well as P4/PGR regulate mi RNAs expression,which provide a theoretical basis for further studying the role of mi RNAs and P4/PGR in female reproduction.
引文
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[7]Song XD,Cao GH,Jing LL,Lin SC,Wang XZ,Zhang JJ,Wang MR,Liu WL,Lv CJ.Analysing the relationship between lnc RNA and protein-coding gene and the role of lnc RNA as ce RNA in pulmonary fibrosis.J Cell Mol Med,2014,18(6):991–1003.
[8]Renthal NE,Chen CC,Williams KC,Gerard RD,Prange-Kiel J,Mendelson CR.mi R-200 family and targets,ZEB1 and ZEB2,modulate uterine quiescence and contractility during pregnancy and labor.Proc Natl Acad Sci USA,2010,107(48):20828–20833.
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[10]Lydon JP,De Mayo FJ,Funk CR,Mani SK,Hughes AR,Montgomery CA Jr,Shyamala G,Conneely OM,O'Malley BW.Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.Genes Dev,1995,9(18):2266–2278.
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[14]Finlay-Schultz J,Cittelly DM,Hendricks P,Patel P,Kabos P,Jacobsen BM,Richer JK,Sartorius CA.Progesterone downregulation of mi R-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a.Oncogene,2014,34(28):3676–3687.
[15]Mulac-Jericevic B,Mullinax RA,De Mayo FJ,Lydon JP,Conneely OM.Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform.Science,2000,289(5485):1751–1754.
[16]Robker RL,Akison LK,Russell DL.Control of oocyte release by progesterone receptor-regulated gene expression.Nucl Recept Signal,2009,7:e012.
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[21]Mesiano S.Myometrial progesterone responsiveness.Semin Reprod Med,2007,25(1):5–13.
[22]Li R,Qiao J,Wang LN,Li L,Zhen XM,Liu P,Zheng XY.Micro RNA array and microarray evaluation of endometrial receptivity in patients with high serum progesterone levels on the day of h CG administration.Reprod Biol Endocrinol,2011,9:29.
[23]Li R,Qiao J,Wang L,Zhen X,Lu Y.Serum progesterone concentration on day of HCG administration and IVF outcome.Reprod Biomed Online,2008,16(5):627–631.
[24]Gellersen B,Fernandes MS,Brosens JJ.Non-genomic progesterone actions in female reproduction.Hum Reprod Update,2009,15(1):119–138.
[25]Leonhardt SA,Boonyaratanakornkit V,Edwards DP.Progesterone receptor transcription and non-transcription signaling mechanisms.Steroids,2003,68(10–13):761–770.
[26]Yoon S,Seger R.The extracellular signal-regulated kinase:multiple substrates regulate diverse cellular functions.Growth Factors,2006,24(1):21–44.
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