头穴埋线疗法治疗阿尔兹海默病疗效观察
|
摘要
目的:探讨头穴埋线疗法对阿尔兹海默病(AD)患者的临床疗效。方法:将符合标准的80例AD患者在常规内科治疗的基础上随机分为治疗组、对照组,每组40例,治疗组采用头穴埋线结合安理申治疗,对照组采用安理申治疗,共治疗12周,治疗前后检测Blessed-Roth评分、ADAS-Cog评分及治疗前后血清中抗氧化分子:SOD、GSHPx、TAC、CAT、GST、GR含量。结果:治疗前,2组患者Blessed-Roth评分、ADAS-Cog评分比较,差异无统计学意义(P>0.05);2组治疗后,Blessed-Roth评分、ADAS-Cog评分均比治疗前有所降低,治疗组治疗前后评分差值大于对照组(P<0.05),说明2组治疗均有效,但治疗组优于对照组。治疗前,治疗组、对照组氧化应激水平无明显差异(P>0.05)。治疗后,治疗组与对照组SOD、GSH-Px、TAC、CAT、GST、GR水平均较治疗前升高(P<0.05),治疗组SOD、GSH-Px、TAC、CAT、GST、GR水平均较对照组显著升高(P<0.05)。结论:头穴埋线疗法结合安理申治疗能有效提高血清中SOD、GSH-Px、TAC、CAT、GST、GR水平,可通过调节抗氧化分子的表达,改善AD患者学习记忆水平。
Objective: To explore the clinical efficacy of head cavity embedding therapy in patients with AD. Methods:Eighty patients with AD who met the criteria were randomly divided into a treatment group and a control group based on conventional medical treatment, with 40 cases in each group. The treatment group was treated with acupuncture at the acupoint and combined with Aricept. The control group was treated with Aricept. A total of 12 weeks of treatment. Blessed-Roth score,ADAS-Cog score and serum antioxidant molecules: SOD, GSH-Px, TAC, CAT, GST, GR were measured before and after treatment. Results: Before treatment, there was no significant difference in Blessed-Roth score and ADAS-Cog score between the two groups(P>0.05). After 2 groups of treatment, the Blessed-Roth score and the ADAS-Cog score were lower than those before treatment. The difference between the treatment group and the treatment group was greater than that of the control group(P<0.05). Note Both groups were effective, but the treatment group was superior to the control group. There was no significant difference in oxidative stress between the treatment group and the control group before treatment(P>0.05). After treatment, the levels of SOD, GSH-Px, TAC, CAT, GST and GR in the treatment group and the control group were higher than those before treatment(P<0.05). The levels of SOD, GSH-Px, TAC, CAT, GST and GR in the treatment group were significantly higher than those in the control group(P<0.05). Conclusion: The treatment of acupoint embedding therapy combined with Aricept can effectively increase the levels of SOD, GSHPx, TAC, CAT, GST and GR in serum, and improve the learning and memory level of AD patients by regulating the expression of antioxidant molecules.
Objective: To explore the clinical efficacy of head cavity embedding therapy in patients with AD. Methods:Eighty patients with AD who met the criteria were randomly divided into a treatment group and a control group based on conventional medical treatment, with 40 cases in each group. The treatment group was treated with acupuncture at the acupoint and combined with Aricept. The control group was treated with Aricept. A total of 12 weeks of treatment. Blessed-Roth score,ADAS-Cog score and serum antioxidant molecules: SOD, GSH-Px, TAC, CAT, GST, GR were measured before and after treatment. Results: Before treatment, there was no significant difference in Blessed-Roth score and ADAS-Cog score between the two groups(P>0.05). After 2 groups of treatment, the Blessed-Roth score and the ADAS-Cog score were lower than those before treatment. The difference between the treatment group and the treatment group was greater than that of the control group(P<0.05). Note Both groups were effective, but the treatment group was superior to the control group. There was no significant difference in oxidative stress between the treatment group and the control group before treatment(P>0.05). After treatment, the levels of SOD, GSH-Px, TAC, CAT, GST and GR in the treatment group and the control group were higher than those before treatment(P<0.05). The levels of SOD, GSH-Px, TAC, CAT, GST and GR in the treatment group were significantly higher than those in the control group(P<0.05). Conclusion: The treatment of acupoint embedding therapy combined with Aricept can effectively increase the levels of SOD, GSHPx, TAC, CAT, GST and GR in serum, and improve the learning and memory level of AD patients by regulating the expression of antioxidant molecules.
引文
[1]娄艳芳,都文渊,张秀君.针刺干预对阿尔茨海默病患者认知功能及生活质量得影响[J].陕西中医,2017,38(8):1124-1125.
[2]罗琴琴,杜艳军.针灸“补肾益髓”法对阿尔茨海默病模型大鼠海马区脑啡肽酶的作用[J].吉林中医药,2014,34(5):511-514.
[3]王芸,杜艳军.辨经辨证针灸治疗阿尔茨海默病的研究进展[J].针灸临床杂志,2015,31(11):76-78.
[4]Lane RM,Potkin SG,EnzA,et al.Targetingacetyl cholinesterase Andbutyryl cholinesteraseindementia[J].Int JNeuropsychol Phamacol,2005,9(1):101-124.
[5]姚红芳,张海峰,陈小丽.头穴埋线疗法治疗失眠症33例疗效观察[J].针刺研究,2012,37(5):394-397.
[6]臧艳静,冯姗姗,张宸豪.“鸡尾酒疗法”治疗帕金森病痴呆疗效观察[J].临床神经病学杂志,2017,30(1):54-57.
[7]谷巍,金晓仙,张燕军,等.针刺治疗阿尔茨海默病临床研究[J].中国针灸,2014,34(12):1156-1160.
[8]朱晶,国海东,邵水金.针灸治疗阿尔茨海默病机制的研究进展[J].针刺研究,2012,37(5):422-427.
[9]彭文杰,伍大华.中医药对阿尔茨海默病中枢胆碱能系统影响的研究进展[J].中医药导报,2015,21(7):89-91.
[10]姚遥,孙娜,郑萍,等.苦参碱对阿尔茨海默症小鼠学习记忆功能和脑内氧化应激的影响[J].宁夏医科大学学报,2016:38(9):985-988.
[11]邵明璐,李洋,崔华峰,等.针刺预处理对大鼠心肌缺血再灌注氧化应激损伤的保护作用[J].中国针灸,2017,37(3):285-290.
[12]张鹏,关珊珊,姜国华.电针对链脲佐菌AD模型大鼠海马区Aβ阳性细胞表达和脑内SOD活性的影响[J].中国针灸,2010,30(12):1007-1010.
[13]李虹霖,孙兴华,李默,等.头穴丛刺对老年性痴呆大鼠学习记忆能力的影响[J].针灸临床杂志,2015,31(10):74-76.
[14]王珊,范梦男.穴位埋线联合西药治疗脑卒中后便秘随机平行对照研究[J].实用中医内科杂志,2017,31(7):32-35.
[15]林志诚,杨珊莉,薛偕华,等.针刺百会穴改善脑卒中患者记忆力的中枢机制[J].中国康复理论与实践,2015,21(2):184-188.
[16]向齐,刘麒麟,向诗余.针刺四神聪穴为主治疗颈性眩晕临床观察[J].吉林中医药,2016,34(6):633-634,639.
[2]罗琴琴,杜艳军.针灸“补肾益髓”法对阿尔茨海默病模型大鼠海马区脑啡肽酶的作用[J].吉林中医药,2014,34(5):511-514.
[3]王芸,杜艳军.辨经辨证针灸治疗阿尔茨海默病的研究进展[J].针灸临床杂志,2015,31(11):76-78.
[4]Lane RM,Potkin SG,EnzA,et al.Targetingacetyl cholinesterase Andbutyryl cholinesteraseindementia[J].Int JNeuropsychol Phamacol,2005,9(1):101-124.
[5]姚红芳,张海峰,陈小丽.头穴埋线疗法治疗失眠症33例疗效观察[J].针刺研究,2012,37(5):394-397.
[6]臧艳静,冯姗姗,张宸豪.“鸡尾酒疗法”治疗帕金森病痴呆疗效观察[J].临床神经病学杂志,2017,30(1):54-57.
[7]谷巍,金晓仙,张燕军,等.针刺治疗阿尔茨海默病临床研究[J].中国针灸,2014,34(12):1156-1160.
[8]朱晶,国海东,邵水金.针灸治疗阿尔茨海默病机制的研究进展[J].针刺研究,2012,37(5):422-427.
[9]彭文杰,伍大华.中医药对阿尔茨海默病中枢胆碱能系统影响的研究进展[J].中医药导报,2015,21(7):89-91.
[10]姚遥,孙娜,郑萍,等.苦参碱对阿尔茨海默症小鼠学习记忆功能和脑内氧化应激的影响[J].宁夏医科大学学报,2016:38(9):985-988.
[11]邵明璐,李洋,崔华峰,等.针刺预处理对大鼠心肌缺血再灌注氧化应激损伤的保护作用[J].中国针灸,2017,37(3):285-290.
[12]张鹏,关珊珊,姜国华.电针对链脲佐菌AD模型大鼠海马区Aβ阳性细胞表达和脑内SOD活性的影响[J].中国针灸,2010,30(12):1007-1010.
[13]李虹霖,孙兴华,李默,等.头穴丛刺对老年性痴呆大鼠学习记忆能力的影响[J].针灸临床杂志,2015,31(10):74-76.
[14]王珊,范梦男.穴位埋线联合西药治疗脑卒中后便秘随机平行对照研究[J].实用中医内科杂志,2017,31(7):32-35.
[15]林志诚,杨珊莉,薛偕华,等.针刺百会穴改善脑卒中患者记忆力的中枢机制[J].中国康复理论与实践,2015,21(2):184-188.
[16]向齐,刘麒麟,向诗余.针刺四神聪穴为主治疗颈性眩晕临床观察[J].吉林中医药,2016,34(6):633-634,639.