米曲霉次生代谢产物真菌毒素研究进展
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摘要
米曲霉是亚洲发酵食品生产使用的主要丝状真菌,可产生丰富的次生代谢产物,其中一些米曲霉菌株会代谢产生少量的真菌毒素,这些米曲霉真菌毒素可能会对人体健康造成危害。文章从米曲霉真菌毒素的起源、病理毒性、检测方法与防治等方面对4种真菌毒素的研究进展进行了综述。
Aspergillus oryzaeis the main filamentous fungus used in the production of fermented foods in Asia.It can produce abundant secondary metabolites,some of which are metabolized to produce small amount of mycotoxins.These Aspergillus oryzae mycotoxins may be harm to human health.In this paper,the origin,pathological toxicity,detection methods and control of the four mycotoxins are reviewed.
Aspergillus oryzaeis the main filamentous fungus used in the production of fermented foods in Asia.It can produce abundant secondary metabolites,some of which are metabolized to produce small amount of mycotoxins.These Aspergillus oryzae mycotoxins may be harm to human health.In this paper,the origin,pathological toxicity,detection methods and control of the four mycotoxins are reviewed.
引文
[1]杨梅,唐江涛,唐尹萍,等.米曲霉GX0015蔗糖酶基因克隆及生物信息学分析[J].工业微生物,2010,40(3):29-33.
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[4]王文珺,桑华春.真菌毒素免疫检测技术的研究进展[J].食品安全导刊,2017(16):24-26.
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[7]Yokota T,Sakurai A,Iriuchijima S,et al.Isolation and 13C NMR study of cyclopyazionic acid,a toxic alkaloid produced by muscardine fungi Aspergillus flavus and Aspergillus oryzae[J].Journal of the Agricultural Chemical Society of Japan,1981,45(1):53-56.
[8]Tokuoka M,Seshime Y,Fujii I,et al.Identification of a novel polyketide synthase-nonribosomal peptide synthetase(PKS-NRPS)gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae[J].Fungal Genetics&Biology,2008,45(12):1608-1615.
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[15]Kumar P,Padi S S,Naidu P S,et al.Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity[J].Methods&Findings in Experimental&Clinical Pharmacology,2016,29(1):19-25.
[16]Nakamura S,Shimoda C.Studies on an antibiotic substance oryzacidin,produced by Asp.oryzae:Part 5.Existence ofβ-nitropropionic acid[J].Journal of the Agricultural Chemical Society of Japan,1954,28:909-913.
[17]Matsumoto H,Unrau A M,Hylin J W,et al.Spectrophotometric determination of 3-nitropropanoic acid in biological extracts[J].Analytical Chemistry,2002,33(10):38-45.
[18]Suganya S N,Sumathi T.Effect of rutin against a mitochondrial toxin,3-nitropropionic acid induced biochemical,behavioral and histological alterations-a pilot study on Huntington's disease model in rats[J].Metabolic Brain Disease,2016(22):1-11.
[19]Ludolph A C,He F,Spencer P S,et al.3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin[J].Canadian Journal of Neurological Sciences,1991,18(4):492-498.
[20]Haine S,Kari M.Evaluating sex differences in procedural learning and memory deficits caused by 3-nitropropionic acid[D].Maryland:Towson University,2017.
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[22]George A,Burdock I G,Carabin M G.Safety assessment ofβ-nitropropionic acid.A monograph in support of an acceptable daily intake in humans[J].Food Chemistry,2001,75:1-27.
[23]刘勇,吴南,吴永宁,等.3-硝基丙酸的气相色谱-热能检定器测定法及其在大鼠体内的毒物代谢动力学研究[J].卫生研究,1993(1):35-58.
[24]付以同.3-硝基丙酸和3-硝基丙醇的代谢及神经毒性[J].国外医学:卫生学分册,1992,19(1):9-13.
[25]Jang M,Cho I H.Sulforaphane ameliorates 3-nitropropionic acidinduced striatal toxicity by activating the keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-κB pathways[J].Molecular Neurobiology,2016,53(4):2619.
[26]Colle D,Santos D B,Hartwig J M,et al.Succinobucol,a lipid-lowering drug,protects against 3-nitropropionic acidinduced mitochondrial dysfunction and oxidative stress in SH-SY5Ycells via upregulation of glutathione levels and glutamate cysteine ligase activity[J].Molecular Neurobiology,2016,53(2):1280-1295.
[27]Calderón G D,Brizuela N O,Ortíz H M,et al.Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid[J].Acta Pharm,2016,66(3):443-448.
[28]Abdelghany T M,Elnaggar M A,Ganash M A,et al.PCR Identification of Aspergillus niger,with using natural additives for controlling and detection of malformins and maltoryzine production by HPLC[J].Bionanoscience,2017(6):1-9.
[29]Iizuka H,Iida M.Maltoryzine,a new toxic metabolite produced by a strain of Aspergillus oryzae,var.microsporus,isolated from the poisonous malt sprout[J].Nature,1962,196(4855):681-682.
[30]Beélik A.Kojic acid[J].Advances in Carbohydrate Chemistry,1956(11):145-183.
[31]Burdock G A,Soni M G,Carabin I G.Evaluation of health aspects of kojic acid in food[J].Regulatory Toxicology&Pharmacology,2001,33(1):80.
[32]Saghaie L,Pourfarzam M,Fassihi A,et al.Synthesis and tyrosinase inhibitory properties of some novel derivatives of kojic acid[J].Research in Pharmaceutical Sciences,2013,8(4):233-242.
[33]Majmudar G,Jacob G,Laboy Y,et al.An in vitro method for screening skin-whitening products[J].Journal of the Society of Cosmetic Chemists,2013,49(6):361-367.
[34]Nakagawa M,Kawai K.Contact allergy to kojic acid in skin care products[J].Contact Dermatitis,2010,32(1):9-13.
[35]Wang K,Liu C,Di C J,et al.Kojic acid protects C57BL/6mice from gamma-irradiation induced damage[J].Asian Pacific Journal of Cancer Prevention,2014,15(1):291-297.
[36]Jiang Q.Determination of the kojic acid in food or cosmetic with the HPLC-electrochemistry detector[J].Fujian Analysis&Testing,2005(6):23-27.
[2]Keller N P,Turner G,Bennett J W.Fungal secondary metabolism from biochemistry to genomics[J].Nat.Rev.Microbiol,2005,12(3):937-947.
[3]Machida M,Asai K,Sano M,et al.Genome sequencing and analysis of Aspergillus oryzae[J].Nature,2005,438(70):1157.
[4]王文珺,桑华春.真菌毒素免疫检测技术的研究进展[J].食品安全导刊,2017(16):24-26.
[5]Georgianna D R,Fedorova N D,Burroughs J L,et al.Beyond aflatoxin:four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters[J].Molecular Plant Pathology,2010,11(2):213-226.
[6]Holzapfel C W.The isolation and structure of cyclopiazonic acid,a toxic metabolite of Penicillium cyclopium westling[J].Tetrahedron,1968,24(5):2101.
[7]Yokota T,Sakurai A,Iriuchijima S,et al.Isolation and 13C NMR study of cyclopyazionic acid,a toxic alkaloid produced by muscardine fungi Aspergillus flavus and Aspergillus oryzae[J].Journal of the Agricultural Chemical Society of Japan,1981,45(1):53-56.
[8]Tokuoka M,Seshime Y,Fujii I,et al.Identification of a novel polyketide synthase-nonribosomal peptide synthetase(PKS-NRPS)gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae[J].Fungal Genetics&Biology,2008,45(12):1608-1615.
[9]Hill J E,Lomax L G,Cole R J,et al.Toxicologic and immunologic effects of sublethal doses of cyclopiazonic acid in rats[J].American of Journal Vertefinary Reserch,1986,47(5):1174-1177.
[10]Blumenthal C Z.Production of toxic metabolites in Aspergillus niger,Aspergillus oryzae,and Trichoderma reesei:justification of mycotoxin testing in food grade enzyme preparations derived from the three fungi[J].Regul Toxicol Pharmacol,2004,39(2):214-228.
[11]Lalitha R B,Husain A.Presence of cyclopiazonic acid in kodo millet(Paspalum scrobiculatum)causing"kodua poisoning"in man and its production by associated fungi[J].Mycopathologia,1985,89(3):177-180.
[12]Dorner J W.Recent advances in analytical methodology for cyclopiazonic acid[J].Oxygen Transport to Tissue XXXIII,2002,504(48):107-116.
[13]赵删,李业鹏,计融,等.反相高效液相色谱法分析米曲霉发酵液中的圆弧偶氮酸[J].中国食品卫生杂志,2003,15(2):128-130
[14]Rodríguez A,Werning M L,Rodríguez M,et al.Quantitative real-time PCR method with internal amplification control to quantify cyclopiazonic acid producing molds in foods[J].Food Microbiology,2012,32(2):397-405.
[15]Kumar P,Padi S S,Naidu P S,et al.Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity[J].Methods&Findings in Experimental&Clinical Pharmacology,2016,29(1):19-25.
[16]Nakamura S,Shimoda C.Studies on an antibiotic substance oryzacidin,produced by Asp.oryzae:Part 5.Existence ofβ-nitropropionic acid[J].Journal of the Agricultural Chemical Society of Japan,1954,28:909-913.
[17]Matsumoto H,Unrau A M,Hylin J W,et al.Spectrophotometric determination of 3-nitropropanoic acid in biological extracts[J].Analytical Chemistry,2002,33(10):38-45.
[18]Suganya S N,Sumathi T.Effect of rutin against a mitochondrial toxin,3-nitropropionic acid induced biochemical,behavioral and histological alterations-a pilot study on Huntington's disease model in rats[J].Metabolic Brain Disease,2016(22):1-11.
[19]Ludolph A C,He F,Spencer P S,et al.3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin[J].Canadian Journal of Neurological Sciences,1991,18(4):492-498.
[20]Haine S,Kari M.Evaluating sex differences in procedural learning and memory deficits caused by 3-nitropropionic acid[D].Maryland:Towson University,2017.
[21]Borlongan C V,Koutouzis T K,Randall T S,et al.Systemic3-nitropropionic acid:behavioral deficits and striatal damage in adult rats[J].Brain Research Bulletin,1995,36(6):549-556.
[22]George A,Burdock I G,Carabin M G.Safety assessment ofβ-nitropropionic acid.A monograph in support of an acceptable daily intake in humans[J].Food Chemistry,2001,75:1-27.
[23]刘勇,吴南,吴永宁,等.3-硝基丙酸的气相色谱-热能检定器测定法及其在大鼠体内的毒物代谢动力学研究[J].卫生研究,1993(1):35-58.
[24]付以同.3-硝基丙酸和3-硝基丙醇的代谢及神经毒性[J].国外医学:卫生学分册,1992,19(1):9-13.
[25]Jang M,Cho I H.Sulforaphane ameliorates 3-nitropropionic acidinduced striatal toxicity by activating the keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-κB pathways[J].Molecular Neurobiology,2016,53(4):2619.
[26]Colle D,Santos D B,Hartwig J M,et al.Succinobucol,a lipid-lowering drug,protects against 3-nitropropionic acidinduced mitochondrial dysfunction and oxidative stress in SH-SY5Ycells via upregulation of glutathione levels and glutamate cysteine ligase activity[J].Molecular Neurobiology,2016,53(2):1280-1295.
[27]Calderón G D,Brizuela N O,Ortíz H M,et al.Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid[J].Acta Pharm,2016,66(3):443-448.
[28]Abdelghany T M,Elnaggar M A,Ganash M A,et al.PCR Identification of Aspergillus niger,with using natural additives for controlling and detection of malformins and maltoryzine production by HPLC[J].Bionanoscience,2017(6):1-9.
[29]Iizuka H,Iida M.Maltoryzine,a new toxic metabolite produced by a strain of Aspergillus oryzae,var.microsporus,isolated from the poisonous malt sprout[J].Nature,1962,196(4855):681-682.
[30]Beélik A.Kojic acid[J].Advances in Carbohydrate Chemistry,1956(11):145-183.
[31]Burdock G A,Soni M G,Carabin I G.Evaluation of health aspects of kojic acid in food[J].Regulatory Toxicology&Pharmacology,2001,33(1):80.
[32]Saghaie L,Pourfarzam M,Fassihi A,et al.Synthesis and tyrosinase inhibitory properties of some novel derivatives of kojic acid[J].Research in Pharmaceutical Sciences,2013,8(4):233-242.
[33]Majmudar G,Jacob G,Laboy Y,et al.An in vitro method for screening skin-whitening products[J].Journal of the Society of Cosmetic Chemists,2013,49(6):361-367.
[34]Nakagawa M,Kawai K.Contact allergy to kojic acid in skin care products[J].Contact Dermatitis,2010,32(1):9-13.
[35]Wang K,Liu C,Di C J,et al.Kojic acid protects C57BL/6mice from gamma-irradiation induced damage[J].Asian Pacific Journal of Cancer Prevention,2014,15(1):291-297.
[36]Jiang Q.Determination of the kojic acid in food or cosmetic with the HPLC-electrochemistry detector[J].Fujian Analysis&Testing,2005(6):23-27.