高尿酸血症患者血清尿酸水平与糖耐量异常的相关性分析
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摘要
目的分析高尿酸血症(HUA)血清尿酸水平与糖耐量异常指标的相关性。方法选取北京市垂杨柳医院心内科2014年4月—2017年4月收治的92例HUA患者为观察组,选择同期健康体检者60例作为对照组,比较两组血清尿酸(UA)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)水平及胰岛素抵抗(IR)、胰岛素敏感指数(ISI)变化,分析血清尿酸水平与血糖相关指标的相关性。结果 HUA组血清UA、FPG、2 h PG、FINS和IR均高于对照组,ISI值低于健康组(P<0.05)。HUA患者UA与FPG、2 h PG、FINS、IR均呈正相关(r=0.692、0.821、0.769、0.772;P<0.05),与ISI值呈负相关(r=-0.78,P<0.05)。结论高尿酸水平可引发糖耐量异常,导致血糖升高及IR。
Objective To analyze correlation between serum uric acid( UA) level and glucose tolerance abnormal indexes in patients with hyperuricemia( HUA). Methods A total of 92 HUA patients admitted during April 2014 and April 2017 were selected as HUA group,and other 60 healthy people taking medical examination at the same period were used as control group. Changes of serum UA,fasting plasma glucose( FPG),2 h postprandial glucose( 2 h PG),fasting insulin( FINS),insulin resistance( IR) and insulin sensitivity index( ISI) levels were compared between in two groups,and correlations between serum UA level and related blood glucose indexes were analyzed. Results In HUA group,serum UA,FPG,2 h PG,FINS and IR levels were significantly higher,while ISI level was significantly lower than those in control group( P < 0. 05). UA level was positively correlated with FPG,2 h PG,FINS and IR levels( r =0. 692,0. 821,0. 769 and 0. 772; P < 0. 05),and the level was negatively correlated with ISI level in HUA group( r =-0. 78; P < 0. 05) Conclusion High UA level may lead to impaired glucose tolerance,elevated blood glucose and increased insulin resistance.
Objective To analyze correlation between serum uric acid( UA) level and glucose tolerance abnormal indexes in patients with hyperuricemia( HUA). Methods A total of 92 HUA patients admitted during April 2014 and April 2017 were selected as HUA group,and other 60 healthy people taking medical examination at the same period were used as control group. Changes of serum UA,fasting plasma glucose( FPG),2 h postprandial glucose( 2 h PG),fasting insulin( FINS),insulin resistance( IR) and insulin sensitivity index( ISI) levels were compared between in two groups,and correlations between serum UA level and related blood glucose indexes were analyzed. Results In HUA group,serum UA,FPG,2 h PG,FINS and IR levels were significantly higher,while ISI level was significantly lower than those in control group( P < 0. 05). UA level was positively correlated with FPG,2 h PG,FINS and IR levels( r =0. 692,0. 821,0. 769 and 0. 772; P < 0. 05),and the level was negatively correlated with ISI level in HUA group( r =-0. 78; P < 0. 05) Conclusion High UA level may lead to impaired glucose tolerance,elevated blood glucose and increased insulin resistance.
引文
[1]Borghi C,Rosei E A,Bardin T,et al.Serum uric acid and the risk of cardiovascular and renal disease[J].J Hypertens,2015,33(9):1729-1741.
[2]黄雨晴,张莹,莫与京,等.原发性老年高血压患者高尿酸血症患病率的调查研究[J].中华老年心脑血管病杂志,2015,17(5):530-531.
[3]张媛媛,张日华,杜新丽,等.血清尿酸水平与糖尿病各代谢因子的相关性研究[J].南京医科大学学报:自然科学版,2013,41(1):62-67.
[4]万伟,赵东宝.2011年欧洲抗风湿联盟痛风和高尿酸血症最新诊治指南[J].中华风湿病学杂志,2012,16(11):781-782.
[5]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,22(7):447-498.
[6]唐颖茜,白文伟.无症状高尿酸血症与心血管疾病发生的机制[J].云南医药,2017,38(3):283-286.
[7]Zurlo A,Veronese N,Giantin V,et al.High serum uric acid levels increase the risk of metabolic syndrome in elderly women:the PRO.V.A study[J].Nutr Metab Cardiovasc Dis,2016,26(1):27-35.
[8]刘玲丽,张其梅,张颖.2型糖尿病患者血清尿酸与白蛋白尿及代谢异常的相关性研究[J].中国糖尿病杂志,2013,21(10):890-892.
[9]Puddu P,Puddu G M,Cravero E,et al.Relationships among hyperuricemia,endothelial dysfunction and cardiovascular disease:molecular mechanisms and clinical implications[J].J Cardiol,2012,59(3):235-42.
[10]陈金逸,符茂雄.高尿酸血症对2型糖尿病血管并发症的影响及作用机制[J].检验医学与临床,2015,12(23):3489-3491.
[11]孙雪,贾伟平,胡承.高尿酸血症与糖尿病及其血管并发症[J].中华老年多器官疾病杂志,2013,12(11):859-862.
[12]桑艳红.2型糖尿病患者血尿酸水平与微血管并发症的关系[J].医药论坛杂志,2012,33(8):25-26.
[13]潘颖.2型糖尿病患者血尿酸水平与肾脏损害关系的分析[J].医学理论与实践,2012,25(9):1014-1015,1017.
[14]李洺,李海龙,杨嫣华.老年2型糖尿病患者无症状脑梗死与高尿酸血症的关系研究[J].陕西医学杂志,2014,22(4):414-415.
[15]Chuang S Y,Chen J H,Yeh W T,et al.Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort[J].Int J Cardiol,2012,154(3):316-321.
[16]Mitrou P,Petsiou E,Papakonstantinou E,et al.The role of acetic acid on glucose uptake and blood flow rates in the skeletal muscle in humans with impaired glucose tolerance[J].Eur J Clin Nutr,2015,69(6):734-739.
[17]Qiu Q,Gong Y,Liu X,et al.Serum Uric Acid and Impaired Glucose Tolerance:The Cardiometabolic Risk in Chinese(CRC)Study[J].Cell Biochem Biophys,2015,73(1):155-162.
[2]黄雨晴,张莹,莫与京,等.原发性老年高血压患者高尿酸血症患病率的调查研究[J].中华老年心脑血管病杂志,2015,17(5):530-531.
[3]张媛媛,张日华,杜新丽,等.血清尿酸水平与糖尿病各代谢因子的相关性研究[J].南京医科大学学报:自然科学版,2013,41(1):62-67.
[4]万伟,赵东宝.2011年欧洲抗风湿联盟痛风和高尿酸血症最新诊治指南[J].中华风湿病学杂志,2012,16(11):781-782.
[5]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,22(7):447-498.
[6]唐颖茜,白文伟.无症状高尿酸血症与心血管疾病发生的机制[J].云南医药,2017,38(3):283-286.
[7]Zurlo A,Veronese N,Giantin V,et al.High serum uric acid levels increase the risk of metabolic syndrome in elderly women:the PRO.V.A study[J].Nutr Metab Cardiovasc Dis,2016,26(1):27-35.
[8]刘玲丽,张其梅,张颖.2型糖尿病患者血清尿酸与白蛋白尿及代谢异常的相关性研究[J].中国糖尿病杂志,2013,21(10):890-892.
[9]Puddu P,Puddu G M,Cravero E,et al.Relationships among hyperuricemia,endothelial dysfunction and cardiovascular disease:molecular mechanisms and clinical implications[J].J Cardiol,2012,59(3):235-42.
[10]陈金逸,符茂雄.高尿酸血症对2型糖尿病血管并发症的影响及作用机制[J].检验医学与临床,2015,12(23):3489-3491.
[11]孙雪,贾伟平,胡承.高尿酸血症与糖尿病及其血管并发症[J].中华老年多器官疾病杂志,2013,12(11):859-862.
[12]桑艳红.2型糖尿病患者血尿酸水平与微血管并发症的关系[J].医药论坛杂志,2012,33(8):25-26.
[13]潘颖.2型糖尿病患者血尿酸水平与肾脏损害关系的分析[J].医学理论与实践,2012,25(9):1014-1015,1017.
[14]李洺,李海龙,杨嫣华.老年2型糖尿病患者无症状脑梗死与高尿酸血症的关系研究[J].陕西医学杂志,2014,22(4):414-415.
[15]Chuang S Y,Chen J H,Yeh W T,et al.Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort[J].Int J Cardiol,2012,154(3):316-321.
[16]Mitrou P,Petsiou E,Papakonstantinou E,et al.The role of acetic acid on glucose uptake and blood flow rates in the skeletal muscle in humans with impaired glucose tolerance[J].Eur J Clin Nutr,2015,69(6):734-739.
[17]Qiu Q,Gong Y,Liu X,et al.Serum Uric Acid and Impaired Glucose Tolerance:The Cardiometabolic Risk in Chinese(CRC)Study[J].Cell Biochem Biophys,2015,73(1):155-162.