α硫辛酸对2型糖尿病周围神经病变患者功能恢复及预后的影响
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摘要
目的探讨分析α硫辛酸(ALA)对2型糖尿病周围神经病变(DPN)患者的功能恢复及预后的影响。方法选择2017年4月~2018年4月我院住院收治的100例2型DPN患者进行研究,按照随机数字表法分为对照组和观察组,每组各50例。对照组给予甲钴胺治疗,观察组给予ALA治疗,两组均以2周为1个疗程,观察评估症状改善及神经传导速度变化。结果观察组总有效率为96%,高于对照组(82%),差异有统计学意义(P<0.05)。观察组的腓总神经传导速度为(42.03±1.20)m/s,高于对照组的(35.19±1.52)m/s;观察组的正中神经传导速度为(42.88±3.11)m/s,高于对照组的(39.89±2.98)m/s,差异均有统计学意义(P<0.05)。结论 ALA治疗2型DPN可显著改善患者肌电图神经传导速度,从而提高治疗效果,降低不良反应发生率,在临床上值得推广应用。
Objective To investigate the effect of alpha-Lipoic Acid(ALA) on functional recovery and prognosis in patients with peripheral neuropathy of type 2 diabetes mellitus(DPN). Methods A total of 100 patients with type 2 DPN received in our hospital from April 2017 to April 2018 were selected for study. They were divided into the control group and observation group according to random number table method, 50 cases in each group. The control group was given Methylcobalamin treatment, the observation group was given ALA treatment, both groups were 2 weeks for 1 courses to observe the improvement of the two groups of symptoms, and the determination of nerve conduction velocity, evaluation of the two groups of clinical effects. Results The total effective rate of the observation group was 96%, higher than that of the control group(82%), and there was significant difference(P<0.05). The total peroneal nerve conduction velocity of the observation group was(42.03±1.20) m/s, higher than that of the control group(35.19±1.52) m/s; The median nerve conduction velocity of the observation group was(42.88±3.11) m/s, higher than that of the control group(39.89±2.98) m/s, the differences were statistically significant(P<0.05). Conclusion The treatment of type 2 DPN by ALA can improve the nerve conduction velocity, improve the clinical treatment effect and reduce the incidence of adverse reactions.
Objective To investigate the effect of alpha-Lipoic Acid(ALA) on functional recovery and prognosis in patients with peripheral neuropathy of type 2 diabetes mellitus(DPN). Methods A total of 100 patients with type 2 DPN received in our hospital from April 2017 to April 2018 were selected for study. They were divided into the control group and observation group according to random number table method, 50 cases in each group. The control group was given Methylcobalamin treatment, the observation group was given ALA treatment, both groups were 2 weeks for 1 courses to observe the improvement of the two groups of symptoms, and the determination of nerve conduction velocity, evaluation of the two groups of clinical effects. Results The total effective rate of the observation group was 96%, higher than that of the control group(82%), and there was significant difference(P<0.05). The total peroneal nerve conduction velocity of the observation group was(42.03±1.20) m/s, higher than that of the control group(35.19±1.52) m/s; The median nerve conduction velocity of the observation group was(42.88±3.11) m/s, higher than that of the control group(39.89±2.98) m/s, the differences were statistically significant(P<0.05). Conclusion The treatment of type 2 DPN by ALA can improve the nerve conduction velocity, improve the clinical treatment effect and reduce the incidence of adverse reactions.
引文
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[5]邹艺,刘英,李素荣,等.甲钴胺联合α-硫辛酸治疗糖尿病周围神经病变对神经电生理的影响[J].现代电生理学杂志,2016,23(3):138-142.
[6]叶立英.α-硫辛酸与甲钴胺治疗2型糖尿病周围神经病变的疗效比较[C]//中国医院药学杂志学术年会,2016.
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[9]黎清现,熊祖员,何海洪,等.α-硫辛酸联合前列地尔治疗糖尿病周围神经病变的疗效及机制[J].中国实用神经疾病杂志,2016,19(10):13-15.
[10]黄家庆,林昱,徐衡.2型糖尿病周围神经病变患者联合应用α-硫辛酸、甲钴胺及普瑞巴林治疗的疗效分析[J].齐齐哈尔医学院学报,2016,37(11):1445-1447.
[11]郑茂,荆春艳,叶山东.α-硫辛酸治疗糖尿病周围神经病变的临床疗效及机制[J].临床与病理杂志,2014,34(3):307-311.
[12]桑艳红,董瑞鸿.α-硫辛酸治疗2型糖尿病周围神经病变疗效分析[J].中国实用神经疾病杂志,2012,15(21):78-80.
[13]谷雪静,王燕,樊海英.α-硫辛酸治疗2型糖尿病周围神经病变22例疗效观察[J].实用老年医学,2012,26(1):47-49.
[14]韩亚娟.甲钴胺和硫辛酸治疗2型糖尿病周围神经病变的疗效差异及机制的初步探讨[D].广州:南方医科大学,2011.
[15]赵立,马宇航,彭永德.α-硫辛酸治疗糖尿病周围神经病变的疗效观察[J].中国糖尿病杂志,2014,22(3):207-209.
[2]朱志良,刘嘉悦,李丹丹.α-硫辛酸治疗老年糖尿病周围神经病变患者的疗效及作用机制[J].中国老年学杂志,2017,37(8):56.
[3]谷晓林,魏丽萍.甲钴胺联合α-硫辛酸治疗2型糖尿病周围神经病变的疗效及对神经传导速度和氧化应激的影响[J].中国慢性病预防与控制,2018,26(6):426-429.
[4]张金梅.α-硫辛酸联合甲钴胺治疗2型糖尿病周围神经病变的疗效观察[J].天津药学,2016,28(6):43-44.
[5]邹艺,刘英,李素荣,等.甲钴胺联合α-硫辛酸治疗糖尿病周围神经病变对神经电生理的影响[J].现代电生理学杂志,2016,23(3):138-142.
[6]叶立英.α-硫辛酸与甲钴胺治疗2型糖尿病周围神经病变的疗效比较[C]//中国医院药学杂志学术年会,2016.
[7]朱蕾.α-硫辛酸联合甲钴胺治疗2型糖尿病周围神经病变的疗效分析及对氧化应激的影响[J].世界最新医学信息文摘,2016,16(79):50-51.
[8]李玉桂.α-硫辛酸治疗2型糖尿病周围神经病变的疗效及机制探讨[D].石河子:石河子大学,2016.
[9]黎清现,熊祖员,何海洪,等.α-硫辛酸联合前列地尔治疗糖尿病周围神经病变的疗效及机制[J].中国实用神经疾病杂志,2016,19(10):13-15.
[10]黄家庆,林昱,徐衡.2型糖尿病周围神经病变患者联合应用α-硫辛酸、甲钴胺及普瑞巴林治疗的疗效分析[J].齐齐哈尔医学院学报,2016,37(11):1445-1447.
[11]郑茂,荆春艳,叶山东.α-硫辛酸治疗糖尿病周围神经病变的临床疗效及机制[J].临床与病理杂志,2014,34(3):307-311.
[12]桑艳红,董瑞鸿.α-硫辛酸治疗2型糖尿病周围神经病变疗效分析[J].中国实用神经疾病杂志,2012,15(21):78-80.
[13]谷雪静,王燕,樊海英.α-硫辛酸治疗2型糖尿病周围神经病变22例疗效观察[J].实用老年医学,2012,26(1):47-49.
[14]韩亚娟.甲钴胺和硫辛酸治疗2型糖尿病周围神经病变的疗效差异及机制的初步探讨[D].广州:南方医科大学,2011.
[15]赵立,马宇航,彭永德.α-硫辛酸治疗糖尿病周围神经病变的疗效观察[J].中国糖尿病杂志,2014,22(3):207-209.