二甲双胍对多囊卵巢综合征患者空腹血清YY肽水平影响的临床观察
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摘要
目的观察二甲双胍对多囊卵巢综合征(PCOS)患者空腹血清YY肽(PYY)的影响。方法选取2011年10月至2012年2月于安徽医科大学第一附属医院生殖中心就诊的48例PCOS患者,观察二甲双胍干预前后空腹PYY与临床指标相关性。比较干预12周前后空腹PYY水平。结果二甲双胍干预后,空腹PYY水平较治疗前升高[(131. 85±7. 36)vs(136. 74±7. 02)pg/ml,P<0. 01];Pearson相关性分析显示,二甲双胍干预前后空腹PYY水平与BMI(r=-0. 412,P<0. 01)、WC(r=-0. 356,P<0. 05)呈负相关;多元线性回归分析显示,WC是空腹PYY的影响因素(P<0. 05)。结论二甲双胍能升高新诊断PCOS患者空腹PYY水平,但具体机制尚需进一步研究。
Objective To investigate the influence of metformin on fasting serum peptide YY(PYY)level in newly-diagnosed polycystic ovary syndrome(PCOS). Methods A total of 48 newly diagnosed patients with PCOS were enrolled in this study. The correlation between fasting serum PYY and clinical indicators was observed. After 12 weeks of intervention with metformin,the fasting serum PYY levels before and after intervention were compared. Results After metformin intervention,the fasting serum PYY in patients with PCOS was higher than that before treatmen[t(131. 85±7. 36)v(s 134. 95±8. 52)pg/ml,P<0. 01]. Pearson correlation analysis showed that fasting serum PYY concentration was negatively correlatedwith BMI(r=-0. 412,P<0. 01)and WC(r=-0. 356,P<0. 05)before metformin intervention. Multiple stepwise regression analysis showed that WC was an independent influencing factor of PYY(P<0. 05). Conclusion Metformin can increase the fasting serum PYY in patients with PCOS,but its mechanism needs further study.
Objective To investigate the influence of metformin on fasting serum peptide YY(PYY)level in newly-diagnosed polycystic ovary syndrome(PCOS). Methods A total of 48 newly diagnosed patients with PCOS were enrolled in this study. The correlation between fasting serum PYY and clinical indicators was observed. After 12 weeks of intervention with metformin,the fasting serum PYY levels before and after intervention were compared. Results After metformin intervention,the fasting serum PYY in patients with PCOS was higher than that before treatmen[t(131. 85±7. 36)v(s 134. 95±8. 52)pg/ml,P<0. 01]. Pearson correlation analysis showed that fasting serum PYY concentration was negatively correlatedwith BMI(r=-0. 412,P<0. 01)and WC(r=-0. 356,P<0. 05)before metformin intervention. Multiple stepwise regression analysis showed that WC was an independent influencing factor of PYY(P<0. 05). Conclusion Metformin can increase the fasting serum PYY in patients with PCOS,but its mechanism needs further study.
引文
[1]Velazquez EM,Mendoza S,Hamer T,et al.Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia,insulinresistance,hyperandrogenemia,and systolic blood pressure,while facilitating normal menses and pregnancy.Metabolism,1994,43:647-654.
[2]Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS).Hum Reprod,2004,19:41-47.
[3]Golay A.Metformin and body weight.Int J Obes(Lond),2008,32:61-72.
[4]Batterham RL,Cohen MA,Ellis SM,et al.Inhibition of food intake in obese subjects by peptide YY3-36.N Engl J Med,2003,349:941-948.
[5]杜娟,胡红琳,代芳,等.多囊卵巢综合征患者血清内源性YY肽水平的观察.中国糖尿病杂志,2013,21:699-701.
[6]杨文英.肠道激素与肥胖和糖尿病.中国糖尿病杂志,2015,23:1142-1148.
[7]高寅生,侯亚勃,杨晓军,等.胃饥饿素/肽YY/刺鼠相关蛋白信号在胃旁路手术治疗2型糖尿病中的作用.中华实验外科杂志,2016,33:1247-1249.
[8]Tsilchorozidou T,Batterham RL,Conway GS.Metformin increases fasting plasma peptide tyrosine tyrosine(PYY)in women with polycystic ovarian syndrome(PCOS).Clin Endocrinol(Oxf),2008,69:936-942.
[9]吴朝明,王靓,金建,等.2型糖尿病患者应用二甲双胍治疗前后血浆胃促生长素及YY肽水平.中华内分泌代谢,2011,27:805-809.
[2]Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS).Hum Reprod,2004,19:41-47.
[3]Golay A.Metformin and body weight.Int J Obes(Lond),2008,32:61-72.
[4]Batterham RL,Cohen MA,Ellis SM,et al.Inhibition of food intake in obese subjects by peptide YY3-36.N Engl J Med,2003,349:941-948.
[5]杜娟,胡红琳,代芳,等.多囊卵巢综合征患者血清内源性YY肽水平的观察.中国糖尿病杂志,2013,21:699-701.
[6]杨文英.肠道激素与肥胖和糖尿病.中国糖尿病杂志,2015,23:1142-1148.
[7]高寅生,侯亚勃,杨晓军,等.胃饥饿素/肽YY/刺鼠相关蛋白信号在胃旁路手术治疗2型糖尿病中的作用.中华实验外科杂志,2016,33:1247-1249.
[8]Tsilchorozidou T,Batterham RL,Conway GS.Metformin increases fasting plasma peptide tyrosine tyrosine(PYY)in women with polycystic ovarian syndrome(PCOS).Clin Endocrinol(Oxf),2008,69:936-942.
[9]吴朝明,王靓,金建,等.2型糖尿病患者应用二甲双胍治疗前后血浆胃促生长素及YY肽水平.中华内分泌代谢,2011,27:805-809.