针刺脑效应功能磁共振成像研究进展
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摘要
功能磁共振脑成像是无创动态脑功能可视化现代技术,近年在针灸作用的脑机制研究中,取得了令人瞩目的进展,成为了揭示针灸"密码"的重要"现代望诊"技术。目前主要围绕经穴效应特异性、针灸疗效机制、针刺效应影响因素等开展了系列研究,未来可深入针灸优势病种机制研究,探索针灸影像学生物标记物,促进针灸现代化进程。
Functional magnetic resonance imaging is a non-invasive dynamic visualization of brain function, as an aid for TCM inspection, remarkable progress has been made in brain mechanism of acupuncture effect. Specific effects of acupuncture points, brain mechanisms of acupuncture and influence factors of the efficacy of acupuncture are mainstream of previous studies.Imaging biomarkers and mechanisms of acupuncture for dominant diseases may further facilitate modernization process of acupuncture.
Functional magnetic resonance imaging is a non-invasive dynamic visualization of brain function, as an aid for TCM inspection, remarkable progress has been made in brain mechanism of acupuncture effect. Specific effects of acupuncture points, brain mechanisms of acupuncture and influence factors of the efficacy of acupuncture are mainstream of previous studies.Imaging biomarkers and mechanisms of acupuncture for dominant diseases may further facilitate modernization process of acupuncture.
引文
[1]荣培晶,方继良,俞裕天,等.基于针灸脑科学的神经调控技术研究进展.科技导报,2017,35(11):77-84
[2]张丽丽,张春红,申鹏飞,等.浅析经穴效应特异性.中华中医药杂志,2014,29(2):344-347
[3]Hui K K,Liu J,Makris N,et al.Acupuncture modulates the limbic system and subcortical gray structures of the human brain:Evidence from fMRI studies in normal subjects.Human Brain Mapping,2000,9(1):13-25
[4]Fang J L,Jin Z Y,Li K,et al.The salient characteristics of the central effects of acupuncture needling:limbic-paralimbicneocortical network modulation.Human Brain Mapping,2009,30(4):1196-1206
[5]刘振宇,唐振超,徐敏,等.时空编码脑网络与针刺潜在作用机制研究.中国体视学与图像分析,2016,21(1):28-32
[6]Dhond R P,Yeh C,Park K,et al.Acupuncture modulates resting state connectivity in default and sensorimotor brain networks.Pain,2008,136(3):407-418
[7]Chen Z,Li Y,Zhang X,et al.Sham electroacupuncture methods in randomized controlled trials.Scientific Reports,2017,7(1):1-19
[8]Hui Kathleen K S,Marina Ovidiu,Claunch Joshua D.Acupuncture mobilizes the brain’s default mode and its anti-correlated network in healthy subjects. Brain Research,2009,1287:84-103
[9]Kong J,Spaeth R,Cook A,et al.Are all placebo effects equal?Placebo pills,sham acupuncture,cue conditioning and their association.Plos One,2013,8(7):1-9
[10]陈凤英,沈智威,关计添,等.手法针刺合谷穴得气与脑功能激活关系的探讨.磁共振成像,2011,2(2):112-117
[11]蔡依妏,裴建,傅勤慧.基于功能磁共振成像技术对“面口合谷收”的机制研究概述.环球中医药,2017,10(11):1412-1416
[12]Huang W,Pach D,Napadow V,et al.Characterizing acupuncture stimuli using brain imaging with fMRI-A systematic review and meta-analysis of the literature.Plos One,2012,7(4):26-28
[13]刘朝,方继良,杨金生,等.基于分数低频振幅的针刺对吸烟渴求的即刻效应与中枢机制:f MRI脑功能研究.中华中医药杂志,2016,31(5):1572-1578
[14]Li C,Yang J,Park K,et al.Prolonged repeated acupuncture stimulation induces habituation effects in pain-related brain areas:An fMRI study.Plos One,2014,9(5):e97502
[15]方继良,洪洋,范洋洋,等.经皮电针刺激正常人耳甲迷走神经的功能MRI脑效应研究.磁共振成像,2014,5(6):416-422
[16]Fang J,Rong P,Hong Y,et al.Transcutaneous vagus nerve stimulationmodulatesdefaultmodenetworkinmajor depressivedisorder.BiologicalPsychiatry,2016,79(4):266-273
[17]Lin Yii-Jeng,Kung Yen-Ying,Kuo Wen-Jui,et al.Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain.Acupunct Med,2016,34(6):425-432
[18]Fengyan L,Junhong G,Yuanyuan W,et al.Effects of three needling manipulations of the right-side Zusanli(ST 36)on brain using functional magnetic resonance imaging.Journal of Traditional Chinese Medicine,2017,37(3):298-307
[19]Shi Yu,Zhang Shanshan,Li Qiang et al.A study of the brain functional network of Deqi via acupuncturing stimulation at BL40by rs-f MRI.Complement Ther Med,2016,25:71-77
[20]董悦,董玉茹,姜胤,等.手针、电针及经皮穴位电刺激调节人脑功能的功能性磁共振观察.中国疼痛医学杂志,2013,19(2):75-79
[21]Jiang Yin,Wang Hong,Liu Zhenyu et al.Manipulation of and sustained effects on the human brain induced by different modalities of acupuncture:an fMRI study.Plos One,2013,8:e66815
[22]鲁凌云,赵妍,张树森,等.运用f MRI技术探究针刺得气中枢机制的研究现状分析.中华中医药杂志,2017,32(8):3758-3763
[23]史宇,吴文,张珊珊,等.基于功能性磁共振成像技术研究针刺得气脑机制.中华中医药杂志,2016,31(2):445-450
[24]李鑫举,陈波,郭义,等.腧穴配伍机制研究进展.辽宁中医杂志,2015,42(11):2254-2256
[25]Wang Zhiqun,Liang Peipeng,Zhao Zhilian,et al.Acupuncture modulates resting state hippocampal functional connectivity in Alzheimer disease.Plos One,2014,9:e91160
[26]单保慈.针灸功能成像研究进展与存在的问题.科技导报,2017,35(11):85-90
[27]许能贵,方继良.针灸影像学.北京:人民卫生出版社,2018:322-323
[2]张丽丽,张春红,申鹏飞,等.浅析经穴效应特异性.中华中医药杂志,2014,29(2):344-347
[3]Hui K K,Liu J,Makris N,et al.Acupuncture modulates the limbic system and subcortical gray structures of the human brain:Evidence from fMRI studies in normal subjects.Human Brain Mapping,2000,9(1):13-25
[4]Fang J L,Jin Z Y,Li K,et al.The salient characteristics of the central effects of acupuncture needling:limbic-paralimbicneocortical network modulation.Human Brain Mapping,2009,30(4):1196-1206
[5]刘振宇,唐振超,徐敏,等.时空编码脑网络与针刺潜在作用机制研究.中国体视学与图像分析,2016,21(1):28-32
[6]Dhond R P,Yeh C,Park K,et al.Acupuncture modulates resting state connectivity in default and sensorimotor brain networks.Pain,2008,136(3):407-418
[7]Chen Z,Li Y,Zhang X,et al.Sham electroacupuncture methods in randomized controlled trials.Scientific Reports,2017,7(1):1-19
[8]Hui Kathleen K S,Marina Ovidiu,Claunch Joshua D.Acupuncture mobilizes the brain’s default mode and its anti-correlated network in healthy subjects. Brain Research,2009,1287:84-103
[9]Kong J,Spaeth R,Cook A,et al.Are all placebo effects equal?Placebo pills,sham acupuncture,cue conditioning and their association.Plos One,2013,8(7):1-9
[10]陈凤英,沈智威,关计添,等.手法针刺合谷穴得气与脑功能激活关系的探讨.磁共振成像,2011,2(2):112-117
[11]蔡依妏,裴建,傅勤慧.基于功能磁共振成像技术对“面口合谷收”的机制研究概述.环球中医药,2017,10(11):1412-1416
[12]Huang W,Pach D,Napadow V,et al.Characterizing acupuncture stimuli using brain imaging with fMRI-A systematic review and meta-analysis of the literature.Plos One,2012,7(4):26-28
[13]刘朝,方继良,杨金生,等.基于分数低频振幅的针刺对吸烟渴求的即刻效应与中枢机制:f MRI脑功能研究.中华中医药杂志,2016,31(5):1572-1578
[14]Li C,Yang J,Park K,et al.Prolonged repeated acupuncture stimulation induces habituation effects in pain-related brain areas:An fMRI study.Plos One,2014,9(5):e97502
[15]方继良,洪洋,范洋洋,等.经皮电针刺激正常人耳甲迷走神经的功能MRI脑效应研究.磁共振成像,2014,5(6):416-422
[16]Fang J,Rong P,Hong Y,et al.Transcutaneous vagus nerve stimulationmodulatesdefaultmodenetworkinmajor depressivedisorder.BiologicalPsychiatry,2016,79(4):266-273
[17]Lin Yii-Jeng,Kung Yen-Ying,Kuo Wen-Jui,et al.Effect of acupuncture ‘dose’ on modulation of the default mode network of the brain.Acupunct Med,2016,34(6):425-432
[18]Fengyan L,Junhong G,Yuanyuan W,et al.Effects of three needling manipulations of the right-side Zusanli(ST 36)on brain using functional magnetic resonance imaging.Journal of Traditional Chinese Medicine,2017,37(3):298-307
[19]Shi Yu,Zhang Shanshan,Li Qiang et al.A study of the brain functional network of Deqi via acupuncturing stimulation at BL40by rs-f MRI.Complement Ther Med,2016,25:71-77
[20]董悦,董玉茹,姜胤,等.手针、电针及经皮穴位电刺激调节人脑功能的功能性磁共振观察.中国疼痛医学杂志,2013,19(2):75-79
[21]Jiang Yin,Wang Hong,Liu Zhenyu et al.Manipulation of and sustained effects on the human brain induced by different modalities of acupuncture:an fMRI study.Plos One,2013,8:e66815
[22]鲁凌云,赵妍,张树森,等.运用f MRI技术探究针刺得气中枢机制的研究现状分析.中华中医药杂志,2017,32(8):3758-3763
[23]史宇,吴文,张珊珊,等.基于功能性磁共振成像技术研究针刺得气脑机制.中华中医药杂志,2016,31(2):445-450
[24]李鑫举,陈波,郭义,等.腧穴配伍机制研究进展.辽宁中医杂志,2015,42(11):2254-2256
[25]Wang Zhiqun,Liang Peipeng,Zhao Zhilian,et al.Acupuncture modulates resting state hippocampal functional connectivity in Alzheimer disease.Plos One,2014,9:e91160
[26]单保慈.针灸功能成像研究进展与存在的问题.科技导报,2017,35(11):85-90
[27]许能贵,方继良.针灸影像学.北京:人民卫生出版社,2018:322-323