低渗口服补液盐联合益生菌治疗小儿急性非感染性腹泻病的临床疗效观察
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摘要
目的观察低渗口服补液盐(口服补液盐Ⅲ)联合益生菌治疗小儿急性非感染性腹泻病的临床效果。方法选取2017年1～10月某儿童医院收治的60例急性非感染性腹泻并伴有轻、中度脱水的患儿,随机分为实验组和对照组。对照给予益生菌、蒙脱石散等常规治疗;实验组在对照组患者治疗的基础上联合了低渗口服补液盐,观察两组患者治疗效果情况。结果实验组患者治疗后总有效率为93.33%,明显高于对照组的73.33%(P=0.038);实验组大便性状改善所需时间为(47.62±7.13)h,明显短于对照组的(59.78±10.32)h(P=0.026);实验组患者腹泻总病程时间为(84.34±7.41)h,明显小于对照组的(107.63±11.50)h(P=0.017)。结论低渗口服补液盐联合益生菌治疗小儿急性非感染性腹泻效果好,值得在临床上推广使用。
Objective To observe the clinical curative effects of hypotonic oral rehydration salt(oral rehydration salt III) combined with probiotics in treatment of children with acute non-infectious diarrhea. Methods 60 patients with acute non-infectious diarrhea accompanied by mild or moderate dehydration in a children' hospital from January 2017 to October 2017 were selected. They were randomly divided into the experimental group and the control group. The control group was given routine treatment of probiotics and montmorillonite. On the basis of the same treatment in the control group, the experimental group was also given hypotonic oral rehydration salt. Curative effects of patients in two groups were observed. Results After treatment, the total effective rate in the experimental group was 93.33%, significantly higher than 73.33% in the control group(P=0.038). The time required for improvement of defecate character in the experimental group was(47.62±7.13)h, significantly shorter than(59.78±10.32)h in the control group(P=0.026). The total duration of diarrhea in the experimental group was(84.34±7.41)h, significantly less than(107.63±11.50) h in the control group(P=0.017). Conclusion Hypotonic oral rehydration salt combined with probiotics in treatment of children with acute non-infectious diarrhea has good curative effects, and it is worth popularizing and applying in clinical practice.
Objective To observe the clinical curative effects of hypotonic oral rehydration salt(oral rehydration salt III) combined with probiotics in treatment of children with acute non-infectious diarrhea. Methods 60 patients with acute non-infectious diarrhea accompanied by mild or moderate dehydration in a children' hospital from January 2017 to October 2017 were selected. They were randomly divided into the experimental group and the control group. The control group was given routine treatment of probiotics and montmorillonite. On the basis of the same treatment in the control group, the experimental group was also given hypotonic oral rehydration salt. Curative effects of patients in two groups were observed. Results After treatment, the total effective rate in the experimental group was 93.33%, significantly higher than 73.33% in the control group(P=0.038). The time required for improvement of defecate character in the experimental group was(47.62±7.13)h, significantly shorter than(59.78±10.32)h in the control group(P=0.026). The total duration of diarrhea in the experimental group was(84.34±7.41)h, significantly less than(107.63±11.50) h in the control group(P=0.017). Conclusion Hypotonic oral rehydration salt combined with probiotics in treatment of children with acute non-infectious diarrhea has good curative effects, and it is worth popularizing and applying in clinical practice.
引文
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[7]袁绍曲,刘重海,王修石.布拉氏酵母菌治疗小儿急性腹泻临床疗效观察[J].中国药业,2017,26(11):55-57.
[8]邹姣云.蒙脱石散联合布拉氏酵母菌散治疗小儿急性腹泻的效果[J].实用临床医学,2018(3):63-64.
[9]张定芬.布拉氏酵母菌散联合蒙脱石散治疗小儿腹泻的临床效果观察[J].白求恩医学杂志,2018(2):177-178.
[10]李传义.口服补液盐联合蒙脱石混悬液治疗小儿腹泻的临床疗效观察[J].中国处方药,2018(3):67-68.
[11]王勇伟.低渗口服补液盐治疗小儿急性腹泻的疗效观察[J].世界临床医学,2017(23):111.
[12]Pulungsih S P,Punjabi N H,Rafli K,et al.Standard WHO-ORS versus reduced-osmolarity ORS in the management of cholera patients[J].J Health Popul Nutr,2006,24(1):107-112.
[13]黄娟,舒俊华,罗燕军,等.口服补液盐Ⅲ治疗儿童单纯型抗生素相关性腹泻病疗效观察[J].儿科药学杂志,2013(11):15-18.
[14]宁桦,温鸿飞,彭越,等.低渗口服补液盐治疗小儿急性腹泻病临床疗效观察[J].实用临床医药杂志,2012,16(23):174-175.
[15]王小仙.低渗口服补液盐治疗儿童急性腹泻轻中度脱水的疗效和安全性评价[J].中国现代医生,2012,50(11):47-48,50.
[16]林莉.口服低渗补液盐联合锌剂治疗小儿急性腹泻疗效观察[J].中国临床研究,2014(11):1387-1388.
[17]胡斌,梁新文.急性感染性腹泻病原菌的分布及耐药性[J].西部中医药,2012,30(7):77-79.
[2]周志强,赵小燕,徐武军.低渗透压ORS溶液(口服补液盐Ⅲ)治疗小儿腹泻病疗效分析[J].中国当代医药,2016,23(18):75-77.
[3]中华医学会儿科学分会消化学组,编辑委员会中华儿科杂志.中国儿童急性感染性腹泻病临床实践指南[J].中华儿科杂志,2016,54(7):483-488.
[4]方鹤松,段恕诚,董宗祈.中国腹泻病的诊断治疗方案[J].中国实用儿科杂志,1998,13(6):381-384.
[5]腹泻病诊断治疗指南[J].实用儿科临床杂志,2009(19):1538-1540.
[6]中华医学会儿科学分会消化学组,中华医学会儿科学分会感染学组,编辑委员会中华儿科杂志.儿童腹泻病诊断治疗原则的专家共识[J].中华儿科杂志,2009(8):634-636.
[7]袁绍曲,刘重海,王修石.布拉氏酵母菌治疗小儿急性腹泻临床疗效观察[J].中国药业,2017,26(11):55-57.
[8]邹姣云.蒙脱石散联合布拉氏酵母菌散治疗小儿急性腹泻的效果[J].实用临床医学,2018(3):63-64.
[9]张定芬.布拉氏酵母菌散联合蒙脱石散治疗小儿腹泻的临床效果观察[J].白求恩医学杂志,2018(2):177-178.
[10]李传义.口服补液盐联合蒙脱石混悬液治疗小儿腹泻的临床疗效观察[J].中国处方药,2018(3):67-68.
[11]王勇伟.低渗口服补液盐治疗小儿急性腹泻的疗效观察[J].世界临床医学,2017(23):111.
[12]Pulungsih S P,Punjabi N H,Rafli K,et al.Standard WHO-ORS versus reduced-osmolarity ORS in the management of cholera patients[J].J Health Popul Nutr,2006,24(1):107-112.
[13]黄娟,舒俊华,罗燕军,等.口服补液盐Ⅲ治疗儿童单纯型抗生素相关性腹泻病疗效观察[J].儿科药学杂志,2013(11):15-18.
[14]宁桦,温鸿飞,彭越,等.低渗口服补液盐治疗小儿急性腹泻病临床疗效观察[J].实用临床医药杂志,2012,16(23):174-175.
[15]王小仙.低渗口服补液盐治疗儿童急性腹泻轻中度脱水的疗效和安全性评价[J].中国现代医生,2012,50(11):47-48,50.
[16]林莉.口服低渗补液盐联合锌剂治疗小儿急性腹泻疗效观察[J].中国临床研究,2014(11):1387-1388.
[17]胡斌,梁新文.急性感染性腹泻病原菌的分布及耐药性[J].西部中医药,2012,30(7):77-79.