中药溃疡方联合三联疗法治疗Hp阳性消化性溃疡临床疗效观察
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摘要
目的探讨中药溃疡方联合三联疗法治疗Hp阳性消化性溃疡的临床疗效。方法选取我院在2016年5月~2017年9月期间所收治的60例Hp阳性消化性溃疡者作为样本人群,利用抽签法将所有患者均分为研究组与对照组,每组各30例。对照组患者口服西药四联疗法,研究组患者中药溃疡方联合三联疗法,对比分析两组患者经不同治疗后的组间数据。结果研究组患者的食欲减退(0.75±0.21)分、烧心泛酸(0.42±0.33)分、胃脘疼痛(0.21±0.11)分、脘腹胀满(1.45±0.58)分、口苦口臭(1.03±0.06)分、神疲倦怠(0.25±0.19)分、大便稀溏(0.18±0.08)分、hs-CRP(2.07±0.54)mg/m L、PCT(1.19±0.63)ng/m L、临床显效率(90.0%)、Hp复发率(26.67%)、不良反应(16.7%)均优于对照组。结论在Hp阳性消化性溃疡患者的治疗过程中应用中药溃疡方联合三联疗法,可明显提高临床疗效,降低Hp复发率,减少药物不良反应的发生,值得临床上借鉴。
Objective To investigate the curative effect of traditional Chinese medicine ulcer prescription combined with triple therapy in the treatment of Hp-positive peptic ulcer. Methods 60 patients with Hp-positive gastrointestinal ulcer admitted in our hospital between May 2016 and September 2017 were selected as the sample population. All patients were equally divided into study group and control group by lottery method, with 30 cases in each group. Patients in the control group were given oral quadruple Western medicine therapy, and the patients in the study group were given traditional Chinese medicine ulcer prescription combined with triple therapy. The data between two groups after treatment were compared. Results The anorexia(0.75±0.21) points, pantothenic?acid and heartburn(0.42±0.33) points,stomach pain(0.21±0.11) points, belly fullness(1.45±0.58) points, bitter mouth and bad breath(1.03±0.06) points, fatigue(0.25±0.19) points, loose stool(0.18±0.08) points, hs-CRP(2.07 ±0.54) mg/m L, PCT(1.19 ±0.63) ng/m L, clinical effective rate(90.0%),Hp recurrence rate(26.67%)and adverse reactions rate(16.7%) in the study group were better than those of the control group. Conclusion The application of Chinese medicine ulcer prescription combined with triple therapy in the treatment of patients with Hp-positive peptic ulcer can significantly improve the clinical curative effect, reduce the recurrence rate of Hp and the occurrence of adverse drug reactions, which deserves clinical reference.
Objective To investigate the curative effect of traditional Chinese medicine ulcer prescription combined with triple therapy in the treatment of Hp-positive peptic ulcer. Methods 60 patients with Hp-positive gastrointestinal ulcer admitted in our hospital between May 2016 and September 2017 were selected as the sample population. All patients were equally divided into study group and control group by lottery method, with 30 cases in each group. Patients in the control group were given oral quadruple Western medicine therapy, and the patients in the study group were given traditional Chinese medicine ulcer prescription combined with triple therapy. The data between two groups after treatment were compared. Results The anorexia(0.75±0.21) points, pantothenic?acid and heartburn(0.42±0.33) points,stomach pain(0.21±0.11) points, belly fullness(1.45±0.58) points, bitter mouth and bad breath(1.03±0.06) points, fatigue(0.25±0.19) points, loose stool(0.18±0.08) points, hs-CRP(2.07 ±0.54) mg/m L, PCT(1.19 ±0.63) ng/m L, clinical effective rate(90.0%),Hp recurrence rate(26.67%)and adverse reactions rate(16.7%) in the study group were better than those of the control group. Conclusion The application of Chinese medicine ulcer prescription combined with triple therapy in the treatment of patients with Hp-positive peptic ulcer can significantly improve the clinical curative effect, reduce the recurrence rate of Hp and the occurrence of adverse drug reactions, which deserves clinical reference.
引文
[1]赵云清.中药联合三联疗法治疗消化道溃疡的疗效分析[J].医学美学美容(中旬刊),2015,75(5):253-254.
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[11]张劲松.针对幽门螺杆菌阳性消化道溃疡患者采用三联疗法治疗的临床观察[J].当代临床医刊,2015,28(6):1721-1722.
[12]张宏,侯波,严江,等.常规三联与四联疗法治疗幽门螺杆菌阳性消化道溃疡的疗效比较[J].中国药房,2017,28(3):321-323.
[13]林娜,张天翔.标准四联法对幽门螺旋杆菌相关性消化道溃疡的临床研究[J].中国微生态学杂志,2015,27(3):318-321.
[14]余柏山.三联用药治疗消化道溃疡临床疗效观察[J].实用中西医结合临床,2015,15(11):67,78.
[15]梁小辉.新三联疗法治疗Hp阳性的小儿消化道溃疡疗效分析[J].中国实用医刊,2015,42(7):81-82.
[16]常旭.兰索拉唑治疗消化道溃疡上消化道出血的综合疗效观察[J].中国实用医药,2016,11(34):129-130.
[17]党叶川.左氧氟沙星三联疗法与阿莫西林三联疗法治疗消化性溃疡的疗效比较[J].中国实用医药,2015,10(36):148-149.
[18]陈剑.埃索美拉唑联合莫西沙星与阿莫西林根除幽门螺旋杆菌的临床观察[J].数理医药学杂志,2015,45(11):1614-1615.
[19]罗杰.阿莫西林联合碳酸铝镁片与兰索拉唑治疗消化道溃疡的临床观察[J].北方药学,2017,14(9):136-137.
[20]梁小辉.新三联疗法治疗Hp阳性的小儿消化道溃疡疗效分析[J].中国实用医刊,2015,42(7):81-82.
[2]袁东.中药三七方治疗上消化道溃疡出血疗效分析[J].临床医药文献电子杂志,2017,4(46):9064-9065.
[3]常青.中西医结合治疗消化道溃疡的临床疗效和远期复发率的研究[J].中医临床研究,2015,55(2):58-60.
[4]石淑青.上消化道出血的中医辨证论治[J].中国中医急症,2014,23(6):1135-1136.
[5]李本斐.中西医结合方法治疗上消化道溃疡临床疗效评价[J].中国医疗前沿,2013,23(7):46.
[6]马迎儿.中西医结合治疗上消化道溃疡合并出血75例疗效分析[J].中国中医药科技,2014,55(z1):122-123.
[7]李虹,肖宏伟.两种三联疗法治疗幽门螺杆菌阳性消化道溃疡的效果比较[J].中国基层医药,2014,67(16):2535-2536.
[8]张宏,侯波,严江等.常规三联与四联疗法治疗幽门螺杆菌阳性消化道溃疡的疗效比较[J].中国药房,2017,28(3):321-323.
[9]赵江,吴洁群,王志英,等.慢性消化道溃疡联合用药治疗的效果观察[J].辽宁医学杂志,2016,30(1):66-68.
[10]刘培凤,刘启华,凌江红,等.活血化瘀类中药注射液治疗中、重型颅脑损伤患者的系统评价[J].中成药,2016,38(1):38-46.
[11]张劲松.针对幽门螺杆菌阳性消化道溃疡患者采用三联疗法治疗的临床观察[J].当代临床医刊,2015,28(6):1721-1722.
[12]张宏,侯波,严江,等.常规三联与四联疗法治疗幽门螺杆菌阳性消化道溃疡的疗效比较[J].中国药房,2017,28(3):321-323.
[13]林娜,张天翔.标准四联法对幽门螺旋杆菌相关性消化道溃疡的临床研究[J].中国微生态学杂志,2015,27(3):318-321.
[14]余柏山.三联用药治疗消化道溃疡临床疗效观察[J].实用中西医结合临床,2015,15(11):67,78.
[15]梁小辉.新三联疗法治疗Hp阳性的小儿消化道溃疡疗效分析[J].中国实用医刊,2015,42(7):81-82.
[16]常旭.兰索拉唑治疗消化道溃疡上消化道出血的综合疗效观察[J].中国实用医药,2016,11(34):129-130.
[17]党叶川.左氧氟沙星三联疗法与阿莫西林三联疗法治疗消化性溃疡的疗效比较[J].中国实用医药,2015,10(36):148-149.
[18]陈剑.埃索美拉唑联合莫西沙星与阿莫西林根除幽门螺旋杆菌的临床观察[J].数理医药学杂志,2015,45(11):1614-1615.
[19]罗杰.阿莫西林联合碳酸铝镁片与兰索拉唑治疗消化道溃疡的临床观察[J].北方药学,2017,14(9):136-137.
[20]梁小辉.新三联疗法治疗Hp阳性的小儿消化道溃疡疗效分析[J].中国实用医刊,2015,42(7):81-82.