顺尔宁佐治儿童分泌性中耳炎的临床疗效
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摘要
目的探讨顺尔宁佐治儿童分泌性中耳炎的临床疗效。方法选择我院2013年3月~2014年3月保守治疗的分泌性中耳炎患儿100例,所有入组患儿均符合分泌性中耳炎诊断标准,随机分为对照组和治疗组,各50例,对照组患儿给予静脉滴注头孢哌酮治疗,2次/d,治疗组在对照组的基础上辅以顺尔宁口服治疗,1次/d,每天于患儿睡前口服。比较两组的患耳疼痛、鼓膜膨隆内陷、中耳腔渗液及听力好转、体征消失时间。结果治疗组在患耳疼痛、鼓膜膨隆内陷及中耳腔渗液消失、听力好转时间比对照组短,治疗组和对照组总有效率为98%、82%,两组差异有统计学意义(P<0.01);治疗组与对照组患儿治疗后患儿及家属满意度分别为100%、84%,差异具有统计学意义(P<0.05)。结论顺尔宁佐治儿童分泌性中耳炎疗效确切,未见不良反应,值得临床推广使用。
Objective To evaluate the clinical efficacy of montelukast in the treatment of children with secretory otitis media(SOM).Methods 100 children with confirmed SOM admitted to our hospital from March 2013 to March 2014 were included.They were randomly divided into control group and treatment group, with 50 cases in each group. While both groups received intravenous infusion of cefoperazone twice a day, the treatment group also received additional oral administration of montelukast once a day before sleep. Clinical symptoms and the duration that signs and symptoms disappeared were compared. Results The signs and symptoms, including earache, invagination of swelled tympanic membrane and exudate in the middle ear cavity, disappeared sooner in the treatment group than that in the control group, and the treatment group exhibited a shorter hearing recovery time than that of the control group. The effective rates of the treatment and control group were 98% and 82% respectively, which showed a significant difference(P<0.01). The degrees of family member satisfaction after treatment for the treatment and control group were 100% and 84% respectively(P<0.05). Conclusion The curative effect of montelukast in the treatment of children with secretory otitis media is obvious with no adverse reactions, thus worthy to be recommended for clinical applications.
Objective To evaluate the clinical efficacy of montelukast in the treatment of children with secretory otitis media(SOM).Methods 100 children with confirmed SOM admitted to our hospital from March 2013 to March 2014 were included.They were randomly divided into control group and treatment group, with 50 cases in each group. While both groups received intravenous infusion of cefoperazone twice a day, the treatment group also received additional oral administration of montelukast once a day before sleep. Clinical symptoms and the duration that signs and symptoms disappeared were compared. Results The signs and symptoms, including earache, invagination of swelled tympanic membrane and exudate in the middle ear cavity, disappeared sooner in the treatment group than that in the control group, and the treatment group exhibited a shorter hearing recovery time than that of the control group. The effective rates of the treatment and control group were 98% and 82% respectively, which showed a significant difference(P<0.01). The degrees of family member satisfaction after treatment for the treatment and control group were 100% and 84% respectively(P<0.05). Conclusion The curative effect of montelukast in the treatment of children with secretory otitis media is obvious with no adverse reactions, thus worthy to be recommended for clinical applications.
引文
[1]尹学金,王选胜.综合治疗儿童分泌性中耳炎296例疗效观察[J].中国中西医结合儿科学,2013,5(1):62-4.
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[4]张桂芬,王丽.儿童分泌性中耳炎选择性鼓膜切开治疗的临床分析[J].中国医疗前沿,2010,5(14):70-3.
[5]李星玉,江华,杨建.糖皮质激素在急性分泌性中耳炎治疗中的作用[J].内分泌外科杂志,2008,3(2):129-80.
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[7]张莹莹.糖皮质激素治疗分泌性中耳炎的临床疗效观察[J].听力学及言语疾病杂志,2008,4(16):329-30.
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[11]邓森.糖皮质激素治疗儿童分泌性中耳炎的疗效分析[J].中外妇儿健康,2011,19(5):65-7.
[12]刘建治,刘静波.儿童分泌性中耳炎62例临床分析[J].武汉大学学报:医学版,2014,35(5):808-10,815.
[13]韩德民.耳鼻咽喉头颈科学[M].北京:北京大学医学出版社,2004:76-8.
[14]胡亚美,江载芳,诸福棠.实用儿科学[M]7版.北京:人民卫生出版社,2002.
[15]周涵,陈智斌,王登元,等.口服和鼓室内注射糖皮质激素治疗分泌性中耳炎的疗效观察[J].听力学及言语疾病杂志,2009,17(6):560-2.
[16]梁小辉.顺尔宁治疗儿童哮喘疗效分析[J].中原医刊,2007,34(18):47-8.
[17]Glodbart AD,Goldman JL,Vleing MC,et al.Leukotriene modifier therapy for mild sleep-disorderd breathing in children[J].Am JRespir Crit Care Med,2005,172(3):364-70.
[18]Combs JT.The effect of montelukast Sodium on the duration of effusion of otitis media[J].Clin Pediatr(Phila),2004,43(6):529-33.
[19]Tada N,Furukawa M,Ogura M,et al.Experimental otitis media with effusion induced by leukotriene D-4[J].Auris Nasus Larynx,2002,29(2):127-32.
[20]胡叶养,林广裕.白三烯受体拮抗剂在儿科疾病中的应用现状[J].临床儿科杂志,2009,27(2):189-92.
[2]陈萍,郭欲.中西医结合治疗分泌性中耳炎的疗效[J].上海医学,2007,30(9):711-2.
[3]黄选兆,汪吉宝,孔维佳,等.实用耳鼻咽喉头颈外科学[M]2版.北京:人民卫生出版社,2008:848-55.
[4]张桂芬,王丽.儿童分泌性中耳炎选择性鼓膜切开治疗的临床分析[J].中国医疗前沿,2010,5(14):70-3.
[5]李星玉,江华,杨建.糖皮质激素在急性分泌性中耳炎治疗中的作用[J].内分泌外科杂志,2008,3(2):129-80.
[6]张鹏.儿童分泌性中耳炎的疗效观察与分析[J].中华耳科学杂志,2010,8(3):319-21.
[7]张莹莹.糖皮质激素治疗分泌性中耳炎的临床疗效观察[J].听力学及言语疾病杂志,2008,4(16):329-30.
[8]Fornadley JA,Burns JK.The effect of surfactant on eustachian tube function in a gerbil model of otitis media with effusion[J].Otolaryngol Head Neck Surg,1994,110(1):110-4.
[9]王俊周,胡书君,毛艳民.鼓室内注射抗组胺药治疗分泌性中耳炎的疗效观察[J].中国厂矿医学,2004,17(4):327-30.
[10]刘兆华.耳鼻喉科学[M].北京:人民卫生出版社,2002:20-1.
[11]邓森.糖皮质激素治疗儿童分泌性中耳炎的疗效分析[J].中外妇儿健康,2011,19(5):65-7.
[12]刘建治,刘静波.儿童分泌性中耳炎62例临床分析[J].武汉大学学报:医学版,2014,35(5):808-10,815.
[13]韩德民.耳鼻咽喉头颈科学[M].北京:北京大学医学出版社,2004:76-8.
[14]胡亚美,江载芳,诸福棠.实用儿科学[M]7版.北京:人民卫生出版社,2002.
[15]周涵,陈智斌,王登元,等.口服和鼓室内注射糖皮质激素治疗分泌性中耳炎的疗效观察[J].听力学及言语疾病杂志,2009,17(6):560-2.
[16]梁小辉.顺尔宁治疗儿童哮喘疗效分析[J].中原医刊,2007,34(18):47-8.
[17]Glodbart AD,Goldman JL,Vleing MC,et al.Leukotriene modifier therapy for mild sleep-disorderd breathing in children[J].Am JRespir Crit Care Med,2005,172(3):364-70.
[18]Combs JT.The effect of montelukast Sodium on the duration of effusion of otitis media[J].Clin Pediatr(Phila),2004,43(6):529-33.
[19]Tada N,Furukawa M,Ogura M,et al.Experimental otitis media with effusion induced by leukotriene D-4[J].Auris Nasus Larynx,2002,29(2):127-32.
[20]胡叶养,林广裕.白三烯受体拮抗剂在儿科疾病中的应用现状[J].临床儿科杂志,2009,27(2):189-92.