加减八珍汤辅助治疗小儿神经母细胞瘤的效果观察
|
摘要
目的:观察加减八珍汤辅助治疗小儿神经母细胞瘤的临床疗效。方法:将80例小儿神经母细胞瘤患者按照随机数字表法分为2组,每组各40例。实验组在基础治疗上给予加减八珍汤治疗,对照组在基础治疗上予以安慰剂,均连续治疗4周,同时观察治疗期间中医证候变化、治疗效果、生活质量、肿瘤进展、不良反应等情况。4周后,以生活质量评分表、中医症状量表进行问卷调查,统计药物干预前后各组患者评分并进行数据分析。结果:两组患儿治疗前各症状程度比较,差异无统计学意义;服加减八珍汤治疗后,实验组疗效评价较治疗前均改善(P <0. 05),且实验组总体生活质量评分均优于对照组(P <0. 05)。结论:加减八珍汤辅助治疗小儿神经母细胞瘤有显著效果,可提高患者生存质量,且疗效安全、可行。
Objective: To observed the clinical effect of adjuvant treatment of Bazhen decoction on pediatric neuroblastoma. Methods: Eighty children with neuroblastoma were divided into two groups according to the random number table: 40 in each group. The experimental group was treated with addition and subtraction of Bazhen decoction on the basis of treatment,while the control group was given placebo on the basis of treatment for 4 weeks. Meanwhile,we observed the changes of TCM syndrome,treatment affect,quality of life,tumor progression,adverse reactions and so on.After 4 weeks,questionnaires were made with the quality of life scale and Chinese symptom checklist,and the scores of all the patients before and after drug intervention were statistically analyzed. Results: There was no significant difference in symptoms between the two groups before treatment. After treatment with Bazhen decoction,the curative effect of the experimental group was better than that before treatment( P < 0. 05),and the overall quality of life score was better than the control group( P < 0. 05). Conclusion: The addition and subtraction Bazhen Decoction adjuvant treatment of children with neuroblastoma have a significant effect,which can improve the quality of life of patients,and the efficacy of safe and feasible.
Objective: To observed the clinical effect of adjuvant treatment of Bazhen decoction on pediatric neuroblastoma. Methods: Eighty children with neuroblastoma were divided into two groups according to the random number table: 40 in each group. The experimental group was treated with addition and subtraction of Bazhen decoction on the basis of treatment,while the control group was given placebo on the basis of treatment for 4 weeks. Meanwhile,we observed the changes of TCM syndrome,treatment affect,quality of life,tumor progression,adverse reactions and so on.After 4 weeks,questionnaires were made with the quality of life scale and Chinese symptom checklist,and the scores of all the patients before and after drug intervention were statistically analyzed. Results: There was no significant difference in symptoms between the two groups before treatment. After treatment with Bazhen decoction,the curative effect of the experimental group was better than that before treatment( P < 0. 05),and the overall quality of life score was better than the control group( P < 0. 05). Conclusion: The addition and subtraction Bazhen Decoction adjuvant treatment of children with neuroblastoma have a significant effect,which can improve the quality of life of patients,and the efficacy of safe and feasible.
引文
[1]Riley RD,Burchill SA,Abrams KR,et al.A systematic review of molecular and biological markers in tumours of the Ewing's sarcoma family[J].European Journal of Cancer,2003,39(1):19-30.
[2]Franks LM,Bollen A,Seeger RC,et al.Neuroblastoma in adults and adolescents.An indolent course with poor survival[J].The Journal of Urology Cancer,2015,79(10):2028-2035.
[3]Zhang Y,Zhang WL,Huang DS,et al.Clinical features and outcomes of neuroblastoma patients aged above 5 years[J].Chinese Journal of Contemporary Pediatrics,2016,18(12):1217-1221.[张谊,张伟令,黄东生,等.5岁以上神经母细胞瘤患者的临床特点及疗效分析[J].中国当代儿科杂志,2016,18(12):1217-1221.]
[4]Tang SQ.Diagnosis and therapy of neuroblastorma in children[J].Journal of Applied Clinical Pediatrics,2005,20(1):4-6.[唐锁勤.神经母细胞瘤的诊断及治疗[J].中华实用儿科临床杂志,2005,20(1):4-6.]
[5]Gong ZH,Chuan CJG,Su SY.Combining therapy for neuroblastoma[J].Journal of Clinical Pediatric Surgery,2005,4(2):81-84.[龚振华,川村健児,栗山裕.神经母细胞瘤的综合治疗[J].临床小儿外科杂志,2005,4(2):81-84.]
[6]Zheng XY.Guiding principles of clinical research on new drugs of traditional chinese medicine[M].Beijing:China Medical Science and Technology Press,2002:65-73.[郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:65-73]
[7]Xue XJ.Development of self-rating scale for cancer-induced fatigue and research on its validity[D].Shandong:Taishan Medical University,2013:29-33.[薛秀娟.癌因性疲乏自评量表的研制及其信效度研究[D].山东:泰山医学院,2013:29-33.]
[8]Qiu YM.Nursing intervention on insomnia in patients with malignant tumor[J].Gansu Medical Journal,2011,30(5):292-294.[邱玉梅.恶性肿瘤患者失眠症状的中医护理干预[J].甘肃医药,2011,30(5):292-294.]
[9]Lin YR,Jia LQ,Li LY,et al.The clinical observation of the traditional Chinese medicine with external therapy on hyperhidrosis in neoplasms[J].Chinese Journal of Difficult and Complicated Cases,2010,9(3):168-170.[林宥任,贾立群,李利亚,等.中医外治法治疗肿瘤患者多汗症临床观察[J].疑难病杂志,2010,9(3):168-170.]
[10]Wang CH,Chen MQ,Zhang CZ,et al.The Chinese version of EORTC QLQ-C3 form in evaluation of quality of life for patients with cancer[J].Journal of Practical Oncology,2005,20(4):353-355.[万崇华,陈明清,张灿珍,等.癌症患者生命质量测定量表EORTC QLQ-C30中文版评价[J].实用肿瘤杂志,2005,20(4):353-355.]
[11]Maris JM,Hogarty MD,Bagatell R,et al.Neuroblastoma[J].Lancet,2007,369(9579):2106-2120.
[12]Yang HY,Wang YN,Gao J,et al.Clinical analysis of neuroblastoma in children[J].Chinese Journal of Pediatric Surgery,2014,35(2):100-103.[杨合英,王艳娜,高建,等.小儿神经母细胞瘤的临床分析[J]..中华小儿外科杂志,2014,35(2):100-103.]
[13]Tan WQ.Study on the mechanism of artemisinin inhibiting the proliferation of neuroblastoma cells[D].Shanghai:Fudan University,2013:18-21.[谈卫强.青蒿素抑制神经母细胞瘤细胞增殖的机制研究[D].上海:复旦大学,2013:18-21.]
[14]Wang GJ,Yu WY,Li Q,et al.Experiences of Professor Fan Zhongze in treatment of childhood neuroblastoma[J].World Journal of Integrated Traditional and Western Medicine,2013,8(3):290-292.[王国娟,余文燕,李琦,等.范忠泽教授诊治小儿神经母细胞瘤经验[J].世界中西医结合杂志,2013,8(3):290-292.]
[15]Xue HL.Progress in the study of the effect of bazhen decoction tonifying qi and blood[J].Henan Traditional Chinese Medicine,2010,30(10):1039-1041.[薛红莉.八珍汤补益气血作用研究进展[J].河南中医,2010,30(10):1039-1041.]
[16]Zhu R.Analyses and anti-tumor activitives of the polysaccharides from codonopsis pillosula[D].Jilin:Northeast Normal University,2013:78-84.[朱瑞.党参多糖的分析及抗肿瘤活性研究[D].吉林:东北师范大学,2013:78-84.]
[17]Wang JW,Wang YP,Wang SL,et al.Synergistic effects of total saponins of panax ginseng in combination with hematopoietic growth factor on proliferation and differentiation of CD34+cells Ex vivo[J].Journal of Experimental Hematology,2006,14(5):959-963.[王建伟,王亚平,王莎莉,等.人参总皂甙协同造血生长因子体外诱导CD34+造血干/祖细胞扩增与分化的作用[J].中国实验血液学杂志,2006,14(5):959-963.]
[18]Yu M,Wang XX.Progress in pharmacological study of cornel[J].Military Medical Journal of Southeast China,2010,12(3):240-243.[于淼,王晓先.山茱萸的药理作用研究进展[J].东南国防医药,2010,12(3):240-243.]
[2]Franks LM,Bollen A,Seeger RC,et al.Neuroblastoma in adults and adolescents.An indolent course with poor survival[J].The Journal of Urology Cancer,2015,79(10):2028-2035.
[3]Zhang Y,Zhang WL,Huang DS,et al.Clinical features and outcomes of neuroblastoma patients aged above 5 years[J].Chinese Journal of Contemporary Pediatrics,2016,18(12):1217-1221.[张谊,张伟令,黄东生,等.5岁以上神经母细胞瘤患者的临床特点及疗效分析[J].中国当代儿科杂志,2016,18(12):1217-1221.]
[4]Tang SQ.Diagnosis and therapy of neuroblastorma in children[J].Journal of Applied Clinical Pediatrics,2005,20(1):4-6.[唐锁勤.神经母细胞瘤的诊断及治疗[J].中华实用儿科临床杂志,2005,20(1):4-6.]
[5]Gong ZH,Chuan CJG,Su SY.Combining therapy for neuroblastoma[J].Journal of Clinical Pediatric Surgery,2005,4(2):81-84.[龚振华,川村健児,栗山裕.神经母细胞瘤的综合治疗[J].临床小儿外科杂志,2005,4(2):81-84.]
[6]Zheng XY.Guiding principles of clinical research on new drugs of traditional chinese medicine[M].Beijing:China Medical Science and Technology Press,2002:65-73.[郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:65-73]
[7]Xue XJ.Development of self-rating scale for cancer-induced fatigue and research on its validity[D].Shandong:Taishan Medical University,2013:29-33.[薛秀娟.癌因性疲乏自评量表的研制及其信效度研究[D].山东:泰山医学院,2013:29-33.]
[8]Qiu YM.Nursing intervention on insomnia in patients with malignant tumor[J].Gansu Medical Journal,2011,30(5):292-294.[邱玉梅.恶性肿瘤患者失眠症状的中医护理干预[J].甘肃医药,2011,30(5):292-294.]
[9]Lin YR,Jia LQ,Li LY,et al.The clinical observation of the traditional Chinese medicine with external therapy on hyperhidrosis in neoplasms[J].Chinese Journal of Difficult and Complicated Cases,2010,9(3):168-170.[林宥任,贾立群,李利亚,等.中医外治法治疗肿瘤患者多汗症临床观察[J].疑难病杂志,2010,9(3):168-170.]
[10]Wang CH,Chen MQ,Zhang CZ,et al.The Chinese version of EORTC QLQ-C3 form in evaluation of quality of life for patients with cancer[J].Journal of Practical Oncology,2005,20(4):353-355.[万崇华,陈明清,张灿珍,等.癌症患者生命质量测定量表EORTC QLQ-C30中文版评价[J].实用肿瘤杂志,2005,20(4):353-355.]
[11]Maris JM,Hogarty MD,Bagatell R,et al.Neuroblastoma[J].Lancet,2007,369(9579):2106-2120.
[12]Yang HY,Wang YN,Gao J,et al.Clinical analysis of neuroblastoma in children[J].Chinese Journal of Pediatric Surgery,2014,35(2):100-103.[杨合英,王艳娜,高建,等.小儿神经母细胞瘤的临床分析[J]..中华小儿外科杂志,2014,35(2):100-103.]
[13]Tan WQ.Study on the mechanism of artemisinin inhibiting the proliferation of neuroblastoma cells[D].Shanghai:Fudan University,2013:18-21.[谈卫强.青蒿素抑制神经母细胞瘤细胞增殖的机制研究[D].上海:复旦大学,2013:18-21.]
[14]Wang GJ,Yu WY,Li Q,et al.Experiences of Professor Fan Zhongze in treatment of childhood neuroblastoma[J].World Journal of Integrated Traditional and Western Medicine,2013,8(3):290-292.[王国娟,余文燕,李琦,等.范忠泽教授诊治小儿神经母细胞瘤经验[J].世界中西医结合杂志,2013,8(3):290-292.]
[15]Xue HL.Progress in the study of the effect of bazhen decoction tonifying qi and blood[J].Henan Traditional Chinese Medicine,2010,30(10):1039-1041.[薛红莉.八珍汤补益气血作用研究进展[J].河南中医,2010,30(10):1039-1041.]
[16]Zhu R.Analyses and anti-tumor activitives of the polysaccharides from codonopsis pillosula[D].Jilin:Northeast Normal University,2013:78-84.[朱瑞.党参多糖的分析及抗肿瘤活性研究[D].吉林:东北师范大学,2013:78-84.]
[17]Wang JW,Wang YP,Wang SL,et al.Synergistic effects of total saponins of panax ginseng in combination with hematopoietic growth factor on proliferation and differentiation of CD34+cells Ex vivo[J].Journal of Experimental Hematology,2006,14(5):959-963.[王建伟,王亚平,王莎莉,等.人参总皂甙协同造血生长因子体外诱导CD34+造血干/祖细胞扩增与分化的作用[J].中国实验血液学杂志,2006,14(5):959-963.]
[18]Yu M,Wang XX.Progress in pharmacological study of cornel[J].Military Medical Journal of Southeast China,2010,12(3):240-243.[于淼,王晓先.山茱萸的药理作用研究进展[J].东南国防医药,2010,12(3):240-243.]