盐酸氨溴索联合阿奇霉素治疗小儿支气管肺炎的效果
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摘要
目的:分析盐酸氨溴索联合阿奇霉素治疗小儿支气管肺炎的临床疗效及对患儿中性粒细胞功能的影响。方法 :选取2015年1月—2016年12月我院收治的200例支气管肺炎患儿作为观察对象,根据治疗方案的不同分为观察组与对照组,各100例。对照组采用常规阿奇霉素序贯疗法治疗,观察组在对照组基础上采用盐酸氨溴索注射液(六岁及以下患儿7.5 mg,bid;7岁及以上患儿15 mg,bid)治疗。观察两组临床疗效、症状缓解时间以及中性粒细胞功能的变化,以及不良反应发生情况。结果 :观察组治疗有效率高于对照组,症状缓解时间短于对照组,中性粒细胞吞噬率和杀伤率明显高于对照组,差异有统计学意义(P <0.05);两组治疗期间均无明显不良反应发生。结论 :盐酸氨溴索联合阿奇霉素治疗小儿支气管肺炎的疗效显著,可有效改善患儿的中性粒细胞功能,缩短症状缓解时间,且安全性高。
Objective: To analyze the clinical efficacy of ambroxol hydrochloride combined with azithromycin in the treatment of pediatric bronchopneumonia and its effect on neutrophil functions. Methods: 200 children with bronchopneumonia admitted to our hospital from January 2015 to December 2016 were selected as observation subjects, and they were divided into an observation group and a control group according to different treatment options, 100 cases each. The children in the control group were treated with conventional azithromycin sequential therapy, and the children in the observation group were treated with ambroxol hydrochloride injection(7.5 mg for children aged 6 and younger, bid; 15 mg for children aged 7 and older, bid). The clinical efficacy, symptom remission time, changes in neutrophil functions as well as adverse events in the two groups were observed. Results: The effective rate of the treatment in the observation group was higher than that in the control group, the symptom remission time was shorter than that in the control group, and the phagocytosis rate and killing rate of neutrophils were significantly higher than those in the control group, with statistically significant differences(P<0.05). There were no significant adverse reactions in the two groups during the treatment period. Conclusion: Ambroxol hydrochloride combined with azithromycin is significantly effective in the treatment of pediatric bronchopneumonia, which can effectively improve the neutrophil functions and shorten the symptom remission time, and has high safety.
Objective: To analyze the clinical efficacy of ambroxol hydrochloride combined with azithromycin in the treatment of pediatric bronchopneumonia and its effect on neutrophil functions. Methods: 200 children with bronchopneumonia admitted to our hospital from January 2015 to December 2016 were selected as observation subjects, and they were divided into an observation group and a control group according to different treatment options, 100 cases each. The children in the control group were treated with conventional azithromycin sequential therapy, and the children in the observation group were treated with ambroxol hydrochloride injection(7.5 mg for children aged 6 and younger, bid; 15 mg for children aged 7 and older, bid). The clinical efficacy, symptom remission time, changes in neutrophil functions as well as adverse events in the two groups were observed. Results: The effective rate of the treatment in the observation group was higher than that in the control group, the symptom remission time was shorter than that in the control group, and the phagocytosis rate and killing rate of neutrophils were significantly higher than those in the control group, with statistically significant differences(P<0.05). There were no significant adverse reactions in the two groups during the treatment period. Conclusion: Ambroxol hydrochloride combined with azithromycin is significantly effective in the treatment of pediatric bronchopneumonia, which can effectively improve the neutrophil functions and shorten the symptom remission time, and has high safety.
引文
[1]彭亿平.氧气驱动雾化吸入盐酸氨溴索治疗小儿肺炎的效果评价[J].中国实用护理杂志,2015,28(27):50-51.
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[4]赵鹤进,宋晓光.儿童碳青霉烯类耐药肺炎克雷伯菌耐药机制及同源性相关分析[J].中国合理用药探索,2017,14(8):1-4,9.
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[6]罗欢.盐酸氨溴索雾化吸入治疗小儿肺炎58例临床疗效观察[J].儿科药学杂志,2011,17(3):29-31.
[7]Gorospe L,Gallego-Rivera JI,Hervás-Morón A.Exogenous lipoid pneumonia secondary to Vaseline application to the tracheostomy in a laryngectomy patient:PET/CT and MRimaging findings[J].Clin Imaging,2013,37(1):163-166.
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[9]梅向阳,张爱雪,潘少华,等.暖胃止痛贴缓解静滴阿奇霉素在治疗小儿肺炎中胃肠道不良反应的疗效观察及护理体会[J].实用药物与临床,2013,16(10):979-980,992.
[10]Sumikawa H,Johkoh T,Fujimoto K,et al.Usual interstitial pneumonia and nonspecific interstitial pneumonia:correlation between CT findings at the site of biopsy with pathological diagnoses[J].Eur J Radiol,2012,81(10):2919-2924.
[11]鱼建飞,梅玲华,贺兆平.特布他林辅助阿奇霉素序贯治疗小儿肺炎的疗效及其对患儿气道炎症因子的影响[J].海南医学,2017,28(1):73-76.
[12]Marciniak C,Korutz AW,Lin E et al.Examination of selected clinical factors and medication use as risk factors for pneumonia during stroke rehabilitation:a case-control study[J].Am J Phys Med Rehabil,2009,88(1):30-38.
[13]戴道华,赖志光,刘满姣.不同阿奇霉素静脉滴注时间对小儿肺炎的治疗效果影响差异分析[J].山西医药杂志,2015,44(10):1101-1103.
[14]舒菊娟,张炫化.清热化痰法联合阿奇霉素治疗小儿肺炎支原体感染的支气管炎临床疗效研究[J].世界中西医结合杂志,2017,12(2):226-229.
[15]张华,丁玎.盐酸氨溴索联合阿奇霉素对小儿肺炎患儿血清CRP、sTREM-1水平的影响[J].现代诊断与治疗,2017,28(3):436-437.
[2]吴芝兰,陈正,余文华,等.盐酸氨溴索联合阿奇霉素治疗小儿肺炎的疗效[J].中国生化药物杂志,2016,36(2):73-75.
[3]朱庆纪,吴伟华.盐酸氨溴索联合布地奈德、糜蛋白酶雾化吸入辅助治疗小儿肺炎的疗效[J].实用儿科临床杂志,2009,24(11):872,880.
[4]赵鹤进,宋晓光.儿童碳青霉烯类耐药肺炎克雷伯菌耐药机制及同源性相关分析[J].中国合理用药探索,2017,14(8):1-4,9.
[5]王久胜.阿奇霉素序贯疗法治疗小儿支原体肺炎的疗效观察[J].中国合理用药探索,2017,14(10):58-59,63.
[6]罗欢.盐酸氨溴索雾化吸入治疗小儿肺炎58例临床疗效观察[J].儿科药学杂志,2011,17(3):29-31.
[7]Gorospe L,Gallego-Rivera JI,Hervás-Morón A.Exogenous lipoid pneumonia secondary to Vaseline application to the tracheostomy in a laryngectomy patient:PET/CT and MRimaging findings[J].Clin Imaging,2013,37(1):163-166.
[8]井学文.小儿肺炎采用氧气驱动雾化吸入盐酸氨溴索治疗效果观察[J].中国卫生产业,2014,11(9):128-129.
[9]梅向阳,张爱雪,潘少华,等.暖胃止痛贴缓解静滴阿奇霉素在治疗小儿肺炎中胃肠道不良反应的疗效观察及护理体会[J].实用药物与临床,2013,16(10):979-980,992.
[10]Sumikawa H,Johkoh T,Fujimoto K,et al.Usual interstitial pneumonia and nonspecific interstitial pneumonia:correlation between CT findings at the site of biopsy with pathological diagnoses[J].Eur J Radiol,2012,81(10):2919-2924.
[11]鱼建飞,梅玲华,贺兆平.特布他林辅助阿奇霉素序贯治疗小儿肺炎的疗效及其对患儿气道炎症因子的影响[J].海南医学,2017,28(1):73-76.
[12]Marciniak C,Korutz AW,Lin E et al.Examination of selected clinical factors and medication use as risk factors for pneumonia during stroke rehabilitation:a case-control study[J].Am J Phys Med Rehabil,2009,88(1):30-38.
[13]戴道华,赖志光,刘满姣.不同阿奇霉素静脉滴注时间对小儿肺炎的治疗效果影响差异分析[J].山西医药杂志,2015,44(10):1101-1103.
[14]舒菊娟,张炫化.清热化痰法联合阿奇霉素治疗小儿肺炎支原体感染的支气管炎临床疗效研究[J].世界中西医结合杂志,2017,12(2):226-229.
[15]张华,丁玎.盐酸氨溴索联合阿奇霉素对小儿肺炎患儿血清CRP、sTREM-1水平的影响[J].现代诊断与治疗,2017,28(3):436-437.