妊娠期高血压患者随机尿微量白蛋白/肌酐比值与母婴妊娠结局的相关性
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摘要
目的分析妊娠期高血压患者随机尿微量蛋白/肌酐比值(ACR)与母婴妊娠结局的相关性。方法以广州市花都区妇幼保健院2015年8月~2017年7月收治的86例妊娠期高血压患者作为观察对象,均进行随机尿微量蛋白、肌酐的检测,后计算ACR。根据ACR水平对患者进行分组,其中≤30mg/mmol的45例为甲组,而>30mg/mmol的41例则为乙组。对比两组一般情况及不良妊娠结局。结果两组年龄及产次差异无统计学意义(P>0.05);乙组血压明显高于甲组(P<0.05);乙组终止妊娠时间较甲组早(P<0.05);乙组不良妊娠结局发生率明显高于甲组(P<0.05)。结论随机ACR与妊娠期高血压患者不良妊娠结局具有一定的关系,对其进行检测有助于临床快速、方便的评估和判断患者的病情情况。
Objective To analyze the relationship between random urinary microalbumin/creatinine ratio(ACR) and pregnancy outcome in the patients with hypertensive disorder complicating pregnancy. Methods From August 2015 to July 2017, 86 cases of hypertensive disorder complicating pregnancy in Huadu District Maternal and Child Health Care Hospital of Guangzhou City were selected as the observation subjects, all their random urinary microalbumin, creatinine were detected, urinary ACR was then calculated. According to the level of ACR, 45 patients with ACR ≤ 30 mg/mmol were divided into the group A, 41 cases with ACR > 30 mg/mmol in the group B, the normal condition and adverse pregnancy outcome of two groups were compared. Results There were no significant difference in age and delivery between the two groups(P > 0.05). The blood pressure in the group B was significantly higher than that in the group A(P < 0.05). The termination time of pregnancy in the group B was earlier than that in the group A(P < 0.05). The incidence of adverse pregnancy outcome in the group B was significantly higher than that in group A(P < 0.05). Conclusion There is a certain relationship between random ACR and adverse pregnancy outcome in the patients with hypertensive disorder complicating pregnancy. It is helpful to evaluate and judge the patient's condition quickly and conveniently.
Objective To analyze the relationship between random urinary microalbumin/creatinine ratio(ACR) and pregnancy outcome in the patients with hypertensive disorder complicating pregnancy. Methods From August 2015 to July 2017, 86 cases of hypertensive disorder complicating pregnancy in Huadu District Maternal and Child Health Care Hospital of Guangzhou City were selected as the observation subjects, all their random urinary microalbumin, creatinine were detected, urinary ACR was then calculated. According to the level of ACR, 45 patients with ACR ≤ 30 mg/mmol were divided into the group A, 41 cases with ACR > 30 mg/mmol in the group B, the normal condition and adverse pregnancy outcome of two groups were compared. Results There were no significant difference in age and delivery between the two groups(P > 0.05). The blood pressure in the group B was significantly higher than that in the group A(P < 0.05). The termination time of pregnancy in the group B was earlier than that in the group A(P < 0.05). The incidence of adverse pregnancy outcome in the group B was significantly higher than that in group A(P < 0.05). Conclusion There is a certain relationship between random ACR and adverse pregnancy outcome in the patients with hypertensive disorder complicating pregnancy. It is helpful to evaluate and judge the patient's condition quickly and conveniently.
引文
[1]邓瀚.妊娠期高血压危险因素及其对妊娠结局的影响[J].宁夏医科大学学报,2013,35(8):931-933.
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[5]阴红,高云飞,何淑明,等.随机尿白蛋白/肌酐比值对妊娠期高血压疾病的预测价值[J].实用医学杂志,2015,31(9):1441-1443.
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[8]陈静静.硝苯吡啶联合硫酸镁治疗对妊娠期高血压疾病患者血压值、妊娠相关蛋白A及血管内皮生长因子的影响[J].中国妇幼保健,2017,32(18):4373-4376.
[9]成丽,黄群敏.血清TGF-B1和尿微量白蛋白在妊娠高血压早期肾损害诊断中的意义[J].中国妇幼健康研究,2016,27(8):968-970.
[10]杨昱,钟群英,陈瑞坚.肾素-血管紧张素-醛固酮系统与妊娠高血压病的关系[J].中国医药科学,2016,6(8):20-22.
[11]周俏苗,郑海玲.尿微量白蛋白与妊娠期高血压疾病早期肾损伤的关系研究[J].海南医学,2014,25(21):3188-3190.
[12]徐静,刘晓丹,王克俊.ACR水平在妊娠高血压患者中的检测价值[J].海南医学,2016,27(13):2195-2196.
[13]Shivamurthy HM,Praveen Kumar KS.Comparison of protein/creatinine ratio in Single voided urine sample with 24 hours Urine protein for estimation of proteinuria in pregnancy induced hypertension[J].Medica Innovatica,2016,59(5):424-426..
[14]龚洵,杨美桃,刘海意,等.子痫前期患者24h尿蛋白定量与妊娠结局的相关性[J].新乡医学院学报,2017,34(9):808-812.
[15]张军,余文洪,樊小利,等.尿白蛋白肌酐比值与妊娠期高血压疾病严重程度关系[J].现代仪器与医疗,2017,23(3):80-81.
[16]阴红,钟梅.随机尿白蛋白/肌酐比值在妊娠期高血压疾病中的诊断价值[J].天津医药,2015,43(7):777-780.
[2]龚源,陈晓辉,张纯萍.妊娠相关血浆蛋白A与妊娠高血压综合征的相关性研究[J].海南医学,2016,27(6):994-995,996.
[3]Buurma AJ,Turner RJ,Driessen JH,et a1.Genetic variants in preeclampsia:a meta-analysis[J].Hum Reprod Update,2013,19(3):289-303.
[4]Nielsen LH,Ovesen P,Hansen MR,et a1.Changes in the renin-angiotensin-aldosterone system in response to dietary salt intake in normal and hypertensive pregnancy.A randomized trial[J].J Am Soc Hypertens,2016,10(11):881-890.
[5]阴红,高云飞,何淑明,等.随机尿白蛋白/肌酐比值对妊娠期高血压疾病的预测价值[J].实用医学杂志,2015,31(9):1441-1443.
[6]乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2008:92.
[7]李佳琦,李兰,吴继蓉.妊娠高血压患者血压变异性与尿微量白蛋白关系的研究[J].中国妇幼健康研究,2017,28(6):681-683.
[8]陈静静.硝苯吡啶联合硫酸镁治疗对妊娠期高血压疾病患者血压值、妊娠相关蛋白A及血管内皮生长因子的影响[J].中国妇幼保健,2017,32(18):4373-4376.
[9]成丽,黄群敏.血清TGF-B1和尿微量白蛋白在妊娠高血压早期肾损害诊断中的意义[J].中国妇幼健康研究,2016,27(8):968-970.
[10]杨昱,钟群英,陈瑞坚.肾素-血管紧张素-醛固酮系统与妊娠高血压病的关系[J].中国医药科学,2016,6(8):20-22.
[11]周俏苗,郑海玲.尿微量白蛋白与妊娠期高血压疾病早期肾损伤的关系研究[J].海南医学,2014,25(21):3188-3190.
[12]徐静,刘晓丹,王克俊.ACR水平在妊娠高血压患者中的检测价值[J].海南医学,2016,27(13):2195-2196.
[13]Shivamurthy HM,Praveen Kumar KS.Comparison of protein/creatinine ratio in Single voided urine sample with 24 hours Urine protein for estimation of proteinuria in pregnancy induced hypertension[J].Medica Innovatica,2016,59(5):424-426..
[14]龚洵,杨美桃,刘海意,等.子痫前期患者24h尿蛋白定量与妊娠结局的相关性[J].新乡医学院学报,2017,34(9):808-812.
[15]张军,余文洪,樊小利,等.尿白蛋白肌酐比值与妊娠期高血压疾病严重程度关系[J].现代仪器与医疗,2017,23(3):80-81.
[16]阴红,钟梅.随机尿白蛋白/肌酐比值在妊娠期高血压疾病中的诊断价值[J].天津医药,2015,43(7):777-780.