摘要
目的探讨硫酸镁联合拉贝洛尔、硝苯地平控释片治疗妊娠合并高血压的效果。方法选择2017年6月~2018年12月期间我院收治的妊娠合并高血压患者中随机抽取60例为研究对象,并将其随机分为两组,对照组患者接受硫酸镁+拉贝洛尔进行治疗,观察组患者予以硫酸镁+拉贝洛尔+硝苯地平控释片进行治疗。通过观察两组患者临床治疗有效率及治疗前后血压变化效果等方面的差异,判定二者的治疗效果。结果观察组患者治疗有效率高于对照组(93.33%vs 66.67%,χ2=11.924,P=0.001)。观察组治疗后收缩压、舒张压水平显著低于对照组,且24 h蛋白尿定量水平、脐动脉阻力指数等指标改善效果均显著优于对照组,差异有统计学意义(P<0.05)。结论硫酸镁联合拉贝洛尔、硝苯地平治疗妊娠合并高血压疗效显著,能够有效平衡患者血压水平,控制24 h尿蛋白定量,安全性高,值得推广。
Objective To investigate the effect of magnesium sulfate combined with labetalol and nifedipine controlled release tablets in the treatment of pregnancy complicated with hypertension. Methods A total of 60 patients with pregnancy complicated with hypertension admitted in our hospital from June 2017 to December 2018 were randomly divided into two groups. The control group received magnesium sulfate +labetalol. Patients in the observation group were treated with magnesium sulfate+labetalol+nifedipine controlled release tablets. The therapeutic effects of the two groups were determined by observing the difference between the clinical treatment efficiency of the two groups of patients and the effects of blood pressure changes before and after treatment. Results The effective rate of treatment in the observation group was higher than that in the control group(93.33% vs 66.67%, χ2=11.924, P=0.001). The systolic blood pressure and diastolic blood pressure levels in the observation group were significantly lower than those in the control group, and the improvement effect of 24 h proteinuria and umbilical artery resistance index in the observation group was significantly better than that of control group, and the difference was statistically significant(P<0.05). Conclusion Magnesium sulfate combined with labetalol and nifedipine is significantly effective in the treatment of pregnancy complicated with hypertension. It can effectively balance the blood pressure level of patients and control the 24-hour urine protein quantitation. It is safe and worth promoting.
引文
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