口炎清颗粒联合甲硝唑治疗慢性牙周炎的临床研究
|
摘要
目的探讨口炎清颗粒联合甲硝唑片治疗慢性牙周炎的临床疗效。方法选取2017年4月—2018年7月秦皇岛市第二医院收治的慢性牙周炎患者120例作为研究对象,按照随机数字表法分为对照组和治疗组,每组各有60例。对照组口服甲硝唑片,0.6 g/次,3次/d。治疗组在对照组治疗的基础上口服口炎清颗粒,10 g/次,2次/d。两组患者连续治疗4周。观察两组的临床疗效,比较两组的牙周指标和炎症因子。结果治疗后,对照组、治疗组的总有效率分别为80.00%、91.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组的牙周袋深度(PD)、附着丧失水平(AL)、龈沟出血指数(SBI)、菌斑指数(PLI)均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组的PD、AL、SBI、PLI明显低于对照组,两组差异有统计学意义(P<0.05)。治疗后,两组的高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组的炎症因子水平均明显低于对照组,两组差异有统计学意义(P<0.05)。结论口炎清颗粒联合甲硝唑片治疗慢性牙周炎具有较好的疗效,可改善牙周症状,降低炎症因子的水平,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Kouyanqing Granules combined with Metronidazole Tablets in treatment of chronic periodontitis. Methods Patients(120 cases) with chronic periodontitis in the Second Hospital of Qinhuangdao from April2017 to July 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Metronidazole Tablets, 0.6 g/time, three times daily. Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes and inflammatory factors in two group were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 91.67%, respectively,and there was difference between two groups(P < 0.05). After treatment, PD, AL, SBI, and PLI in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of hs-CRP, TNF-α, IL-6, and IL-1β in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Kouyanqing Granules combined with Metronidazole Tablets has clinical curative effect in treatment of chronic periodontitis, can improve periodontal symptoms, and reduce the level of inflammatory factors, which has a certain clinical application value.
Objective To investigate the clinical efficacy of Kouyanqing Granules combined with Metronidazole Tablets in treatment of chronic periodontitis. Methods Patients(120 cases) with chronic periodontitis in the Second Hospital of Qinhuangdao from April2017 to July 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Metronidazole Tablets, 0.6 g/time, three times daily. Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes and inflammatory factors in two group were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 91.67%, respectively,and there was difference between two groups(P < 0.05). After treatment, PD, AL, SBI, and PLI in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of hs-CRP, TNF-α, IL-6, and IL-1β in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Kouyanqing Granules combined with Metronidazole Tablets has clinical curative effect in treatment of chronic periodontitis, can improve periodontal symptoms, and reduce the level of inflammatory factors, which has a certain clinical application value.
引文
[1]欧阳翔英,曹采方,Henry Liu,等.不同程度慢性牙周炎患者病情的二年自然进展[J].中华口腔医学杂志,2004,39(3):193-196.
[2]刘继华,刘卫锋,闫慧鑫,等.阿莫西林联合甲硝唑治疗慢性牙周炎疗效评价[J].西南国防医药,2016,26(11):98-100.
[3]王春玉.中药独家品种白云山口炎清颗粒成功入选2012年版《国家基本药物目录》[J].中国中医药信息杂志,2013,20(4):96.
[4]孟焕新.牙周病学[M].第3版.北京:人民卫生出版社,2008:119-123.
[5]孙传兴.临床疾病诊断依据治愈好转标准[M].第2版.北京:人民军医出版社,1998:638.
[6]李德懿,富饶,赵隽隽,等.龋齿、牙周炎患牙和健康牙的菌斑生物膜特征[J].口腔医学,2005,25(3):129-131.
[7]刘宇,隋强,姚万俊,等.甲硝唑和替硝唑缓释药膜对慢性牙周炎的疗效[J].解放军药学学报,2011,27(2):161-163.
[8]杨静,辛自芳,胡江东.辨证论治慢性牙周炎86例[J].西部中医药,2017,30(9):93-95.
[9]姚小华,黄竹英,文殊,等.口炎清颗粒调整菌群失调有效组分的研究[J].中国微生态学杂志,2012,24(11):984-986,991.
[10]龚芸,张丽,冯泽会,等.口炎清颗粒防治鼻咽癌患者放射性口腔炎的疗效观察[J].华西口腔医学杂志,2016,34(1):37-40.
[11]张凤秋,吴织芬,万玲.牙周优势菌内毒素的生物学活性及与牙周炎相关的发病机制[J].牙体牙髓牙周病学杂志,2003,13(3):166-169.
[12]罗志晓,解晓琴,周作华,等.慢性牙周炎和冠心病患者血清CRP、s ICAM-1水平的研究[J].临床口腔医学杂志,2009,25(11):660-662.
[13]刘荣坤,曹采方,孟焕新,等.TNF-α及IL-1β与多形核白细胞在牙周炎症组织中浸润的关系[J].中华口腔医学杂志,2000,35(5):327-329.
[14]林梅,张冬雪,刘志强,等.慢性牙周炎患者血清IL-33、TNF-α、IL-6的检测及意义[J].首都医科大学学报,2016,37(3):255-259.
[15]蒲玉梅,高静,吴文蕾,等.IL-6在牙周炎中的作用及其调控因素[J].牙体牙髓牙周病学杂志,2005,15(3):176-180.
[2]刘继华,刘卫锋,闫慧鑫,等.阿莫西林联合甲硝唑治疗慢性牙周炎疗效评价[J].西南国防医药,2016,26(11):98-100.
[3]王春玉.中药独家品种白云山口炎清颗粒成功入选2012年版《国家基本药物目录》[J].中国中医药信息杂志,2013,20(4):96.
[4]孟焕新.牙周病学[M].第3版.北京:人民卫生出版社,2008:119-123.
[5]孙传兴.临床疾病诊断依据治愈好转标准[M].第2版.北京:人民军医出版社,1998:638.
[6]李德懿,富饶,赵隽隽,等.龋齿、牙周炎患牙和健康牙的菌斑生物膜特征[J].口腔医学,2005,25(3):129-131.
[7]刘宇,隋强,姚万俊,等.甲硝唑和替硝唑缓释药膜对慢性牙周炎的疗效[J].解放军药学学报,2011,27(2):161-163.
[8]杨静,辛自芳,胡江东.辨证论治慢性牙周炎86例[J].西部中医药,2017,30(9):93-95.
[9]姚小华,黄竹英,文殊,等.口炎清颗粒调整菌群失调有效组分的研究[J].中国微生态学杂志,2012,24(11):984-986,991.
[10]龚芸,张丽,冯泽会,等.口炎清颗粒防治鼻咽癌患者放射性口腔炎的疗效观察[J].华西口腔医学杂志,2016,34(1):37-40.
[11]张凤秋,吴织芬,万玲.牙周优势菌内毒素的生物学活性及与牙周炎相关的发病机制[J].牙体牙髓牙周病学杂志,2003,13(3):166-169.
[12]罗志晓,解晓琴,周作华,等.慢性牙周炎和冠心病患者血清CRP、s ICAM-1水平的研究[J].临床口腔医学杂志,2009,25(11):660-662.
[13]刘荣坤,曹采方,孟焕新,等.TNF-α及IL-1β与多形核白细胞在牙周炎症组织中浸润的关系[J].中华口腔医学杂志,2000,35(5):327-329.
[14]林梅,张冬雪,刘志强,等.慢性牙周炎患者血清IL-33、TNF-α、IL-6的检测及意义[J].首都医科大学学报,2016,37(3):255-259.
[15]蒲玉梅,高静,吴文蕾,等.IL-6在牙周炎中的作用及其调控因素[J].牙体牙髓牙周病学杂志,2005,15(3):176-180.