掺杂低含量SiO_2对激光熔覆CaP生物陶瓷涂层性能的影响
|
摘要
为提高医用TC4钛合金表面熔覆羟基磷灰石(HA)涂层的植入稳定性和生物活性,采用激光熔覆方法制备出不同含硅量的CaP生物陶瓷涂层。利用扫描电子显微镜(SEM)和X射线衍射仪(XRD)表征了熔覆层组织形貌和物相组成。结果表明:添加SiO_2(1wt.%、3wt.%)后形成Ca_2SiO_4相,熔覆层中部组织细化。通过电化学腐蚀和体外SBF浸泡实验研究了SiO_2含量对涂层耐腐蚀性和生物活性的影响。电化学腐蚀结果表明:随着SiO_2含量的增大,涂层表面腐蚀电流密度逐渐减小;体外SBF浸泡结果表明:添加SiO_2可以加快涂层表面类骨磷灰石的形成,其中,添加SiO_2为1wt.%时涂层表面类骨磷灰石呈均匀分布。因此,低含量SiO_2可以提高生物陶瓷涂层的耐腐蚀性和生物活性。
To improve the implantation stability and biological activity of the hydroxyapatite(HA) coating on the surface of medical TC4 titanium alloy, CaP bioceramic coating with different silicon contents were prepared by laser cladding method. Scanning electron microscopy(SEM) and X-ray diffractometry(XRD)were used to characterize the morphology and phase composition of the cladding layer. The results showed that the Ca_2SiO_4 phase was formed and the microstructure of the middle zone of the cladding layer was refined after adding SiO_2(1 wt.%, 3 wt.%). The effects of SiO_2 content on the corrosion resistance and bioactivity of the coating were investigated by electrochemical corrosion and in vitro SBF immersion experiments. Electrochemical corrosion results showed that the corrosion current density of the coating surface decreased with the increase of SiO_2 content; The results of SBF soaking in vitro showed that the addition of SiO_2 could accelerate the formation of bone-like apatite on the surface of the coating.When the content SiO_2 was 1 wt.%, the surface of the coating-like bone apatite was uniformly distributed.Therefore, low-content SiO_2 can improve the corrosion resistance and bioactivity of bioceramic coatings.
To improve the implantation stability and biological activity of the hydroxyapatite(HA) coating on the surface of medical TC4 titanium alloy, CaP bioceramic coating with different silicon contents were prepared by laser cladding method. Scanning electron microscopy(SEM) and X-ray diffractometry(XRD)were used to characterize the morphology and phase composition of the cladding layer. The results showed that the Ca_2SiO_4 phase was formed and the microstructure of the middle zone of the cladding layer was refined after adding SiO_2(1 wt.%, 3 wt.%). The effects of SiO_2 content on the corrosion resistance and bioactivity of the coating were investigated by electrochemical corrosion and in vitro SBF immersion experiments. Electrochemical corrosion results showed that the corrosion current density of the coating surface decreased with the increase of SiO_2 content; The results of SBF soaking in vitro showed that the addition of SiO_2 could accelerate the formation of bone-like apatite on the surface of the coating.When the content SiO_2 was 1 wt.%, the surface of the coating-like bone apatite was uniformly distributed.Therefore, low-content SiO_2 can improve the corrosion resistance and bioactivity of bioceramic coatings.
引文
[1] Legeros R Z. Calcium phosphates in oral biology and medicine[J]. Monogr Oral Sci, 1991, 15(15):1-201.
[2] Kumari R, Majumdar J D. Wear behavior of plasma spray deposited and post heat-treated hydroxyapatite(HA)-based composite coating on titanium alloy(Ti-6Al-4V)substrate[J]. Metallurgical&Materials Transactions A, 2018, 49(7):3122-3132.
[3] Yong-Hoon Jeong, Han-Cheol Choe, William A Brantley.Hydroxyapatite-silicon film deposited on Ti-Nb-10Zr by electrochemical and magnetron sputtering method[J]. Thin Solid Films, 2016, 620:114-118.
[4] Rajesh P, Muraleedharan C V, Komath M, et al. Pulsed laser deposition of hydroxyapatite on titanium substrate with titania interlayer[J]. Journal of Materials Science Materials in Medicine, 2011, 22(3):497-505.
[5] Sun Chuguang, Liu Junhuan, Chen Zhiyong, et al. Cladding bio-ceramic coatings of low SiO2-HA on the surface of titanium alloy[J]. Infrared and Laser Engineering, 2018, 47(3):0306003.(in Chinese)
[6] Fujishiro Y, Hench L L, Oonishi H. Quantitative rates of in vivo bone generation for Bioglass and hydroxyapatite particles as bone graft substitute.[J]. Journal of Materials Science Materials in Medicine, 1997, 8(11):649-652.
[7] Zhou X, Zhang N, Mankoci S, et al. Silicates in Orthopaedics and Bone Tissue Engineering Materials[J].Journal of Biomedical Materials Research Part A, 2017,105(7):2090-2102.
[8] Morks M F, Fahim N F, Kobayashi A. Structure, mechanical performance and electrochemical characterization of plasma sprayed SiO2/Ti-reinforced hydroxyapatite biomedical coatings[J]. Applied Surface Science, 2008, 255(5):3426-3433.
[9] Morks M F. Fabrication and characterization of plasmasprayed HA/SiO2coatings for biomedical application[J].Journal of the Mechanical Behavior of Biomedical Materials, 2008, 1(1):105-111.
[10] Yang Y L, Paital S R, Dahotre N B. Wetting and bioactivity of laser processed Ca P coating with presence and variation of SiO2on Ti-6Al-4V[J]. Materials Technology, 2013, 25(3-4):137-142.
[11] Yang Y, Serpersu K, He W, et al. Osteoblast interaction with laser cladded HA and SiO2-HA coatings on Ti-6Al-4V[J].Materials Science&Engineering C, 2011, 31(8):1643-1652.
[12] Douard N, Detsch R, Chotard-Ghodsnia R, et al. Processing,physico-chemical characterisation and in vitro, evaluation of silicon containingβ-tricalcium phosphate ceramics[J].Materials Science&Engineering C, 2011, 31(3):531-539.
[13] Seaborn C D, Nielsen F H. Effects of germanium and silicon on bone mineralization[J]. Biological Trace Element Research, 1994, 42(2):151-164.
[14] Hing K A, Revell P A, Smith N, et al. Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds[J].Biomaterials, 2006, 27(29):5014-5026.
[15] Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity?[J]. Biomaterials, 2006, 27(15):2907-2915.
[16] Wang W, Wang M, Jie Z, et al. Research on the microstructure and wear resistance of titanium alloy structural members repaired by laser cladding[J]. Optics&Lasers in Engineering, 2008, 46(11):810-816.
[17] Liao C J, Lin F H, Chen K S, et al. Thermal decomposition and reconstitution of hydroxyapatite in air atmosphere[J].Biomed Sci Instrum, 1999, 35(19):99-104.
[18] Zhang X L, Jiang Z H, Yao Z P, et al. Effects of scan rate on the potentiodynamic polarization curve obtained to determine the Tafel slopes and corrosion current density[J].Corrosion Science, 2009, 51(3):581-587.
[19] Dehghanian C, Aboudzadeh N, Shokrgozar M A.Characterization of silicon-substituted nano hydroxyapatite coating on magnesium alloy for biomaterial application[J].Materials Chemistry&Physics, 2017, 203:27-33.
[20] Ramakrishna S, Ramalingam M, Kumar T S S, et al.Biomaterials:A Nano Approach[M]. Boca Raton, Florida,CRC Press, 2010.
[21] Zubair M A, Leach C. The effect of SiO2addition on the development of low-Σgrain boundaries in PTC thermistors[J]. Journal of the European Ceramic Society, 2010, 30(1):107-112.
[2] Kumari R, Majumdar J D. Wear behavior of plasma spray deposited and post heat-treated hydroxyapatite(HA)-based composite coating on titanium alloy(Ti-6Al-4V)substrate[J]. Metallurgical&Materials Transactions A, 2018, 49(7):3122-3132.
[3] Yong-Hoon Jeong, Han-Cheol Choe, William A Brantley.Hydroxyapatite-silicon film deposited on Ti-Nb-10Zr by electrochemical and magnetron sputtering method[J]. Thin Solid Films, 2016, 620:114-118.
[4] Rajesh P, Muraleedharan C V, Komath M, et al. Pulsed laser deposition of hydroxyapatite on titanium substrate with titania interlayer[J]. Journal of Materials Science Materials in Medicine, 2011, 22(3):497-505.
[5] Sun Chuguang, Liu Junhuan, Chen Zhiyong, et al. Cladding bio-ceramic coatings of low SiO2-HA on the surface of titanium alloy[J]. Infrared and Laser Engineering, 2018, 47(3):0306003.(in Chinese)
[6] Fujishiro Y, Hench L L, Oonishi H. Quantitative rates of in vivo bone generation for Bioglass and hydroxyapatite particles as bone graft substitute.[J]. Journal of Materials Science Materials in Medicine, 1997, 8(11):649-652.
[7] Zhou X, Zhang N, Mankoci S, et al. Silicates in Orthopaedics and Bone Tissue Engineering Materials[J].Journal of Biomedical Materials Research Part A, 2017,105(7):2090-2102.
[8] Morks M F, Fahim N F, Kobayashi A. Structure, mechanical performance and electrochemical characterization of plasma sprayed SiO2/Ti-reinforced hydroxyapatite biomedical coatings[J]. Applied Surface Science, 2008, 255(5):3426-3433.
[9] Morks M F. Fabrication and characterization of plasmasprayed HA/SiO2coatings for biomedical application[J].Journal of the Mechanical Behavior of Biomedical Materials, 2008, 1(1):105-111.
[10] Yang Y L, Paital S R, Dahotre N B. Wetting and bioactivity of laser processed Ca P coating with presence and variation of SiO2on Ti-6Al-4V[J]. Materials Technology, 2013, 25(3-4):137-142.
[11] Yang Y, Serpersu K, He W, et al. Osteoblast interaction with laser cladded HA and SiO2-HA coatings on Ti-6Al-4V[J].Materials Science&Engineering C, 2011, 31(8):1643-1652.
[12] Douard N, Detsch R, Chotard-Ghodsnia R, et al. Processing,physico-chemical characterisation and in vitro, evaluation of silicon containingβ-tricalcium phosphate ceramics[J].Materials Science&Engineering C, 2011, 31(3):531-539.
[13] Seaborn C D, Nielsen F H. Effects of germanium and silicon on bone mineralization[J]. Biological Trace Element Research, 1994, 42(2):151-164.
[14] Hing K A, Revell P A, Smith N, et al. Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds[J].Biomaterials, 2006, 27(29):5014-5026.
[15] Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity?[J]. Biomaterials, 2006, 27(15):2907-2915.
[16] Wang W, Wang M, Jie Z, et al. Research on the microstructure and wear resistance of titanium alloy structural members repaired by laser cladding[J]. Optics&Lasers in Engineering, 2008, 46(11):810-816.
[17] Liao C J, Lin F H, Chen K S, et al. Thermal decomposition and reconstitution of hydroxyapatite in air atmosphere[J].Biomed Sci Instrum, 1999, 35(19):99-104.
[18] Zhang X L, Jiang Z H, Yao Z P, et al. Effects of scan rate on the potentiodynamic polarization curve obtained to determine the Tafel slopes and corrosion current density[J].Corrosion Science, 2009, 51(3):581-587.
[19] Dehghanian C, Aboudzadeh N, Shokrgozar M A.Characterization of silicon-substituted nano hydroxyapatite coating on magnesium alloy for biomaterial application[J].Materials Chemistry&Physics, 2017, 203:27-33.
[20] Ramakrishna S, Ramalingam M, Kumar T S S, et al.Biomaterials:A Nano Approach[M]. Boca Raton, Florida,CRC Press, 2010.
[21] Zubair M A, Leach C. The effect of SiO2addition on the development of low-Σgrain boundaries in PTC thermistors[J]. Journal of the European Ceramic Society, 2010, 30(1):107-112.