卡前列甲酯栓与卡前列素氨丁三醇联合缩宫素对瘢痕子宫剖宫产患者产后出血的影响
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摘要
目的探讨卡前列甲酯栓与卡前列素氨丁三醇联合缩宫素对瘢痕子宫剖宫产患者产后出血的影响。方法选取2016年1月至2017年12月于本院行剖宫产的104例瘢痕子宫患者为研究对象,采用随机数表法分为两组,各52例。对照组应用卡前列甲酯栓联合缩宫素进行产后出血预防治疗,观察组则应用卡前列素氨丁三醇联合缩宫素进行产后出血预防治疗。观察两组产后出血情况,并对比两组术后不良反应发生率。结果产后2 h、24 h,观察组患者阴道出血量均低于对照组,差异有统计学意义(P<0.05);产后24 h,观察组头痛、寒战、面部潮红、恶心呕吐、腹泻等总发生率低于对照组,差异有统计学意义(P<0.05)。结论在瘢痕子宫剖宫产患者中应用卡前列素氨丁三醇联合缩宫素效果好于卡前列甲酯栓联合缩宫素,可减少产后出血量,且安全性高。
Objective To investigate the effect of carboprostol and carboprost tromethamine combined with oxytocin on postpartum hemorrhage in patients with cesarean section of scar. Methods A total of 104 patients with scar uterus who underwent cesarean section from January 2016 to December 2017 were enrolled in the study. They were randomly divided into two groups, 52 cases each. The control group was treated with carboprostol suppository combined with oxytocin for postpartum hemorrhage prevention and treatment. The observation group was treated with carprostol tromethamine combined with oxytocin for postpartum hemorrhage prevention and treatment. The postpartum hemorrhage in the two groups was observed and the incidence of postoperative adverse reactions was compared between the two groups. Results The vaginal bleeding volume of the observation group was lower than that of the control group at 2 h and 24 h postpartum, the difference was statistically significant(P<0.05). At 24 h postpartum, the total incidence of headache, chills, facial flushing, nausea and vomiting, diarrhea was low. In the control group, the difference was statistically significant(P<0.05). Conclusion The application of carprostol tromethamine combined with oxytocin in patients with cesarean section of scar uterus is better than carprostol suppository combined with oxytocin, which can reduce the amount of postpartum hemorrhage and is safe.
Objective To investigate the effect of carboprostol and carboprost tromethamine combined with oxytocin on postpartum hemorrhage in patients with cesarean section of scar. Methods A total of 104 patients with scar uterus who underwent cesarean section from January 2016 to December 2017 were enrolled in the study. They were randomly divided into two groups, 52 cases each. The control group was treated with carboprostol suppository combined with oxytocin for postpartum hemorrhage prevention and treatment. The observation group was treated with carprostol tromethamine combined with oxytocin for postpartum hemorrhage prevention and treatment. The postpartum hemorrhage in the two groups was observed and the incidence of postoperative adverse reactions was compared between the two groups. Results The vaginal bleeding volume of the observation group was lower than that of the control group at 2 h and 24 h postpartum, the difference was statistically significant(P<0.05). At 24 h postpartum, the total incidence of headache, chills, facial flushing, nausea and vomiting, diarrhea was low. In the control group, the difference was statistically significant(P<0.05). Conclusion The application of carprostol tromethamine combined with oxytocin in patients with cesarean section of scar uterus is better than carprostol suppository combined with oxytocin, which can reduce the amount of postpartum hemorrhage and is safe.
引文
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[9]和旭华,范晶晶,李艳霞.缩宫素卡前列甲酯栓及卡前列素氨丁三醇注射液治疗宫缩乏力性产后出血的临床观察[J].中国药物与临床,2018,18(2):239-240.
[10]刘洁,王本昀.欣母沛防治高危剖宫产孕妇产后出血的疗效分析[J].中国妇幼保健,2016,31(4):873-874.
[11]冯朝霞.欣母沛联合宫腔填纱治疗前置胎盘剖宫产产后出血的应用效果研究[J].当代医学,2018,24(33):57-59.
[12]汪枫红,王天成.剖宫产后瘢痕子宫再次妊娠分娩方式选择及安全性分析[J].临床军医杂志,2018,46(1):79-80,83.
[13]罗红玉.瘢痕子宫妊娠分娩时机及分娩方式的选择[J].当代医学,2018,24(36):152-154.
[2]李莉,刘媛媛,邹佑军.卡前列甲酯栓联合缩宫素对瘢痕子宫剖宫产患者产后出血的影响[J].中国计划生育和妇产科,2017,9(2):33-35.
[3]方芳,刘志茹,刘清.卡前列素氨丁三醇预防瘢痕子宫阴道分娩产后出血的效果及其对凝血功能的影响[J].实用临床医药杂志,2017,21(15):142-143.
[4]高涛,马锦琪,荣琴英,等.卡孕栓在预防和治疗剖宫产产后出血及术后恢复中的临床疗效观察[J].中国妇幼保健,2017,32(1):18-20.
[5]陈淑红,贾晓玲,吴冬梅,等.瘢痕子宫剖宫产术后置冰袋并加压法防治产后出血临床研究[J].陕西医学杂志,2018,47(2):174-176.
[6]吕志莲.卡孕栓与缩宫素应用于剖宫产术后的临床观察[J].中国药物与临床,2016,16(7):1044-1045.
[7]吴平,宫美娟.卡前列甲酯栓联合缩宫素预防瘢痕子宫剖宫产产后出血80例临床观察[J].临床军医杂志,2015,43(4):421-422.
[8]林笑丹.卡前列甲酯栓联合缩宫素预防瘢痕子宫患者剖宫产术后出血效果观察[J].中国基层医药,2015,22(3):329-331.
[9]和旭华,范晶晶,李艳霞.缩宫素卡前列甲酯栓及卡前列素氨丁三醇注射液治疗宫缩乏力性产后出血的临床观察[J].中国药物与临床,2018,18(2):239-240.
[10]刘洁,王本昀.欣母沛防治高危剖宫产孕妇产后出血的疗效分析[J].中国妇幼保健,2016,31(4):873-874.
[11]冯朝霞.欣母沛联合宫腔填纱治疗前置胎盘剖宫产产后出血的应用效果研究[J].当代医学,2018,24(33):57-59.
[12]汪枫红,王天成.剖宫产后瘢痕子宫再次妊娠分娩方式选择及安全性分析[J].临床军医杂志,2018,46(1):79-80,83.
[13]罗红玉.瘢痕子宫妊娠分娩时机及分娩方式的选择[J].当代医学,2018,24(36):152-154.