~(18)F-氟代脱氧葡萄糖正电子发射断层成像/CT在噬血细胞综合征中的临床价值
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摘要
目的探讨~(18)F-氟代脱氧葡萄糖正电子发射断层成像/CT(~(18)F-FDG PET/CT)在噬血细胞综合征(HPS)中的应用价值。方法回顾性分析38例HPS患者的实验室指标及~(18)F-FDG PET/CT显像资料,并收集50例同期行健康体检者为对照组。比较两组研究对象肝脏、脾脏及骨骼的最大标准化摄取值(SUVmax),并分析HPS患者的肝脏、脾脏及骨骼SUVmax与实验室指标的相关性。结果两组研究对象的肝脏、脾脏及骨骼SUVmax比较,差异均具有统计学意义(均P <0. 05)。38例HPS患者~(18)F-FDG PET/CT显像特征均为肝脾肿大并葡萄糖代谢增高,但骨骼未见骨质破坏。HPS患者肝脏、脾脏及骨骼SUVmax与血清铁蛋白含量均呈正相关(均P <0. 05)。结论 ~(18)F-FDG PET/CT在HPS的诊断中具有一定的临床应用价值。
Objective To explore the clinical value of ~(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(~(18)F-FDG PET/CT) in hemophagocytic syndrome( HPS). Methods Laboratory parameters and ~(18)F-FDG PET/CT imaging data of 38 patients with HPS were analyzed retrospectively,with 50 healthy examinees at the same period as the control group. Maximum standardized uptake value( SUVmax) of liver,spleen and bone were compared between the two groups,and correlation between laboratory parameters and SUVmax of liver,spleen,and bone in patients with HPS was analyzed. Results There were statistically significant differences in SUVmax of liver,spleen and bone between the two groups( all P < 0. 05).~(18)F-FDG PET/CT imaging of 38 patients with HPS featured hepatosplenomegaly with increased glucose metabolism,increasing glucose metabolism in bone marrow,but with no bone destruction. There was a positive correlation between the SUVmax of liver,spleen,bone and serum ferritin content in patients with HPS( all P < 0. 05). Conclusion ~(18)F-FDG PET/CT has certain clinical application value in the diagnosis of HPS.
Objective To explore the clinical value of ~(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(~(18)F-FDG PET/CT) in hemophagocytic syndrome( HPS). Methods Laboratory parameters and ~(18)F-FDG PET/CT imaging data of 38 patients with HPS were analyzed retrospectively,with 50 healthy examinees at the same period as the control group. Maximum standardized uptake value( SUVmax) of liver,spleen and bone were compared between the two groups,and correlation between laboratory parameters and SUVmax of liver,spleen,and bone in patients with HPS was analyzed. Results There were statistically significant differences in SUVmax of liver,spleen and bone between the two groups( all P < 0. 05).~(18)F-FDG PET/CT imaging of 38 patients with HPS featured hepatosplenomegaly with increased glucose metabolism,increasing glucose metabolism in bone marrow,but with no bone destruction. There was a positive correlation between the SUVmax of liver,spleen,bone and serum ferritin content in patients with HPS( all P < 0. 05). Conclusion ~(18)F-FDG PET/CT has certain clinical application value in the diagnosis of HPS.
引文
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[11]杨文平,李天女,李洋洋,等.淋巴瘤相关噬血细胞综合征18F-FDG PET/CT显像特征及其影响预后的因素[J].江苏医药,2016,42(4):431-434.
[2] Ramos-Casals M,Brito-Zerón P,López-Guillermo A,et al.Adult haemophagocytic syndrome[J]. Lancet,2014,383(9 927):1 503-1 516.
[3] Tothova Z,Berliner N. Hemophagocytic syndrome and critical illness:new insights into diagnosis and management[J].J Intensive Care Med,2015,30(7):401-412.
[4] Hayden A,Park S,Giustini D,et al. Hemophagocytic syndromes(HPSs)including hemophagocytic lymphohisti-ocytosis(HLH)in adults:a systematic scoping review[J].Blood Rev,2016,30(6):411-420.
[5] Henter JI,Horne A,AricóM,et al. HLH-2004:Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis[J]. Pediatr Blood Cancer,2007,48(2):124-131.
[6]周玉兰,张荣艳,李菲.恶性肿瘤相关噬血细胞综合征的研究新进展[J].中国肿瘤临床,2016,43(21):958-961.
[7]丁重阳,刘红宇,郭喆,等. 18F-FDG PET/CT对B细胞淋巴瘤相关噬血细胞综合征患者的临床价值[J].中国实验血液学杂志,2017,25(1):133-137.
[8]王昭,王天有.噬血细胞综合征诊治中国专家共识[J].中华医学杂志,2018,98(2):91-95.
[9]吉婷,匡安仁,尹锐.继发性噬血细胞综合征18FFDGPET/CT显像一例及文献回顾[J].中华核医学与分子影像杂志,2014,34(6):511-512.
[10] Yiu CR,Kao YH,Phipps C,et al. Positron emission tomography fingings in patients with lymphoma-assoicated haemophagocytic syndrome[J]. Singapore Med J,2011,52(7):e156-e159.
[11]杨文平,李天女,李洋洋,等.淋巴瘤相关噬血细胞综合征18F-FDG PET/CT显像特征及其影响预后的因素[J].江苏医药,2016,42(4):431-434.