家兔眼肌及视神经磁共振三维成像序列研究
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摘要
目的探讨家兔眼肌及视神经的磁共振三维成像效果及序列优选。方法对10只健康家兔眼眶应用三维各向同性序列行磁共振成像,序列分别为T_2加权三维双回波稳态进动序列(3D-DESS),T_2加权可变翻转角三维快速自旋回波序列(3D-SPACE),T_1加权三维容积内插式屏气检查序列(3D-VIBE)。总结分析家兔眼肌及视神经在3种三维序列上的成像效果,分析比较3种序列的图像信噪比(SNR)及对比度噪声比(CNR),并对所得图像的家兔眼肌和视神经的显示效果进行评分,选出家兔眼眶结构最佳的磁共振成像序列。结果 3D-DESS的眼肌、视神经SNR与其余两种序列比较,差异有统计学意义(P<0.05);3D-DESS的眼肌、视神经CNR与其余两种序列比较,除了3D-DESS与3D-SPACE的视神经CNR无明显差异(P>0.05),其余差异均有统计学意义(P<0.05);在显示眼肌及视神经效果方面3D-DESS显示的完整度、均匀度、轮廓清晰度显著优于3D-VIBE(P<0.05),除了眼肌完整度及轮廓清晰度以及视神经完整度方面3D-DESS没有显著优于3D-SPACE(P>0.05),其余评分均显著优于3DSPACE(P<0.05)。结论 3种3D成像序列相比较,3D-DESS具有良好的SNR及CNR,可以清楚地显示家兔眼肌和视神经的解剖与走行,可作为家兔眼眶和视神经成像的首选序列。
Objective To analyze the 3D( three-dimensional,3D) MRI features of rabbit extraocular muscle and optic nerve and optimize the imaging sequence. Methods Three-dimensional isotropic sequences,including three-dimensional double-echo steady state( 3D-DESS),3D sampling perfection with application optimized contrasts using different flip angle evolutions( 3D-SPACE),three-dimensional volumetric interpolated breath-hold examination( 3D-VIBE) were performed in the orbits of 10 healthy rabbits. The signal noise ratio( SNR),contrast to noise ratio( CNR) and displaying score of rabbit extraocular muscle and optic nerve were compared among the above three 3D MRI sequences. Results 3D-DESS was significantly superior to 3D-VIBE( P < 0. 05) in SNR and CNR of orbital soft tissue,except for CNR of optic nerve in 3D SPACE( P > 0. 05). There were significant differences in all display scores of rabbit extraocular muscle and optic nerve between 3D-DESS and 3D-VIBE. 3D-DESS was superior to 3D-SPACE in displaying scores of uniformity of extraocular muscle and optic nerve and clarity of the optic nerve. Conclusion Compared with the other two 3D MRI sequences,3D-DESS improves the spatial resolution and contrast resolution of rabbit orbital soft tissues. 3D-DESS is the preferred 3D sequence in rabbit extraocular muscle and optic nerve imaging.
Objective To analyze the 3D( three-dimensional,3D) MRI features of rabbit extraocular muscle and optic nerve and optimize the imaging sequence. Methods Three-dimensional isotropic sequences,including three-dimensional double-echo steady state( 3D-DESS),3D sampling perfection with application optimized contrasts using different flip angle evolutions( 3D-SPACE),three-dimensional volumetric interpolated breath-hold examination( 3D-VIBE) were performed in the orbits of 10 healthy rabbits. The signal noise ratio( SNR),contrast to noise ratio( CNR) and displaying score of rabbit extraocular muscle and optic nerve were compared among the above three 3D MRI sequences. Results 3D-DESS was significantly superior to 3D-VIBE( P < 0. 05) in SNR and CNR of orbital soft tissue,except for CNR of optic nerve in 3D SPACE( P > 0. 05). There were significant differences in all display scores of rabbit extraocular muscle and optic nerve between 3D-DESS and 3D-VIBE. 3D-DESS was superior to 3D-SPACE in displaying scores of uniformity of extraocular muscle and optic nerve and clarity of the optic nerve. Conclusion Compared with the other two 3D MRI sequences,3D-DESS improves the spatial resolution and contrast resolution of rabbit orbital soft tissues. 3D-DESS is the preferred 3D sequence in rabbit extraocular muscle and optic nerve imaging.
引文
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12 Garrity JA,Bahn RS.Pathogenesis of graves ophthalmopathy:implications for prediction prevention and treatment[J].Am J Ophthalmol,2006,142:147-153.
2 Weigel M,Lagreze WA,Lazzaro A,et al.Fast and quantitative highresolution magnetic resonance imaging of the optic nerve at 3.0 tesla[J].Invest Radiol,2006,41:83-86.
3 Lagreze WA,Lazzaro A,Weigel M,et al.Morphometry of the retrobuller human optic nerve:comparison between conventional sonography and ultrafast magnetic resonance sequences[J].Invest Ophthalmol Vis Sci,2007,48:1913-1917.
4 梁申芝,朱豫.兔视神经磁共振成像与大体解剖的对照分析[J].郑州大学学报(医学版),2014,49:857-859.
5 Moriya S,Miki Y,Yokobayashi T,et al.Three-dimensional doubleecho steady-state(3D-DESS)magnetic resonance imaging of the knee:contrast optimization by adjusting flip angle[J].Acta Radiol,2009,50:507-511.
6 邓明,王良,李亮.3.0 T磁共振3D-DESS与3D-SPACE对腰骶神经成像的临床应用价值比较[J].磁共振成像,2015,750-756.
7 李凤鸣.中华眼科学[M].第2版.北京:人民卫生出版社,2005,50.
8 朱豫,宋国祥.兔眼眶结构解剖研究[J].眼科研究,1998,16:124-126.
9 Zhang J,Chen L,Wang QX,et al.Diagnostic performance of the three-dimensional fast spin echo-Cube sequence in comparison with a conventional imaging protocol in evaluation of the lachrymal drainage system[J].Eur Radiol,2015,25:635-643.
10 Zhang J,Chen L,Wang QX,et al.Isotropic three-dimensional fast spin-echo Cube magnetic resonance dacryocystography:comparison with the three-dimensional fast-recovery fast spin-echo technique[J].Neuroradiology,2015,57:357-365.
11 罗清礼.甲状腺相关眼病[M].北京:人民卫生出版社,2005,20-31.
12 Garrity JA,Bahn RS.Pathogenesis of graves ophthalmopathy:implications for prediction prevention and treatment[J].Am J Ophthalmol,2006,142:147-153.