MMP-9、GA、HbA1c和脂肪因子水平与DR的相关性分析
|
摘要
目的:探讨基质金属蛋白酶-9(MMP-9)、糖化白蛋白(GA)、糖化血红蛋白(Hb A1c)和脂肪因子(包括内脂素、抵抗素和瘦素)与糖尿病视网膜病变(DR)的相关性。方法:选取2015-03/2017-03在我院治疗的DR患者74例148眼,其中非增生性糖尿病视网膜病变患者(NPDR)40例80眼,增生性糖尿病视网膜病变患者(PDR)34例68眼,同时选取非DR单纯糖尿病患者(NDR)40例80眼以及健康志愿者40例80眼作为对照,检测各组MMP-9、GA、Hb A1c、内脂素、抵抗素和瘦素水平。结果:PDR组内脂素为4.41±0.82ng/m L,明显低于NPDR组、NDR和对照组(P<0.05),而抵抗素、瘦素和MMP-9分别为9.01±1.04ng/m L、17.96±2.03μg/L和740.06±84.43μg/L,GA和Hb A1c分别为26.14%±4.57%、17.60%±1.91%,明显高于NPDR组、NDR组和对照组(P<0.05);NPDR组内脂素为6.44±0.79ng/m L,明显低于NDR和对照组(P<0.05),而抵抗素、瘦素和MMP-9分别为7.80±0.87ng/m L、15.68±1.98μg/L、634.12±80.22μg/L,GA和Hb A1c分别为22.06%±4.38%、12.46%±1.69%,明显高于NDR组和对照组(P<0.05);MMP-9、GA、Hb A1c与DR水平呈正相关(r_s=0.523、0.461、0.414,P<0.05);内脂素与DR呈负相关(r_s=-0.433,P<0.05),抵抗素和瘦素与DR水平呈正相关结论:MMP-9、GA、Hb A1c和脂肪因子可能在DR发生发展中有一定作用,其中MMP-9和脂肪因子有相关性,两者与GA、Hb A1c水平无明显关系。
AIM:To investigate the correlation of matrix metalloproteinase-9( M M P-9),glycated albumin( GA),glycosylated hemoglobin( HbA1c) and adipokines( including visfatin,resistin and leptin) with diabetic retinopathy( DR).METHODS:From March 2015 to March 2017,74 patients with DR were treated in our hospital,including 40 patients( 80 eyes) with non proliferative diabetic retinopathy( NPDR) and 34 patients( 68 eyes) with proliferative diabetic retinopathy( PDR),and diabetes mellitus 40 patients( 80 eyes) with non DR( NDR) and 40 healthy volunteer_s( 80 eyes) were selected as controls,the levels of M M P-9,GA,HbA1c,visfatin,resistin and leptin in each group were detected. RESULTS:PDR group visfatin was 4.41 ± 0.82 ng/mL,was significantly lower than the NPDR group,NDR group and control group( P < 0.05),while,resistin,leptin and M M P-9 were 9.01 ± 1.04 ng/mL,17.96 ± 2.03μ g/L and740.06 ± 84.43μ g/L,GA and HbA1c were 26.14% ± 4.57%and 17.60% ± 1.91%,significantly higher than those of NPDR group,NDR group and control group( P < 0.05).NPDR group visfatin was 6.44 ± 0.79 ng/mL,was significantly lower than that of NDR group and control group( P<0.05),while,resistin,leptin and M M P-9 were7.80±0.87 ng/ml,15.68± 1.98μ g/L and 634.12± 80.22μ g/L,GA and HbA1c were 22.06% ± 4.38% and 12.46% ± 1.69%,significantly higher than those of NDR group and control group( P < 0.05).M M P-9,GA,HbA1c were positively with DR levels( r_s= 0.523,0.461 and 0.414,P < 0.05);visfatin was negatively correlated with DR levels( r_s=-0.433,P < 0.05),resistin and leptin were positively correlated with DR levels( r_s= 0.401 and 0.460,P<0.05).CONCLUSION:MMP-9,GA,HbA1c,and adipokines may play a role in the development and progression of DR,in which M M P-9 is associated with adipokines,both are not significantly related to the levels of GA and HbA1c.
AIM:To investigate the correlation of matrix metalloproteinase-9( M M P-9),glycated albumin( GA),glycosylated hemoglobin( HbA1c) and adipokines( including visfatin,resistin and leptin) with diabetic retinopathy( DR).METHODS:From March 2015 to March 2017,74 patients with DR were treated in our hospital,including 40 patients( 80 eyes) with non proliferative diabetic retinopathy( NPDR) and 34 patients( 68 eyes) with proliferative diabetic retinopathy( PDR),and diabetes mellitus 40 patients( 80 eyes) with non DR( NDR) and 40 healthy volunteer_s( 80 eyes) were selected as controls,the levels of M M P-9,GA,HbA1c,visfatin,resistin and leptin in each group were detected. RESULTS:PDR group visfatin was 4.41 ± 0.82 ng/mL,was significantly lower than the NPDR group,NDR group and control group( P < 0.05),while,resistin,leptin and M M P-9 were 9.01 ± 1.04 ng/mL,17.96 ± 2.03μ g/L and740.06 ± 84.43μ g/L,GA and HbA1c were 26.14% ± 4.57%and 17.60% ± 1.91%,significantly higher than those of NPDR group,NDR group and control group( P < 0.05).NPDR group visfatin was 6.44 ± 0.79 ng/mL,was significantly lower than that of NDR group and control group( P<0.05),while,resistin,leptin and M M P-9 were7.80±0.87 ng/ml,15.68± 1.98μ g/L and 634.12± 80.22μ g/L,GA and HbA1c were 22.06% ± 4.38% and 12.46% ± 1.69%,significantly higher than those of NDR group and control group( P < 0.05).M M P-9,GA,HbA1c were positively with DR levels( r_s= 0.523,0.461 and 0.414,P < 0.05);visfatin was negatively correlated with DR levels( r_s=-0.433,P < 0.05),resistin and leptin were positively correlated with DR levels( r_s= 0.401 and 0.460,P<0.05).CONCLUSION:MMP-9,GA,HbA1c,and adipokines may play a role in the development and progression of DR,in which M M P-9 is associated with adipokines,both are not significantly related to the levels of GA and HbA1c.
引文
1陈一丁,姚伟峰,钱铁镛,等.Hb A1c和FPG水平与2型糖尿病患者视网膜病变的相关性分析.现代生物医学进展2013;13(34):6700-6702
2 花蒂豪,徐奕爽,邢怡桥.糖尿病视网膜病变患者的病变程度及糖化血红蛋白水平与视网膜血管血氧饱和度相关性研究.中华眼底病杂志2017;33(1):36-39
3 杨浩,李乔.糖化血红蛋白水平与2型糖尿病老年患者视网膜病变相关性分析.检验医学与临床2013;10(11):1441-1442
4 程金涛,戚金泽,梁佳美,等.糖尿病视网膜病变患者血清apelin与血脂水平观察.中华眼底病杂志2015;31(2):139-142
5 王志慧,于新,陈长香.糖化血红蛋白与糖尿病视网膜病变患者视力损害程度的相关性.职业与健康2015;31(3):430-432
6 徐清田,马宁,成兴波.血清中期因子水平与糖尿病视网膜病变的相关性研究.中国糖尿病杂志2015;23(11):991-994
7 信中,袁明霞,冯建萍,等.空腹血糖、OGTT2h血糖和糖化血红蛋白同糖尿病视网膜病变的相关性比较.首都医科大学学报2012;33(4):477-480
8 李宜川,母传贤,沈永杰,等.糖尿病视网膜病变与血清标志物的相关性研究.现代预防医学2012;39(13):3404-3405
9 刘薇,华琳,张雪莲,等.2型糖尿病患者C肽水平与糖尿病视网膜病变的关系研究.中国全科医学2013;16(23):2667-2670
10 纪丽君,孙景莹,梁俊芳,等.糖尿病视网膜病变与血糖控制情况临床分析.中国实用眼科杂志2014;32(4):478-480
11 何永文,李春花.糖尿病视网膜病变患者血清网膜素-1、同型半胱氨酸及糖化血红蛋白水平变化的研究.中国医师杂志2015;17(9):1384-1385
12 边海霞,张红兵.糖尿病视网膜病变脂肪因子与血管病变相关因子关系的研究.昆明医科大学学报2015;36(1):108-111
13 杨桂珍.糖尿病患者血浆糖化血红蛋白与微血管并发症的相关性.实用预防医学2012;19(8):143-144,155
14 李娜,杨秀芬,邓禹,等.2型糖尿病患者自我管理水平与糖尿病视网膜病变的相关性研究.中华眼科杂志2013;49(6):500-506
15 陈永生.2型糖尿病视网膜病变与visfatin和SAA的相关性研究.国际眼科杂志2012;12(1):39-42
2 花蒂豪,徐奕爽,邢怡桥.糖尿病视网膜病变患者的病变程度及糖化血红蛋白水平与视网膜血管血氧饱和度相关性研究.中华眼底病杂志2017;33(1):36-39
3 杨浩,李乔.糖化血红蛋白水平与2型糖尿病老年患者视网膜病变相关性分析.检验医学与临床2013;10(11):1441-1442
4 程金涛,戚金泽,梁佳美,等.糖尿病视网膜病变患者血清apelin与血脂水平观察.中华眼底病杂志2015;31(2):139-142
5 王志慧,于新,陈长香.糖化血红蛋白与糖尿病视网膜病变患者视力损害程度的相关性.职业与健康2015;31(3):430-432
6 徐清田,马宁,成兴波.血清中期因子水平与糖尿病视网膜病变的相关性研究.中国糖尿病杂志2015;23(11):991-994
7 信中,袁明霞,冯建萍,等.空腹血糖、OGTT2h血糖和糖化血红蛋白同糖尿病视网膜病变的相关性比较.首都医科大学学报2012;33(4):477-480
8 李宜川,母传贤,沈永杰,等.糖尿病视网膜病变与血清标志物的相关性研究.现代预防医学2012;39(13):3404-3405
9 刘薇,华琳,张雪莲,等.2型糖尿病患者C肽水平与糖尿病视网膜病变的关系研究.中国全科医学2013;16(23):2667-2670
10 纪丽君,孙景莹,梁俊芳,等.糖尿病视网膜病变与血糖控制情况临床分析.中国实用眼科杂志2014;32(4):478-480
11 何永文,李春花.糖尿病视网膜病变患者血清网膜素-1、同型半胱氨酸及糖化血红蛋白水平变化的研究.中国医师杂志2015;17(9):1384-1385
12 边海霞,张红兵.糖尿病视网膜病变脂肪因子与血管病变相关因子关系的研究.昆明医科大学学报2015;36(1):108-111
13 杨桂珍.糖尿病患者血浆糖化血红蛋白与微血管并发症的相关性.实用预防医学2012;19(8):143-144,155
14 李娜,杨秀芬,邓禹,等.2型糖尿病患者自我管理水平与糖尿病视网膜病变的相关性研究.中华眼科杂志2013;49(6):500-506
15 陈永生.2型糖尿病视网膜病变与visfatin和SAA的相关性研究.国际眼科杂志2012;12(1):39-42