摘要
脾脏是一种免疫器官,具有清除丧失功能的血细胞和抵御细菌感染的功能。随着脾切除术的广泛应用,术后感染性并发症已越来越得到重视。本文主要介绍脾切除术后感染性并发症,并从患者教育、药物预防、疫苗接种、建立患者管理系统以及改进手术等方面讨论其预防措施的相关研究进展。
The spleen, an immunogical organ, can filtrate blood to clear unfunctional blood cells and defend bacterial infection. Nowadays, with the wide application of splenectomy, postsplenectomy infective complications get more and more attention. In this article, we discuss about postsplenctomy infective complications and the research progress of the precautions through patient education, medication, vaccination and operation improvement.
引文
[1]姜洪池.从百年回眸视角看脾脏外科进展[J].中华消化外科杂志, 2015, 14(1):前插13-14.
[2]Leone G, Pizzigallo E. Bacterial infections following splenectomy for malignant and nonmalignant hematologic diseases[J]. Mediterr J Hematol Infect Dis, 2015, 7(1):e2015057.
[3]Thomsen RW, Schoonen WM, Farkas DK, et al. Risk for hospital contact with infection in patients with splenectomy:a populationbased cohort study[J]. Ann Intern Med, 2009, 151(8):546-555.
[4]Barmparas G, Lamb AW, Lee D, et al. Postoperative infection risk after splenectomy:A prospective cohort study[J]. Int J Surg, 2015,17:10-14.
[5]汪大伟,姜洪池.脾切除术后并发症及处理[J].腹部外科,2012, 25(1):7-8.
[6]Boyle S, White RH, Brunson A, et al. Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia[J]. Blood, 2013, 121(23):4782-4790.
[7]Bisharat N, Omari H, Lavi I, et al. Risk of infection and death among post-splenectomy patients[J]. J Infect, 2001, 43(3):182-186.
[8]Sinwar PD. Overwhelming post splenectomy infection syndromereview study[J]. Int J Surg, 2014,12(12):1314-1316.
[9]Chong J, Jones P, Spelman D, et al. Overwhelming postsplenectomy sepsis in patients with asplenia and hyposplenia:A retrospective cohort study[J]. Epidemiol Infect, 2017, 145(2):397-400.
[10] Madenci AL, Armstrong LB, Kwon NK, et al. Incidence and risk factors for sepsis after childhood splenectomy[J]. J Pediatr Surg,2018, 3468(18):30401-30409.
[11] Benz F, Roy S, Trautwein C, et al. Circulating microRNAs as biomarkers for sepsis[J]. Int J Mol Sci, 2016, 17(1):78.
[12] Brigden ML. Detection, education and management of the asplenic or hyposplenic patient[J]. Am Fam Physician, 2001, 63(3):499-506, 508.
[13] El-Alfy MS, El-Sayed MH. Overwhelming postsplenectomy infection:is quality of patient knowledge enough for prevention?[J].Hematol J, 2004, 5(1):77-80.
[14] Chaturvedi S, Arnold DM, McCrae KR. Splenectomy for immune thrombocytopenia:down but not out[J]. Blood, 2018, 131(11):1172-1182.
[15] Coccolini F, Montori G, Catena F, et al. Splenic trauma:WSES classification and guidelines for adult and pediatric patients[J].World J Emerg Surg, 2017, 12:40.
[16] Engelhardt M, Eber S W, Germing U, et al. Pr?vention von Infektionen und Thrombosen nach Splenektomie oder funktioneller Asplenie[J]. DGHO Onkopedia. Available online at:http://www.dghoonkopedia. de/de/onkopedia/leitlinien/praevention-voninfektionenund-thrombosen-nach/pra-vention-von-infektionenund-thrombosennach. pdf. Accessed, 2014, 12.
[17] Davies IL, Cho J, Lewis MH. Splenectomy results from an 18-year single centre experience[J]. Ann R Coll Surg Engl, 2014, 96(2):147-150.
[18] Jones P, Leder K, Woolley I, et al. Postsplenectomy infection--strategies for prevention in general practice[J]. Aust Fam Physician, 2010, 39(6):383-386.
[19] BonanniP, GrazziniM,NiccolaiG,et al.Recommended vaccinations for asplenic and hyposplenic adult patients[J]. Hum Vaccin Immunother, 2017, 13(2):359-368
[20] Klein NP, Habanec T, Kosina P, et al. Immunogenicity and safetyof thequadrivalentmeningococcalACWY-tetanus toxoid conjugate vaccine(MenACWY-TT)in splenectomized or hyposplenic children and adolescents:Results of a phase III, open,non-randomized study[J]. Vaccine, 2018, 36(17):2356-2363.
[21] Langley JM, Dodds L, Fell D, et al. Pneumococcal and influenza immunization in asplenic persons:a retrospective populationbased cohort study 1990-2002[J]. BMC Infect Dis, 2010, 10(1):219.
[22] Stanford E, Print F, Falconer M, et al. Immune response to pneumococcal conjugate vaccination in asplenic individuals[J].Hum Vaccin, 2009, 5(2):85-91.
[23] Blaabjerg AK, Schumacher AH, Kants?B, et al. Recurrent invasive pneumococcal disease serotype 12F in a vaccinated splenectomized patient[J]. Eur J Microbiol Immunol(Bp), 2016,6(1):81-84.
[24] Luu S, Dendle C, Jones P, et al. Impact of a spleen registry on optimal post-splenectomy vaccination and care[J]. Hum Vaccin Immunother, 2018:1-6.