非参数概率法评估2015—2017年深圳地区9类食品黄曲霉毒素膳食暴露风险
|
摘要
目的对深圳居民通过市售9类食品产生的黄曲霉毒素膳食暴露及其健康风险进行评价。方法 2015年3月至2017年11月收集深圳地区10个行政区9大类26种1038份食品样品,利用食品中黄曲霉毒素(AFT)污染水平数据和当地居民膳食消费数据,使用蒙特卡洛非参数评估方法,评估食品中黄曲霉毒素对深圳地区人群健康的影响。结果深圳地区居民全人群9类食品黄曲霉毒素平均暴露量和高消费暴露量分别为0.8533 ng/(kg·BW·d)和2.1646 ng/(kg·BW·d);对黄曲霉毒素B1(AFB1)平均暴露量和高消费暴露量分别为0.5113 ng/(kg·BW·d)和1.3264 ng/(kg·BW·d);AFB1膳食摄入增加肝癌年发病率为0.0199/万人和0.0517/万人。深圳地区黄曲霉毒素膳食摄入主要暴露贡献食品为玉米制品、米及米制品、花生油/玉米油。结论深圳地区膳食中黄曲霉毒素引发肝癌的总体健康风险较低,但应持续监管特殊人群主要暴露贡献食品的暴露水平。
Objective To assess Shenzhen residents' dietary exposure to aflatoxins from 9 kinds of foods and health risk. Methods Dietary intake of aflatoxins from local concentration data and foodstuff consumption data was simulated by Mont Carlo nonparametric probability approach. Results Aflatoxins( AFT) average intake and high intake were 0. 8533 ng/( kg·BW·d) and 2. 1646 ng/( kg·BW·d),respectively. Aflatoxin B1( AFB1) average level intake and higher level intake were 0. 5113 ng/( kg·BW·d) and1. 3264 ng/( kg·BW·d),respectively. The potential risk for cancer using average data was estimated at 0. 0199 people/( ten thousand people·year),even though this was0. 0517 people/( ten thousand people·year) in higher level. Major exposure contribution to food were corn and products,rice and products,and peanut oil,corn oil. Conclusion The current dietary intake of AFB1 and AFT in Shenzhen has no appreciable effect on health. Government action should be maintained and improved in order to guarantee,aiming at major exposure contribution to food,that special human exposure levels are kept was low as possible.
Objective To assess Shenzhen residents' dietary exposure to aflatoxins from 9 kinds of foods and health risk. Methods Dietary intake of aflatoxins from local concentration data and foodstuff consumption data was simulated by Mont Carlo nonparametric probability approach. Results Aflatoxins( AFT) average intake and high intake were 0. 8533 ng/( kg·BW·d) and 2. 1646 ng/( kg·BW·d),respectively. Aflatoxin B1( AFB1) average level intake and higher level intake were 0. 5113 ng/( kg·BW·d) and1. 3264 ng/( kg·BW·d),respectively. The potential risk for cancer using average data was estimated at 0. 0199 people/( ten thousand people·year),even though this was0. 0517 people/( ten thousand people·year) in higher level. Major exposure contribution to food were corn and products,rice and products,and peanut oil,corn oil. Conclusion The current dietary intake of AFB1 and AFT in Shenzhen has no appreciable effect on health. Government action should be maintained and improved in order to guarantee,aiming at major exposure contribution to food,that special human exposure levels are kept was low as possible.
引文
[1]International Agency for Research on Cancer(IARC).WHO IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.Some traditional herbal medicines,some mycotoxins,naphthalene and styrene.Aflatoxins[R].Lyon:IARC,2002,82:1-556.
[2]Joint Food and Agricultural Organization/World Health Organization(FAO/WHO)Expert Committee on Food Additives(JECFA).Safety evaluation of certain food additives and contaminants[R].Geneva:JECFA,2008:330-332.
[3]European Commission.Commission Regulation:No.1881/2006 setting maximum levels for certain contaminants in foodstuffs[J].Off J Eur Union,2006,364:5-24.
[4]中国国家卫生和计划生育委员会,国家食品药品监督管理总局.食品安全国家标准食品中真菌毒素限量:GB 2761—2017[S].北京:中国标准出版社,2017.
[5]SUGITA-KONISHI Y,SATO T,SAITO S,et al.Exposure to aflatoxins in Japan:risk assessment for aflatoxin B1[J].Food Addit Contam,2010,27(3):365-372.
[6]SIGNORINI M L,GAGGIOTTI M,MOLINERI A,et al.Exposure assess-ment of mycotoxins in cow's milk in Argentina[J].Food Chem Toxicol,2012,50(2):250-257.
[7]丁小霞,李培武,白艺珍,等.中国花生黄曲霉毒素风险评估中膳食暴露非参数概率评估方法[J].中国油料作物学报,2011,33(4):402-408.
[8]刘文静,潘葳.福建产后花生黄曲霉毒素污染分布及膳食暴露评估[J].粮食与饲料工业,2016,11(7):28-31.
[9]耿梦梦,徐明芳,王阳,等.基于Monte Carlo模拟法对液态乳中黄曲霉毒素M1的风险评估[J].食品科学,2018,39(5):226-233.
[10]郭耀东,陈璐,袁亚宏.基于概率分析的玉米食品中黄曲霉毒素B1膳食暴露及风险评估[J].食品科学,2013,34(11):24-27.
[11]王君,刘秀梅.中国人群黄曲霉毒素膳食暴露量评估[J].中国食品卫生杂志,2007,19(3):238-240.
[12]张宸.我国主要食品中黄曲霉毒素B1调查与风险评估[D].西安:西北农林科技大学,2008:18-33.
[13]李可,丘汾,蒋立新,等.深圳地区人群粮油食品中黄曲霉毒素膳食暴露评估[J].卫生研究,2014,43(4):630-636.
[14]李杉,杨丽,袁蒲.河南省居民黄曲霉毒素河南省居民黄曲霉毒素膳食暴露量评估[J].现代预防医学,2016,43(6):1008-1010.
[15]World Health Organization.Reliable evaluation of low-level contamination of food-workshop in the frame of GEMS/Food-EURO.Kulmbach,Germany,26-27 May 1995-ADDENDUM January 2013[EB/OL].[2013-03-09].http://www.who.int/foodsafety/publications/chem./lowl Level_may1995/en/index.html.
[16]中国国家质量监督检验检疫总局.食品中黄曲霉毒素的测定免疫亲和层析净化高效液相色谱法:GB/T 18979—2003[S].北京:中国标准出版社,2003.
[17]Food and Agriculture Organization of the United Nations/World Health Organization(FAO/WHO).2005.Dietary exposure assessment of chemicals in food:report of a joint FAO/WHO consultation[EB/OL].[2012-08-29].http://whqlibdoc.who.int/publications/2008/97892415597470_eng.pdf.
[18]张磊,刘爱东,刘兆平,等.食品化学物高端暴露膳食模型的建立[J].中华预防医学杂志,2013,47(6):565-568.
[19]European Food Safety Authority.Guidance Document for the use of the Concise European Food Consumption Database in Exposure Assessment[EB/OL].[2008-03-01].http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/datexfooddbguidance.pdf.
[20]WHO.Evaluation of Certain Food Additives and Contaminationes.Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives[R].Geneva:WHO,1999:69-77.
[21]梁剑,邵晓萍,吴承刚,等.广东省乙型病毒性肝炎表面抗原携带率的变化分析[J].华南预防医学2011,37(4):40-42.
[22]ANDRADE P D,HOMEM DE MELLO M,FRANCA J A.Aflatoxins in food products consumed in Brazil:a preliminary dietary risk assessment[J].Food Addit Contam,2013,30(1):127-136.
[23]European Food Safety Authority(EFSA).Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to the potential increase of consumer health risk by a possible increase of the existing maximum levels for aflatoxins in almonds,hazelnuts and pistachios and derived products[R].EFSA J,2007,446:1-127.
[2]Joint Food and Agricultural Organization/World Health Organization(FAO/WHO)Expert Committee on Food Additives(JECFA).Safety evaluation of certain food additives and contaminants[R].Geneva:JECFA,2008:330-332.
[3]European Commission.Commission Regulation:No.1881/2006 setting maximum levels for certain contaminants in foodstuffs[J].Off J Eur Union,2006,364:5-24.
[4]中国国家卫生和计划生育委员会,国家食品药品监督管理总局.食品安全国家标准食品中真菌毒素限量:GB 2761—2017[S].北京:中国标准出版社,2017.
[5]SUGITA-KONISHI Y,SATO T,SAITO S,et al.Exposure to aflatoxins in Japan:risk assessment for aflatoxin B1[J].Food Addit Contam,2010,27(3):365-372.
[6]SIGNORINI M L,GAGGIOTTI M,MOLINERI A,et al.Exposure assess-ment of mycotoxins in cow's milk in Argentina[J].Food Chem Toxicol,2012,50(2):250-257.
[7]丁小霞,李培武,白艺珍,等.中国花生黄曲霉毒素风险评估中膳食暴露非参数概率评估方法[J].中国油料作物学报,2011,33(4):402-408.
[8]刘文静,潘葳.福建产后花生黄曲霉毒素污染分布及膳食暴露评估[J].粮食与饲料工业,2016,11(7):28-31.
[9]耿梦梦,徐明芳,王阳,等.基于Monte Carlo模拟法对液态乳中黄曲霉毒素M1的风险评估[J].食品科学,2018,39(5):226-233.
[10]郭耀东,陈璐,袁亚宏.基于概率分析的玉米食品中黄曲霉毒素B1膳食暴露及风险评估[J].食品科学,2013,34(11):24-27.
[11]王君,刘秀梅.中国人群黄曲霉毒素膳食暴露量评估[J].中国食品卫生杂志,2007,19(3):238-240.
[12]张宸.我国主要食品中黄曲霉毒素B1调查与风险评估[D].西安:西北农林科技大学,2008:18-33.
[13]李可,丘汾,蒋立新,等.深圳地区人群粮油食品中黄曲霉毒素膳食暴露评估[J].卫生研究,2014,43(4):630-636.
[14]李杉,杨丽,袁蒲.河南省居民黄曲霉毒素河南省居民黄曲霉毒素膳食暴露量评估[J].现代预防医学,2016,43(6):1008-1010.
[15]World Health Organization.Reliable evaluation of low-level contamination of food-workshop in the frame of GEMS/Food-EURO.Kulmbach,Germany,26-27 May 1995-ADDENDUM January 2013[EB/OL].[2013-03-09].http://www.who.int/foodsafety/publications/chem./lowl Level_may1995/en/index.html.
[16]中国国家质量监督检验检疫总局.食品中黄曲霉毒素的测定免疫亲和层析净化高效液相色谱法:GB/T 18979—2003[S].北京:中国标准出版社,2003.
[17]Food and Agriculture Organization of the United Nations/World Health Organization(FAO/WHO).2005.Dietary exposure assessment of chemicals in food:report of a joint FAO/WHO consultation[EB/OL].[2012-08-29].http://whqlibdoc.who.int/publications/2008/97892415597470_eng.pdf.
[18]张磊,刘爱东,刘兆平,等.食品化学物高端暴露膳食模型的建立[J].中华预防医学杂志,2013,47(6):565-568.
[19]European Food Safety Authority.Guidance Document for the use of the Concise European Food Consumption Database in Exposure Assessment[EB/OL].[2008-03-01].http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/datexfooddbguidance.pdf.
[20]WHO.Evaluation of Certain Food Additives and Contaminationes.Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives[R].Geneva:WHO,1999:69-77.
[21]梁剑,邵晓萍,吴承刚,等.广东省乙型病毒性肝炎表面抗原携带率的变化分析[J].华南预防医学2011,37(4):40-42.
[22]ANDRADE P D,HOMEM DE MELLO M,FRANCA J A.Aflatoxins in food products consumed in Brazil:a preliminary dietary risk assessment[J].Food Addit Contam,2013,30(1):127-136.
[23]European Food Safety Authority(EFSA).Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to the potential increase of consumer health risk by a possible increase of the existing maximum levels for aflatoxins in almonds,hazelnuts and pistachios and derived products[R].EFSA J,2007,446:1-127.