中性粒细胞产生活性氧在肿瘤发生发展中作用的研究进展
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摘要
中性粒细胞是人体固有免疫系统的重要组成部分,在抵抗病原体入侵、肿瘤免疫监视等方面起着重要作用。中性粒细胞内产生的活性氧对肿瘤的发生发展具有双向作用。一方面,它可以促进肿瘤细胞的生长和转移;另一方面,它又可通过不同的作用机制诱导肿瘤细胞的死亡。文中将归纳总结近年来中性粒细胞内产生的活性氧在肿瘤发展中的作用和肿瘤治疗中的前景,以期为肿瘤防治领域的研究提供新的思路。
Neutrophil is an important part of innate immune system,and plays a key role in resisting pathogen invasion and tumor immune surveillance. Meanwhile,neutrophil could produce reactive oxygen species,which are side products of cell metabo?lism. It is closely related to tumor development and progression. On the one hand,neutrophil could produce ROS to promote tumor growth and metastasis. On the other hand,it could also induce tumor cell death through different mechanisms. In this review,we sum?marize the roles of neutrophil-derived ROS in tumor development and discuss its prospects in cancer treatment.
Neutrophil is an important part of innate immune system,and plays a key role in resisting pathogen invasion and tumor immune surveillance. Meanwhile,neutrophil could produce reactive oxygen species,which are side products of cell metabo?lism. It is closely related to tumor development and progression. On the one hand,neutrophil could produce ROS to promote tumor growth and metastasis. On the other hand,it could also induce tumor cell death through different mechanisms. In this review,we sum?marize the roles of neutrophil-derived ROS in tumor development and discuss its prospects in cancer treatment.
引文
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[33]Granot Z,Henke E,Comen EA,et al.Tumor entrained neutrophils inhibit seeding in the premetastatic lung[J].Cancer Cell,2011,20(3):300-314.
[34]Raccosta L,Fontana R,Maggioni D,et al.The oxysterol-CX-CR2 axis plays a key role in the recruitment of tumor-promoting neutrophils[J].J Exp Med,2013,210(9):1711-1728.
[35]Rao HL,Chen JW,Li M,et al.Increased intratumoral neutrophil in colorectal carcinomas correlates closely with malignant phenotype and predicts patients′adverse prognosis[J].PLoSOne,2012,7(1):e30806.
[36]Motomura T,Shirabe K,Mano Y,et al.Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment[J].J Hepatol,2013,58(1):58-64.
[37]Lai Q,Castro Santa E,Rico Juri JM,et al.Neutrophil and platelet-to-lymphocyte ratio as new predictors of dropout and recurrence after liver transplantation for hepatocellular cancer[J].Transpl Int,2014,27(1):32-41.
[38]李文,王璐,张军成,等.术前外周血中性粒细胞及血小板与淋巴细胞比值对子宫内膜癌患者预后的影响[J].医学研究生学报,2018,31(1):60-64.
[39]Blache CA,Manuel ER,Kaltcheva TI,et al.Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth[J].Cancer Res,2012,72(24):6447-6456.
[2]Shen M,Hu P,Donskov F,et al.Tumor-associated neutrophils as a new prognostic factor in cancer:a systematic review and meta-analysis[J].PLoS One,2014,9(6):e98259.
[3]Lippitz BE.Cytokine patterns in patients with cancer:a systematic review[J].Lancet Oncol,2013,14(6):e218-228.
[4]Landskron G,De la Fuente M,Thuwajit P,et al.Chronic inflammation and cytokines in the tumor microenvironment[J].JImmunol Res,2014,2014:149185.
[5]Jaganjac M,Cipak A,Schaur RJ,et al.Pathophysiology of neutrophil-mediated extracellular redox reactions[J].Front Biosci(Landmark Ed),2016,11(21):839-855.
[6]Winterbourn CC,Kettle AJ,Hampton MB.Reactive Oxygen Species and Neutrophil Function[J].Annu Rev Biochem,2016,85:765-792.
[7]Kim J,Bae JS.Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment[J].Mediators Inflamm,2016,2016:6058147.
[8]McCracken JM,Allen LA.Regulation of human neutrophil apoptosis and lifespan in health and disease[J].J Cell Death,2014,7:15-23.
[9]Thieblemont N,Wright HL,Edwards SW,et al.Human neutrophils in auto-immunity[J].Semin Immunol,2016,28(2):159-173.
[10]Endo D,Fujimoto K,Hirose R,et al.Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans-Induced Inflammation in Mouse Lungs[J].Inflammation,2017,40(1):123-135.
[11]孙全贵,龙子,张晓迪,等.抗氧化系统研究新进展[J].现代生物医学进展,2016,16(11):2197-2200+2190.
[12]Yang Y,Karakhanova S,Werner J,et al.Reactive oxygen species in cancer biology and anticancer therapy[J].Curr Med Chem,2013,20(30):3677-3692.
[13]Liochev SI.Reactive oxygen species and the free radical theory of aging[J].Free Radic Biol Med,2013,60:1-4.
[14]Reuter S,Gupta SC,Chaturvedi MM,et al.Oxidative stress,inflammation,and cancer:how are they linked?[J]Free Radic Biol Med,2010,49(11):1603-1616.
[15]Wilson CL,Jurk D,Fullard N,et al.NFkappaB1 is a suppressor of neutrophil-driven hepatocellular carcinoma[J].Nat Commun,2015,6:6818.
[16]Jackson JH,Gajewski E,Schraufstatter IU,et al.Damage to the bases in DNA induced by stimulated human neutrophils[J].J Clin Invest,1989,84(5):1644-1649.
[17]Gungor N,Knaapen AM,Munnia A,et al.Genotoxic effects of neutrophils and hypochlorous acid[J].Mutagenesis,2010,25(2):149-154.
[18]Ayala A,Munoz MF,Arguelles S.Lipid peroxidation:production,metabolism,and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal[J].Oxid Med Cell Longev,2014,2014:360438.
[19]朱茂祥,杨陟华,龚诒芬,等.活性氧诱发人类11号染色体基因突变[J].中国生物化学与分子生物学学报,2002,18(1):92-98.
[20]Shrihari TG.Dual role of inflammatory mediators in cancer[J].Ecancermedicalscience,2017,11:721.
[21]De Larco JE,Wuertz BR,Furcht LT.The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8[J].Clin Cancer Res,2004,10(15):4895-4900.
[22]Klink M,Jastrzembska K,Nowak M,et al.Ovarian cancer cells modulate human blood neutrophils response to activation in vitro[J].Scand J Immunol,2008,68(3):328-336.
[23]Lood C,Blanco LP,Purmalek MM,et al.Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease[J].Nat Med,2016,22(2):146-153.
[24]Wang J,Shi Q,Yuan TX,et al.Matrix metalloproteinase 9(MMP-9)in osteosarcoma:review and meta-analysis[J].Clin Chim Acta,2014,433:225-231.
[25]Li H,Zhang K,Liu LH,et al.A systematic review of matrix metalloproteinase 9 as a biomarker of survival in patients with osteosarcoma[J].Tumour Biol,2014,35(6):5487-5491.
[26]Demers M,Wagner DD.NETosis:a new factor in tumor progression and cancer-associated thrombosis[J].Semin Thromb Hemost,2014,40(3):277-283.
[27]Mishalian I,Bayuh R,Levy L,et al.Tumor-associated neutrophils(TAN)develop pro-tumorigenic properties during tumor progression[J].Cancer Immunol Immunother,2013,62(11):1745-1756.
[28]Sionov RV,Fridlender ZG,Granot Z.The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment[J].Cancer Microenviron,2015,8(3):125-158.
[29]Yan J,Kloecker G,Fleming C,et al.Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells[J].Oncoimmunology,2014,3(7):e950163.
[30]Chen CL,Wang Y,Huang CY,et al.IL-17 induces antitumor immunity by promoting beneficial neutrophil recruitment and activation in esophageal squamous cell carcinoma[J].Oncoimmunology,2017,7(1):e1373234.
[31]Takeshimaa T,Popb LM,Lainea A,et al.Key role for neutrophils in radiation-induced antitumor immune responses:Potentiation with G-CSF[J].Proc Natl Acad Sci USA,2016,113(40):11300-11305.
[32]Pizzimenti S,Toaldo C,Pettazzoni P,et al.The“two-faced”effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancer[J].Cancers(Basel),2010,2(2):338-363.
[33]Granot Z,Henke E,Comen EA,et al.Tumor entrained neutrophils inhibit seeding in the premetastatic lung[J].Cancer Cell,2011,20(3):300-314.
[34]Raccosta L,Fontana R,Maggioni D,et al.The oxysterol-CX-CR2 axis plays a key role in the recruitment of tumor-promoting neutrophils[J].J Exp Med,2013,210(9):1711-1728.
[35]Rao HL,Chen JW,Li M,et al.Increased intratumoral neutrophil in colorectal carcinomas correlates closely with malignant phenotype and predicts patients′adverse prognosis[J].PLoSOne,2012,7(1):e30806.
[36]Motomura T,Shirabe K,Mano Y,et al.Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment[J].J Hepatol,2013,58(1):58-64.
[37]Lai Q,Castro Santa E,Rico Juri JM,et al.Neutrophil and platelet-to-lymphocyte ratio as new predictors of dropout and recurrence after liver transplantation for hepatocellular cancer[J].Transpl Int,2014,27(1):32-41.
[38]李文,王璐,张军成,等.术前外周血中性粒细胞及血小板与淋巴细胞比值对子宫内膜癌患者预后的影响[J].医学研究生学报,2018,31(1):60-64.
[39]Blache CA,Manuel ER,Kaltcheva TI,et al.Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth[J].Cancer Res,2012,72(24):6447-6456.